PL1668014T3 - Skondensowane związki heterocykliczne jako modulatory receptora serotoninowego - Google Patents

Skondensowane związki heterocykliczne jako modulatory receptora serotoninowego

Info

Publication number: PL1668014T3
Authority: PL; Poland
Prior art keywords: heterocyclic compounds; receptor modulators; fused heterocyclic; serotonin receptor; serotonin
Prior art date: 2003-09-17

Application number

PL04816874T

Other languages

English (en)

Inventor

Nicholas I Carruthers

Wenying Chai

Xiaohu Deng

Curt A Dvorak

Annette K Kwok

Jimmy T Liang

Neelakandha Mani

Dale A Rudolph

Victoria D Wong

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-17

Filing date

2004-09-15

Publication date

2009-06-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34526458&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1668014(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-09-15 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2009-06-30 Publication of PL1668014T3 publication Critical patent/PL1668014T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
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- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Addiction (AREA)
Obesity (AREA)
Reproductive Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Anesthesiology (AREA)
Gynecology & Obstetrics (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

PL04816874T 2003-09-17 2004-09-15 Skondensowane związki heterocykliczne jako modulatory receptora serotoninowego PL1668014T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US50452803P	2003-09-17	2003-09-17
US55267304P	2004-03-11	2004-03-11
PCT/US2004/030190 WO2005040169A2 (en)	2003-09-17	2004-09-15	Fused heterocyclic compounds as serotonin receptor modulators
EP04816874A EP1668014B1 (en)	2003-09-17	2004-09-15	Fused heterocyclic compounds as serotonin receptor modulators

Publications (1)

Publication Number	Publication Date
PL1668014T3 true PL1668014T3 (pl)	2009-06-30

Family

ID=34526458

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04816874T PL1668014T3 (pl)	2003-09-17	2004-09-15	Skondensowane związki heterocykliczne jako modulatory receptora serotoninowego

Country Status (29)

Country	Link
US (5)	US7402680B2 (pl)
EP (1)	EP1668014B1 (pl)
JP (1)	JP5069907B2 (pl)
KR (1)	KR101151653B1 (pl)
CN (1)	CN103788089A (pl)
AR (1)	AR047218A1 (pl)
AT (1)	ATE420881T1 (pl)
AU (1)	AU2004283196B2 (pl)
BR (1)	BRPI0414541B8 (pl)
CA (1)	CA2539426C (pl)
CL (1)	CL2009000943A1 (pl)
CR (1)	CR8302A (pl)
CY (1)	CY1109416T1 (pl)
DE (1)	DE602004019118D1 (pl)
DK (1)	DK1668014T3 (pl)
EA (2)	EA010905B1 (pl)
EC (1)	ECSP066436A (pl)
ES (1)	ES2319539T3 (pl)
IL (2)	IL174283A (pl)
IS (1)	IS2756B (pl)
MX (1)	MXPA06003150A (pl)
NI (1)	NI200600094A (pl)
NZ (1)	NZ545836A (pl)
PL (1)	PL1668014T3 (pl)
PT (1)	PT1668014E (pl)
SG (1)	SG146683A1 (pl)
SI (1)	SI1668014T1 (pl)
TW (1)	TWI345565B (pl)
WO (1)	WO2005040169A2 (pl)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA06003150A (es) *	2003-09-17	2006-08-31	Johnson & Johnson	Compuestos heterociclicos fusionados.
WO2005079845A1 (ja) *	2004-02-20	2005-09-01	Astellas Pharma Inc.	片頭痛予防薬
CN1980710B (zh) *	2004-06-30	2013-06-12	阿特西斯公司	作为5-羟色胺受体调节剂的取代的氮杂环庚烯衍生物
WO2006066133A2 (en)	2004-12-16	2006-06-22	Takeda San Diego, Inc.	Histone deacetylase inhibitors
JP4998258B2 (ja) *	2005-02-08	2012-08-15	アステラス製薬株式会社	過敏性腸症候群の治療薬
WO2006122319A2 (en)	2005-05-11	2006-11-16	Takeda San Diego, Inc.	Histone deacetylase inhibitors
GB0513886D0 (en) *	2005-07-06	2005-08-10	Glaxo Group Ltd	Novel compounds
KR101353268B1 (ko) *	2005-08-04	2014-02-06	얀센 파마슈티카 엔.브이.	세로토닌 수용체 모듈레이터로서의 피리미딘 화합물
US7598255B2 (en) *	2005-08-04	2009-10-06	Janssen Pharmaceutica Nv	Pyrimidine compounds as serotonin receptor modulators
EP1923387B1 (en)	2005-08-08	2011-10-19	Astellas Pharma Inc.	Acylguanidine derivative or salt thereof
CA2636992C (en)	2006-01-19	2015-10-06	Athersys, Inc.	Thiophenyl and pyrrolyl azepines as serotonin 5-ht2c receptor ligands and uses thereof
WO2007112402A1 (en) *	2006-03-27	2007-10-04	Janssen Pharmaceutica N.V.	Tetrahydro-1h-1,2,6-triaza-azulene cannabinoid modulators
ATE459614T1 (de) *	2006-05-05	2010-03-15	Janssen Pharmaceutica Nv	Herstellungsverfahren für pyrazolhaltige verbindungen
ATE458740T1 (de) *	2006-08-28	2010-03-15	Actelion Pharmaceuticals Ltd	1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulen- derivate als orexinrezeptor-antagonisten
WO2009058810A1 (en) *	2007-11-02	2009-05-07	Janssen Pharmaceutica N.V.	Process for the preparation of substituted 2,4,5,6,7,8-hexahydro-1,2,6-triaza-azulene derivatives
US8404863B2 (en)	2008-01-03	2013-03-26	Allergan, Inc.	Tetrahydroindoles having sphingosine-1-phosphate receptor activity
WO2010053825A1 (en)	2008-10-29	2010-05-14	Janssen Pharmaceutica Nv	2-aminopyrimidine compounds as serotonin receptor modulators
AU2009317386B2 (en)	2008-11-18	2013-07-25	F. Hoffmann-La Roche Ag	Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
EP2370437B1 (en) *	2008-11-25	2013-09-04	Nerviano Medical Sciences S.r.l.	Bicyclic pyrazole and isoxazole derivatives as antitumor and antineurodegenerative agents
TWI410418B (zh) *	2009-04-29	2013-10-01	Ind Tech Res Inst	氮雜薁化合物、藥學組合物與抑制一細胞中蛋白質激酶之活性的方法
GB201004311D0 (en)	2010-03-15	2010-04-28	Proximagen Ltd	New enzyme inhibitor compounds
EP2699563B3 (en)	2011-04-21	2024-06-12	Basf Se	Novel pesticidal pyrazole compounds
EA201490451A1 (ru)	2011-09-14	2014-12-30	Проксимаген Лимитед	Новые соединения - ингибиторы ферментов
WO2013156318A1 (en)	2012-04-16	2013-10-24	Basf Se	Substituted pesticidal pyrazole compounds
BR122019015121B1 (pt)	2012-06-20	2020-04-07	Basf Se	mistura pesticida, composição, composição agrícola, métodos para o combate ou controle das pragas de invertebrados, para a proteção dos vegetais em crescimento ou dos materias de propagação vegetal, para a proteção de material de propagação vegetal, uso de uma mistura pesticida e métodos para o combate dos fungos fitopatogênicos nocivos e para proteger vegetais de fungos fitopatogênicos nocivos
EP2885304B8 (en) *	2012-08-16	2016-12-07	Janssen Pharmaceutica NV	Pyrrolopyrazoles as n-type calcium channel blockers
WO2014063942A1 (en)	2012-10-23	2014-05-01	Basf Se	Substituted pesticidal pyrazole compounds
SG11201504749TA (en)	2012-12-21	2015-07-30	Abt Holding Co	Benzazepines as serotonin 5-ht2c receptor ligands and uses thereof
US9309262B2 (en)	2013-03-13	2016-04-12	Abt Holding Company	Thienylindole azepines as serotonin 5-HT2C receptor ligands and uses thereof
US9453002B2 (en)	2013-08-16	2016-09-27	Janssen Pharmaceutica Nv	Substituted imidazoles as N-type calcium channel blockers
WO2015055497A1 (en)	2013-10-16	2015-04-23	Basf Se	Substituted pesticidal pyrazole compounds
WO2016081918A1 (en) *	2014-11-21	2016-05-26	Akarna Therapeutics, Ltd.	Fused bicyclic compounds for the treatment of disease
CA2975997A1 (en) *	2015-02-11	2016-08-18	Merck Sharp & Dohme Corp.	Substituted pyrazole compounds as rorgammat inhibitors and uses thereof
CN105503647A (zh) *	2015-12-10	2016-04-20	苏州昊帆生物科技有限公司	环丙基肼盐酸盐的制备方法
WO2017175045A1 (en) *	2016-04-08	2017-10-12	The Hong Kong Polytechnic University	Pyrimidines for treatment of bacterial infections
KR101917264B1 (ko) *	2016-12-22	2018-11-13	한국과학기술연구원	5-ht7 수용체 조절제로 작용하는 아제핀 유도체
KR102037494B1 (ko)	2017-12-11	2019-10-28	씨제이헬스케어 주식회사	광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법
WO2019137995A1 (en)	2018-01-11	2019-07-18	Basf Se	Novel pyridazine compounds for controlling invertebrate pests
CN112300169B (zh) *	2019-07-26	2022-03-04	上海美迪西生物医药股份有限公司	吡咯并吡唑类衍生物、其制备方法及其在医药上的应用
KR20190120112A (ko)	2019-10-08	2019-10-23	씨제이헬스케어 주식회사	광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법
MX2022008665A (es) *	2020-01-13	2022-08-10	Aptabio Therapeutics Inc	Nuevo derivado de pirazol.
HUE068174T2 (hu)	2020-02-07	2024-12-28	Gasherbrum Bio Inc	Heterociklusos GLP-1 agonisták
CN120957993A (zh)	2023-02-16	2025-11-14	加舒布鲁姆生物公司	杂环glp-1激动剂

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1197466B (de) *	1962-03-22	1965-07-29	Thomae Gmbh Dr K	Verfahren zur Herstellung von neuen 5, 6, 7, 8-Tetrahydropyrido-[4, 3-d]pyrimidinen
US3312716A (en) *	1964-08-11	1967-04-04	Aldrich Chem Co Inc	4-hydroxy-3-pyrrolidinemethanols
GB1422263A (en) *	1973-01-30	1976-01-21	Ferrosan As	4-phenyl-piperidine compounds
US4314081A (en) *	1974-01-10	1982-02-02	Eli Lilly And Company	Arloxyphenylpropylamines
GB1484140A (en)	1974-04-24	1977-08-24	Wyeth John & Brother Ltd	Pyrrolopyridine derivatives
US3969355A (en) *	1974-11-01	1976-07-13	Morton-Norwich Products, Inc.	5-Aminoethyl-2,4-diphenylpyrimidine dihydrobromide
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
US4536518A (en) *	1979-11-01	1985-08-20	Pfizer Inc.	Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
DK27383A (da) *	1982-02-17	1983-08-18	Lepetit Spa	Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner
US4576604A (en) *	1983-03-04	1986-03-18	Alza Corporation	Osmotic system with instant drug availability
US4673405A (en) *	1983-03-04	1987-06-16	Alza Corporation	Osmotic system with instant drug availability
US4857330A (en) *	1986-04-17	1989-08-15	Alza Corporation	Chlorpheniramine therapy
JPH03148265A (ja)	1989-11-01	1991-06-25	Sumitomo Chem Co Ltd	５，７―ジフェニル―４，６―ジアザインダン誘導体、その製造法およびそれを有効成分とする除草剤
US5137890A (en) *	1990-02-14	1992-08-11	Ortho Pharmaceutical Corporation	4-phenyl tetrahydropyrido(4,3-d)pyrimidines
US5053508A (en)	1990-03-09	1991-10-01	American Home Products Corporation	Fused heterotricyclic imides with psychotropic activity and intermedrates thereof
US5648352A (en)	1991-09-13	1997-07-15	Merck & Co., Inc.	Piperazinylcamphorsulfonyl oxytocin antagonists
ATE151418T1 (de)	1992-12-28	1997-04-15	Eisai Co Ltd	Heterocyclische carbonsäure-derivate, die an rar rezeptoren binden können
US5843912A (en)	1994-07-06	1998-12-01	Universy Of Maryland	Ring-expanded nucleosides and nucleotides
US6677310B1 (en)	1999-04-21	2004-01-13	Nabi	Ring-expanded nucleosides and nucleotides
US5405848A (en) *	1993-12-22	1995-04-11	Ortho Pharmaceutical Corporation	Substituted thiazolylaminotetrahydropyridopyrimidines derivatives useful as platelet aggregation inhibitors
US5663178A (en) *	1995-02-06	1997-09-02	Eli Lilly And Company	Tetrahydro-beta carbolines
FI964340A0 (fi)	1994-04-29	1996-10-28	Pfizer	Uudet asykliset ja sykliset amidit hermoston välittäjäaineen vapautumisen tehostimina
AU5317996A (en)	1995-04-18	1996-11-07	Eli Lilly And Company	Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptor
JP2000504677A (ja)	1996-02-09	2000-04-18	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	５ｈｔ７レセプター・アンタゴニスト用のスルホンアミド誘導体
TW470745B (en)	1996-05-23	2002-01-01	Janssen Pharmaceutica Nv	Hexahydro-pyrido[4,3-b]indole derivatives
JP3531169B2 (ja)	1996-06-11	2004-05-24	三菱ウェルファーマ株式会社	縮合ヘテロ環化合物およびその医薬用途
GB9612884D0 (en)	1996-06-20	1996-08-21	Smithkline Beecham Plc	Novel compounds
US6025367A (en) *	1996-06-25	2000-02-15	Smithkline Beecham Plc	Sulfonamide derivatives as 5HT7 receptor antagonists
ES2243999T3 (es)	1996-06-28	2005-12-01	Meiji Seika Kaisha Ltd.	Compuestos de tetrahidrobencindol.
GB9700899D0 (en)	1997-01-17	1997-03-05	Smithkline Beecham Plc	Novel treatment
EP0973778A1 (en)	1997-03-07	2000-01-26	Novo Nordisk A/S	4,5,6,7-TETRAHYDRO-THIENO 3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
US6177443B1 (en)	1997-03-07	2001-01-23	Novo Nordisk A/S	4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use
EP0905136A1 (en)	1997-09-08	1999-03-31	Janssen Pharmaceutica N.V.	Tetrahydro gamma-carbolines
US5951518A (en)	1997-10-31	1999-09-14	Teleflex, Incorporated	Introducing device with flared sheath end
WO1999024022A2 (en)	1997-11-10	1999-05-20	F. Hoffmann-La Roche Ag	Isoquinoline derivatives for treating disorders associated with 5ht7 receptors
KR20010042904A (ko) *	1998-04-22	2001-05-25	기따자또 이찌로	광학 활성 테트라하이드로벤즈인돌 유도체
EP0958824A3 (en)	1998-05-22	1999-12-01	Eli Lilly And Company	Olanzapine (zyprexa) in combination with fluoxetine (prozac), lithium or anticonvulsant for therapy of refractory depression
US5997905A (en) *	1998-09-04	1999-12-07	Mcneil-Ppc	Preparation of pharmaceutically active particles
WO2000024399A1 (en)	1998-10-23	2000-05-04	Sepracor Inc.	Compositions and methods employing r(-) fluoxetine and other active ingredients
US6245785B1 (en)	1998-11-30	2001-06-12	Warner Lambert Company	Dissolution of triprolidine hydrochloride
GB9828004D0 (en)	1998-12-18	1999-02-10	Smithkline Beecham Plc	Use
GB9906624D0 (en)	1999-03-23	1999-05-19	Smithkline Beecham Plc	Novel compounds
NZ514144A (en) *	1999-04-01	2001-09-28	Pfizer Prod Inc	Aminopyrimidines as sorbitol dehydrogenase inhibitors
GB9912701D0 (en)	1999-06-01	1999-08-04	Smithkline Beecham Plc	Novel compounds
EP1211246B1 (en)	1999-09-09	2004-02-25	Kumiai Chemical Industry Co., Ltd.	Pyrimidine derivatives and herbicides containing the same
AU1025601A (en)	1999-10-18	2001-04-30	Smithkline Beecham Plc	Tetrahydrobenzindolone derivatives, their preparation and their use as 5-ht7 receptor antagonists
UA77650C2 (en)	1999-12-06	2007-01-15	Lundbeck & Co As H	Use of serotonin reuptake inhibitor in combination with deramcyclane
CA2399545A1 (en)	2000-02-04	2001-08-09	Michael Gerard Kelly	Pyrrolo-isoquinoline and tetrahydropyrrolo-isoquinoline derivatives and their use as mediators of the 5-ht7 receptor
WO2001068585A1 (en)	2000-03-14	2001-09-20	Fujisawa Pharmaceutical Co., Ltd.	Novel amide compounds
US6586469B2 (en)	2000-07-25	2003-07-01	Medpointe Healthcare Inc.	Antihistaminic/antitussive compositions
WO2002014314A2 (en)	2000-08-14	2002-02-21	Ortho Mcneil Pharmaceutical, Inc.	Substituted pyrazoles
WO2002020011A2 (en) *	2000-09-06	2002-03-14	Ortho Mcneil Pharmaceutical, Inc.	A method for treating allergies using substituted pyrazoles
US20040267010A1 (en)	2001-02-02	2004-12-30	Forbes Ian Thomson	Sulfonamide compounds, their preparation and use
SI1368358T1 (sl)	2001-02-21	2007-02-28	Janssen Pharmaceutica Nv	Izoksazolinski derivati kot antidepresivi
US20020183519A1 (en) *	2001-03-13	2002-12-05	Herbert Nar	Antithrombotic carboxylic acid amides
DE10111842A1 (de)	2001-03-13	2002-09-19	Boehringer Ingelheim Pharma	Antithrombotische Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
US6559174B2 (en)	2001-03-20	2003-05-06	Merck & Co., Inc.	N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors
US6806380B2 (en) *	2001-10-02	2004-10-19	Lexicon Pharmaceuticals, Inc.	Modified safe and efficient process for the environmentally friendly synthesis of imidoesters
CA2465247C (en) *	2001-10-26	2010-05-18	Aventis Pharmaceuticals Inc.	Benzimidazoles and analogues and their use as protein kinases inhibitors
US6806279B2 (en)	2001-12-17	2004-10-19	Sunesis Pharmaceuticals, Inc.	Small-molecule inhibitors of interleukin-2
SE0104340D0 (sv)	2001-12-20	2001-12-20	Astrazeneca Ab	New compounds
US20030199544A1 (en)	2002-04-18	2003-10-23	Woods Keith W.	Farnesyltransferase inhibitors
US20030199542A1 (en)	2002-04-18	2003-10-23	Woods Keith W.	Farnesyltransferase inhibitors
HRP20020452A2 (en)	2002-05-23	2004-02-29	Pliva D D	1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
CA2487679A1 (en) *	2002-05-30	2003-12-11	Vertex Pharmaceuticals Incorporated	Inhibitors of jak and cdk2 protein kinases
CN100430063C (zh) *	2002-06-20	2008-11-05	H.隆德贝克有限公司	使用5-羟色胺再摄取抑制剂的联合药物
AU2003244649A1 (en)	2002-07-25	2004-02-23	Pharmacia Italia Spa	Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
JP2005536526A (ja)	2002-07-25	2005-12-02	ファルマシア・イタリア・エス・ピー・エー	キナーゼ阻害剤として活性なビシクロ−ピラゾール類、その製造方法、およびそれを含有する薬学的組成物
JPWO2004011467A1 (ja)	2002-07-29	2005-12-15	北興化学工業株式会社	トリアゾロピリミジン誘導体および農園芸用殺菌剤
US20040132826A1 (en)	2002-10-25	2004-07-08	Collegium Pharmaceutical, Inc.	Modified release compositions of milnacipran
MXPA05004607A (es)	2002-10-30	2005-06-08	Ciba Sc Holding Ag	Dispositivo electroluminiscente.
CA2514656A1 (en) *	2003-01-31	2004-08-12	Pfizer Products Inc.	5ht7 antagonists and inverse agonists
GB0308208D0 (en)	2003-04-09	2003-05-14	Glaxo Group Ltd	Chemical compounds
US7145012B2 (en) *	2003-04-23	2006-12-05	Pfizer Inc.	Cannabinoid receptor ligands and uses thereof
GB0316128D0 (en)	2003-07-10	2003-08-13	Univ Aston	Novel sulfonamide compounds
EP1648408A4 (en)	2003-07-23	2006-11-29	Exelixis Inc	AZEPINE DERIVATIVES AS PHARMACEUTICAL AGENTS
MXPA06003150A (es) *	2003-09-17	2006-08-31	Johnson & Johnson	Compuestos heterociclicos fusionados.
EP1668013B1 (en)	2003-09-23	2012-02-22	Vertex Pharmaceuticals Incorporated	Pyrazolopyrrole derivatives as protein kinase inhibitors
JP2007517766A (ja)	2003-09-24	2007-07-05	コンビナトアールエックスインコーポレーティッド	薬物の組み合わせを投与するための治療法
EP1696896A2 (en)	2003-12-15	2006-09-06	H. Lundbeck A/S	The combination of a serotonin reuptake inhibitor and a histamine 3 receptor antagonist, inverse agonist or partial agonist
US20050232986A1 (en) *	2003-12-17	2005-10-20	David Brown	Dosage form containing promethazine and another drug
US20090227562A1 (en)	2004-08-10	2009-09-10	Pfizer Inc.	Combination of a Selective Noradrenaline Reuptake Unhibitor and a PDEV Inhibitor
US20060037652A1 (en)	2004-08-23	2006-02-23	Ranco Incorporated Of Delaware	Reversing valve assembly with improved pilot valve mounting structure
EP1831173B1 (en) *	2004-12-17	2011-01-26	Janssen Pharmaceutica NV	Tetrahydroisoquinoline compounds for treatment of cns disorders
EP1893613A1 (en) *	2005-06-17	2008-03-05	Janssen Pharmaceutica N.V.	Hexahydro-pyrrolo-isoquinoline compounds for the treatment of cns disorders
EP1899334B1 (en) *	2005-06-17	2008-09-24	Janssen Pharmaceutica N.V.	Naphthyridine compounds
KR101353268B1 (ko)	2005-08-04	2014-02-06	얀센 파마슈티카 엔.브이.	세로토닌 수용체 모듈레이터로서의 피리미딘 화합물
US7598255B2 (en) *	2005-08-04	2009-10-06	Janssen Pharmaceutica Nv	Pyrimidine compounds as serotonin receptor modulators
AU2007225273A1 (en) *	2006-03-10	2007-09-20	Neurogen Corporation	Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues
ATE459614T1 (de) *	2006-05-05	2010-03-15	Janssen Pharmaceutica Nv	Herstellungsverfahren für pyrazolhaltige verbindungen
CN101511785A (zh) *	2006-06-29	2009-08-19	詹森药业有限公司	取代的苄基胺化合物
CN101511790A (zh) *	2006-06-29	2009-08-19	詹森药业有限公司	取代的氨基甲基苯甲酰胺化合物
CN101511775A (zh) *	2006-06-29	2009-08-19	詹森药业有限公司	丁基和丁炔基苄基胺化合物
US20080139564A1 (en) *	2006-11-16	2008-06-12	Keith John M	Substituted phenyl propyl amines as histamine h3 receptor and serotonin transporter modulators

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Also Published As

Publication number	Publication date
ES2319539T3 (es)	2009-05-08
SI1668014T1 (sl)	2009-06-30
JP2007505908A (ja)	2007-03-15
US20050119295A1 (en)	2005-06-02
EP1668014B1 (en)	2009-01-14
MXPA06003150A (es)	2006-08-31
NI200600094A (es)	2014-02-25
IL209082A0 (en)	2011-01-31
US7897771B2 (en)	2011-03-01
JP5069907B2 (ja)	2012-11-07
KR20070023633A (ko)	2007-02-28
WO2005040169A2 (en)	2005-05-06
US7402680B2 (en)	2008-07-22
IS8348A (is)	2006-03-09
PT1668014E (pt)	2009-03-17
US8618288B2 (en)	2013-12-31
BRPI0414541B8 (pt)	2021-05-25
CY1109416T1 (el)	2014-08-13
SG146683A1 (en)	2008-10-30
CA2539426C (en)	2012-07-10
AU2004283196A1 (en)	2005-05-06
BRPI0414541A (pt)	2006-11-07
CN103788089A (zh)	2014-05-14
NZ545836A (en)	2009-09-25
DK1668014T3 (da)	2009-04-20
TW200521123A (en)	2005-07-01
US20110040088A1 (en)	2011-02-17
WO2005040169A3 (en)	2006-03-30
CR8302A (es)	2008-09-10
TWI345565B (en)	2011-07-21
EP1668014A2 (en)	2006-06-14
CA2539426A1 (en)	2005-05-06
US20090270370A1 (en)	2009-10-29
DE602004019118D1 (de)	2009-03-05
EA200801812A1 (ru)	2009-06-30
ATE420881T1 (de)	2009-01-15
KR101151653B1 (ko)	2012-06-28
AR047218A1 (es)	2006-01-11
BRPI0414541A8 (pt)	2019-01-02
EA010905B1 (ru)	2008-12-30
CL2009000943A1 (es)	2009-08-21
US20100016281A1 (en)	2010-01-21
IS2756B (is)	2011-10-15
US20080103132A1 (en)	2008-05-01
IL174283A (en)	2012-06-28
BRPI0414541B1 (pt)	2019-02-26
EA200600433A1 (ru)	2006-08-25
AU2004283196B2 (en)	2011-08-25
HK1118550A1 (en)	2009-02-13
IL174283A0 (en)	2006-08-01
US7579470B2 (en)	2009-08-25
ECSP066436A (es)	2006-09-18

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PT1668014E (pt)	2009-03-17	Compostos heterocíclicos fundidos como moduladores do receptor de serotonina
EP1687002A4 (en)	2008-07-23	CONDENSED HETEROCYCLIC COMPOUNDS
IL190280A0 (en)	2009-09-22	Fused heterocyclic compounds useful as kinase modulators
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ZA200604778B (en)	2007-12-27	Azabicyclic heterocycles as cannabinoid receptor modulators
AU2003296405A1 (en)	2004-08-10	Fused heterocyclic derivatives as ppar modulators
ZA200603881B (en)	2010-01-27	Substituted fused heterocyclic C-glycosides
IL175489A0 (en)	2009-02-11	Substituted fused heterocyclic c-glycosides
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IL172921A0 (en)	2006-06-11	Cck-1 receptor modulators
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