ES2687282T3 - Anticuerpos humanizados ANTI-CD134 (OX40) y sus usos - Google Patents
Anticuerpos humanizados ANTI-CD134 (OX40) y sus usos Download PDFInfo
- Publication number
- ES2687282T3 ES2687282T3 ES14715138T ES14715138T ES2687282T3 ES 2687282 T3 ES2687282 T3 ES 2687282T3 ES 14715138 T ES14715138 T ES 14715138T ES 14715138 T ES14715138 T ES 14715138T ES 2687282 T3 ES2687282 T3 ES 2687282T3
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- Prior art keywords
- seq
- amino acid
- acid sequence
- humanized antibodies
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Links
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 title abstract 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 8
- 238000006467 substitution reaction Methods 0.000 abstract 3
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Un anticuerpo aislado que se une a CD134 humano, que comprende una región variable de cadena liviana (VL) de SEQ ID NO: 98, o que tiene 1, 2 o 3 sustituciones de aminoácidos en la VL de SEQ ID NO: 98 y una región variable de cadena pesada (VH), en donde la VH comprende la secuencia de aminoácidos de la SEQ ID NO: 134, o que tiene 1, 2 o 3 sustituciones de aminoácidos en la VH de la SEQ ID NO: 134 o la VH comprende la secuencia de aminoácidos de la SEQ ID NO: 97, o que tiene 1, 2 o 3 sustituciones de aminoácidos en la VH de SEQ ID NO: 97, en donde a. la HCDR3 comprende la secuencia de aminoácidos de SEQ ID NOs: 8, 139 o 140; b. la HCDR2 comprende la secuencia de aminoácidos de las SEQ ID NOs: 7, 135, 136, 137 o 138; y c. la HCDR1 comprende la secuencia de aminoácidos de SEQ ID NO: 6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13159794 | 2013-03-18 | ||
| PCT/NL2014/050162 WO2014148895A1 (en) | 2013-03-18 | 2014-03-18 | Humanized anti-cd134 (ox40) antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2687282T3 true ES2687282T3 (es) | 2018-10-24 |
Family
ID=47891522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14715138T Active ES2687282T3 (es) | 2013-03-18 | 2014-03-18 | Anticuerpos humanizados ANTI-CD134 (OX40) y sus usos |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US9790281B2 (es) |
| EP (2) | EP3409690A1 (es) |
| JP (1) | JP2016515544A (es) |
| KR (1) | KR20160006168A (es) |
| CN (1) | CN105229032A (es) |
| AU (2) | AU2014238546C1 (es) |
| BR (1) | BR112015023862A2 (es) |
| CA (1) | CA2907436A1 (es) |
| CL (2) | CL2015002793A1 (es) |
| CR (1) | CR20150498A (es) |
| CY (1) | CY1120752T1 (es) |
| DK (1) | DK2976361T3 (es) |
| EA (1) | EA201591495A1 (es) |
| ES (1) | ES2687282T3 (es) |
| HK (1) | HK1215035A1 (es) |
| HR (1) | HRP20181478T1 (es) |
| HU (1) | HUE040234T2 (es) |
| IL (1) | IL241701A0 (es) |
| LT (1) | LT2976361T (es) |
| MD (2) | MD20180107A2 (es) |
| MX (2) | MX2015013288A (es) |
| NZ (1) | NZ712903A (es) |
| PE (1) | PE20160690A1 (es) |
| PH (1) | PH12015502185A1 (es) |
| PL (1) | PL2976361T3 (es) |
| PT (1) | PT2976361T (es) |
| RS (1) | RS57840B1 (es) |
| SG (2) | SG10201708048XA (es) |
| SI (1) | SI2976361T1 (es) |
| SM (1) | SMT201800503T1 (es) |
| UA (1) | UA119319C2 (es) |
| WO (1) | WO2014148895A1 (es) |
| ZA (1) | ZA201507021B (es) |
Families Citing this family (136)
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| EP2972348B1 (en) | 2013-03-14 | 2018-08-15 | The Board of Trustees of The Leland Stanford Junior University | Methods of detecting donor-specific antibodies |
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| AU2014364606A1 (en) | 2013-12-17 | 2016-07-07 | Genentech, Inc. | Combination therapy comprising OX40 binding agonists and PD-1 axis binding antagonists |
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| SG11201703448QA (en) | 2014-11-03 | 2017-05-30 | Genentech Inc | Assays for detecting t cell immune subsets and methods of use thereof |
| RU2017119231A (ru) | 2014-11-03 | 2018-12-06 | Дженентек, Инк. | Способы и биомаркеры для прогнозирования эффективности и оценки лечения агонистом ох40 |
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| MY198562A (en) | 2015-11-03 | 2023-09-05 | Janssen Biotech Inc | Antibodies specifically binding pd-1 and their uses |
| GB201519481D0 (en) | 2015-11-04 | 2015-12-16 | Cancer Rec Tech Ltd | Immunomodulatory antibodies |
| US10527613B2 (en) * | 2015-11-10 | 2020-01-07 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarker detection methods and systems and kits for practicing same |
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| SG11201900746RA (en) | 2016-08-12 | 2019-02-27 | Janssen Biotech Inc | Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions |
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2014
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