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PE20161211A1 - Anticuerpos y conjugados de anticuerpo y farmaco anti-egfr - Google Patents

Anticuerpos y conjugados de anticuerpo y farmaco anti-egfr

Info

Publication number
PE20161211A1
PE20161211A1 PE2016001657A PE2016001657A PE20161211A1 PE 20161211 A1 PE20161211 A1 PE 20161211A1 PE 2016001657 A PE2016001657 A PE 2016001657A PE 2016001657 A PE2016001657 A PE 2016001657A PE 20161211 A1 PE20161211 A1 PE 20161211A1
Authority
PE
Peru
Prior art keywords
antibody
refers
drug
conjugates
antibodies
Prior art date
Application number
PE2016001657A
Other languages
English (en)
Inventor
Lorenzo Benatuil
Fritz G Buchanan
Chung-Ming Hsieh
Edward B Reilly
Jennifer Perez
Andrew C Phillips
Jonathan A Meulbroek
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52997522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20161211(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20161211A1 publication Critical patent/PE20161211A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6847—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a hormone or a hormone-releasing or -inhibiting factor
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Abstract

Se refiere a un anticuerpo anti-receptor de factor de crecimiento epidermico humano (anti-hEGFR). Tambien se refiere a un conjugado anticuerpo-farmaco (ADC) que comprende el anticuerpo y un farmaco tal como un agente antiapoptotico; un inhibidor mitotico tal como dolastatina, una auristatina tal como MMAF o MMAE, un maitansinoide tal como DM1, DM2, DM3 y DM4, o un alcaloide vegetal; un antibiotico antitumoral tal como actinomicina, antraciclina, entre otros; un agente inmunomodulador; entre otros. Tambien se refiere a una composicion farmaceutica que comprende dicho conjugado, siendo util en el tratamiento de cancer de mama, cancer de pulmon, entre otros
PE2016001657A 2014-03-21 2015-03-20 Anticuerpos y conjugados de anticuerpo y farmaco anti-egfr PE20161211A1 (es)

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