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PL1694360T3 - Zastosowanie antagonistycznych przeciwciał anty-CD40 do leczenia chorób autoimmunologicznych i zapalnych oraz odrzucenia przeszczepu narządów - Google Patents

Zastosowanie antagonistycznych przeciwciał anty-CD40 do leczenia chorób autoimmunologicznych i zapalnych oraz odrzucenia przeszczepu narządów

Info

Publication number
PL1694360T3
PL1694360T3 PL04810420T PL04810420T PL1694360T3 PL 1694360 T3 PL1694360 T3 PL 1694360T3 PL 04810420 T PL04810420 T PL 04810420T PL 04810420 T PL04810420 T PL 04810420T PL 1694360 T3 PL1694360 T3 PL 1694360T3
Authority
PL
Poland
Prior art keywords
antagonist anti
dosing regimen
autoimmune
antibodies
treatment
Prior art date
Application number
PL04810420T
Other languages
English (en)
Inventor
Li Long
Mohammad Luqman
Asha Yabannavar
Isabel Zaror
Original Assignee
Novartis Vaccines & Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34577667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1694360(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Vaccines & Diagnostics Inc filed Critical Novartis Vaccines & Diagnostics Inc
Publication of PL1694360T3 publication Critical patent/PL1694360T3/pl

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
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    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • AHUMAN NECESSITIES
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    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Hematology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
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  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
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PL04810420T 2003-11-04 2004-11-04 Zastosowanie antagonistycznych przeciwciał anty-CD40 do leczenia chorób autoimmunologicznych i zapalnych oraz odrzucenia przeszczepu narządów PL1694360T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US51733703P 2003-11-04 2003-11-04
US52557903P 2003-11-26 2003-11-26
US56571004P 2004-04-27 2004-04-27
EP04810420A EP1694360B1 (en) 2003-11-04 2004-11-04 Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection
PCT/US2004/036957 WO2005044306A2 (en) 2003-11-04 2004-11-04 Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection

Publications (1)

Publication Number Publication Date
PL1694360T3 true PL1694360T3 (pl) 2011-04-29

Family

ID=34577667

Family Applications (4)

Application Number Title Priority Date Filing Date
PL09075395T PL2149585T3 (pl) 2003-11-04 2004-11-04 Zastosowanie antagonistycznych przeciwciał monoklonalnych anty-CD40
PL04810510T PL1682180T3 (pl) 2003-11-04 2004-11-04 Antagonistyczne przeciwciała monoklonalne anty-CD40 i sposoby ich zastosowania
PL04810421T PL1682178T3 (pl) 2003-11-04 2004-11-04 Sposoby terapii nowotworów wykazujących ekspresje antygenu CD40
PL04810420T PL1694360T3 (pl) 2003-11-04 2004-11-04 Zastosowanie antagonistycznych przeciwciał anty-CD40 do leczenia chorób autoimmunologicznych i zapalnych oraz odrzucenia przeszczepu narządów

Family Applications Before (3)

Application Number Title Priority Date Filing Date
PL09075395T PL2149585T3 (pl) 2003-11-04 2004-11-04 Zastosowanie antagonistycznych przeciwciał monoklonalnych anty-CD40
PL04810510T PL1682180T3 (pl) 2003-11-04 2004-11-04 Antagonistyczne przeciwciała monoklonalne anty-CD40 i sposoby ich zastosowania
PL04810421T PL1682178T3 (pl) 2003-11-04 2004-11-04 Sposoby terapii nowotworów wykazujących ekspresje antygenu CD40

Country Status (22)

Country Link
EP (6) EP1694360B1 (pl)
JP (6) JP4765039B2 (pl)
KR (2) KR101125127B1 (pl)
CN (2) CN1938045B (pl)
AT (3) ATE476448T1 (pl)
AU (3) AU2004287482B2 (pl)
CA (3) CA2544949C (pl)
CY (3) CY1110231T1 (pl)
DE (3) DE602004028505D1 (pl)
DK (4) DK1694360T3 (pl)
EC (2) ECSP066607A (pl)
ES (3) ES2333971T3 (pl)
HR (2) HRP20100066T1 (pl)
IL (1) IL175225A (pl)
MA (1) MA28331A1 (pl)
PL (4) PL2149585T3 (pl)
PT (4) PT1682180E (pl)
RS (2) RS51230B (pl)
SG (1) SG148143A1 (pl)
SI (3) SI1682178T1 (pl)
WO (3) WO2005044854A2 (pl)
ZA (1) ZA200604419B (pl)

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DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
EP2236172A1 (en) * 2003-11-04 2010-10-06 Novartis Vaccines and Diagnostics, Inc. Combination therapy comprising anti-CD20 and anti-CD40 antibodies for the treatment of B cell-related cancers
SI1682178T1 (sl) * 2003-11-04 2010-11-30 Novartis Vaccines & Diagnostic Postopki za terapijo raka ob eksprimiranju CD antigena
US8277810B2 (en) 2003-11-04 2012-10-02 Novartis Vaccines & Diagnostics, Inc. Antagonist anti-CD40 antibodies
US20050281815A1 (en) * 2004-02-26 2005-12-22 Dani Eshel CD40 splice variants and their uses
JP5421590B2 (ja) * 2005-05-18 2014-02-19 ノバルティス アーゲー 自己免疫および/または炎症性成分を有する疾患の診断および治療のための方法
CA2608751A1 (en) * 2005-05-18 2006-11-23 Novartis Ag Methods for diagnosis and treatment of proliferative disorders mediated by cd40 signaling
CN101217979A (zh) 2005-06-14 2008-07-09 安姆根有限公司 自缓冲蛋白制剂
BRPI0618217A2 (pt) * 2005-11-01 2011-08-23 Novartis Ag usos de anticorpos anti-cd40
JP2009517339A (ja) * 2005-11-01 2009-04-30 ノバルティス アーゲー 抗cd40抗体の使用
PL1976877T5 (pl) 2005-11-30 2017-09-29 Abbvie Inc Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania
CN117903302A (zh) 2005-11-30 2024-04-19 Abbvie 公司 抗-Aβ球聚体抗体,其相关产品,生产所述抗体的方法,所述抗体的应用以及使用方法
EP3327117A1 (en) 2005-12-09 2018-05-30 Academisch Medisch Centrum bij de Universiteit van Amsterdam Means and methods for influencing the stability of antibody producing cells
WO2007067032A1 (en) 2005-12-09 2007-06-14 Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam Means and methods for influencing the stability of cells
AR059066A1 (es) 2006-01-27 2008-03-12 Amgen Inc Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
GEP20125628B (en) * 2006-04-21 2012-09-10 Novartis Ag Pharmaceutical compositions containing antagonist anti-cd40 antibody
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
AU2007338791B2 (en) * 2006-12-21 2014-03-13 Amgen Inc Stable buffered formulations containing polypeptides
EP2486928A1 (en) 2007-02-27 2012-08-15 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
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ATE447412T1 (de) 2009-11-15
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