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CL2008001670A1 - Compuestos derivados de piperidina o piperazina, inhibidores de dgat1; composicion farmaceutica; combinacion farmaceutica; y uso para la prevencion o tratamiento de enfermedades tales como obesidad, hipercolesterolemia, dislipidemia, entre otras. - Google Patents

Compuestos derivados de piperidina o piperazina, inhibidores de dgat1; composicion farmaceutica; combinacion farmaceutica; y uso para la prevencion o tratamiento de enfermedades tales como obesidad, hipercolesterolemia, dislipidemia, entre otras.

Info

Publication number
CL2008001670A1
CL2008001670A1 CL2008001670A CL2008001670A CL2008001670A1 CL 2008001670 A1 CL2008001670 A1 CL 2008001670A1 CL 2008001670 A CL2008001670 A CL 2008001670A CL 2008001670 A CL2008001670 A CL 2008001670A CL 2008001670 A1 CL2008001670 A1 CL 2008001670A1
Authority
CL
Chile
Prior art keywords
dyslipidemia
hypercholesterolemia
obesity
treatment
compound
Prior art date
Application number
CL2008001670A
Other languages
English (en)
Inventor
Jean Pierre Andre Marc Bongartz
Lommen Guy Rosalia Eugeen Van
Christophe Francis Robert Nestor Buyck
Erwin Coesemans
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CL2008001670A1 publication Critical patent/CL2008001670A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN COMPUESTO DE FÓRMULA (1), DONDE A, X, Y, R1. R2, R3, R4. R9 SON COMO SE DEFINE EN LAS REIVINDICACIONES, UN N-ÓXIDO DE LOS MISMOS, UNA SAL FARMACÉUTICAMENTE ACEPTABLE DE LOS MISMOS O UN SOLVATO DE LOS MISMOS; Y QUE INCLUYE CUALQUIER FORMA ESTEREOQUÍMICAMENTE ISOMÉRICA DEL MISMO. USO DE DICHO COMPUESTO PARA EL TRATAMIENTO DE LA OBESIDAD, HIPERCOLESTEROLEMIA, HIPERLIPIDEMIA, DISLIPIDEMIA, DISLIPIDEMIA MIXTA, HIPERTRIGLICERIDEMIA, HÍGADO GRASO, ENFERMEDAD DEL HÍGADO GRASO NO ALCOHÓLICO, FIBROSIS HEPÁTICA, ESTEATOHEPATITIS NO ALCOHÓLICA O DIABETES. UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE UN VEHÍCULO FARMACÉUTICAMENTE ACEPTABLE, Y COMO UN COMPONENTE ACTIVO UNA CANTIDAD EFECTIVA DE DICHO COMPUESTO. UNA COMBINACIÓN FARMACÉUTICA QUE COMPRENDE DICHO COMPUESTO Y UN AGONISTA DEL RECEPTOR DEL ACTIVADOR-PROLIFERADOR DE PEROXISOMA.
CL2008001670A 2007-06-08 2008-06-06 Compuestos derivados de piperidina o piperazina, inhibidores de dgat1; composicion farmaceutica; combinacion farmaceutica; y uso para la prevencion o tratamiento de enfermedades tales como obesidad, hipercolesterolemia, dislipidemia, entre otras. CL2008001670A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07109864 2007-06-08

Publications (1)

Publication Number Publication Date
CL2008001670A1 true CL2008001670A1 (es) 2009-07-17

Family

ID=38667044

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008001670A CL2008001670A1 (es) 2007-06-08 2008-06-06 Compuestos derivados de piperidina o piperazina, inhibidores de dgat1; composicion farmaceutica; combinacion farmaceutica; y uso para la prevencion o tratamiento de enfermedades tales como obesidad, hipercolesterolemia, dislipidemia, entre otras.

Country Status (10)

Country Link
US (1) US8633197B2 (es)
EP (1) EP2152269B1 (es)
JP (1) JP5464709B2 (es)
AR (1) AR066154A1 (es)
AU (1) AU2008258560C1 (es)
CA (1) CA2687918C (es)
CL (1) CL2008001670A1 (es)
ES (1) ES2483898T3 (es)
TW (1) TWI436989B (es)
WO (1) WO2008148851A1 (es)

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SI2402317T1 (sl) 2006-03-31 2013-10-30 Novartis Ag DGAT inhibitor
ATE492541T1 (de) 2006-05-30 2011-01-15 Astrazeneca Ab Substituierte 5-phenylamino-1,3,4-oxadiazol-2- ylcarbonylamino-4-phenoxycyclohexancarbonsäuren als inhibitoren von acetylcoenzym-a- diacylglycerolacyltransferase
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Also Published As

Publication number Publication date
AU2008258560A1 (en) 2008-12-11
AU2008258560C1 (en) 2014-04-10
CA2687918C (en) 2016-11-08
WO2008148851A1 (en) 2008-12-11
AR066154A1 (es) 2009-07-29
ES2483898T3 (es) 2014-08-08
AU2008258560B2 (en) 2013-11-14
TW200911770A (en) 2009-03-16
US8633197B2 (en) 2014-01-21
CA2687918A1 (en) 2008-12-11
JP5464709B2 (ja) 2014-04-09
US20100184776A1 (en) 2010-07-22
EP2152269A1 (en) 2010-02-17
TWI436989B (zh) 2014-05-11
EP2152269B1 (en) 2014-04-23
JP2010529086A (ja) 2010-08-26

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