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PE20190502A1 - Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos - Google Patents

Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos

Info

Publication number
PE20190502A1
PE20190502A1 PE2019000295A PE2019000295A PE20190502A1 PE 20190502 A1 PE20190502 A1 PE 20190502A1 PE 2019000295 A PE2019000295 A PE 2019000295A PE 2019000295 A PE2019000295 A PE 2019000295A PE 20190502 A1 PE20190502 A1 PE 20190502A1
Authority
PE
Peru
Prior art keywords
lactam
spiro
nmda
bis
same use
Prior art date
Application number
PE2019000295A
Other languages
English (en)
Inventor
M Amin Khan
Original Assignee
Aptinyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aptinyx Inc filed Critical Aptinyx Inc
Publication of PE20190502A1 publication Critical patent/PE20190502A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se refiere a un compuesto representado por la Formula I o Formula II; o una sal farmaceuticamente aceptable, un estereoisomero, y/o un N-oxido del mismo, caracterizado porque: R1 y R2 se seleccionan de forma independiente de H, alquilo-C1-C6, entre otros; R3 se selecciona de H, alquilo-C1-C6, entre otros; y R4, R5, R6 y R7 se seleccionan de forma independiente de H, halogeno, hidroxilo, entre otros; y a una formulacion o composicion farmaceutica que comprende al compuesto de la invencion (puede ser su mezcla racemica o estereoisomerica variada) junto a un excipiente farmaceuticamente aceptable (segun la via de administracion). Tambien se refiere a metodos de preparacion y de tratamiento (para esto se pueden emplear tambien terapias de combinacion con uno o mas de otros agentes activos). La presente invencion es util para el tratamiento de afecciones tales como depresion y trastornos relacionados mediante la modulacion de la actividad del receptor de N-metil-d-aspartato (NMDA).
PE2019000295A 2016-08-01 2017-08-01 Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos PE20190502A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662369534P 2016-08-01 2016-08-01

Publications (1)

Publication Number Publication Date
PE20190502A1 true PE20190502A1 (es) 2019-04-10

Family

ID=59593195

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019000295A PE20190502A1 (es) 2016-08-01 2017-08-01 Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos

Country Status (17)

Country Link
US (2) US11028095B2 (es)
EP (1) EP3490994B8 (es)
JP (1) JP2019527235A (es)
KR (1) KR102462288B1 (es)
CN (1) CN109661398B (es)
AU (1) AU2017306158B2 (es)
BR (1) BR112019001926A2 (es)
CA (1) CA3031562A1 (es)
CL (1) CL2019000249A1 (es)
CO (1) CO2019000944A2 (es)
EA (1) EA201990425A1 (es)
ES (1) ES2979128T3 (es)
IL (1) IL264496B (es)
MX (1) MX383292B (es)
PE (1) PE20190502A1 (es)
SG (1) SG11201900546UA (es)
WO (1) WO2018026792A1 (es)

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JP2019527232A (ja) 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド スピロ−ラクタムｎｍｄａ修飾因子及びこれを用いた方法
JP7036792B2 (ja) 2016-08-01 2022-03-15 アプティニックス インコーポレイテッド スピロ－ラクタムｎｍｄａ受容体修飾因子およびその使用
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Also Published As

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BR112019001926A2 (pt) 2019-08-06
CA3031562A1 (en) 2018-02-08
AU2017306158A1 (en) 2019-01-31
KR102462288B1 (ko) 2022-11-01
EP3490994A1 (en) 2019-06-05
EA201990425A1 (ru) 2019-08-30
US20200181159A1 (en) 2020-06-11
KR20190037276A (ko) 2019-04-05
US11028095B2 (en) 2021-06-08
ES2979128T3 (es) 2024-09-24
EP3490994B8 (en) 2024-03-13
AU2017306158B2 (en) 2021-10-14
SG11201900546UA (en) 2019-02-27
MX383292B (es) 2025-03-13
CN109661398A (zh) 2019-04-19
CL2019000249A1 (es) 2019-06-21
IL264496B (en) 2022-09-01
CO2019000944A2 (es) 2019-02-08
IL264496A (es) 2019-03-31
EP3490994C0 (en) 2024-02-07
WO2018026792A1 (en) 2018-02-08
EP3490994B1 (en) 2024-02-07
JP2019527235A (ja) 2019-09-26
MX2019001322A (es) 2019-09-11
CN109661398B (zh) 2022-07-05
US20220098211A1 (en) 2022-03-31

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