PT1668014E - Compostos heterocíclicos fundidos como moduladores do receptor de serotonina - Google Patents

Compostos heterocíclicos fundidos como moduladores do receptor de serotonina Download PDF

Info

Publication number: PT1668014E
Authority: PT; Portugal
Prior art keywords: heterocyclic compounds; receptor modulators; fused heterocyclic; serotonin receptor; serotonin
Prior art date: 2003-09-17

Application number

PT04816874T

Other languages

English (en)

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-17

Filing date

2004-09-15

Publication date

2009-03-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34526458&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1668014(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-09-15 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2009-03-17 Publication of PT1668014E publication Critical patent/PT1668014E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Addiction (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Nutrition Science (AREA)
Vascular Medicine (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

PT04816874T 2003-09-17 2004-09-15 Compostos heterocíclicos fundidos como moduladores do receptor de serotonina PT1668014E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US50452803P	2003-09-17	2003-09-17
US55267304P	2004-03-11	2004-03-11

Publications (1)

Publication Number	Publication Date
PT1668014E true PT1668014E (pt)	2009-03-17

Family

ID=34526458

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT04816874T PT1668014E (pt)	2003-09-17	2004-09-15	Compostos heterocíclicos fundidos como moduladores do receptor de serotonina

Country Status (29)

Country	Link
US (5)	US7402680B2 (pt)
EP (1)	EP1668014B1 (pt)
JP (1)	JP5069907B2 (pt)
KR (1)	KR101151653B1 (pt)
CN (1)	CN103788089A (pt)
AR (1)	AR047218A1 (pt)
AT (1)	ATE420881T1 (pt)
AU (1)	AU2004283196B2 (pt)
BR (1)	BRPI0414541B8 (pt)
CA (1)	CA2539426C (pt)
CL (1)	CL2009000943A1 (pt)
CR (1)	CR8302A (pt)
CY (1)	CY1109416T1 (pt)
DE (1)	DE602004019118D1 (pt)
DK (1)	DK1668014T3 (pt)
EA (2)	EA010905B1 (pt)
EC (1)	ECSP066436A (pt)
ES (1)	ES2319539T3 (pt)
IL (2)	IL174283A (pt)
IS (1)	IS2756B (pt)
MX (1)	MXPA06003150A (pt)
NI (1)	NI200600094A (pt)
NZ (1)	NZ545836A (pt)
PL (1)	PL1668014T3 (pt)
PT (1)	PT1668014E (pt)
SG (1)	SG146683A1 (pt)
SI (1)	SI1668014T1 (pt)
TW (1)	TWI345565B (pt)
WO (1)	WO2005040169A2 (pt)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7402680B2 (en) *	2003-09-17	2008-07-22	Janssen Pharmaceutica, N.V.	Fused heterocyclic compounds
CA2557158A1 (en) *	2004-02-20	2005-09-01	Astellas Pharma Inc.	Prophylactic antimigraine agents
JP5025469B2 (ja)	2004-06-30	2012-09-12	アサーシス，インク．	セロトニン受容体モジュレーターとしての置換アゼピン誘導体
EP1824831A2 (en)	2004-12-16	2007-08-29	Takeda San Diego, Inc.	Histone deacetylase inhibitors
WO2006085510A1 (ja) *	2005-02-08	2006-08-17	Astellas Pharma Inc.	過敏性腸症候群の治療薬
US7642253B2 (en)	2005-05-11	2010-01-05	Takeda San Diego, Inc.	Histone deacetylase inhibitors
GB0513886D0 (en) *	2005-07-06	2005-08-10	Glaxo Group Ltd	Novel compounds
US7598255B2 (en)	2005-08-04	2009-10-06	Janssen Pharmaceutica Nv	Pyrimidine compounds as serotonin receptor modulators
WO2007019083A1 (en) *	2005-08-04	2007-02-15	Janssen Pharmaceutica N.V.	Pyrimidine compounds as serotonin receptor modulators
JP5092746B2 (ja) *	2005-08-08	2012-12-05	アステラス製薬株式会社	アシルグアニジン誘導体またはその塩
CN101404882A (zh)	2006-01-19	2009-04-08	阿特西斯公司	作为5-羟色胺5-HT2c受体配体的噻吩基和吡咯基氮杂类及其用途
US8012957B2 (en)	2006-03-27	2011-09-06	Janssen Pharmaceutica Nv	Tetrahydro-1H-1,2,6-triaza-azulene cannabinoid modulators
EP2016064B1 (en) *	2006-05-05	2010-03-03	Janssen Pharmaceutica, N.V.	Methods for the preparation of pyrazole-containing compounds
DE602007004999D1 (de) *	2006-08-28	2010-04-08	Actelion Pharmaceuticals Ltd	1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulen-derivate als orexinrezeptor-antagonisten
WO2009058810A1 (en) *	2007-11-02	2009-05-07	Janssen Pharmaceutica N.V.	Process for the preparation of substituted 2,4,5,6,7,8-hexahydro-1,2,6-triaza-azulene derivatives
EP2229361A1 (en) *	2008-01-03	2010-09-22	Allergan, Inc.	Tetrahydroindoles having sphingosine-1-phosphate receptor activity
WO2010053825A1 (en)	2008-10-29	2010-05-14	Janssen Pharmaceutica Nv	2-aminopyrimidine compounds as serotonin receptor modulators
KR101385433B1 (ko)	2008-11-18	2014-04-14	에프. 호프만-라 로슈 아게	다이하이드로테트라아자벤조아줄렌의 알킬사이클로헥실에터
JP5063815B2 (ja) *	2008-11-25	2012-10-31	ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ	抗腫瘍および抗神経変性剤としての二環式ピラゾールおよびイソオキサゾール誘導体
US8492374B2 (en) *	2009-04-29	2013-07-23	Industrial Technology Research Institute	Azaazulene compounds
GB201004311D0 (en)	2010-03-15	2010-04-28	Proximagen Ltd	New enzyme inhibitor compounds
CN103492378B (zh)	2011-04-21	2016-09-28	巴斯夫欧洲公司	杀虫吡唑化合物
BR112014005793A2 (pt)	2011-09-14	2017-03-28	Proximagen Ltd	compostos inibidores de enzimas
WO2013156318A1 (en)	2012-04-16	2013-10-24	Basf Se	Substituted pesticidal pyrazole compounds
PL3300602T3 (pl)	2012-06-20	2020-08-24	Basf Se	Mieszaniny szkodnikobójcze zawierające związek pirazolowy
AU2013302473B2 (en) *	2012-08-16	2017-08-10	Janssen Pharmaceutica Nv	Pyrrolopyrazoles as N-type calcium channel blockers
WO2014063942A1 (en)	2012-10-23	2014-05-01	Basf Se	Substituted pesticidal pyrazole compounds
KR20150108840A (ko)	2012-12-21	2015-09-30	에이비티 홀딩 컴퍼니	세로토닌 5-ht2c 수용체 리간드로서 벤즈아제핀 및 그의 용도
US9309262B2 (en)	2013-03-13	2016-04-12	Abt Holding Company	Thienylindole azepines as serotonin 5-HT2C receptor ligands and uses thereof
US9453002B2 (en)	2013-08-16	2016-09-27	Janssen Pharmaceutica Nv	Substituted imidazoles as N-type calcium channel blockers
WO2015055497A1 (en)	2013-10-16	2015-04-23	Basf Se	Substituted pesticidal pyrazole compounds
JP7224102B2 (ja) *	2014-11-21	2023-02-17	アカーナ・セラピューティクス・リミテッド	疾患治療用の縮合二環式化合物
JP2018510135A (ja) *	2015-02-11	2018-04-12	メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋＳｈａｒｐ＆ＤｏｈｍｅＣｏｒｐ．	ＲＯＲγＴ阻害剤としての置換ピラゾール化合物及びその使用
CN105503647A (zh) *	2015-12-10	2016-04-20	苏州昊帆生物科技有限公司	环丙基肼盐酸盐的制备方法
US9951039B2 (en) *	2016-04-08	2018-04-24	The Hong Kong Polytechnic University	Pyrimidines for treatment of bacterial infections
KR101917264B1 (ko) *	2016-12-22	2018-11-13	한국과학기술연구원	5-ht7 수용체 조절제로 작용하는 아제핀 유도체
KR102037494B1 (ko)	2017-12-11	2019-10-28	씨제이헬스케어 주식회사	광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법
WO2019137995A1 (en)	2018-01-11	2019-07-18	Basf Se	Novel pyridazine compounds for controlling invertebrate pests
CN112300169B (zh) *	2019-07-26	2022-03-04	上海美迪西生物医药股份有限公司	吡咯并吡唑类衍生物、其制备方法及其在医药上的应用
KR20190120112A (ko)	2019-10-08	2019-10-23	씨제이헬스케어 주식회사	광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법
BR112022013849A2 (pt) *	2020-01-13	2022-09-13	Aptabio Therapeutics Inc	Novo derivado de pirazol
PL4097099T3 (pl)	2020-02-07	2024-11-04	Gasherbrum Bio, Inc.	Heterocykliczne agonisty glp-1
IL322686A (en)	2023-02-16	2025-10-01	Gasherbrum Bio Inc	Heterocyclic glp-1 agonists

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1197466B (de) *	1962-03-22	1965-07-29	Thomae Gmbh Dr K	Verfahren zur Herstellung von neuen 5, 6, 7, 8-Tetrahydropyrido-[4, 3-d]pyrimidinen
US3312716A (en) *	1964-08-11	1967-04-04	Aldrich Chem Co Inc	4-hydroxy-3-pyrrolidinemethanols
GB1422263A (en) *	1973-01-30	1976-01-21	Ferrosan As	4-phenyl-piperidine compounds
US4314081A (en) *	1974-01-10	1982-02-02	Eli Lilly And Company	Arloxyphenylpropylamines
GB1484140A (en) *	1974-04-24	1977-08-24	Wyeth John & Brother Ltd	Pyrrolopyridine derivatives
US3969355A (en) *	1974-11-01	1976-07-13	Morton-Norwich Products, Inc.	5-Aminoethyl-2,4-diphenylpyrimidine dihydrobromide
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
US4536518A (en) *	1979-11-01	1985-08-20	Pfizer Inc.	Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
DK27383A (da) *	1982-02-17	1983-08-18	Lepetit Spa	Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner
US4673405A (en) *	1983-03-04	1987-06-16	Alza Corporation	Osmotic system with instant drug availability
US4576604A (en) *	1983-03-04	1986-03-18	Alza Corporation	Osmotic system with instant drug availability
US4857330A (en) *	1986-04-17	1989-08-15	Alza Corporation	Chlorpheniramine therapy
JPH03148265A (ja)	1989-11-01	1991-06-25	Sumitomo Chem Co Ltd	５，７―ジフェニル―４，６―ジアザインダン誘導体、その製造法およびそれを有効成分とする除草剤
US5137890A (en) *	1990-02-14	1992-08-11	Ortho Pharmaceutical Corporation	4-phenyl tetrahydropyrido(4,3-d)pyrimidines
US5053508A (en)	1990-03-09	1991-10-01	American Home Products Corporation	Fused heterotricyclic imides with psychotropic activity and intermedrates thereof
US5648352A (en) *	1991-09-13	1997-07-15	Merck & Co., Inc.	Piperazinylcamphorsulfonyl oxytocin antagonists
FI943948A7 (fi)	1992-12-28	1994-08-26	Eisai Co Ltd	Heterosykliset hiilihappojohdannaiset
US5843912A (en) *	1994-07-06	1998-12-01	Universy Of Maryland	Ring-expanded nucleosides and nucleotides
US6677310B1 (en) *	1999-04-21	2004-01-13	Nabi	Ring-expanded nucleosides and nucleotides
US5405848A (en) *	1993-12-22	1995-04-11	Ortho Pharmaceutical Corporation	Substituted thiazolylaminotetrahydropyridopyrimidines derivatives useful as platelet aggregation inhibitors
US5663178A (en) *	1995-02-06	1997-09-02	Eli Lilly And Company	Tetrahydro-beta carbolines
WO1995029909A1 (en)	1994-04-29	1995-11-09	Pfizer Inc.	Novel acyclic and cyclic amides as neurotransmitter release enhancers
CA2218143A1 (en)	1995-04-18	1996-10-24	Eli Lilly And Company	Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptor
JP2000504677A (ja)	1996-02-09	2000-04-18	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	５ｈｔ７レセプター・アンタゴニスト用のスルホンアミド誘導体
TW470745B (en) *	1996-05-23	2002-01-01	Janssen Pharmaceutica Nv	Hexahydro-pyrido[4,3-b]indole derivatives
AU2980797A (en)	1996-06-11	1998-01-07	Yoshitomi Pharmaceutical Industries, Ltd.	Fused heterocyclic compounds and medicinal uses thereof
GB9612884D0 (en)	1996-06-20	1996-08-21	Smithkline Beecham Plc	Novel compounds
WO1997049695A1 (en)	1996-06-25	1997-12-31	Smithkline Beecham P.L.C.	Sulfonamide derivatives as 5ht7 receptor antagonists
ATE296801T1 (de) *	1996-06-28	2005-06-15	Meiji Seika Kaisha	Tetrahydrobezindol derivate
GB9700899D0 (en)	1997-01-17	1997-03-05	Smithkline Beecham Plc	Novel treatment
US6177443B1 (en) *	1997-03-07	2001-01-23	Novo Nordisk A/S	4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use
EP0973778A1 (en)	1997-03-07	2000-01-26	Novo Nordisk A/S	4,5,6,7-TETRAHYDRO-THIENO 3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
EP0905136A1 (en) *	1997-09-08	1999-03-31	Janssen Pharmaceutica N.V.	Tetrahydro gamma-carbolines
US5951518A (en)	1997-10-31	1999-09-14	Teleflex, Incorporated	Introducing device with flared sheath end
AU1558899A (en)	1997-11-10	1999-05-31	F. Hoffmann-La Roche Ag	Isoquinoline derivatives for use against cns disorders
US6407112B1 (en) *	1998-04-22	2002-06-18	Meiji Seika Kaisha, Ltd.	Optically active tetrahydrobenzindole derivative
EA004539B1 (ru)	1998-05-22	2004-06-24	Эли Лилли Энд Компани	Комбинационная терапия для лечения резистентной депрессии
US5997905A (en) *	1998-09-04	1999-12-07	Mcneil-Ppc	Preparation of pharmaceutically active particles
WO2000024399A1 (en)	1998-10-23	2000-05-04	Sepracor Inc.	Compositions and methods employing r(-) fluoxetine and other active ingredients
US6245785B1 (en)	1998-11-30	2001-06-12	Warner Lambert Company	Dissolution of triprolidine hydrochloride
GB9828004D0 (en)	1998-12-18	1999-02-10	Smithkline Beecham Plc	Use
GB9906624D0 (en)	1999-03-23	1999-05-19	Smithkline Beecham Plc	Novel compounds
AU768720B2 (en) *	1999-04-01	2004-01-08	Pfizer Products Inc.	Aminopyrimidines as sorbitol dehydrogenase inhibitors
GB9912701D0 (en)	1999-06-01	1999-08-04	Smithkline Beecham Plc	Novel compounds
CA2384354C (en)	1999-09-09	2009-06-23	Kumiai Chemical Industry Co., Ltd.	Pyrimidine derivatives and herbicides containing them
EP1222185A1 (en)	1999-10-18	2002-07-17	Smithkline Beecham Plc	Tetrahydrobenzindolone derivatives, their preparation and their use as 5-ht7 receptor antagonists
UA77650C2 (en)	1999-12-06	2007-01-15	Lundbeck & Co As H	Use of serotonin reuptake inhibitor in combination with deramcyclane
BR0108007A (pt)	2000-02-04	2002-10-29	Wyeth Corp	Derivados da pirrolo-isoquinolina e tetraidropirrolo-isoquinolina e seus usos como mediadores do receptor da 5-ht7
AU2001241128A1 (en)	2000-03-14	2001-09-24	Fujisawa Pharmaceutical Co. Ltd.	Novel amide compounds
US6586469B2 (en)	2000-07-25	2003-07-01	Medpointe Healthcare Inc.	Antihistaminic/antitussive compositions
NZ524193A (en)	2000-08-14	2004-12-24	Ortho Mcneil Pharm Inc	Substituted pyrazoles
ATE413878T1 (de) *	2000-09-06	2008-11-15	Ortho Mcneil Pharm Inc	Methode zum bekämpfen der allergien durch verwendung von substituierten pyrazolen
US20040267010A1 (en)	2001-02-02	2004-12-30	Forbes Ian Thomson	Sulfonamide compounds, their preparation and use
DE60214138T2 (de) *	2001-02-21	2007-03-29	Janssen Pharmaceutica N.V.	Isoxazolin-derivate als antidepressiva
DE10111842A1 (de)	2001-03-13	2002-09-19	Boehringer Ingelheim Pharma	Antithrombotische Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
US20020183519A1 (en) *	2001-03-13	2002-12-05	Herbert Nar	Antithrombotic carboxylic acid amides
US6559174B2 (en) *	2001-03-20	2003-05-06	Merck & Co., Inc.	N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors
US6806380B2 (en) *	2001-10-02	2004-10-19	Lexicon Pharmaceuticals, Inc.	Modified safe and efficient process for the environmentally friendly synthesis of imidoesters
MXPA04003954A (es) *	2001-10-26	2004-11-29	Aventis Pharma Inc	Bencimidazoles.
US6806279B2 (en)	2001-12-17	2004-10-19	Sunesis Pharmaceuticals, Inc.	Small-molecule inhibitors of interleukin-2
SE0104340D0 (sv)	2001-12-20	2001-12-20	Astrazeneca Ab	New compounds
US20030199542A1 (en) *	2002-04-18	2003-10-23	Woods Keith W.	Farnesyltransferase inhibitors
US20030199544A1 (en) *	2002-04-18	2003-10-23	Woods Keith W.	Farnesyltransferase inhibitors
HRP20020452A2 (en)	2002-05-23	2004-02-29	Pliva D D	1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
CN1665810A (zh) *	2002-05-30	2005-09-07	沃泰克斯药物股份有限公司	Jak和cdk2蛋白激酶的抑制剂
PT1545552E (pt) *	2002-06-20	2007-06-15	Lundbeck & Co As H	Terapia de combinação em que é utilizada um inibidor de reabsorção de serotonina
US20060100233A1 (en) *	2002-07-25	2006-05-11	Manuela Villa	Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
JP2005537290A (ja) *	2002-07-25	2005-12-08	ファルマシア・イタリア・エス・ピー・エー	キナーゼ阻害剤として活性なビシクロピラゾール類、その製造方法、およびそれを含有する薬学的組成物
JPWO2004011467A1 (ja)	2002-07-29	2005-12-15	北興化学工業株式会社	トリアゾロピリミジン誘導体および農園芸用殺菌剤
US20040132826A1 (en)	2002-10-25	2004-07-08	Collegium Pharmaceutical, Inc.	Modified release compositions of milnacipran
AU2003274050A1 (en)	2002-10-30	2004-05-25	Ciba Specialty Chemicals Holding Inc.	Electroluminescent device
JP2006516604A (ja) *	2003-01-31	2006-07-06	ファイザー・プロダクツ・インク	５ｈｔ７アンタゴニストおよび逆アゴニスト
GB0308208D0 (en)	2003-04-09	2003-05-14	Glaxo Group Ltd	Chemical compounds
US7145012B2 (en) *	2003-04-23	2006-12-05	Pfizer Inc.	Cannabinoid receptor ligands and uses thereof
GB0316128D0 (en)	2003-07-10	2003-08-13	Univ Aston	Novel sulfonamide compounds
CA2532798C (en)	2003-07-23	2013-02-19	X-Ceptor Therapeutics Inc.	Azepine derivatives as pharmaceutical agents
US7402680B2 (en)	2003-09-17	2008-07-22	Janssen Pharmaceutica, N.V.	Fused heterocyclic compounds
WO2005030776A1 (en) *	2003-09-23	2005-04-07	Vertex Pharmaceuticals Incorporated	Pyrazolopyrrole derivatives as protein kinase inhibitors
MXPA06003320A (es)	2003-09-24	2006-06-08	Combinatorx Inc	Regimenes terapeuticos para administrar combinaciones de farmacos.
AU2004296531A1 (en)	2003-12-15	2005-06-23	H. Lundbeck A/S	The combination of a serotonin reuptake inhibitor and a histamine 3 receptor antagonist, inverse agonist or partial agonist
US20050232986A1 (en) *	2003-12-17	2005-10-20	David Brown	Dosage form containing promethazine and another drug
US20090227562A1 (en)	2004-08-10	2009-09-10	Pfizer Inc.	Combination of a Selective Noradrenaline Reuptake Unhibitor and a PDEV Inhibitor
US20060037652A1 (en)	2004-08-23	2006-02-23	Ranco Incorporated Of Delaware	Reversing valve assembly with improved pilot valve mounting structure
JP2008524252A (ja)	2004-12-17	2008-07-10	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｃｎｓ障害の処置のためのテトラヒドロイソキノリン化合物
AU2006261162A1 (en) *	2005-06-17	2006-12-28	Janssen Pharmaceutica N.V.	Naphthyridine compounds
EP1893613A1 (en) *	2005-06-17	2008-03-05	Janssen Pharmaceutica N.V.	Hexahydro-pyrrolo-isoquinoline compounds for the treatment of cns disorders
WO2007019083A1 (en)	2005-08-04	2007-02-15	Janssen Pharmaceutica N.V.	Pyrimidine compounds as serotonin receptor modulators
US7598255B2 (en)	2005-08-04	2009-10-06	Janssen Pharmaceutica Nv	Pyrimidine compounds as serotonin receptor modulators
KR20080109841A (ko) *	2006-03-10	2008-12-17	뉴로젠 코포레이션	피페라지닐 옥소알킬 테트라히드로이소퀴놀린 및 관련유사체
EP2016064B1 (en) *	2006-05-05	2010-03-03	Janssen Pharmaceutica, N.V.	Methods for the preparation of pyrazole-containing compounds
EP2049466A1 (en) *	2006-06-29	2009-04-22	Janssen Pharmaceutica N.V.	Butyl and butynyl benzyl amine compounds
EP2046747A1 (en) *	2006-06-29	2009-04-15	Janssen Pharmaceutica N.V.	Substituted aminomethyl benzamide compounds
JP2009544579A (ja) *	2006-06-29	2009-12-17	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	置換ベンジルアミン化合物
WO2008064036A1 (en) *	2006-11-16	2008-05-29	Janssen Pharmaceutica N.V.	Substituted phenyl propyl amines as histamine h3 receptor and serotonin transporter modulators

2004
- 2004-09-15 US US10/941,664 patent/US7402680B2/en active Active
- 2004-09-15 AU AU2004283196A patent/AU2004283196B2/en not_active Ceased
- 2004-09-15 BR BRPI0414541A patent/BRPI0414541B8/pt not_active IP Right Cessation
- 2004-09-15 PT PT04816874T patent/PT1668014E/pt unknown
- 2004-09-15 KR KR1020067007322A patent/KR101151653B1/ko not_active Expired - Fee Related
- 2004-09-15 MX MXPA06003150A patent/MXPA06003150A/es active IP Right Grant
- 2004-09-15 SI SI200431089T patent/SI1668014T1/sl unknown
- 2004-09-15 SG SG200807152-4A patent/SG146683A1/en unknown
- 2004-09-15 CN CN201410027820.XA patent/CN103788089A/zh active Pending
- 2004-09-15 WO PCT/US2004/030190 patent/WO2005040169A2/en not_active Ceased
- 2004-09-15 JP JP2006526993A patent/JP5069907B2/ja not_active Expired - Fee Related
- 2004-09-15 AT AT04816874T patent/ATE420881T1/de active
- 2004-09-15 EP EP04816874A patent/EP1668014B1/en not_active Expired - Lifetime
- 2004-09-15 DK DK04816874T patent/DK1668014T3/da active
- 2004-09-15 EA EA200600433A patent/EA010905B1/ru unknown
- 2004-09-15 EA EA200801812A patent/EA200801812A1/ru unknown
- 2004-09-15 CA CA2539426A patent/CA2539426C/en not_active Expired - Fee Related
- 2004-09-15 DE DE602004019118T patent/DE602004019118D1/de not_active Expired - Lifetime
- 2004-09-15 NZ NZ545836A patent/NZ545836A/en not_active IP Right Cessation
- 2004-09-15 ES ES04816874T patent/ES2319539T3/es not_active Expired - Lifetime
- 2004-09-15 PL PL04816874T patent/PL1668014T3/pl unknown
- 2004-09-16 TW TW093128049A patent/TWI345565B/zh not_active IP Right Cessation
- 2004-09-17 AR ARP040103363A patent/AR047218A1/es active IP Right Grant
2006
- 2006-03-09 IS IS8348A patent/IS2756B/is unknown
- 2006-03-13 IL IL174283A patent/IL174283A/en active IP Right Grant
- 2006-03-17 CR CR8302A patent/CR8302A/es unknown
- 2006-03-17 EC EC2006006436A patent/ECSP066436A/es unknown
- 2006-04-20 NI NI200600094A patent/NI200600094A/es unknown
2007
- 2007-10-25 US US11/924,277 patent/US7579470B2/en not_active Expired - Lifetime
2009
- 2009-04-10 CY CY20091100428T patent/CY1109416T1/el unknown
- 2009-04-20 CL CL2009000943A patent/CL2009000943A1/es unknown
- 2009-07-02 US US12/496,866 patent/US7897771B2/en not_active Expired - Fee Related
- 2009-09-11 US US12/557,661 patent/US8618288B2/en active Active
2010
- 2010-10-25 US US12/911,523 patent/US20110040088A1/en not_active Abandoned
- 2010-11-02 IL IL209082A patent/IL209082A0/en active IP Right Grant

Also Published As

Publication number	Publication date
BRPI0414541A (pt)	2006-11-07
JP2007505908A (ja)	2007-03-15
TWI345565B (en)	2011-07-21
TW200521123A (en)	2005-07-01
SI1668014T1 (sl)	2009-06-30
ES2319539T3 (es)	2009-05-08
CY1109416T1 (el)	2014-08-13
NI200600094A (es)	2014-02-25
JP5069907B2 (ja)	2012-11-07
US8618288B2 (en)	2013-12-31
IL174283A (en)	2012-06-28
CN103788089A (zh)	2014-05-14
PL1668014T3 (pl)	2009-06-30
EP1668014B1 (en)	2009-01-14
EA010905B1 (ru)	2008-12-30
ECSP066436A (es)	2006-09-18
AU2004283196B2 (en)	2011-08-25
DK1668014T3 (da)	2009-04-20
US20100016281A1 (en)	2010-01-21
US7402680B2 (en)	2008-07-22
US20090270370A1 (en)	2009-10-29
IL174283A0 (en)	2006-08-01
EA200600433A1 (ru)	2006-08-25
CA2539426A1 (en)	2005-05-06
US7897771B2 (en)	2011-03-01
BRPI0414541A8 (pt)	2019-01-02
IL209082A0 (en)	2011-01-31
KR101151653B1 (ko)	2012-06-28
BRPI0414541B8 (pt)	2021-05-25
MXPA06003150A (es)	2006-08-31
AU2004283196A1 (en)	2005-05-06
CR8302A (es)	2008-09-10
WO2005040169A2 (en)	2005-05-06
US7579470B2 (en)	2009-08-25
EP1668014A2 (en)	2006-06-14
EA200801812A1 (ru)	2009-06-30
CA2539426C (en)	2012-07-10
BRPI0414541B1 (pt)	2019-02-26
DE602004019118D1 (de)	2009-03-05
KR20070023633A (ko)	2007-02-28
AR047218A1 (es)	2006-01-11
HK1118550A1 (en)	2009-02-13
IS8348A (is)	2006-03-09
NZ545836A (en)	2009-09-25
US20110040088A1 (en)	2011-02-17
CL2009000943A1 (es)	2009-08-21
US20050119295A1 (en)	2005-06-02
SG146683A1 (en)	2008-10-30
US20080103132A1 (en)	2008-05-01
WO2005040169A3 (en)	2006-03-30
ATE420881T1 (de)	2009-01-15
IS2756B (is)	2011-10-15

Publication	Publication Date	Title
PT1668014E (pt)	2009-03-17	Compostos heterocíclicos fundidos como moduladores do receptor de serotonina
EP1687002A4 (en)	2008-07-23	CONDENSED HETEROCYCLIC COMPOUNDS
IL190280A0 (en)	2009-09-22	Fused heterocyclic compounds useful as kinase modulators
HUS1700010I1 (hu)	2017-03-28	Új vegyületek mint ópioid receptor modulátorok
ZA200604645B (en)	2007-11-28	Azabicyclic heterocycles as cannabinoid receptor modulators
AU2003296405A1 (en)	2004-08-10	Fused heterocyclic derivatives as ppar modulators
ZA200603881B (en)	2010-01-27	Substituted fused heterocyclic C-glycosides
IL175489A0 (en)	2009-02-11	Substituted fused heterocyclic c-glycosides
IL180676A0 (en)	2007-06-03	Fused ring heterocycle kinase modulators
IL179414A0 (en)	2007-05-15	Fused heterocyclic compound
IL186407A0 (en)	2008-01-20	Fused heterocyclic compounds
EP1644335A4 (en)	2008-06-04	TETRAHYDROQUINOLINE DERIVATIVES COMPRISING MODULATORS OF CANNABINOID RECEPTORS
ZA200700684B (en)	2008-10-29	Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators
AU2003300131A8 (en)	2004-11-04	Indole derivatives as ppar modulators
NO20070494L (no)	2007-03-23	Substituerte azepinderivater som serotoninreseptormodulatorer
AU2003256922A8 (en)	2004-02-16	Substituted heterocyclic compounds as modulators of the ccr5 receptor
IL183647A (en)	2013-06-27	The heterocyclic compounds are converted into 3-ethylidenehydrazino
DE602004014772D1 (de)	2008-08-14	Pyrrol-2,5-dithionderivate als modulatoren des liver-x-rezeptors
ZA200802549B (en)	2010-03-31	Fused heterocyclic compounds useful as kinase modulators
PL376659A1 (pl)	2006-01-09	Skondensowane związki heterocykliczne
IL172921A0 (en)	2006-06-11	Cck-1 receptor modulators
ZA200708844B (en)	2009-08-26	Fused heterocyclic compounds
SI1697371T1 (sl)	2007-10-31	Azabiciklični heterocikli kot modulatorji kanabinoidnega receptorja
SI1697370T1 (sl)	2007-10-31	Azabiciklični heterocikli kot modulatorji kanabinoidnega receptorja
HK1093691A (en)	2007-03-09	Fused heterocyclic compounds