AR063096A1 - Pirazolopirimidinas como inhibidores de quinasa dependientes de ciclina - Google Patents
Pirazolopirimidinas como inhibidores de quinasa dependientes de ciclinaInfo
- Publication number
- AR063096A1 AR063096A1 ARP070104358A ARP070104358A AR063096A1 AR 063096 A1 AR063096 A1 AR 063096A1 AR P070104358 A ARP070104358 A AR P070104358A AR P070104358 A ARP070104358 A AR P070104358A AR 063096 A1 AR063096 A1 AR 063096A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- pirazolopirimidinas
- cycline
- inhibitors
- dependent kinase
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 108091007914 CDKs Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000006872 improvement Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Composiciones farmacéuticas que contienen uno o más de dichos compuestos, métodos para preparar formulaciones farmacéuticas que comprenden uno o más de dichos compuestos, y métodos de tratamiento, prevencion, inhibicion o mejoramiento de una o más enfermedades proliferativas asociadas con las CDKs usando dichos compuestos o composiciones farmacéuticas. Reivindicacion 1: Un compuesto seleccionado del grupo que consiste en los compuestos del grupo de formulas (1) o una sal, solvato, éster o profármaco farmacéuticamente aceptable de éstos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/542,920 US7605155B2 (en) | 2002-09-04 | 2006-10-04 | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063096A1 true AR063096A1 (es) | 2008-12-30 |
Family
ID=39111854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104358A AR063096A1 (es) | 2006-10-04 | 2007-10-02 | Pirazolopirimidinas como inhibidores de quinasa dependientes de ciclina |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7605155B2 (es) |
| EP (1) | EP2069349B1 (es) |
| JP (1) | JP2010505839A (es) |
| CN (1) | CN101573363B (es) |
| AR (1) | AR063096A1 (es) |
| CA (1) | CA2665127A1 (es) |
| CL (1) | CL2007002856A1 (es) |
| PE (1) | PE20080974A1 (es) |
| TW (1) | TW200821313A (es) |
| WO (1) | WO2008045267A2 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI421078B (zh) * | 2005-10-06 | 2014-01-01 | Merck Sharp & Dohme | 關卡激酶抑制劑及其用途 |
| CN101495481A (zh) * | 2006-05-22 | 2009-07-29 | 先灵公司 | 作为CDK抑制剂的吡唑并[1,5-α]嘧啶 |
| EP2296475A4 (en) * | 2008-06-20 | 2014-03-05 | Genentech Inc | TRIAZOLOPYRIDINE COMPOUNDS JAK KINASE INHIBITORS AND METHODS |
| CA2727036C (en) | 2008-06-20 | 2017-03-21 | Genentech, Inc. | Triazolopyridine jak inhibitor compounds and methods |
| US8993535B2 (en) | 2009-09-04 | 2015-03-31 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
| WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
| AP2012006294A0 (en) | 2009-11-05 | 2012-06-30 | Rhizen Pharmaceuticals Sa | Novel kinase modulators. |
| EP2525659B1 (en) * | 2010-01-19 | 2019-02-27 | Merck Sharp & Dohme Corp. | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS |
| WO2011119457A1 (en) * | 2010-03-26 | 2011-09-29 | Schering Corporation | Process for synthesizing 6-bromo-3-(1-methyl-1h-pyrazol-4-yl)-5-(3(r)-piperidinyl)pyrazolo[1,5-a]pyrimidin-7-amine |
| EP2608668B1 (en) * | 2010-08-23 | 2016-06-01 | Merck Sharp & Dohme Corp. | Fused tricyclic inhibitors of mammalian target of rapamycin |
| US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
| DK2705029T3 (en) | 2011-05-04 | 2019-02-18 | Rhizen Pharmaceuticals S A | Hitherto UNKNOWN RELATIONS AS MODULATORS OF PROTEIN KINASES |
| MX357043B (es) | 2012-07-04 | 2018-06-25 | Rhizen Pharmaceuticals Sa | Inhibidores selectivos de pi3k delta. |
| AU2013344716B2 (en) | 2012-11-16 | 2018-03-01 | University Health Network | Pyrazolopyrimidine compounds |
| ES2900829T3 (es) * | 2013-08-14 | 2022-03-18 | Novartis Ag | Terapia combinada para el tratamiento del cáncer |
| KR20160049003A (ko) | 2013-09-05 | 2016-05-04 | 제넨테크, 인크. | 항증식성 화합물 |
| CN106727474A (zh) * | 2017-01-04 | 2017-05-31 | 仪修南 | 苯氧乙酸类除草剂作为化学治疗剂治疗疾病的应用 |
| CN108653282B (zh) * | 2018-06-28 | 2020-08-14 | 中国科学院昆明植物研究所 | 苯并噻唑类及苯并吡咯类化合物在制备抗肿瘤药物中的应用 |
| US11414431B2 (en) | 2018-10-15 | 2022-08-16 | Nimbus Lakshmi, Inc. | Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors |
| AU2019370200B2 (en) * | 2018-10-30 | 2024-12-19 | Kronos Bio, Inc. | Compounds, compositions, and methods for modulating CDK9 activity |
| CN111393447B (zh) * | 2020-05-14 | 2021-01-15 | 苏州信诺维医药科技有限公司 | 一种嘧啶并吡唑类化合物、其制备方法及应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE335737T1 (de) | 2000-09-15 | 2006-09-15 | Vertex Pharma | Isoxazole und ihre verwendung als erk-inhibitoren |
| CN100376580C (zh) * | 2002-09-04 | 2008-03-26 | 先灵公司 | 作为细胞周期蛋白依赖性激酶抑制剂的吡唑并嘧啶 |
| US7196078B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corpoartion | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| NZ539162A (en) * | 2002-09-04 | 2006-07-28 | Schering Corp | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| EP1537116B1 (en) * | 2002-09-04 | 2010-06-02 | Schering Corporation | Pyrazolopyrimidines suitable for the treatment of cancer diseases |
| EP1608652A1 (en) * | 2003-03-31 | 2005-12-28 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| AR049769A1 (es) * | 2004-01-22 | 2006-09-06 | Novartis Ag | Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina |
| TWI421078B (zh) * | 2005-10-06 | 2014-01-01 | Merck Sharp & Dohme | 關卡激酶抑制劑及其用途 |
-
2006
- 2006-10-04 US US11/542,920 patent/US7605155B2/en not_active Expired - Lifetime
-
2007
- 2007-10-02 AR ARP070104358A patent/AR063096A1/es not_active Application Discontinuation
- 2007-10-02 WO PCT/US2007/021274 patent/WO2008045267A2/en not_active Ceased
- 2007-10-02 EP EP07839218.0A patent/EP2069349B1/en active Active
- 2007-10-02 JP JP2009531445A patent/JP2010505839A/ja not_active Ceased
- 2007-10-02 CA CA002665127A patent/CA2665127A1/en not_active Abandoned
- 2007-10-02 PE PE2007001331A patent/PE20080974A1/es not_active Application Discontinuation
- 2007-10-02 CN CN2007800446523A patent/CN101573363B/zh not_active Expired - Fee Related
- 2007-10-03 TW TW096137089A patent/TW200821313A/zh unknown
- 2007-10-03 CL CL2007002856A patent/CL2007002856A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20080974A1 (es) | 2008-07-19 |
| TW200821313A (en) | 2008-05-16 |
| CN101573363A (zh) | 2009-11-04 |
| US20070072881A1 (en) | 2007-03-29 |
| JP2010505839A (ja) | 2010-02-25 |
| CL2007002856A1 (es) | 2008-01-18 |
| CA2665127A1 (en) | 2008-04-17 |
| WO2008045267A3 (en) | 2008-07-31 |
| CN101573363B (zh) | 2013-03-06 |
| EP2069349B1 (en) | 2016-06-15 |
| US7605155B2 (en) | 2009-10-20 |
| WO2008045267A2 (en) | 2008-04-17 |
| EP2069349A2 (en) | 2009-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |