PE20110115A1 - Cristal de derivados de espirocetal y procedimiento para la preparacion de derivados de espirocetal - Google Patents
Cristal de derivados de espirocetal y procedimiento para la preparacion de derivados de espirocetalInfo
- Publication number
- PE20110115A1 PE20110115A1 PE2010001159A PE2010001159A PE20110115A1 PE 20110115 A1 PE20110115 A1 PE 20110115A1 PE 2010001159 A PE2010001159 A PE 2010001159A PE 2010001159 A PE2010001159 A PE 2010001159A PE 20110115 A1 PE20110115 A1 PE 20110115A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- spirocetal
- derivatives
- compound
- hydroxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 3
- 229910021645 metal ion Inorganic materials 0.000 abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910001385 heavy metal Inorganic materials 0.000 abstract 1
- CBEQRNSPHCCXSH-UHFFFAOYSA-N iodine monobromide Chemical compound IBr CBEQRNSPHCCXSH-UHFFFAOYSA-N 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/04—Carbocyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN PROCESO PARA PREPARAR DERIVADOS DE ESPIROCETAL DE FORMULA (I) DONDE n ES DE 0 A 3; m ES DE 0 A 5; R1 Y R2 SON CADA UNO ALQUILO(C1-C10), CICLOALQUILO(C3-C10), ALQUENILO(C2-C10), ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON Ra, EN DONDE Ra ES HIDROXI, HALOGENO, CN, ENTRE OTROS; DONDE DICHO PROCESO COMPRENDE: A) TRATAR UN COMPUESTO DE FORMULA (II) CON UN REACTIVO ORGANOMETAL DURANTE 15 A 300 MIN Y CON UN COMPUESTO DE FORMULA (III) PARA OBTENER EL COMPUESTO DE FORMULA (IVa), DONDE X1 Y X2 SON BROMO O YODO; P1 ES UN ION DE METAL, H U OH; R41 ES R1; P2, P3, P4 Y P5 SON HIDROXI; X ES UN ION DE METAL O H; B) TRATAR UN COMPUESTO DE FORMULA (IVb) CON UN REACTIVO DE ORGANOMETAL Y CON UN COMPUESTO DE FORMULA (V), DONDE P6 ES UN ION DE METAL, H U HIDROXI; R42 ES R2; Y C) UNO O MAS PASOS PARA INTRODUCIR O REMOVER UN GRUPO PROTECTOR. SE REFIERE TAMBIEN A CRISTALES DE LOS COMPUESTOS DE FORMULA (I). DICHO PROCESO ES UTIL PARA PREPARAR DERIVADOS DE ESPIROCETAL SIN EL USO DE UN METAL PESADO TAL COMO ESTANO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008162073 | 2008-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110115A1 true PE20110115A1 (es) | 2011-02-14 |
Family
ID=41434188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010001159A PE20110115A1 (es) | 2008-06-20 | 2009-06-19 | Cristal de derivados de espirocetal y procedimiento para la preparacion de derivados de espirocetal |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US8569520B2 (es) |
| EP (3) | EP3170834B8 (es) |
| JP (2) | JP4823385B2 (es) |
| KR (1) | KR101856784B1 (es) |
| CN (1) | CN102046645B (es) |
| AR (1) | AR072211A1 (es) |
| AU (1) | AU2009261129A1 (es) |
| CA (1) | CA2727923A1 (es) |
| CL (1) | CL2010001485A1 (es) |
| CO (1) | CO6351798A2 (es) |
| CR (1) | CR20110033A (es) |
| EC (1) | ECSP11010773A (es) |
| ES (1) | ES2907611T3 (es) |
| IL (1) | IL210098A0 (es) |
| MA (1) | MA32530B1 (es) |
| MX (1) | MX2010014023A (es) |
| NZ (1) | NZ589961A (es) |
| PE (1) | PE20110115A1 (es) |
| PL (1) | PL3170834T3 (es) |
| RU (1) | RU2011101972A (es) |
| SG (1) | SG193795A1 (es) |
| TW (1) | TW201011043A (es) |
| WO (1) | WO2009154276A1 (es) |
| ZA (1) | ZA201100016B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011074675A1 (ja) * | 2009-12-18 | 2011-06-23 | 中外製薬株式会社 | スピロケタール誘導体の製造方法 |
| WO2012115249A1 (ja) * | 2011-02-25 | 2012-08-30 | 中外製薬株式会社 | スピロケタール誘導体の結晶 |
| PL2763987T3 (pl) * | 2011-10-06 | 2019-01-31 | Bayer Cropscience Ag | Heterocyklilopiry(mi)dynylopirazole jako środki grzybobójcze |
| RU2700164C2 (ru) | 2013-12-27 | 2019-09-13 | Чугаи Сейяку Кабусики Кайся | Твердые препараты, содержащие тофоглифлозин, и способ их получения |
| CN106188190B (zh) * | 2016-07-28 | 2020-08-25 | 迪嘉药业集团有限公司 | 一种托格列净一水合物的制备方法 |
| US20210212968A1 (en) | 2016-10-19 | 2021-07-15 | Boehringer Ingelheim International Gmbh | Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof |
| CN108640958B (zh) * | 2017-05-05 | 2021-03-30 | 镇江圣安医药有限公司 | 异苯并呋喃衍生物、其药物组合物和制剂以及用途 |
| AU2019254371A1 (en) | 2018-04-17 | 2020-10-08 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| CN112955214B (zh) | 2018-10-29 | 2024-05-07 | 勃林格殷格翰国际有限公司 | 吡啶基磺酰胺衍生物、药物组合物及其用途 |
| FI3873600T3 (fi) | 2018-10-29 | 2023-12-07 | Boehringer Ingelheim Int | Pyridinyylisulfonamidijohdannaisia, farmaseuttisia koostumuksia ja niiden käytöt |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL63968A (en) * | 1980-10-01 | 1985-10-31 | Glaxo Group Ltd | Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it |
| HU196775B (en) | 1986-08-05 | 1989-01-30 | Richter Gedeon Vegyeszet | Process for production of morfologically unique new modifications of famotidin and medical compositions containing such substances |
| PT98344B (pt) | 1991-07-17 | 1999-04-30 | Lneti Lab Nac De Eng Tec Ind D | Processo para a obtencao de espirocetais labdanicos do tipo ambar cinzento |
| GB9426103D0 (en) | 1994-12-23 | 1995-02-22 | Merck Sharp & Dohme | Therapeutic agents |
| JP2000044534A (ja) * | 1998-07-28 | 2000-02-15 | Mitsui Chemicals Inc | Ｎ保護基アミノ酸の製造法 |
| EP1253152B1 (en) | 2000-02-02 | 2009-11-04 | Banyu Pharmaceutical Co., Ltd. | Method of converting functional group through halogen-metal exchange reaction |
| JP3849024B2 (ja) | 2003-03-26 | 2006-11-22 | 国立大学法人 東京大学 | 有機亜鉛錯体およびその製造方法 |
| TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
| DK1971608T3 (da) | 2005-12-23 | 2012-07-02 | Ecobiotics Ltd | Spiroketaler |
| WO2007140191A2 (en) * | 2006-05-23 | 2007-12-06 | Theracos, Inc. | Glucose transport inhibitors and methods of use |
| TWI403516B (zh) | 2006-07-27 | 2013-08-01 | Chugai Pharmaceutical Co Ltd | To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes |
-
2009
- 2009-06-18 TW TW098120460A patent/TW201011043A/zh unknown
- 2009-06-19 EP EP16202285.9A patent/EP3170834B8/en active Active
- 2009-06-19 PE PE2010001159A patent/PE20110115A1/es not_active Application Discontinuation
- 2009-06-19 PL PL16202285T patent/PL3170834T3/pl unknown
- 2009-06-19 JP JP2010517979A patent/JP4823385B2/ja active Active
- 2009-06-19 EP EP22155547.7A patent/EP4036100A1/en not_active Withdrawn
- 2009-06-19 RU RU2011101972/04A patent/RU2011101972A/ru not_active Application Discontinuation
- 2009-06-19 WO PCT/JP2009/061226 patent/WO2009154276A1/ja not_active Ceased
- 2009-06-19 ES ES16202285T patent/ES2907611T3/es active Active
- 2009-06-19 MX MX2010014023A patent/MX2010014023A/es not_active Application Discontinuation
- 2009-06-19 NZ NZ589961A patent/NZ589961A/xx not_active IP Right Cessation
- 2009-06-19 CN CN200980119081.4A patent/CN102046645B/zh active Active
- 2009-06-19 KR KR1020117000778A patent/KR101856784B1/ko active Active
- 2009-06-19 EP EP09766724.0A patent/EP2308886B1/en active Active
- 2009-06-19 CA CA2727923A patent/CA2727923A1/en not_active Abandoned
- 2009-06-19 SG SG2013061510A patent/SG193795A1/en unknown
- 2009-06-19 AR ARP090102252A patent/AR072211A1/es not_active Application Discontinuation
- 2009-06-19 AU AU2009261129A patent/AU2009261129A1/en not_active Abandoned
- 2009-06-19 US US13/000,208 patent/US8569520B2/en not_active Expired - Fee Related
-
2010
- 2010-12-19 IL IL210098A patent/IL210098A0/en unknown
- 2010-12-20 CL CL2010001485A patent/CL2010001485A1/es unknown
- 2010-12-20 MA MA33442A patent/MA32530B1/fr unknown
-
2011
- 2011-01-03 ZA ZA2011/00016A patent/ZA201100016B/en unknown
- 2011-01-19 CR CR20110033A patent/CR20110033A/es not_active Application Discontinuation
- 2011-01-20 CO CO11005627A patent/CO6351798A2/es not_active Application Discontinuation
- 2011-01-20 EC EC2011010773A patent/ECSP11010773A/es unknown
- 2011-09-05 JP JP2011193271A patent/JP5485237B2/ja active Active
-
2013
- 2013-09-24 US US14/034,880 patent/US9163051B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |