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PE20091269A1 - Moleculas de union al receptor ox40 humano - Google Patents

Moleculas de union al receptor ox40 humano

Info

Publication number
PE20091269A1
PE20091269A1 PE2008002051A PE2008002051A PE20091269A1 PE 20091269 A1 PE20091269 A1 PE 20091269A1 PE 2008002051 A PE2008002051 A PE 2008002051A PE 2008002051 A PE2008002051 A PE 2008002051A PE 20091269 A1 PE20091269 A1 PE 20091269A1
Authority
PE
Peru
Prior art keywords
seq
heavy
chain
amino acid
acid sequence
Prior art date
Application number
PE2008002051A
Other languages
English (en)
Inventor
Jing Min
Yanli Wu
Rory Francis Finn
Barrett Richard Thiele
Wei Laio
Ronald Paul Gladue
Arvind Rajpal
Timothy Joseph Paradis
Peter Brams
Brigitte Devaux
Yiji Wu
Kristopher Toy
Heidi N Leblanc
Haichun Huang
Original Assignee
Medarex Inc
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40552119&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091269(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medarex Inc, Pfizer filed Critical Medarex Inc
Publication of PE20091269A1 publication Critical patent/PE20091269A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)

Abstract

REFERIDA A UNA MOLECUA DE UNION AISLADA QUE COMPITE POR LA UNION A OX40R HUMANO CON UN ANTICUERPO QUE COMPRENDE: a) UNA REGION VARIABLE DE CADENA PESADA QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE LA SEC ID NO: 7 Y b) UNA REGION VARIABLE DE CADENA LIVIANA QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE LA SEC ID NO:8. TAMBIEN ESTA REFERIDA A UNA MOLECULA DE UNION AISLADA QUE SE UNE AL OX40R HUMANO QUE COMPRENDE: a) UNA CDR1 DE CADENA PESADA QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE LA SEC ID NO:1, b) UNA CDR2 DE CADENA PESADA QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE LA SEC ID NO:2 Y c) UNA CDR3 DE CADENA PESADA QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE LA SEC ID NO:3; UN ANTICUERPO MONOCLONAL; UNA MOLECULA DE ACIDO NUCLEICO, UNA COMPOSICION Y UN VECTOR
PE2008002051A 2007-12-14 2008-12-11 Moleculas de union al receptor ox40 humano PE20091269A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1394707P 2007-12-14 2007-12-14

Publications (1)

Publication Number Publication Date
PE20091269A1 true PE20091269A1 (es) 2009-09-09

Family

ID=40552119

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002051A PE20091269A1 (es) 2007-12-14 2008-12-11 Moleculas de union al receptor ox40 humano

Country Status (29)

Country Link
US (7) US7960515B2 (es)
EP (4) EP2594590B1 (es)
JP (4) JP5761997B2 (es)
KR (2) KR20150061041A (es)
CN (1) CN101918447B (es)
AR (2) AR069681A1 (es)
AU (1) AU2008338591B8 (es)
BR (1) BRPI0820875B1 (es)
CA (2) CA2707773C (es)
CL (1) CL2008003706A1 (es)
CO (1) CO6280541A2 (es)
DK (3) DK2851374T3 (es)
ES (3) ES2628093T3 (es)
HR (1) HRP20141188T8 (es)
HU (1) HUE032735T2 (es)
IL (3) IL206297A (es)
MX (1) MX2010006466A (es)
PA (1) PA8807601A1 (es)
PE (1) PE20091269A1 (es)
PH (1) PH12015500806A1 (es)
PL (2) PL2594590T3 (es)
PT (3) PT2242771E (es)
RU (1) RU2010129045A (es)
SG (2) SG186656A1 (es)
SI (3) SI2594590T1 (es)
TW (1) TW200932268A (es)
UY (1) UY31533A1 (es)
WO (1) WO2009079335A1 (es)
ZA (1) ZA201003579B (es)

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AU2008338591A8 (en) 2014-02-20
PH12015500806A1 (en) 2015-12-02
KR20100102657A (ko) 2010-09-24
SI2242771T1 (sl) 2013-09-30
IL239674A (en) 2017-08-31
US9028824B2 (en) 2015-05-12
SI2851374T1 (sl) 2017-08-31
WO2009079335A1 (en) 2009-06-25
AU2008338591A1 (en) 2009-06-25
PT2851374T (pt) 2017-06-20
JP2011505836A (ja) 2011-03-03
US20150218279A1 (en) 2015-08-06
PT2594590E (pt) 2015-01-14
DK2594590T3 (en) 2015-01-12
JP5761997B2 (ja) 2015-08-12
KR20150061041A (ko) 2015-06-03
JP6420379B2 (ja) 2018-11-07
AR109355A2 (es) 2018-11-21
TW200932268A (en) 2009-08-01
DK2851374T3 (en) 2017-06-19
CL2008003706A1 (es) 2009-06-12
HRP20141188T1 (en) 2015-03-13
US20180057600A1 (en) 2018-03-01
IL245876A0 (en) 2016-07-31
CA2707773C (en) 2017-01-10
EP2594590B1 (en) 2014-11-12
AU2008338591B8 (en) 2014-02-20
SI2594590T1 (sl) 2015-03-31

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