SE0401300D0 - Novel Galactoside Inhibitors of Galectins - Google Patents
Novel Galactoside Inhibitors of GalectinsInfo
- Publication number
- SE0401300D0 SE0401300D0 SE0401300A SE0401300A SE0401300D0 SE 0401300 D0 SE0401300 D0 SE 0401300D0 SE 0401300 A SE0401300 A SE 0401300A SE 0401300 A SE0401300 A SE 0401300A SE 0401300 D0 SE0401300 D0 SE 0401300D0
- Authority
- SE
- Sweden
- Prior art keywords
- galectins
- novel
- galectin
- inhibitors
- galactoside inhibitors
- Prior art date
Links
- 102000007563 Galectins Human genes 0.000 title abstract 3
- 108010046569 Galectins Proteins 0.000 title abstract 3
- 150000008195 galaktosides Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 102000000802 Galectin 3 Human genes 0.000 abstract 1
- 108010001517 Galectin 3 Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401300A SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Novel Galactoside Inhibitors of Galectins |
| CA2567694A CA2567694C (en) | 2004-05-21 | 2005-05-20 | Novel galactoside inhibitors of galectins |
| PCT/SE2005/000757 WO2005113568A1 (en) | 2004-05-21 | 2005-05-20 | Novel galactoside inhibitors of galectins |
| AT05745033T ATE525383T1 (de) | 2004-05-21 | 2005-05-20 | Neue galactosidinhibitoren von galectinen |
| EP05745033A EP1751171B1 (en) | 2004-05-21 | 2005-05-20 | Novel galactoside inhibitors of galectins |
| US11/561,124 US7638623B2 (en) | 2004-05-21 | 2006-11-17 | Galactoside inhibitors of galectins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401300A SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Novel Galactoside Inhibitors of Galectins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE0401300D0 true SE0401300D0 (sv) | 2004-05-21 |
Family
ID=32589763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE0401300A SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Novel Galactoside Inhibitors of Galectins |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7638623B2 (sv) |
| EP (1) | EP1751171B1 (sv) |
| AT (1) | ATE525383T1 (sv) |
| CA (1) | CA2567694C (sv) |
| SE (1) | SE0401300D0 (sv) |
| WO (1) | WO2005113568A1 (sv) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003046207A2 (en) | 2001-11-27 | 2003-06-05 | Fred Hutchinson Cancer Research Center | Methods for inhibiting deacetylase activity |
| WO2009139719A1 (en) * | 2008-05-16 | 2009-11-19 | Forskarpatent I Syd Ab | Novel synthesis of galactoside inhibitors |
| US8703720B2 (en) | 2009-04-28 | 2014-04-22 | Galecto Biotech Ab | Galactoside inhibitors of galectins |
| US9243021B2 (en) | 2012-10-31 | 2016-01-26 | Galecto Biotech Ab | Galactoside inhibitor of galectins |
| AR086543A1 (es) * | 2011-05-25 | 2014-01-08 | Bg Medicine Inc | Inhibidores de galectina-3 y metodos de uso de los mismos, composicion farmaceutica |
| EP2620443A1 (en) * | 2012-01-25 | 2013-07-31 | Galecto Biotech AB | Novel galactoside inhibitors of galectins |
| BR112015005772A2 (pt) | 2012-09-17 | 2017-08-08 | Galectin Therapeutics Inc | método para a intensificação de imunoterapias específicas no tratamento de câncer |
| JP6055928B2 (ja) | 2012-10-10 | 2016-12-27 | ガレクティン・セラピューティクス・インコーポレイテッドＧａｌｅｃｔｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 糖尿病性腎症および関連障害の処置のためのガラクトース分枝炭水化物化合物 |
| EP2914269B1 (en) | 2012-10-31 | 2020-07-29 | Galecto Biotech AB | Galactoside inhibitor of galectin-3 and its use for treating pulmonary fibrosis |
| JP6366598B2 (ja) * | 2012-11-15 | 2018-08-01 | タフツ ユニバーシティー | ガレクチンタンパク質阻害剤を用いて被験体の眼の血管新生または繊維症を処置し、調節し、または、予防する方法、組成物、およびキット |
| US12390486B2 (en) | 2012-12-20 | 2025-08-19 | Henry Ford Health System | Method for treating diastolic heart failure by inhibiting galectin-3 |
| JP2016507503A (ja) | 2012-12-20 | 2016-03-10 | ヘンリー フォード ヘルス システム | ガレクチン−３を阻害することによる拡張期心不全を治療する方法 |
| ES2784873T3 (es) * | 2014-07-09 | 2020-10-01 | Galecto Biotech Ab | Novedoso inhibidor galactósido híbrido de galectinas |
| EP3245216B1 (en) | 2015-01-16 | 2019-12-11 | Galecto Biotech AB | Novel galactoside inhibitor of galectins |
| WO2016120403A1 (en) | 2015-01-30 | 2016-08-04 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
| EP3374368B1 (en) | 2015-11-09 | 2022-06-01 | Galecto Biotech AB | 1,1'-sulfanediyl-di-beta-d-galactopyranosides as inhibitors of galectins |
| EP3484903A1 (en) | 2016-07-12 | 2019-05-22 | Galecto Biotech AB | Alpha-d-galactoside inhibitors of galectins |
| US10889610B2 (en) | 2016-07-12 | 2021-01-12 | Galecto Biotech Ab | Alpha-D-galactoside inhibitors of galectins |
| CA3062648A1 (en) | 2017-05-12 | 2018-11-15 | Galectin Sciences, Llc | Compounds for the prevention and treatment of diseases and the use thereof |
| US11267811B2 (en) | 2017-09-27 | 2022-03-08 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| US11072626B2 (en) | 2017-10-11 | 2021-07-27 | Bristol-Myers Squibb Company | Small molecule inhibitors of Galectin-3 |
| BR112020013198A2 (pt) | 2017-12-29 | 2020-12-01 | Glycomimetics, Inc. | inibidores heterobifuncionais de e-selectina e galectina-3 |
| BR112020013647A2 (pt) | 2018-01-10 | 2020-12-01 | Galecto Biotech Ab | novo inibidor galactosídeo de galectinas |
| EP3807290B1 (en) | 2018-06-15 | 2022-03-30 | Bristol-Myers Squibb Company | Tetrahydropyran-based thiodisaccharide mimics as galectin-3 inhibitors |
| JP2021529163A (ja) | 2018-06-29 | 2021-10-28 | グリコス バイオメディカル オーワイ | コンジュゲート |
| WO2020078808A1 (en) | 2018-10-15 | 2020-04-23 | Galecto Biotech Ab | Galactoside inhibitor of galectins |
| WO2020078807A1 (en) | 2018-10-15 | 2020-04-23 | Galecto Biotech Ab | Prodrug of galactoside inhibitors of galectins |
| CN113412267B (zh) | 2018-11-21 | 2025-06-27 | 格莱克特生物技术公司 | 半乳糖凝集素的α-D-半乳糖苷抑制剂 |
| WO2020117883A1 (en) | 2018-12-06 | 2020-06-11 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| WO2020139962A1 (en) | 2018-12-27 | 2020-07-02 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
| KR20210110645A (ko) | 2018-12-27 | 2021-09-08 | 글리코미메틱스, 인크. | 갈렉틴-3 억제 c-글리코사이드 |
| CN113727988A (zh) | 2019-03-26 | 2021-11-30 | 百时美施贵宝公司 | 半乳糖凝集素-3的小分子抑制剂 |
| BR112021019566A2 (pt) * | 2019-03-29 | 2021-12-07 | Nagase & Co Ltd | Novo composto e uso do mesmo |
| JP7577682B2 (ja) | 2019-04-10 | 2024-11-05 | ブリストル－マイヤーズ スクイブ カンパニー | ガレクチン－３の低分子阻害剤 |
| CA3136661A1 (en) | 2019-04-24 | 2020-10-29 | Glycomimetics, Inc. | Galactose-linked multimeric glycomimetic inhibitors of e-selectins, galectin-3, and/or cxcr4 chemokine receptors |
| US12291547B2 (en) | 2019-06-14 | 2025-05-06 | UNIVERSITé LAVAL | Synthesis of 3-azido-3-deoxy-D-galactopyranose |
| CN114555620A (zh) | 2019-07-03 | 2022-05-27 | 格莱克特生物技术公司 | 半乳糖凝集素的新型半乳糖苷抑制剂 |
| CN114514235A (zh) | 2019-07-03 | 2022-05-17 | 格莱克特生物技术公司 | 半乳糖凝集素的新型半乳糖苷抑制剂 |
| CN114450282A (zh) | 2019-07-05 | 2022-05-06 | 格莱克特生物技术公司 | 半乳糖凝集素的新型半乳糖苷抑制剂 |
| US12404295B2 (en) | 2019-08-09 | 2025-09-02 | Idorsia Pharmaceuticals Ltd | (Hetero)aryl-methyl-thio-beta-D-galactopyranoside derivatives |
| JP7612663B2 (ja) | 2019-08-09 | 2025-01-14 | イドルシア・ファーマシューティカルズ・リミテッド | （２－アセタミジル）チオ－ベータ－ｄ－ガラクトピラノシド誘導体 |
| ES3015725T3 (en) | 2019-08-15 | 2025-05-07 | Idorsia Pharmaceuticals Ltd | 2-hydroxycycloalkane-1-carbamoyl derivatives |
| AU2020338816A1 (en) | 2019-08-29 | 2022-04-14 | Idorsia Pharmaceuticals Ltd | Alpha-D-galactopyranoside derivatives |
| WO2021086816A1 (en) | 2019-10-29 | 2021-05-06 | Glycomimetics, Inc. | Galectin-3 inhibiting c-glycosides |
| WO2021123506A1 (en) | 2019-12-18 | 2021-06-24 | Glykos Biomedical Oy | Stabile conjugate |
| CN115244045A (zh) | 2019-12-24 | 2022-10-25 | 糖模拟物有限公司 | 抑制半乳凝素-3的c-糖苷酮、醚和醇 |
| CN115551855A (zh) | 2020-05-05 | 2022-12-30 | 百时美施贵宝公司 | 半乳凝素-3的小分子抑制剂 |
| US12286424B2 (en) | 2020-05-11 | 2025-04-29 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| WO2021242982A1 (en) | 2020-05-28 | 2021-12-02 | Bristol-Myers Squibb Company | Galectin-3 inhibitors |
| EP4225752B1 (en) | 2020-10-06 | 2024-12-11 | Idorsia Pharmaceuticals Ltd | Spiro derivatives of alpha-d-galactopyranosides |
| EP4237419A1 (en) | 2020-11-02 | 2023-09-06 | Idorsia Pharmaceuticals Ltd | Galectin-3 inhibiting 2-hydroxycycloalkane-1 -carbamoyl derivatives |
| IL304923A (en) | 2021-02-09 | 2023-10-01 | Idorsia Pharmaceuticals Ltd | History of hydroxyheterocycloalkane-carbamoyl |
| ES3033422T3 (en) | 2021-03-03 | 2025-08-04 | Idorsia Pharmaceuticals Ltd | Triazolyl-methyl substituted alpha-d-galactopyranoside derivatives |
| JP2024517936A (ja) | 2021-05-14 | 2024-04-23 | グリコミメティクス， インコーポレイテッド | ガレクチン－３阻害性ｃ－グリコシド |
| US20240287121A1 (en) | 2021-05-28 | 2024-08-29 | Glycomimetics, Inc. | Galectin-3 inhibiting c-glycoside oximes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05247078A (ja) * | 1992-03-03 | 1993-09-24 | Japan Tobacco Inc | 糖化合物、シアル酸含有糖鎖類生合成阻害剤、その製造方法、並びに新規な中間体 |
| DE69931791T2 (de) * | 1998-08-06 | 2007-05-24 | Teijin Ltd. | Pharmazeutische zusammensetzung die ein inhibierendes effekt auf die überproduktion und akkumulation der extrazellulären matrix hat |
| AU2001243622A1 (en) * | 2000-03-13 | 2001-09-24 | La Jolla Institute For Allergy And Immunology | Monocyte chemoattractant activity of galectin-3 |
| US20060148712A1 (en) * | 2000-03-13 | 2006-07-06 | Fu-Tong Liu | Monocyte chemoattractant activity of galectin-3 |
| SE0100172D0 (sv) * | 2001-01-22 | 2001-01-22 | Ulf Nilsson | New inhibitors against galectins |
-
2004
- 2004-05-21 SE SE0401300A patent/SE0401300D0/sv unknown
-
2005
- 2005-05-20 CA CA2567694A patent/CA2567694C/en not_active Expired - Fee Related
- 2005-05-20 AT AT05745033T patent/ATE525383T1/de not_active IP Right Cessation
- 2005-05-20 WO PCT/SE2005/000757 patent/WO2005113568A1/en not_active Ceased
- 2005-05-20 EP EP05745033A patent/EP1751171B1/en not_active Expired - Lifetime
-
2006
- 2006-11-17 US US11/561,124 patent/US7638623B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070185039A1 (en) | 2007-08-09 |
| CA2567694A1 (en) | 2005-12-01 |
| CA2567694C (en) | 2013-07-09 |
| EP1751171A1 (en) | 2007-02-14 |
| US7638623B2 (en) | 2009-12-29 |
| EP1751171B1 (en) | 2011-09-21 |
| ATE525383T1 (de) | 2011-10-15 |
| WO2005113568A1 (en) | 2005-12-01 |
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