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PE20170903A1 - Conjugados de farmacos con anticuerpos anti-cdh6 - Google Patents

Conjugados de farmacos con anticuerpos anti-cdh6

Info

Publication number
PE20170903A1
PE20170903A1 PE2017000173A PE2017000173A PE20170903A1 PE 20170903 A1 PE20170903 A1 PE 20170903A1 PE 2017000173 A PE2017000173 A PE 2017000173A PE 2017000173 A PE2017000173 A PE 2017000173A PE 20170903 A1 PE20170903 A1 PE 20170903A1
Authority
PE
Peru
Prior art keywords
seq
antibody
refers
drug conjugates
chain variable
Prior art date
Application number
PE2017000173A
Other languages
English (en)
Inventor
Carl Uli Bialucha
Scott Collins
Clemens Durr
Tiancen Hu
Mary Jo Janatpour
Matthew John Meyer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20170903A1 publication Critical patent/PE20170903A1/es

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Abstract

SE REFIERE A UN CONJUGADO DE FARMACO-ANTICUERPO DE FORMULA Ab-(L-(D)m)n DONDE Ab ES UN ANTICUERPO O FRAGMENTO DE UNION A ANTIGENO DEL MISMO QUE SE UNE ESPECIFICAMENTE A UN EPITOPO DE CDH6 HUMANO; L ES UN ENLAZADOR; D ES UNA FRACCION DE FARMACO TAL COMO UN MAITANSINOIDE, UN INHIBIDOR DE LA V-ATPasa, ENTRE OTROS; m ES DE 1 A 8; n ES DE 1 A 10; EN DONDE EL ANTICUERPO Ab COMPRENDE UNA REGION VARIABLE DE CADENA LIGERA QUE COMPRENDE UNA LCDR1 DE LA SEQ ID NO: 224, UNA LCDR2 DE LA SEQ ID NO: 225 Y UNA LCDR3 DE LA SEQ ID NO: 226, Y UNA REGION VARIABLE DE CADENA PESADA QUE COMPRENDE UNA HCDR1 DE LA SEQ ID NO: 227, UNA HCDR2 DE LA SEQ ID NO: 228 Y UNA HCDR3 DE LA SEQ ID NO: 229. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO CONJUGADO ES UTIL EN EL TRATAMIENTO DE CANCER
PE2017000173A 2014-08-12 2015-08-07 Conjugados de farmacos con anticuerpos anti-cdh6 PE20170903A1 (es)

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MX2017001946A (es) 2017-06-19
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PH12017500002A1 (en) 2017-05-15
US9982045B2 (en) 2018-05-29
US20160046711A1 (en) 2016-02-18
DOP2017000045A (es) 2017-05-15
KR20170040249A (ko) 2017-04-12
US10238748B2 (en) 2019-03-26
CN106659790A (zh) 2017-05-10
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CO2017001191A2 (es) 2017-04-28
CA2954599A1 (en) 2016-02-18
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AU2015302959B2 (en) 2018-09-20
CL2017000170A1 (es) 2017-07-14
AR104664A1 (es) 2017-08-09
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JP2017524364A (ja) 2017-08-31
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