PE20091947A1 - Derivados de indolina-carboxamida con actividad sobre los canales sodio - Google Patents
Derivados de indolina-carboxamida con actividad sobre los canales sodioInfo
- Publication number
- PE20091947A1 PE20091947A1 PE2009000755A PE2009000755A PE20091947A1 PE 20091947 A1 PE20091947 A1 PE 20091947A1 PE 2009000755 A PE2009000755 A PE 2009000755A PE 2009000755 A PE2009000755 A PE 2009000755A PE 20091947 A1 PE20091947 A1 PE 20091947A1
- Authority
- PE
- Peru
- Prior art keywords
- carboxamide
- indoline
- activity
- benzyl
- sodium channels
- Prior art date
Links
- 108010052164 Sodium Channels Proteins 0.000 title abstract 2
- 102000018674 Sodium Channels Human genes 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- OFLWZAHKUJNRML-UHFFFAOYSA-N 2,3-dihydroindole-1-carboxamide Chemical class C1=CC=C2N(C(=O)N)CCC2=C1 OFLWZAHKUJNRML-UHFFFAOYSA-N 0.000 title 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 3
- -1 INDOLINE-CARBOXAMIDE DERIVATIVE COMPOUND Chemical class 0.000 abstract 3
- VKYTVITWNRXGGT-UHFFFAOYSA-N 2,3-dihydro-1h-isoindole-1-carboxamide Chemical compound C1=CC=C2C(C(=O)N)NCC2=C1 VKYTVITWNRXGGT-UHFFFAOYSA-N 0.000 abstract 2
- 208000002193 Pain Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000001640 Fibromyalgia Diseases 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO INDOLINA-CARBOXAMIDA DE FORMULA (I), DONDE R1 ES H, CN, ALQUILO C1-C3, HALO, ENTRE OTROS; m ES 1, 2 O 3; R2 Y R3 SON H, HALOALQUILO C1-C4, HALOALCOXI C1-C4, ENTRE OTROS; L1 ES ALQUILENO C1-C4, PENTILENO O CICLOALQUILENO C3-C6, OPCIONALMENTE SUSTITUIDOS CON X4; R2 Y R3 NO PUEDESN SER AMBOS H; X4 ES F, ALQUILO C1-C3, CICLOALQUILO C3-C7, ENTRE OTROS; L2 ES ALQUILENO C1-C3 OPCIONALMENTE SUSTITUIDO CON UNO O MAS X4. SON COMPUESTOS PREFERIDOS: 2-(2-CIANOETIL)-3-OXO-N-(4-(TRIFLUOROMETOXI)BENCIL)ISOINDOLINA-1-CARBOXAMIDA, 2-(2-CIANOETIL)-N-(2-METIL-4-(TRIFLUOROMETOXI)BENCIL)-3-OXOISOINDOLINA-1-CARBOXAMIDA, 2-(3-CIANO-3-METILBUTIL)-3-OXO-N-(4-(TRIFLUOROMETOXI)BENCIL)ISOINDOLINA-1-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD SOBRE LOS CANALES DE SODIO NaV1.7 Y SON UTILES EN EL TRATAMIENTO DEL DOLOR TAL COMO DOLOR AGUDO, FIBROMIALGIA, ANGINA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5731908P | 2008-05-30 | 2008-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091947A1 true PE20091947A1 (es) | 2010-01-28 |
Family
ID=41377344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000755A PE20091947A1 (es) | 2008-05-30 | 2009-05-29 | Derivados de indolina-carboxamida con actividad sobre los canales sodio |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR071956A1 (es) |
| CL (1) | CL2009001330A1 (es) |
| PE (1) | PE20091947A1 (es) |
| TW (1) | TW201000447A (es) |
| UY (1) | UY31853A (es) |
| WO (1) | WO2009145719A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013007768A1 (en) | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors |
| WO2015102929A1 (en) * | 2013-12-30 | 2015-07-09 | Novartis Ag | Tricyclic sulfonamide derivatives |
| US11046683B2 (en) | 2016-12-15 | 2021-06-29 | Ono Pharmaceutical Co., Ltd. | Activator of TREK (TWIK RElated K+ channels) channels |
| PL4004002T3 (pl) | 2019-07-22 | 2024-11-18 | Lupin Limited | Związki makrocykliczne jako agoniści sting i sposoby oraz ich zastosowania |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200613272A (en) * | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
| TW200804281A (en) * | 2006-02-16 | 2008-01-16 | Astrazeneca Ab | New metabotropic glutamate receptor-potentiating isoindolones |
| EP2044019A1 (en) * | 2006-07-12 | 2009-04-08 | Astra Zeneca AB | 3-oxoisoindoline-1-carboxamide derivatives as analgesic agents |
| TW200812962A (en) * | 2006-07-12 | 2008-03-16 | Astrazeneca Ab | New compounds I/418 |
| GB0705882D0 (en) * | 2007-03-27 | 2007-05-02 | Glaxo Group Ltd | Novel compounds |
-
2009
- 2009-05-26 TW TW098117512A patent/TW201000447A/zh unknown
- 2009-05-29 CL CL2009001330A patent/CL2009001330A1/es unknown
- 2009-05-29 AR ARP090101938A patent/AR071956A1/es unknown
- 2009-05-29 PE PE2009000755A patent/PE20091947A1/es not_active Application Discontinuation
- 2009-05-29 WO PCT/SE2009/050616 patent/WO2009145719A1/en not_active Ceased
- 2009-05-29 UY UY0001031853A patent/UY31853A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201000447A (en) | 2010-01-01 |
| AR071956A1 (es) | 2010-07-28 |
| WO2009145719A1 (en) | 2009-12-03 |
| CL2009001330A1 (es) | 2010-01-15 |
| UY31853A (es) | 2010-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY30316A1 (es) | Derivados sustituidos de benzamidas, nicotinamidas, propanamidas, acetamidas y carboxamidas n-(2-(piperidin-1-ilmetil)ciclohexil)sustituidas, procesos de preparacion, composiciones conteniéndolos y aplicaciones | |
| PE20141681A1 (es) | Inhibidores de btk | |
| PE20090816A1 (es) | Derivados de pirrolopirimidinona como agentes ligandos de los receptores p2x3 | |
| PE20090649A1 (es) | DERIVADOS DE PIRAZOL COMO INHIBIDORES DE LA ENZIMA 11ßHSD1 | |
| PE20090549A1 (es) | Derivados de imidazolidinona con actividad sobre lxr-alfa y lxr-beta | |
| UY32138A (es) | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables | |
| PE20090772A1 (es) | Derivados de bencimidazol | |
| PE20091573A1 (es) | Derivados heterociclicos de urea como inhibidores de adn girasa y/o topoisomerasa | |
| PE20110062A1 (es) | N-(3-(3,5-dimetoxifenetil)-1h-pirazol-5-il)-4-(3,4-dimetilpiperazin-1-il)benzamida y sales del mismo | |
| PE20120008A1 (es) | Derivados de fenoxi bencenosulfonamida | |
| ECSP11010898A (es) | Pirrolidina-2-carboxamidas sustituidas | |
| PE20091400A1 (es) | Derivados de n-(2-amino-fenil)-amida como inhibidores de hdac | |
| PE20091653A1 (es) | Derivados sustituidos de pirazol y su uso | |
| PE20110416A1 (es) | Compuestos de piperidina puenteada tipo quinoxalina sustituida con actividad sobre el receptor orl-1 | |
| ECSP066958A (es) | Compuestos de morfolina | |
| PE20061150A1 (es) | Derivados de n-(n-sulfonilaminoarilmetil)ciclopropanocarboxamida sustituidos como antagonistas del receptor vainilloide tipo 1 (vdr1) | |
| CL2008001670A1 (es) | Compuestos derivados de piperidina o piperazina, inhibidores de dgat1; composicion farmaceutica; combinacion farmaceutica; y uso para la prevencion o tratamiento de enfermedades tales como obesidad, hipercolesterolemia, dislipidemia, entre otras. | |
| UY30476A1 (es) | Noveles compuestos derivados n-sustituidos de la 3-oxoisoindolin-1-carboxamida, sus sales aceptables, composiciones farmaccuticas y aplicaciones. | |
| PE20120356A1 (es) | Compuestos para el tratamiento de trastornos metabolicos | |
| PE20091947A1 (es) | Derivados de indolina-carboxamida con actividad sobre los canales sodio | |
| UY30363A1 (es) | Derivados sustituidos de la n-(3-oxo-2,3-dihidro-1h-isoindol-4-il)-1-naftamida, procesos de preparacion, composiciones farmacéuticas y aplicaciones | |
| PE20080207A1 (es) | DERIVADOS DE 1-N-AMINO-2-IMIDAZOLIDINONAS COMO INHIBIDORES DEL CANAL DE POTASIO Kv1.5 | |
| PE20100052A1 (es) | Derivados de 3-oxoisoindolin-1-carboxamida como inhibidores de los canales de sodio | |
| AR062082A1 (es) | Derivados de piridazina con actividad microbicida | |
| PE20091455A1 (es) | Triazolopiridazinas como inhibidores de par1, su preparacion y uso como medicamentos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |