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PE20160690A1 - Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos - Google Patents

Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos

Info

Publication number
PE20160690A1
PE20160690A1 PE2015002046A PE2015002046A PE20160690A1 PE 20160690 A1 PE20160690 A1 PE 20160690A1 PE 2015002046 A PE2015002046 A PE 2015002046A PE 2015002046 A PE2015002046 A PE 2015002046A PE 20160690 A1 PE20160690 A1 PE 20160690A1
Authority
PE
Peru
Prior art keywords
human
antibodies
seq
chain variable
variable region
Prior art date
Application number
PE2015002046A
Other languages
English (en)
Inventor
Randall Brezski
Louis Boon
Monica Goldberg
Petrus Johannes Simons
Jinquan Luo
Original Assignee
Biocerox Prod Bv
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47891522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20160690(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biocerox Prod Bv, Janssen Pharmaceuticals Inc filed Critical Biocerox Prod Bv
Publication of PE20160690A1 publication Critical patent/PE20160690A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion proporciona un anticuerpo que se une especificamente al CD134 humano. Los anti-CD134 humanos se unen especificamente al dominio extracelular del CD134 humano, que incluye el ligando no OX40 (OX40L), que se expresan por ejemplo en linfocitos T CD4 y/o CD8 efectores convencionales humanos activados (Teff) y en linfocitos T CD4 reguladores supresores humanos acivados (Tregs). Dicho anticuerpo comprende una region variable de cadena ligera (VL) de la SEQ ID NO: 100 y una region variable de cadena pesada (VH) de la SEQ ID NO: 99, donde cada secuencia tiene de 1, 2 o 3 sustituciones de aminoacidos. Dichos anticuerpos son utiles en el tratamiento del cancer
PE2015002046A 2013-03-18 2014-03-18 Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos PE20160690A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13159794 2013-03-18

Publications (1)

Publication Number Publication Date
PE20160690A1 true PE20160690A1 (es) 2016-08-14

Family

ID=47891522

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015002046A PE20160690A1 (es) 2013-03-18 2014-03-18 Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos

Country Status (33)

Country Link
US (3) US9790281B2 (es)
EP (2) EP2976361B1 (es)
JP (1) JP2016515544A (es)
KR (1) KR20160006168A (es)
CN (1) CN105229032A (es)
AU (2) AU2014238546C1 (es)
BR (1) BR112015023862A2 (es)
CA (1) CA2907436A1 (es)
CL (2) CL2015002793A1 (es)
CR (1) CR20150498A (es)
CY (1) CY1120752T1 (es)
DK (1) DK2976361T3 (es)
EA (1) EA201591495A1 (es)
ES (1) ES2687282T3 (es)
HK (1) HK1215035A1 (es)
HR (1) HRP20181478T1 (es)
HU (1) HUE040234T2 (es)
IL (1) IL241701A0 (es)
LT (1) LT2976361T (es)
MD (2) MD20180107A2 (es)
MX (2) MX2015013288A (es)
NZ (1) NZ712903A (es)
PE (1) PE20160690A1 (es)
PH (1) PH12015502185A1 (es)
PL (1) PL2976361T3 (es)
PT (1) PT2976361T (es)
RS (1) RS57840B1 (es)
SG (2) SG10201708048XA (es)
SI (1) SI2976361T1 (es)
SM (1) SMT201800503T1 (es)
UA (1) UA119319C2 (es)
WO (1) WO2014148895A1 (es)
ZA (1) ZA201507021B (es)

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US9790281B2 (en) 2017-10-17
UA119319C2 (uk) 2019-06-10
KR20160006168A (ko) 2016-01-18
CY1120752T1 (el) 2019-12-11
WO2014148895A1 (en) 2014-09-25

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