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PE20180330A1 - Anticuerpos madurados por afinidad y humanizados para fcrh5 y metodos para su uso - Google Patents

Anticuerpos madurados por afinidad y humanizados para fcrh5 y metodos para su uso

Info

Publication number
PE20180330A1
PE20180330A1 PE2017002723A PE2017002723A PE20180330A1 PE 20180330 A1 PE20180330 A1 PE 20180330A1 PE 2017002723 A PE2017002723 A PE 2017002723A PE 2017002723 A PE2017002723 A PE 2017002723A PE 20180330 A1 PE20180330 A1 PE 20180330A1
Authority
PE
Peru
Prior art keywords
fcrh5
methods
humanized antibodies
affinity matured
refers
Prior art date
Application number
PE2017002723A
Other languages
English (en)
Inventor
Isidro Hotzel
Teemu T Junttila
Ji Li
Justin M Scheer
Danielle Marie Dicara
Diego Ellerman
Christoph Spiess
Paul Carter
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20180330A1 publication Critical patent/PE20180330A1/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
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    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
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    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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Abstract

Esta referido a un anticuerpo similar al receptor anti-Fc 5 (FcRH5) incluso anticuerpos anti-FcRH5, que comprenden un dominio de union a FcRH5 y un dominio de union a CD3 (cumulo de diferenciacion 3), tales como anticuerpos biespecificos dependientes de celulas T (TDB) de FcRH5. Tambien se refiere a una composicion que lo comprende y metodos para utilizarlos para el tratamiento de trastornos proliferativos celulares, tales como canceres positivos a FcRH5 o mieloma multiple
PE2017002723A 2015-06-16 2016-06-16 Anticuerpos madurados por afinidad y humanizados para fcrh5 y metodos para su uso PE20180330A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562180459P 2015-06-16 2015-06-16

Publications (1)

Publication Number Publication Date
PE20180330A1 true PE20180330A1 (es) 2018-02-13

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PE2017002723A PE20180330A1 (es) 2015-06-16 2016-06-16 Anticuerpos madurados por afinidad y humanizados para fcrh5 y metodos para su uso
PE2023001405A PE20240218A1 (es) 2015-06-16 2016-06-16 Anticuerpos madurados por afinidad y humanizados para fcrh5

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US (4) US10323094B2 (es)
EP (2) EP4299073A3 (es)
JP (4) JP6871874B2 (es)
KR (2) KR20250021639A (es)
CN (2) CN114507289A (es)
AR (3) AR105026A1 (es)
AU (3) AU2016280102B2 (es)
CA (1) CA2986928A1 (es)
CL (2) CL2017003195A1 (es)
CO (1) CO2018000244A2 (es)
CR (1) CR20180031A (es)
DK (1) DK3310814T5 (es)
ES (1) ES2957567T3 (es)
FI (1) FI3310814T3 (es)
HR (1) HRP20231134T1 (es)
HU (1) HUE063270T2 (es)
IL (2) IL256079B2 (es)
LT (1) LT3310814T (es)
MA (1) MA42428B1 (es)
MX (3) MX388965B (es)
MY (1) MY189840A (es)
PE (2) PE20180330A1 (es)
PH (1) PH12017502354A1 (es)
PL (1) PL3310814T3 (es)
PT (1) PT3310814T (es)
RS (1) RS64662B1 (es)
RU (1) RU2748943C2 (es)
SI (1) SI3310814T1 (es)
TW (3) TWI731861B (es)
UA (1) UA124615C2 (es)
WO (1) WO2016205520A1 (es)
ZA (2) ZA201707934B (es)

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MX2015003616A (es) 2012-10-08 2015-06-05 Roche Glycart Ag Anticuerpos sin fc que comprenden dos fragmentos fab y metodos de uso.
CN104936986B (zh) 2013-02-26 2019-08-09 罗切格利卡特公司 双特异性t细胞活化性抗原结合分子
MX2015010350A (es) 2013-02-26 2015-10-29 Roche Glycart Ag Moleculas de union a antigeno biespecificas que activan la celula t.
AR096687A1 (es) 2013-06-24 2016-01-27 Genentech Inc Anticuerpos anti-fcrh5
JP6449295B2 (ja) 2013-12-17 2019-01-09 ジェネンテック， インコーポレイテッド 抗ｃｄ３抗体および使用方法
RS65573B1 (sr) 2014-08-04 2024-06-28 Hoffmann La Roche Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije
JP6886398B2 (ja) 2014-09-12 2021-06-16 ジェネンテック， インコーポレイテッド Ａｎｔｉ−ｃｌｌ−１抗体及び免疫複合体
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