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PE20161251A1 - Compuestos heteroarilo o arilo biciclicos fusionados y su uso como inhibidores de irak4 - Google Patents

Compuestos heteroarilo o arilo biciclicos fusionados y su uso como inhibidores de irak4

Info

Publication number
PE20161251A1
PE20161251A1 PE2016001905A PE2016001905A PE20161251A1 PE 20161251 A1 PE20161251 A1 PE 20161251A1 PE 2016001905 A PE2016001905 A PE 2016001905A PE 2016001905 A PE2016001905 A PE 2016001905A PE 20161251 A1 PE20161251 A1 PE 20161251A1
Authority
PE
Peru
Prior art keywords
fusioned
bicyclic heteroaryl
alkyl
hydrogen
compounds
Prior art date
Application number
PE2016001905A
Other languages
English (en)
Inventor
David Randolph Anderson
Christoph Wolfgang Zapf
Mark Edward Bunnage
Kevin Joseph Curran
Christoph Martin Dehnhardt
Lori Krim Gavrin
Joel Adam Goldberg
Seungil Han
David Hepworth
Horng-Chih Huang
Katherine Lin Lee
Arthur Lee
Frank Eldridge Lovering
Michael Dennis Lowe
John Paul Mathias
Akshay Patny
Betsy Susan Pierce
Eddine Saiah
Joseph Walter Strohbach
John David Trzupek
Richard Vargas
Xiaolun Wang
Stephen Wayne Wright
Nikolaos Apaioannou
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20161251A1 publication Critical patent/PE20161251A1/es

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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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Abstract

Se refiere a compuestos de formula (Ia), donde: X, X´ e Y son CR8, N o –N+-O-, siempre que al menos un X, X o Y no sea N ni –N+-O- y que no mas de un X, X´o Y sea –N+-O-; R1 es alquilo C1-C6, alquenilo C2-C6, entre otros; R2 es –(CR3aR3b)m-(cicloalquilo de 3 a 10 miembros); –(CR3aR3b)m-(heterocicloalquilo de 3 a 10 miembros), entre otros; R3a y R3b son hidrogeno o alquilo C1-C3; R6 es –C(O)NHR7, CO2R7 o ciano; R7 es hidrogeno o alquilo C1-C6; R8 es hidrogeno, halogeno, entre otros. Son compuestos preferidos: 5-{[(2S)-5-oxopirrolidin-2-il]metoxi}-3-(propan-2-iloxi)naftalen-2-carboxamida; 1-{[(2S)-4,4-difluoro-5-oxopirrolidin-2-il]metoxi}-7-(propan-2-iloxi)isoquinolin-6-carboxamida; entre otros. Tambien se refiere a un metodo de tratamiento, una combinacion y una formulacion farmaceutica. Dichos compuestos son inhibidores de IRAK4 (quinasa 4 asociada al receptor de interleucina 1) y son utiles en el tratamiento de cancer, enfermedades alergicas, entre otros
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