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PE20120337A1 - Producto conteniendo formas de dosificacion oral de fingolimod - Google Patents

Producto conteniendo formas de dosificacion oral de fingolimod

Info

Publication number
PE20120337A1
PE20120337A1 PE2011001265A PE2011001265A PE20120337A1 PE 20120337 A1 PE20120337 A1 PE 20120337A1 PE 2011001265 A PE2011001265 A PE 2011001265A PE 2011001265 A PE2011001265 A PE 2011001265A PE 20120337 A1 PE20120337 A1 PE 20120337A1
Authority
PE
Peru
Prior art keywords
fingolimod
dosage forms
oral dosage
product containing
containing oral
Prior art date
Application number
PE2011001265A
Other languages
English (en)
Inventor
Robert Schmouder
Thomas Dumortier
Olivier David
Michael Looby
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41667217&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120337(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20120337A1 publication Critical patent/PE20120337A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/10Phosphatides, e.g. lecithin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: (A) UN MODULADOR O AGONISTA DE LOS RECEPTORES DE S1P TAL COMO 2-AMINO-2-[2-(4-OCTIL-FENIL)-ETIL]-PROPANO-1,3-DIOL (FTY720); (B) UNA DOSIFICACION DIARIA QUE ES HASTA 10 VECES MENOR A LA DOSIFICACION TERAPEUTICA DIARIA CONVENCIONAL. DICHA COMPOSICION ES UTIL PARA MEJORAR, PREVENIR O LIMITAR EL EFECTO SECUNDARIO CRONOTROPICO NEGATIVO ASOCIADO CON UN TRATAMIENOT DE UNA ENFERMEDAD AUTOINMUNE
PE2011001265A 2008-12-22 2009-12-21 Producto conteniendo formas de dosificacion oral de fingolimod PE20120337A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13967208P 2008-12-22 2008-12-22
US21853009P 2009-06-19 2009-06-19
US24671509P 2009-09-29 2009-09-29

Publications (1)

Publication Number Publication Date
PE20120337A1 true PE20120337A1 (es) 2012-04-24

Family

ID=41667217

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001265A PE20120337A1 (es) 2008-12-22 2009-12-21 Producto conteniendo formas de dosificacion oral de fingolimod

Country Status (43)

Country Link
US (12) US20110257133A1 (es)
EP (7) EP3453387B1 (es)
JP (7) JP2012513401A (es)
KR (1) KR101347919B1 (es)
CN (1) CN102264359A (es)
AR (1) AR074826A1 (es)
AU (1) AU2009330176C9 (es)
BR (1) BRPI0923500A2 (es)
CA (1) CA2747802C (es)
CL (2) CL2011001529A1 (es)
CO (1) CO6390117A2 (es)
CR (1) CR20110274A (es)
CU (1) CU20110136A7 (es)
CY (4) CY1116990T1 (es)
DK (4) DK2379067T3 (es)
EA (1) EA201100978A1 (es)
EC (1) ECSP11011222A (es)
ES (4) ES2760607T3 (es)
FI (2) FI4098256T3 (es)
FR (2) FR20C1060I1 (es)
HN (1) HN2011001759A (es)
HR (4) HRP20250568T1 (es)
HU (6) HUE052048T2 (es)
IL (3) IL213170A0 (es)
LT (5) LT3453387T (es)
LU (1) LUC00183I2 (es)
MA (1) MA32981B1 (es)
ME (2) ME03594B (es)
MX (3) MX385959B (es)
NO (1) NO2020038I1 (es)
NZ (1) NZ593065A (es)
PE (1) PE20120337A1 (es)
PL (4) PL2379067T3 (es)
PT (4) PT2379067E (es)
RS (3) RS60666B1 (es)
SG (1) SG171404A1 (es)
SI (4) SI3409274T1 (es)
SM (2) SMT202000054T1 (es)
TN (1) TN2011000272A1 (es)
TW (1) TW201028143A (es)
UY (1) UY32352A (es)
WO (1) WO2010075239A1 (es)
ZA (2) ZA201103863B (es)

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HRP20170246T4 (hr) 2008-03-17 2020-02-07 Actelion Pharmaceuticals Ltd. Režim doziranja za selektivni agonist s1p1-receptora
LT3453387T (lt) 2008-12-22 2020-08-25 Novartis Ag S1p receptoriaus antagonisto dozavimo režimas
SG178987A1 (en) 2009-09-29 2012-04-27 Novartis Ag Dosage regimen of an s1p receptor modulator
US20110124605A1 (en) * 2009-11-20 2011-05-26 Shreeram Aradhye Use of an S1P Receptor Agonist
EP4148045A1 (en) 2010-01-27 2023-03-15 Arena Pharmaceuticals, Inc. Intermediate compounds for the preparation of (r)-2-(7-(4-cyclopentyl-3- (trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl)acetic acid and salts thereof
CN102917698A (zh) * 2010-05-06 2013-02-06 诺瓦提斯公司 二芳基硫醚衍生物的给药方案
EP2455080A1 (en) * 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of multiple sclerosis
FR2968556B1 (fr) 2010-12-13 2013-12-27 Centre Nat Rech Scient Inhibiteurs des infections a vih et leurs utilisations
HRP20191842T1 (hr) 2011-01-07 2019-12-27 Novartis Ag Formulacije imunosupresiva
EP3502236B1 (en) 2011-02-18 2023-08-23 The Scripps Research Institute Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
AR085749A1 (es) 2011-04-01 2013-10-23 Novartis Ag Formulaciones
WO2012162392A1 (en) * 2011-05-23 2012-11-29 Timothy Hla Endothelium protective materials and methods of use
TW201320994A (zh) 2011-10-11 2013-06-01 Novartis Ag 投藥療程
EP2885266B1 (en) 2012-08-17 2020-03-18 Actelion Pharmaceuticals Ltd Process for the preparation of (2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process
EP2964249A1 (en) * 2013-03-06 2016-01-13 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a fragment thereof for treatment or prophylaxis of heart failure
EP3054933A4 (en) 2013-10-11 2017-03-15 Teikoku Pharma USA, Inc. Topical sphingosine-1-phosphate receptor agonist formulations and methods of using the same
US10675254B2 (en) 2013-10-11 2020-06-09 Teikoku Seiyaku Co., Ltd. Sphingosine-1-phosphate receptor agonist iontophoretic devices and methods of using the same
TW201622721A (zh) * 2014-04-10 2016-07-01 諾華公司 S1p調節劑之立即釋放劑量療法
KR102590068B1 (ko) 2014-12-11 2023-10-16 액테리온 파마슈티칼 리미티드 선택적 s1p1 수용체 효능제에 대한 투약 섭생
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
AU2016205361C1 (en) * 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
CA2973540A1 (en) 2015-02-26 2016-09-01 Novartis Ag Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
CA3002551A1 (en) 2015-06-22 2016-12-29 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(com pound 1)for use in s1p1 receptor-associated disorders
WO2018151834A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
CA3053418A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
CA3102136A1 (en) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
MX2022005014A (es) 2019-10-31 2022-05-16 Idorsia Pharmaceuticals Ltd Combinacion de un antagonista de cxcr7 con un modulador del receptor s1p1.
WO2021158848A1 (en) * 2020-02-07 2021-08-12 Argentum Pharmaceuticals Llc Dosage regimen of an s1p receptor agonist
US11135197B2 (en) 2020-02-07 2021-10-05 Argentum Pharmaceuticals Llc Dosage regimen of an S1P receptor modulator
JP2023515612A (ja) * 2020-02-28 2023-04-13 アカール・ファーマ・プロプライエタリー・リミテッド S1p受容体調節物質
CN113332435B (zh) * 2021-06-18 2022-10-18 广州中医药大学(广州中医药研究院) 鞘氨醇-1-磷酸4受体激动剂及其与真武汤联合在制备治疗慢性肾小球肾炎药物中的应用

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JP2579602B2 (ja) 1992-10-21 1997-02-05 吉富製薬株式会社 2−アミノ−1,3−プロパンジオール化合物および免疫抑制剤
AU2001285331B2 (en) 2000-08-31 2006-04-06 Merck & Co., Inc. Phosphate derivatives as immunoregulatory agents
PT1505959E (pt) 2002-05-16 2009-02-05 Novartis Ag Utilização de agentes de ligação do receptor edg em cancro
JP4861177B2 (ja) * 2003-09-12 2012-01-25 ニューロノバ エービー 神経系の障害の処置
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CA2925175A1 (en) * 2007-10-12 2009-04-16 Novartis Ag Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators
HRP20170246T4 (hr) * 2008-03-17 2020-02-07 Actelion Pharmaceuticals Ltd. Režim doziranja za selektivni agonist s1p1-receptora
KR20170081755A (ko) * 2008-06-20 2017-07-12 노파르티스 아게 다발성 경화증을 치료하기 위한 소아용 조성물
DK2379069T3 (en) 2008-12-22 2015-06-08 Novartis Ag Dosage Plan for an S1P receptor agonist
LT3453387T (lt) 2008-12-22 2020-08-25 Novartis Ag S1p receptoriaus antagonisto dozavimo režimas

Also Published As

Publication number Publication date
HRP20201167T1 (hr) 2020-12-11
KR101347919B1 (ko) 2014-01-07
CY1116990T1 (el) 2017-04-05
PT2379067E (pt) 2015-12-23
HUS2500026I1 (hu) 2025-07-28
SI2379067T1 (sl) 2016-01-29
PT4098256T (pt) 2025-04-10
CA2747802C (en) 2021-02-09
HUE071189T2 (hu) 2025-08-28
SMT202000054T1 (it) 2020-03-13
TN2011000272A1 (en) 2012-12-17
AU2009330176B2 (en) 2014-03-06
ME03594B (me) 2020-07-20
US20160081949A1 (en) 2016-03-24
LTPA2020005I1 (lt) 2020-12-10
HUE048717T2 (hu) 2020-08-28
IL274756A (en) 2020-07-30
ZA201205942B (en) 2013-03-27
RS59857B1 (sr) 2020-02-28
CY1122812T1 (el) 2021-05-05
PT3453387T (pt) 2020-08-11
HUS2000046I1 (hu) 2020-12-28
DK3409274T3 (da) 2019-12-16
JP7329965B2 (ja) 2023-08-21
US20170189353A1 (en) 2017-07-06
US20200330407A1 (en) 2020-10-22
RS66784B1 (sr) 2025-06-30
CR20110274A (es) 2011-07-19
KR20110096175A (ko) 2011-08-29
UY32352A (es) 2010-07-30
LTPA2025520I1 (es) 2025-06-25
FR20C1060I1 (fr) 2020-12-25
US20100160259A1 (en) 2010-06-24
NZ593065A (en) 2012-11-30
ES2552823T3 (es) 2015-12-02
EP4098256A1 (en) 2022-12-07
SG171404A1 (en) 2011-07-28
JP2016135752A (ja) 2016-07-28
CA2747802A1 (en) 2010-07-01
ES3017254T3 (en) 2025-05-12
CL2013001558A1 (es) 2013-10-25
JP2012513401A (ja) 2012-06-14
FIC20253002I1 (fi) 2025-05-23
PL3453387T3 (pl) 2020-11-02
AU2009330176C9 (en) 2017-01-05
PT3409274T (pt) 2019-12-17
JP2024129030A (ja) 2024-09-26
JP2014144970A (ja) 2014-08-14
PL2379067T3 (pl) 2016-02-29
EP2379067A1 (en) 2011-10-26
CU20110136A7 (es) 2012-01-31
ES2810823T3 (es) 2021-03-09
ES2760607T3 (es) 2020-05-14
JP2022103194A (ja) 2022-07-07
ZA201103863B (en) 2012-10-31
FR25C1012I1 (fr) 2025-06-13
CO6390117A2 (es) 2012-02-29
JP2017141238A (ja) 2017-08-17
US20250262171A1 (en) 2025-08-21
EP3453387A1 (en) 2019-03-13
NO2020038I1 (no) 2020-11-18
EP3120844A1 (en) 2017-01-25
WO2010075239A1 (en) 2010-07-01
LT3453387T (lt) 2020-08-25
EP2379067B1 (en) 2015-09-02
ME03802B (me) 2021-04-20
US20190091180A1 (en) 2019-03-28
PL4098256T3 (pl) 2025-06-09
EP2907511A1 (en) 2015-08-19
CN102264359A (zh) 2011-11-30
SI3409274T1 (sl) 2020-03-31
US20140066657A1 (en) 2014-03-06
TW201028143A (en) 2010-08-01
HRP20192175T1 (hr) 2020-03-20
FI4098256T3 (fi) 2025-03-31
EP3453387B1 (en) 2020-06-03
HUE026869T2 (en) 2016-08-29
HN2011001759A (es) 2013-11-26
EP4098256B1 (en) 2025-02-26
CL2011001529A1 (es) 2012-02-24
RS60666B1 (sr) 2020-09-30
HUE048717T4 (hu) 2022-02-28
EP4098256B9 (en) 2025-06-18
JP2019167360A (ja) 2019-10-03
HUE052048T2 (hu) 2021-04-28
EP3677260A1 (en) 2020-07-08
ECSP11011222A (es) 2011-08-31
CY2020036I2 (el) 2021-06-25
IL213170A0 (en) 2011-07-31
MX385959B (es) 2025-03-18
AU2009330176A1 (en) 2011-07-07
LT3409274T (lt) 2020-02-10
US20220142949A1 (en) 2022-05-12
AU2009330176C1 (en) 2016-12-08
PL3409274T3 (pl) 2020-06-01
HRP20250568T1 (hr) 2025-07-04
MX2011006623A (es) 2011-07-12
RS66784B9 (sr) 2025-08-29
EP3409274B1 (en) 2019-11-20
US20110257133A1 (en) 2011-10-20
AR074826A1 (es) 2011-02-16
US20180289638A1 (en) 2018-10-11
MX2021010759A (es) 2022-07-19
DK2379067T3 (en) 2015-12-07
SMT202000441T1 (it) 2020-09-10
EA201100978A1 (ru) 2012-01-30
LUC00183I2 (es) 2024-07-01
SI3453387T1 (sl) 2020-10-30
US20140148415A1 (en) 2014-05-29
DK3453387T3 (da) 2020-08-10
DK4098256T3 (da) 2025-04-22
CY1123255T1 (el) 2021-10-29
CY2020036I1 (el) 2021-03-12
BRPI0923500A2 (pt) 2018-05-29
IL278914A (en) 2021-01-31
EP3409274A1 (en) 2018-12-05
HRP20151190T1 (hr) 2016-01-01
DK4098256T5 (da) 2025-07-21
LT4098256T (lt) 2025-06-10
SI4098256T1 (sl) 2025-06-30
US20160263061A1 (en) 2016-09-15
MA32981B1 (fr) 2012-01-02

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