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PE20180462A1 - Moduladores cot y metodos de uso de los mismos - Google Patents

Moduladores cot y metodos de uso de los mismos

Info

Publication number
PE20180462A1
PE20180462A1 PE2017002804A PE2017002804A PE20180462A1 PE 20180462 A1 PE20180462 A1 PE 20180462A1 PE 2017002804 A PE2017002804 A PE 2017002804A PE 2017002804 A PE2017002804 A PE 2017002804A PE 20180462 A1 PE20180462 A1 PE 20180462A1
Authority
PE
Peru
Prior art keywords
hydrogen
toc
modulators
methods
cot
Prior art date
Application number
PE2017002804A
Other languages
English (en)
Inventor
Elizabeth M Bacon
Gayatri Balan
Chien-Hung Chou
Christopher T Clark
Jeromy J Cottell
Musong Kim
Thorsten A Kirschberg
John O Link
Gary Phillips
Scott D Schroeder
Neil H Squires
Kirk L Stevens
James G Taylor
William J Watkins
Nathan E Wright
Sheila Zipfel
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of PE20180462A1 publication Critical patent/PE20180462A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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Abstract

Esta referido a un compuesto de la formula I, en donde R1 es hidrogeno, -O-R7, -N(R8)(R9), -C(O)-R7, entre otros; R2 es hidrogeno, -C(O)-R7, -C(O)O-R7, entre otros; R3 y R4 son, independientemente, heterociclico o heteroarilo, opcionalmente sustituidos; R5 es hidrogeno, halo, -CN, -NO, entre otros; R6 es hidrogeno, -C(O)-R7, entre otros, cada R15 es independientemente halo, -CN, -NO2, -O-R7, entre otros; y m es 0, 1, o 2. Tambien se refiere a composiciones farmaceuticas y kits que los incluyen. Dichos compuestos modulan la expresion o actividad de Cot (cancer de tiroides Osaka); por lo tanto, son utiles en el tratamiento de enfermedades, trastornos o afecciones que estan mediadas por Cot
PE2017002804A 2015-07-06 2016-06-30 Moduladores cot y metodos de uso de los mismos PE20180462A1 (es)

Applications Claiming Priority (2)

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US201562189158P 2015-07-06 2015-07-06
US201562269060P 2015-12-17 2015-12-17

Publications (1)

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PE20180462A1 true PE20180462A1 (es) 2018-03-06

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