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PL4301748T3 - Triazolilo-metylo podstawione pochodne alfa-d-galaktopiranozydu - Google Patents

Triazolilo-metylo podstawione pochodne alfa-d-galaktopiranozydu

Info

Publication number
PL4301748T3
PL4301748T3 PL22708569.3T PL22708569T PL4301748T3 PL 4301748 T3 PL4301748 T3 PL 4301748T3 PL 22708569 T PL22708569 T PL 22708569T PL 4301748 T3 PL4301748 T3 PL 4301748T3
Authority
PL
Poland
Prior art keywords
triazolyl
methyl substituted
substituted alpha
galactopyranoside
derivatives
Prior art date
Application number
PL22708569.3T
Other languages
English (en)
Inventor
Martin Bolli
John Gatfield
Corinna Grisostomi
Lubos Remen
Christoph SAGER
Cornelia Zumbrunn
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of PL4301748T3 publication Critical patent/PL4301748T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06Heterocyclic radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
PL22708569.3T 2021-03-03 2022-03-02 Triazolilo-metylo podstawione pochodne alfa-d-galaktopiranozydu PL4301748T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2021055348 2021-03-03
PCT/EP2022/055224 WO2022184755A1 (en) 2021-03-03 2022-03-02 Triazolyl-methyl substituted alpha-d-galactopyranoside derivatives

Publications (1)

Publication Number Publication Date
PL4301748T3 true PL4301748T3 (pl) 2025-09-08

Family

ID=80682779

Family Applications (1)

Application Number Title Priority Date Filing Date
PL22708569.3T PL4301748T3 (pl) 2021-03-03 2022-03-02 Triazolilo-metylo podstawione pochodne alfa-d-galaktopiranozydu

Country Status (18)

Country Link
US (1) US20240109930A1 (pl)
EP (1) EP4301748B1 (pl)
JP (1) JP7771205B2 (pl)
KR (1) KR20230154221A (pl)
CN (1) CN116888113A (pl)
AU (1) AU2022228660A1 (pl)
BR (1) BR112023017624A2 (pl)
CA (1) CA3209917A1 (pl)
CL (1) CL2023002578A1 (pl)
ES (1) ES3033422T3 (pl)
HR (1) HRP20250833T1 (pl)
HU (1) HUE072194T2 (pl)
IL (1) IL305581A (pl)
MA (1) MA63589B1 (pl)
MX (1) MX2023010241A (pl)
PL (1) PL4301748T3 (pl)
RS (1) RS67032B1 (pl)
WO (1) WO2022184755A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12404295B2 (en) 2019-08-09 2025-09-02 Idorsia Pharmaceuticals Ltd (Hetero)aryl-methyl-thio-beta-D-galactopyranoside derivatives
JP7612663B2 (ja) 2019-08-09 2025-01-14 イドルシア・ファーマシューティカルズ・リミテッド (2-アセタミジル)チオ-ベータ-d-ガラクトピラノシド誘導体
ES3015725T3 (en) 2019-08-15 2025-05-07 Idorsia Pharmaceuticals Ltd 2-hydroxycycloalkane-1-carbamoyl derivatives
AU2020338816A1 (en) 2019-08-29 2022-04-14 Idorsia Pharmaceuticals Ltd Alpha-D-galactopyranoside derivatives
EP4225752B1 (en) 2020-10-06 2024-12-11 Idorsia Pharmaceuticals Ltd Spiro derivatives of alpha-d-galactopyranosides
EP4237419A1 (en) 2020-11-02 2023-09-06 Idorsia Pharmaceuticals Ltd Galectin-3 inhibiting 2-hydroxycycloalkane-1 -carbamoyl derivatives
IL304923A (en) 2021-02-09 2023-10-01 Idorsia Pharmaceuticals Ltd History of hydroxyheterocycloalkane-carbamoyl

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100172D0 (sv) 2001-01-22 2001-01-22 Ulf Nilsson New inhibitors against galectins
SE0401301D0 (sv) 2004-05-21 2004-05-21 Forskarpatent I Syd Ab Novel 3-triazolyl-galactoside inhibitors of galectins
SE0401300D0 (sv) 2004-05-21 2004-05-21 Forskarpatent I Syd Ab Novel Galactoside Inhibitors of Galectins
JP6055928B2 (ja) 2012-10-10 2016-12-27 ガレクティン・セラピューティクス・インコーポレイテッドGalectin Therapeutics, Inc. 糖尿病性腎症および関連障害の処置のためのガラクトース分枝炭水化物化合物
EP2914269B1 (en) 2012-10-31 2020-07-29 Galecto Biotech AB Galactoside inhibitor of galectin-3 and its use for treating pulmonary fibrosis
JP6366598B2 (ja) 2012-11-15 2018-08-01 タフツ ユニバーシティー ガレクチンタンパク質阻害剤を用いて被験体の眼の血管新生または繊維症を処置し、調節し、または、予防する方法、組成物、およびキット
WO2016120403A1 (en) 2015-01-30 2016-08-04 Galecto Biotech Ab Alpha-d-galactoside inhibitors of galectins
CN109879859B (zh) 2015-07-06 2022-01-25 吉利德科学公司 Cot调节剂及其使用方法
AU2018265813A1 (en) 2017-05-12 2019-12-05 Galectin Sciences, Llc Compounds for the treatment of systemic insulin resistance disorders and the use thereof
CA3062648A1 (en) * 2017-05-12 2018-11-15 Galectin Sciences, Llc Compounds for the prevention and treatment of diseases and the use thereof
US11267811B2 (en) 2017-09-27 2022-03-08 Bristol-Myers Squibb Company Small molecule inhibitors of galectin-3
US11072626B2 (en) 2017-10-11 2021-07-27 Bristol-Myers Squibb Company Small molecule inhibitors of Galectin-3
AU2018361991A1 (en) 2017-10-31 2020-05-14 Galectin Sciences, Llc Selenogalactoside compounds for the treatment of systemic insulin resistance disorders and the use thereof
CN113412267B (zh) 2018-11-21 2025-06-27 格莱克特生物技术公司 半乳糖凝集素的α-D-半乳糖苷抑制剂
JP7577682B2 (ja) * 2019-04-10 2024-11-05 ブリストル-マイヤーズ スクイブ カンパニー ガレクチン-3の低分子阻害剤
CN114555620A (zh) 2019-07-03 2022-05-27 格莱克特生物技术公司 半乳糖凝集素的新型半乳糖苷抑制剂
CN114450282A (zh) 2019-07-05 2022-05-06 格莱克特生物技术公司 半乳糖凝集素的新型半乳糖苷抑制剂
JP7612663B2 (ja) 2019-08-09 2025-01-14 イドルシア・ファーマシューティカルズ・リミテッド (2-アセタミジル)チオ-ベータ-d-ガラクトピラノシド誘導体
US12404295B2 (en) 2019-08-09 2025-09-02 Idorsia Pharmaceuticals Ltd (Hetero)aryl-methyl-thio-beta-D-galactopyranoside derivatives
ES3015725T3 (en) 2019-08-15 2025-05-07 Idorsia Pharmaceuticals Ltd 2-hydroxycycloalkane-1-carbamoyl derivatives
AU2020338816A1 (en) * 2019-08-29 2022-04-14 Idorsia Pharmaceuticals Ltd Alpha-D-galactopyranoside derivatives

Also Published As

Publication number Publication date
KR20230154221A (ko) 2023-11-07
EP4301748C0 (en) 2025-05-07
CN116888113A (zh) 2023-10-13
CA3209917A1 (en) 2022-09-09
BR112023017624A2 (pt) 2023-10-10
EP4301748A1 (en) 2024-01-10
HRP20250833T1 (hr) 2025-09-12
MX2023010241A (es) 2023-09-12
RS67032B1 (sr) 2025-08-29
MA63589B1 (fr) 2025-07-31
IL305581A (en) 2023-10-01
WO2022184755A1 (en) 2022-09-09
EP4301748B1 (en) 2025-05-07
AU2022228660A1 (en) 2023-10-19
TW202300146A (zh) 2023-01-01
HUE072194T2 (hu) 2025-10-28
JP2024509421A (ja) 2024-03-01
US20240109930A1 (en) 2024-04-04
CL2023002578A1 (es) 2024-03-22
ES3033422T3 (en) 2025-08-04
JP7771205B2 (ja) 2025-11-17

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