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PE20090311A1 - Proteinas de fusion natriureticas - Google Patents

Proteinas de fusion natriureticas

Info

Publication number
PE20090311A1
PE20090311A1 PE2008000956A PE2008000956A PE20090311A1 PE 20090311 A1 PE20090311 A1 PE 20090311A1 PE 2008000956 A PE2008000956 A PE 2008000956A PE 2008000956 A PE2008000956 A PE 2008000956A PE 20090311 A1 PE20090311 A1 PE 20090311A1
Authority
PE
Peru
Prior art keywords
natriuretic peptide
natriuretic
domain
connector
fusion proteins
Prior art date
Application number
PE2008000956A
Other languages
English (en)
Inventor
Keith Canada
Uwe Schoenbeck
Eugene R Hickey
Adam Mezo
Kevin Mcdonnell
Original Assignee
Boehringer Ingelheim Int
Syntonix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717543&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090311(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int, Syntonix Pharmaceuticals Inc filed Critical Boehringer Ingelheim Int
Publication of PE20090311A1 publication Critical patent/PE20090311A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Obesity (AREA)

Abstract

REFERIDA A UNA PROTEINA DE FUSION QUE COMPRENDE UN PEPTIDO NATRIURETICO DE FORMULA: X-La-F:F-La-X O X-La-F:F, Y UN DOMINIO Fc DE ANTICUERPO, DONDE EL PEPTIDO NATRIURETICO ESTA CONJUGADO CON EL DOMINIO Fc DIRECTAMENTE O A TRAVES DE UN CONECTOR Y DONDE X ES UN PEPTIDO NATRIURETICO, L ES UN CONECTOR QUE COMPRENDE RESIDUOS DE AMINOACIDOS, a ES UN NUMERO ENTERO; : ES UNA ASOCIACION QUIMICA O ENTRECRUZAMIENTO; F ES UNA PARTE DE UN DOMINIO Fc DE IMMUNOGLOBULINA QUE COMPRENDE UN SITIO DE UNION PARA FcRn. EL PEPTIDO NATRIURETICO ES UN PEPTIDO NATRIURETICO TIPO A (ANP) O UN PEPTIDO NATRIURETICO TIPO B (BNP); EL CONECTOR TIENE 6, 11, 16 O 20 AMINOACIDOS DE LONGITUD. TAMBIEN ESTA REFERIDA A UN POLIPEPTIDO. DICHAS PROTEINAS DE FUSION TIENEN ACTIVIDAD DIURETICA, NATRIURETICA Y VASODILATADORA Y SON UTILES EN EL TRATAMIENTO DE INSUFICIENCIA CARDIACA CRONICA, FIBROSIS CARDIACA, ENTRE OTRAS
PE2008000956A 2007-06-06 2008-06-05 Proteinas de fusion natriureticas PE20090311A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94245507P 2007-06-06 2007-06-06

Publications (1)

Publication Number Publication Date
PE20090311A1 true PE20090311A1 (es) 2009-04-09

Family

ID=39717543

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000956A PE20090311A1 (es) 2007-06-06 2008-06-05 Proteinas de fusion natriureticas

Country Status (10)

Country Link
US (1) US20100310561A1 (es)
EP (1) EP2162464A1 (es)
JP (1) JP2010530222A (es)
AR (1) AR066885A1 (es)
CA (1) CA2689492A1 (es)
CL (1) CL2008001661A1 (es)
PE (1) PE20090311A1 (es)
TW (1) TW200906849A (es)
UY (1) UY31123A1 (es)
WO (1) WO2008154226A1 (es)

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ES2687786T3 (es) 2004-04-21 2018-10-29 Alexion Pharmaceuticals, Inc. Conjugados para administración ósea y procedimiento de uso de estos para dirigir proteínas al hueso
EP2413969A4 (en) * 2009-03-30 2012-09-05 Boehringer Ingelheim Int FUSION PROTEINS WITH DOG FC ELEMENTS
PL3175863T3 (pl) 2009-05-20 2022-03-21 Biomarin Pharmaceutical Inc. Warianty peptydu natriuretycznego typu C
TW201120210A (en) 2009-11-05 2011-06-16 Hoffmann La Roche Glycosylated repeat-motif-molecule conjugates
CA2797865A1 (en) 2010-04-30 2011-11-03 Alexion Pharma International Sarl Methods, compositions, and kits for the treatment of matrix mineralization disorders
US8921516B2 (en) * 2010-12-08 2014-12-30 Corning Incorporated Synthetic, defined fibronectin mimetic peptides and surfaces modified with the same
AU2011350066A1 (en) 2010-12-27 2013-07-11 Alexion Pharma International Sarl Compositions comprising natriuretic peptides and methods of use thereof
EP2682128B1 (en) 2011-02-28 2017-11-08 National Cerebral and Cardiovascular Center Atrial natriuretic peptide or brain natriuretic peptide for use in preventing metastasis
US9233143B2 (en) * 2011-08-19 2016-01-12 National Cerebral And Cardiovascular Center Medicinal agent for preventing exacerbation of malignant tumor, comprising combination of natriuretic peptide receptor GC-A and GC-B agonists
SG11201401605QA (en) 2011-10-19 2014-09-26 Alexion Pharma Holding Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
US10052366B2 (en) 2012-05-21 2018-08-21 Alexion Pharmaceuticsl, Inc. Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
TW201442721A (zh) 2013-01-23 2014-11-16 Daiichi Sankyo Co Ltd 糖鏈修飾心房利尿鈉肽
KR102475799B1 (ko) * 2014-03-14 2022-12-08 다니엘 제이 카폰 비-펩티드 결합을 함유하는 하이브리드 면역글로불린
TWI593967B (zh) * 2014-05-01 2017-08-01 高雄醫學大學 二級抗體所辨識之抗原決定位及其用途
WO2016007873A1 (en) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions and methods for treating craniosynostosis
MX389350B (es) 2014-12-05 2025-03-19 Alexion Pharma Inc Fosfatasas alcalinas recombinantes y usos de las mismas para el tratamiento de convulsiones.
CA2973883A1 (en) 2015-01-28 2016-08-04 Alexion Pharmaceuticals, Inc. Methods of treating a subject with an alkaline phosphatase deficiency
CN104861075B (zh) * 2015-05-08 2018-06-08 成都金凯生物技术有限公司 一种长效重组人脑钠肽融合蛋白及其制备方法与用途
RU2745528C2 (ru) 2015-08-17 2021-03-26 Алексион Фармасьютикалз, Инк. Производство щелочных фосфатаз
EP3355904A4 (en) 2015-09-28 2019-06-12 Alexion Pharmaceuticals, Inc. IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA
WO2017074466A1 (en) 2015-10-30 2017-05-04 Alexion Pharmaceuticals, Inc. Methods for treating craniosynostosis in a patient
US11065306B2 (en) 2016-03-08 2021-07-20 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
US11186832B2 (en) 2016-04-01 2021-11-30 Alexion Pharmaceuticals, Inc. Treating muscle weakness with alkaline phosphatases
US10898549B2 (en) 2016-04-01 2021-01-26 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in adolescents and adults
WO2017214130A1 (en) 2016-06-06 2017-12-14 Alexion Pharmaceuticals, Inc. Metal impact on manufacturing of alkaline phosphatases
CA3029605C (en) 2016-07-01 2024-01-16 Daiichi Sankyo Company, Limited Hanp-fc-containing molecular conjugate
JP7018933B2 (ja) 2016-08-18 2022-02-14 アレクシオン ファーマシューティカルズ， インコーポレイテッド 気管気管支軟化症の治療方法
WO2018175534A1 (en) * 2017-03-22 2018-09-27 Pharmain Corporation Npra agonists, compositions, and uses thereof
BR112019020506A2 (pt) 2017-03-31 2020-08-04 Alexion Pharmaceuticals, Inc. métodos para o tratamento de hipofosfatasia (hpp) em adultos e adolescentes
WO2019190752A1 (en) 2018-03-30 2019-10-03 Alexion Pharmaceuticals, Inc. Manufacturing of glycoproteins
EP3553082A1 (en) 2018-04-12 2019-10-16 Bayer Aktiengesellschaft Brain natriuretic peptide engrafted antibodies
EP3553079A1 (en) 2018-04-12 2019-10-16 Bayer Aktiengesellschaft C-type natriuretic peptide engrafted antibodies
EP3553081A1 (en) 2018-04-12 2019-10-16 Bayer Aktiengesellschaft Atrial natriuretic peptide engrafted antibodies
WO2020033867A2 (en) 2018-08-10 2020-02-13 Alexion Pharmaceuticals, Inc. Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase
MY205168A (en) * 2018-10-23 2024-10-04 Regeneron Pharma Anti-npr1 antibodies and uses thereof
CN110964098B (zh) * 2019-10-23 2022-10-04 武汉奥科博泰生物科技有限公司 一种n端脑钠肽变体蛋白及其制备方法和应用
CN115175692A (zh) 2019-12-09 2022-10-11 阿雷克森制药公司 碱性磷酸酶多肽及其使用方法
MX2023007023A (es) 2020-12-18 2023-08-29 Regeneron Pharma Proteinas de inmunoglobulina que se unen a agonistas de npr1.
BR112023016048A2 (pt) 2021-02-12 2023-11-14 Alexion Pharma Inc Polipeptídeos de fosfatase alcalina e métodos de uso dos mesmos
KR20250088609A (ko) 2022-10-21 2025-06-17 일라이 릴리 앤드 캄파니 장기-작용 나트륨이뇨 펩티드 및 그의 용도

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JP2006514607A (ja) * 2002-07-31 2006-05-11 コンジュケム，インコーポレーテッド 長時間持続性ナトリウム排泄増加性ペプチド誘導体
US20050176108A1 (en) * 2003-03-13 2005-08-11 Young-Min Kim Physiologically active polypeptide conjugate having prolonged in vivo half-life
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Also Published As

Publication number Publication date
CA2689492A1 (en) 2008-12-18
TW200906849A (en) 2009-02-16
AR066885A1 (es) 2009-09-16
JP2010530222A (ja) 2010-09-09
WO2008154226A1 (en) 2008-12-18
EP2162464A1 (en) 2010-03-17
UY31123A1 (es) 2008-11-28
US20100310561A1 (en) 2010-12-09
CL2008001661A1 (es) 2009-03-20

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