|
US20060134243A1
(en)
*
|
2004-12-17 |
2006-06-22 |
Bionovo, Inc. |
Method of using extracts of epimedium species
|
|
US7482029B2
(en)
|
2005-04-01 |
2009-01-27 |
Bionovo, Inc. |
Composition for treatment of menopause
|
|
US7700136B2
(en)
*
|
2005-11-14 |
2010-04-20 |
Bionovo, Inc. |
Scutellaria barbata extract for the treatment of cancer
|
|
JP5144532B2
(ja)
*
|
2005-11-30 |
2013-02-13 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ｃ−Ｍｅｔ阻害剤及び用法
|
|
US10022352B2
(en)
|
2006-04-07 |
2018-07-17 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
|
ES2882684T3
(es)
|
2006-04-07 |
2021-12-02 |
Vertex Pharma |
Preparación de moduladores de transportadores del casete de unión a ATP
|
|
USRE50453E1
(en)
|
2006-04-07 |
2025-06-10 |
Vertex Pharmaceuticals Incorporated |
Indole derivatives as CFTR modulators
|
|
US7645789B2
(en)
|
2006-04-07 |
2010-01-12 |
Vertex Pharmaceuticals Incorporated |
Indole derivatives as CFTR modulators
|
|
CA2651979A1
(en)
*
|
2006-05-30 |
2007-12-06 |
Pfizer Products Inc. |
Triazolopyridazine derivatives
|
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
PE20121506A1
(es)
*
|
2006-07-14 |
2012-11-26 |
Amgen Inc |
Compuestos triazolopiridinas como inhibidores de c-met
|
|
US8198448B2
(en)
|
2006-07-14 |
2012-06-12 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
US7683060B2
(en)
|
2006-08-07 |
2010-03-23 |
Incyte Corporation |
Triazolotriazines as kinase inhibitors
|
|
EA016527B1
(ru)
*
|
2006-10-23 |
2012-05-30 |
ЭсДжиЭкс ФАРМАСЬЮТИКАЛЗ, ИНК. |
Триазолопиридазиновые модуляторы протеинкиназ
|
|
CA2664114A1
(en)
|
2006-10-27 |
2008-05-02 |
Janssen Pharmaceutica Nv |
A method for profiling kinase inhibitors
|
|
US8563573B2
(en)
|
2007-11-02 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Azaindole derivatives as CFTR modulators
|
|
GEP20125658B
(en)
|
2006-11-22 |
2012-10-10 |
Incyte Corp |
Imidazotriazines and imidazo pyrimidines as kinase inhibitors
|
|
DE102007026341A1
(de)
|
2007-06-06 |
2008-12-11 |
Merck Patent Gmbh |
Benzoxazolonderivate
|
|
EP2170894A1
(en)
|
2007-06-21 |
2010-04-07 |
Janssen Pharmaceutica N.V. |
Polymorphic and hydrate forms, salts and process for preparing 6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline
|
|
US20080319051A1
(en)
*
|
2007-06-22 |
2008-12-25 |
Bionovo, Inc. |
Liquiritigenin and derivatives as selective estrogen receptor beta agonists
|
|
US20090042818A1
(en)
*
|
2007-06-22 |
2009-02-12 |
Bionovo, Inc. |
Liquiritigenin and Derivatives as Selective Estrogen Receptor Beta Agonists
|
|
EP2170337A4
(en)
|
2007-06-28 |
2013-12-18 |
Abbvie Inc |
NEW TRIAZOLOPYRIDAZINE
|
|
DE102007032507A1
(de)
|
2007-07-12 |
2009-04-02 |
Merck Patent Gmbh |
Pyridazinonderivate
|
|
CA2696304A1
(en)
*
|
2007-08-08 |
2009-02-12 |
Bionovo, Inc. |
Estrogenic extracts of ligustrum lucidum ait. of the oleaceae family and uses thereof
|
|
FR2929613B1
(fr)
*
|
2008-04-02 |
2010-12-31 |
Sanofi Aventis |
Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole,leur preparation,comme medicaments et utilisation notamment comme inhibiteurs de met
|
|
FR2919870B1
(fr)
*
|
2007-08-09 |
2014-05-16 |
Sanofi Aventis |
Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzothiazole et benzimidazole, procede, compositions pharmaceutiques et nouvelle utilisation comme inhibiteurs de cmet
|
|
PA8792501A1
(es)
*
|
2007-08-09 |
2009-04-23 |
Sanofi Aventis |
Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met.
|
|
DE102007038957A1
(de)
*
|
2007-08-17 |
2009-02-19 |
Merck Patent Gmbh |
6-Thioxo-pyridazinderivate
|
|
US20090068298A1
(en)
*
|
2007-09-07 |
2009-03-12 |
Bionovo, Inc. |
ESTROGENIC EXTRACTS OF Astragalus membranaceus Fisch. Bge. Var. mongolicus Bge. of the Leguminosae Family AND USES THEREOF
|
|
AU2008296076A1
(en)
*
|
2007-09-07 |
2009-03-12 |
Bionovo, Inc. |
Estrogenic extracts of Pueraria lobata Willd, Ohwi of the Leguminosae family and uses thereof
|
|
JP2010538093A
(ja)
*
|
2007-09-07 |
2010-12-09 |
バイオノボ・インコーポレーテッド |
シソ科ファミリーのセイタカナミキソウのエストロゲン性抽出物およびその使用
|
|
EP2194998A4
(en)
*
|
2007-09-07 |
2012-03-21 |
Bionovo Inc |
STROGENIC EXTRACTS OF ASPARAGUS CONCHINCHINENSIS (LOUR.) MERR OF THE LILIACEAE FAMILY AND USES THEREOF
|
|
AU2008326431A1
(en)
*
|
2007-11-19 |
2009-05-28 |
Bionovo, Inc. |
Scutellaria barbata extract and combinations for the treatment of cancer
|
|
AU2008326429A1
(en)
*
|
2007-11-19 |
2009-05-28 |
Bionovo, Inc. |
Anti-cancer therapy with an extract of scutellaria barbata
|
|
JP2011503237A
(ja)
*
|
2007-11-19 |
2011-01-27 |
バイオノボ・インコーポレーテッド |
Ｓｃｕｔｅｌｌａｒｉａｂａｒｂａｔａｄ．ｄｏｎの精製抽出物を作製するためのプロセス
|
|
US8512961B2
(en)
*
|
2007-11-19 |
2013-08-20 |
Bionovo, Inc. |
Methods of detecting and treatment of cancers using Scutellaria barbata extract
|
|
DE102007061963A1
(de)
*
|
2007-12-21 |
2009-06-25 |
Merck Patent Gmbh |
Pyridazinonderivate
|
|
ES2603302T3
(es)
*
|
2008-02-05 |
2017-02-24 |
Sanofi |
Imidazopiridazinas como inhibidores de PAR1, su obtención y empleo como medicamento
|
|
WO2009097970A1
(de)
*
|
2008-02-05 |
2009-08-13 |
Sanofi-Aventis |
Triazolopyridazine als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel
|
|
AU2009211888B2
(en)
*
|
2008-02-05 |
2013-06-20 |
Sanofi |
Triazolium salts as PAR1 inhibitors, production thereof, and use as medicaments
|
|
AR070487A1
(es)
|
2008-02-28 |
2010-04-07 |
Novartis Ag |
Derivados de 3- metil- imidazo -( 1,2-b)- piridazina
|
|
US20090258942A1
(en)
*
|
2008-04-14 |
2009-10-15 |
Bionovo, Inc. |
Calycosin and analogs thereof for the treatment of estrogen receptor beta-mediated diseases
|
|
DE102008019907A1
(de)
*
|
2008-04-21 |
2009-10-22 |
Merck Patent Gmbh |
Pyridazinonderivate
|
|
WO2009137534A2
(en)
*
|
2008-05-06 |
2009-11-12 |
Bionovo, Inc. |
Estrogenic extracts for use in treating vaginal and vulvar atrophy
|
|
CN103936743B
(zh)
|
2008-05-21 |
2018-04-24 |
因西特控股公司 |
2-氟-N-甲基-4-[7-(喹啉-6-基甲基)咪唑并[1,2-b][1,2,4]三嗪-2-基]苯甲酰胺的盐及与其相关的制备方法
|
|
CA2726982A1
(en)
*
|
2008-06-05 |
2009-12-10 |
Bionovo, Inc. |
Method of quantification of multiple bioactives from botanical compositions
|
|
WO2009148620A2
(en)
*
|
2008-06-06 |
2009-12-10 |
Bionovo, Inc. |
Anthraquinones and analogs from rhuem palmatum for treatment of estrogen receptor beta-mediated conditions
|
|
DE102008028905A1
(de)
*
|
2008-06-18 |
2009-12-24 |
Merck Patent Gmbh |
3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
|
|
FR2941229B1
(fr)
*
|
2009-01-21 |
2012-11-30 |
Sanofi Aventis |
Nouveaux derives triazolo°4,3-a!pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
|
|
CN102159543A
(zh)
*
|
2008-07-18 |
2011-08-17 |
赛诺菲-安万特 |
新颖的三唑并[4,3-a]吡啶衍生物，其制备方法，其作为药物的用途，药物组合物及新颖的尤其是作为MET抑制剂的用途
|
|
TWI365185B
(en)
|
2008-07-24 |
2012-06-01 |
Lilly Co Eli |
Amidophenoxyindazoles useful as inhibitors of c-met
|
|
UY32049A
(es)
|
2008-08-14 |
2010-03-26 |
Takeda Pharmaceutical |
Inhibidores de cmet
|
|
DE102008037790A1
(de)
|
2008-08-14 |
2010-02-18 |
Merck Patent Gmbh |
Bicyclische Triazolderivate
|
|
DE102008038222A1
(de)
|
2008-08-18 |
2010-02-25 |
Merck Patent Gmbh |
Indazol-5-carbonsäurehydrazid-derivate
|
|
DE102008038220A1
(de)
|
2008-08-18 |
2010-02-25 |
Merck Patent Gmbh |
Oxadiazolderivate
|
|
DE102008038221A1
(de)
|
2008-08-18 |
2010-02-25 |
Merck Patent Gmbh |
7-Azaindolderivate
|
|
WO2010028187A2
(en)
*
|
2008-09-03 |
2010-03-11 |
Bionovo, Inc. |
Methods and compositions for the treatment of cancer
|
|
JP2012509342A
(ja)
|
2008-11-20 |
2012-04-19 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン
|
|
DE102008063667A1
(de)
|
2008-12-18 |
2010-07-01 |
Merck Patent Gmbh |
3-(3-Pyrimidin-2-yl-benzyl)-°[1,2,4]triazolo[4,3-b]pyrimidin-derivate
|
|
EA019320B1
(ru)
|
2008-12-22 |
2014-02-28 |
Мерк Патент Гмбх |
Новые полиморфные формы дигидрофосфата 6-(1-метил-1h-пиразол-4-ил)-2-{3-[5-(2-морфолин-4-илэтокси)пиримидин-2-ил]бензил}-2h-пиридазин-3-она и способы их получения
|
|
DE102008062825A1
(de)
|
2008-12-23 |
2010-06-24 |
Merck Patent Gmbh |
3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo [4,3-b]pyridazin-derivate
|
|
FR2941952B1
(fr)
*
|
2009-02-06 |
2011-04-01 |
Sanofi Aventis |
Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
|
|
FR2941951B1
(fr)
*
|
2009-02-06 |
2011-04-01 |
Sanofi Aventis |
Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
|
|
FR2941949B1
(fr)
*
|
2009-02-06 |
2011-04-01 |
Sanofi Aventis |
Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met.
|
|
FR2941950B1
(fr)
*
|
2009-02-06 |
2011-04-01 |
Sanofi Aventis |
Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
|
|
CA2754180A1
(en)
*
|
2009-03-09 |
2010-09-16 |
The Regents Of The University Of California |
Substituted heterocycles and their use as allosteric modulators of nicotinic and gabaa receptors
|
|
JP2012525412A
(ja)
*
|
2009-04-28 |
2012-10-22 |
バイオノボ・インコーポレーテッド |
脂肪蓄積を減少させ、体重減少を誘導する方法
|
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
|
JP5781510B2
(ja)
|
2009-08-12 |
2015-09-24 |
ノバルティス アーゲー |
ヘテロ環式ヒドラゾン化合物および癌および炎症の処置のためのそれらの使用
|
|
CN102548995B
(zh)
*
|
2009-08-12 |
2015-01-28 |
诺华股份有限公司 |
杂环腙化合物以及它们治疗癌症和炎症的用途
|
|
MX2012002179A
(es)
|
2009-08-20 |
2012-03-16 |
Novartis Ag |
Compuestos heterociclicos de oxima.
|
|
DE102009056886A1
(de)
|
2009-12-03 |
2011-06-09 |
Bayer Schering Pharma Aktiengesellschaft |
cMet-Inhibitoren zur Behandlung der Endometriose
|
|
EP2719699B1
(en)
|
2009-12-31 |
2015-07-08 |
Hutchison Medipharma Limited |
Certain triazolopyrazines, compositions thereof and methods of use therefor
|
|
EA025304B1
(ru)
|
2010-02-03 |
2016-12-30 |
Инсайт Холдингс Корпорейшн |
ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИНЫ В КАЧЕСТВЕ c-Met ИНГИБИТОРОВ
|
|
US8802868B2
(en)
|
2010-03-25 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
|
|
RU2569678C2
(ru)
|
2010-04-22 |
2015-11-27 |
Вертекс Фармасьютикалз Инкорпорейтед |
Способ получения циклоалкилкарбоксамидо-индольных соединений
|
|
GB201007286D0
(en)
|
2010-04-30 |
2010-06-16 |
Astex Therapeutics Ltd |
New compounds
|
|
AR081039A1
(es)
|
2010-05-14 |
2012-05-30 |
Osi Pharmaceuticals Llc |
Inhibidores biciclicos fusionados de quinasa
|
|
JP2013526570A
(ja)
|
2010-05-14 |
2013-06-24 |
オーエスアイ・ファーマシューティカルズ，エルエルシー |
縮合二環式キナーゼ阻害剤
|
|
US20130315895A1
(en)
|
2010-07-01 |
2013-11-28 |
Takeda Pharmaceutical Company Limited |
COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
|
|
WO2012006960A1
(en)
*
|
2010-07-14 |
2012-01-19 |
Zhejiang Beta Pharma Inc. |
NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS
|
|
ES2603032T3
(es)
|
2010-07-15 |
2017-02-23 |
Bayer Intellectual Property Gmbh |
Compuestos de 3-piridil-heteroarilcarboxamida como pesticidas
|
|
WO2012065161A2
(en)
|
2010-11-12 |
2012-05-18 |
Scott & White Healthcare |
Antibodies to tumor endothelial marker 8
|
|
GB201020179D0
(en)
|
2010-11-29 |
2011-01-12 |
Astex Therapeutics Ltd |
New compounds
|
|
CN102532141A
(zh)
|
2010-12-08 |
2012-07-04 |
中国科学院上海药物研究所 |
[1，2，4]三唑并[4，3-b][1，2，4]三嗪类化合物、其制备方法和用途
|
|
US20130324526A1
(en)
|
2011-02-10 |
2013-12-05 |
Novartis Ag |
[1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
|
|
US20140088114A1
(en)
|
2011-05-16 |
2014-03-27 |
OSI Pharmaceuticals ,LLC |
Fused bicyclic kinase inhibitors
|
|
CN103958509B
(zh)
*
|
2011-09-15 |
2015-12-23 |
诺华股份有限公司 |
作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物
|
|
WO2013038362A1
(en)
|
2011-09-15 |
2013-03-21 |
Novartis Ag |
6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase
|
|
CN102503959B
(zh)
*
|
2011-10-25 |
2015-04-08 |
南方医科大学 |
一种稠三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用
|
|
CN102516263B
(zh)
*
|
2011-10-25 |
2015-04-08 |
南方医科大学 |
一种螺三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用
|
|
GB201118675D0
(en)
|
2011-10-28 |
2011-12-14 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118652D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118656D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118654D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
KR20130091464A
(ko)
*
|
2012-02-08 |
2013-08-19 |
한미약품 주식회사 |
타이로신 카이네이즈 억제 활성을 갖는 트리아졸로피리딘 유도체
|
|
KR101869534B1
(ko)
*
|
2012-03-05 |
2018-06-20 |
한국화학연구원 |
신규한 트리아졸로 피리다진 유도체 및 그의 용도
|
|
WO2013149581A1
(en)
|
2012-04-03 |
2013-10-10 |
Novartis Ag |
Combination products with tyrosine kinase inhibitors and their use
|
|
US20150051210A1
(en)
|
2012-04-03 |
2015-02-19 |
Novartis Ag |
Tyrosine Kinase Inhibitor Combinations and their Use
|
|
GB201209609D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201209613D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
US9012496B2
(en)
|
2012-07-16 |
2015-04-21 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide and administration thereof
|
|
DK2878594T3
(en)
*
|
2012-07-27 |
2019-02-04 |
Sato Pharma |
DIFLUOROMETHYLENE COMPOUND
|
|
CN103122000B
(zh)
*
|
2012-09-03 |
2013-12-25 |
中美冠科生物技术（太仓）有限公司 |
用作抗肿瘤药物的高选择性的c-Met激酶抑制剂
|
|
US9422290B2
(en)
*
|
2012-11-13 |
2016-08-23 |
Boehringer Ingelheim International Gmbh |
Triazolopyridazine
|
|
US9266891B2
(en)
|
2012-11-16 |
2016-02-23 |
Boehringer Ingelheim International Gmbh |
Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors
|
|
WO2014174478A1
(en)
|
2013-04-26 |
2014-10-30 |
Novartis Ag |
Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor
|
|
GB201307577D0
(en)
|
2013-04-26 |
2013-06-12 |
Astex Therapeutics Ltd |
New compounds
|
|
CN104250257B
(zh)
*
|
2013-06-25 |
2017-06-16 |
上海翰森生物医药科技有限公司 |
3,4‑二氢‑1H‑苯并[c][1,2]噁硼酸类化合物或其可药用盐及其制备方法和用途
|
|
CN103524431B
(zh)
*
|
2013-09-24 |
2016-01-13 |
西安交通大学 |
3-苄基-4-喹唑啉酮类化合物及其合成方法和应用
|
|
GB201321745D0
(en)
*
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
KR102479696B1
(ko)
|
2014-03-26 |
2022-12-22 |
아스텍스 테라퓨틱스 리미티드 |
Fgfr 억제제 및 igf1r 억제제의 조합물
|
|
MX370099B
(es)
|
2014-03-26 |
2019-12-02 |
Astex Therapeutics Ltd |
Combinación que comprende un inhibidor de fgfr y un inhibidor de cmet para el tratamiento del cáncer.
|
|
JO3512B1
(ar)
|
2014-03-26 |
2020-07-05 |
Astex Therapeutics Ltd |
مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
|
|
PT3131582T
(pt)
|
2014-04-15 |
2018-10-08 |
Vertex Pharma |
Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística
|
|
TWI695837B
(zh)
|
2014-12-04 |
2020-06-11 |
比利時商健生藥品公司 |
作為激酶調節劑之三唑並嗒
|
|
ES2764299T3
(es)
|
2014-12-09 |
2020-06-02 |
Inst Nat Sante Rech Med |
Anticuerpos monoclonales humanos contra AXL
|
|
AU2015360006B2
(en)
*
|
2014-12-11 |
2020-07-16 |
Merck Patent Gmbh |
Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a quinazoline derivative
|
|
JOP20200201A1
(ar)
|
2015-02-10 |
2017-06-16 |
Astex Therapeutics Ltd |
تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
|
|
WO2016135041A1
(en)
|
2015-02-26 |
2016-09-01 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Fusion proteins and antibodies comprising thereof for promoting apoptosis
|
|
US10478494B2
(en)
|
2015-04-03 |
2019-11-19 |
Astex Therapeutics Ltd |
FGFR/PD-1 combination therapy for the treatment of cancer
|
|
CN106279176B
(zh)
*
|
2015-06-11 |
2020-09-08 |
中国科学院上海药物研究所 |
氘代的3-[(6-喹啉基)二氟甲基]-6-[(1-甲基)-4-吡唑基][1,2,4]三唑并[4,3-b]哒嗪及其应用
|
|
TN2017000508A1
(en)
|
2015-06-26 |
2019-04-12 |
Takeda Pharmaceuticals Co |
2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor
|
|
KR102691777B1
(ko)
|
2015-09-23 |
2024-08-02 |
얀센 파마슈티카 엔브이 |
비-헤테로아릴 치환된 1,4-벤조디아제핀 및 암의 치료를 위한 이의 용도
|
|
CA2996857C
(en)
|
2015-09-23 |
2024-05-21 |
Janssen Pharmaceutica Nv |
Quinoxaline, quinoline and quinazolinone derivative compounds for the treatment of cancer
|
|
CN105272995B
(zh)
*
|
2015-09-24 |
2017-10-27 |
上海海聚生物科技有限公司 |
喹啉类衍生物、其药物组合物、制备方法及应用
|
|
JP6787913B2
(ja)
|
2015-10-20 |
2020-11-18 |
武田薬品工業株式会社 |
複素環化合物
|
|
CN106924260B
(zh)
*
|
2015-12-31 |
2018-05-25 |
北京浦润奥生物科技有限责任公司 |
化合物在制备用于治疗脑胶质瘤的药物中的用途
|
|
US10875858B2
(en)
*
|
2016-08-16 |
2020-12-29 |
Bayer Cropscience Aktiengesellschaft |
Process for preparing halogenated pyridine derivatives
|
|
DK3548033T3
(da)
*
|
2016-11-28 |
2024-07-15 |
Praxis Prec Medicines Inc |
Forbindelser og deres fremgangsmåde til anvendelse
|
|
US11261188B2
(en)
|
2016-11-28 |
2022-03-01 |
Praxis Precision Medicines, Inc. |
Fused heteroaryl compounds, and methods thereof for treating diseases, disorders, and conditions relating to aberrant function of a sodium channel
|
|
WO2018148745A1
(en)
|
2017-02-13 |
2018-08-16 |
Praxis Precision Medicines , Inc. |
Compounds and their methods of use
|
|
US11731966B2
(en)
|
2017-04-04 |
2023-08-22 |
Praxis Precision Medicines, Inc. |
Compounds and their methods of use
|
|
TWI774755B
(zh)
*
|
2017-04-28 |
2022-08-21 |
日商佐藤製藥股份有限公司 |
二氟甲烯化合物之製造法
|
|
WO2019035951A1
(en)
|
2017-08-15 |
2019-02-21 |
Praxis Precision Medicines, Inc. |
COMPOUNDS AND THEIR METHODS OF USE
|
|
JP2021521228A
(ja)
*
|
2018-04-18 |
2021-08-26 |
ビーエイエスエフ・ソシエタス・エウロパエアＢａｓｆ Ｓｅ |
Ｄ−グルカロ−６，３−ラクトンモノエステル及びその製造方法
|
|
EP3801535A4
(en)
|
2018-05-30 |
2022-03-02 |
Praxis Precision Medicines, Inc. |
ION CHANNEL MODULATORS
|
|
CN109045036B
(zh)
*
|
2018-07-19 |
2020-10-02 |
中山大学 |
[1,2,4]三唑并[4,3-b]哒嗪衍生物在制备抗肿瘤药物中的应用
|
|
EA202092908A1
(ru)
|
2018-09-28 |
2021-05-14 |
Праксис Пресижн Медсинз, Инк. |
Модуляторы ионных каналов
|
|
CA3122575A1
(en)
|
2018-12-14 |
2020-06-18 |
Beta Pharma, Inc. |
Organophosphorus-substituted compounds as c-met inhibitors and therapeutic uses thereof
|
|
EP3898626A1
(en)
|
2018-12-19 |
2021-10-27 |
Array Biopharma, Inc. |
Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases
|
|
CN110156805B
(zh)
*
|
2019-05-22 |
2020-12-11 |
南京合巨药业有限公司 |
一种2, 3-二氢-1, 4-二氧代[2,3-b]吡啶-7-羧酸的制备方法
|
|
US11773099B2
(en)
|
2019-05-28 |
2023-10-03 |
Praxis Precision Medicines, Inc. |
Compounds and their methods of use
|
|
US11505554B2
(en)
|
2019-05-31 |
2022-11-22 |
Praxis Precision Medicines, Inc. |
Substituted pyridines as ion channel modulators
|
|
US11279700B2
(en)
|
2019-05-31 |
2022-03-22 |
Praxis Precision Medicines, Inc. |
Ion channel modulators
|
|
US11767325B2
(en)
|
2019-11-26 |
2023-09-26 |
Praxis Precision Medicines, Inc. |
Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators
|
|
JP2023523295A
(ja)
*
|
2020-04-26 |
2023-06-02 |
アポロミクス インコーポレイテッド |
Ｃ－ｍｅｔ阻害剤のための新規医薬製剤
|
|
TWI728882B
(zh)
|
2020-07-28 |
2021-05-21 |
祥昇機電工業有限公司 |
自吸式抽水機之釋氣機構
|
|
CN117412973A
(zh)
*
|
2021-05-31 |
2024-01-16 |
上海瑛派药业有限公司 |
含氮稠合杂芳双环化合物作为usp1抑制剂及其应用
|
|
WO2024032647A1
(zh)
*
|
2022-08-09 |
2024-02-15 |
上海济煜医药科技有限公司 |
含氮杂环化合物作为泛素-特异性蛋白酶1抑制剂的制备方法、应用及其用途
|
|
WO2025007275A1
(zh)
*
|
2023-07-04 |
2025-01-09 |
北京浦润奥生物科技有限责任公司 |
[1,2,4]三唑[4,3-b]哒嗪化合物的晶型及其制备方法和应用
|