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AR036384A1 - Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentada - Google Patents

Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentada

Info

Publication number
AR036384A1
AR036384A1 ARP020103279A ARP020103279A AR036384A1 AR 036384 A1 AR036384 A1 AR 036384A1 AR P020103279 A ARP020103279 A AR P020103279A AR P020103279 A ARP020103279 A AR P020103279A AR 036384 A1 AR036384 A1 AR 036384A1
Authority
AR
Argentina
Prior art keywords
increased
fusion protein
activity
erythropoyetin
vivid
Prior art date
Application number
ARP020103279A
Other languages
English (en)
Inventor
Dong-Eok Lee
Myung-Suk Oh
Bo-Sup Chung
Ji-Sook Park
Ki-Wan Kim
Original Assignee
Cheil Jedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cheil Jedang Corp filed Critical Cheil Jedang Corp
Publication of AR036384A1 publication Critical patent/AR036384A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Una proteína de fusión que tiene actividad de eritropoyetina in vivo aumentada en donde un fragmento de péptido del extremo carboxilo terminal de tromboyetina es fusionado con el extremo carboxilo terminal de la eritropoyetina humana. Esta proteína de fusión tiene una vida media in vivo muy aumentada debido al contenido aumentado de carbohidratos sin pérdidas de la actividad inherente de la eritropoyetina, y no provoca ninguna antigenicidad cuando se aplica al cuerpo humano.
ARP020103279A 2001-11-29 2002-08-30 Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentada AR036384A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-2001-0074975A KR100467750B1 (ko) 2001-11-29 2001-11-29 생체내 에리스로포이에틴 활성이 증진된 융합단백질

Publications (1)

Publication Number Publication Date
AR036384A1 true AR036384A1 (es) 2004-09-01

Family

ID=36821313

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020103279A AR036384A1 (es) 2001-11-29 2002-08-30 Una proteina de fusion que tiene actividad de eritropoyetina in vivo aumentada

Country Status (23)

Country Link
US (1) US7098318B2 (es)
EP (1) EP1319712B1 (es)
JP (1) JP3860097B2 (es)
KR (1) KR100467750B1 (es)
CN (1) CN100390201C (es)
AR (1) AR036384A1 (es)
AT (1) ATE460483T1 (es)
AU (1) AU2002300359B2 (es)
BR (1) BRPI0203394B1 (es)
CA (1) CA2394572C (es)
DE (2) DE10235248B4 (es)
ES (1) ES2339426T3 (es)
FR (1) FR2832716B1 (es)
GB (1) GB2382580B (es)
IT (1) ITMI20021803A1 (es)
MX (1) MXPA02008131A (es)
MY (1) MY122935A (es)
NZ (1) NZ520442A (es)
RU (1) RU2225220C1 (es)
SG (1) SG117416A1 (es)
TW (1) TWI237056B (es)
WO (1) WO2003046013A1 (es)
ZA (1) ZA200206172B (es)

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US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
KR20070008519A (ko) * 2003-09-29 2007-01-17 워렌 파마슈티칼즈 인코포레이티드 패혈증 및 유착 형성의 치료 및 예방용 조직 보호성사이토카인
US7625564B2 (en) 2006-01-27 2009-12-01 Novagen Holding Corporation Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
WO2007092252A2 (en) * 2006-02-03 2007-08-16 Modigene Inc Long-acting polypeptides and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8067548B2 (en) 2007-07-26 2011-11-29 Novagen Holding Corporation Fusion proteins having mutated immunoglobulin hinge region
CN101863982A (zh) * 2009-04-17 2010-10-20 哈药集团生物工程有限公司 一种用于升高血小板的融合蛋白及其制备方法
US12203113B2 (en) 2009-07-09 2025-01-21 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
CN103864913A (zh) * 2012-12-18 2014-06-18 联亚生技开发股份有限公司 重组蛋白
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
CN107438623B (zh) 2014-12-10 2023-07-14 Opko生物科学有限公司 长效的ctp修饰的生长激素多肽的制备方法
HUE055449T2 (hu) 2015-06-19 2021-11-29 Opko Biologics Ltd Hosszú hatástartamú koagulációs faktorok és eljárások ezek elõállítására
TW202444744A (zh) 2016-07-11 2024-11-16 以色列商歐科生物製品有限公司 長效型凝血因子及其生產方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE148171T1 (de) * 1989-02-21 1997-02-15 Univ Washington Modifizierte formen von fortpflanzungshormonen
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5856298A (en) * 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
KR100221066B1 (ko) * 1989-10-13 1999-10-01 스튜어트 엘.왓트 에리트로포이에틴 유사체와 그를 포함하는 제약학적 조성물
KR960701650A (ko) * 1993-04-29 1996-03-28 찰스 엠. 브룩 에리트로포이에틴 유사체 조성물 및 방법(Eythropoietin analog compositions and methods)
ZA946122B (en) * 1993-08-17 1995-03-20 Amgen Inc Erythropoietin analogs
SG47030A1 (en) * 1994-01-03 1998-03-20 Genentech Inc Thrombopoietin
ITFI940106A1 (it) * 1994-05-27 1995-11-27 Menarini Ricerche Sud Spa Molecola ibrida di formula gm-csf-l-epo o epo-l-gm-csf per la stimolaz ione eritropoietica
CA2212006A1 (en) * 1995-02-03 1996-08-08 G.D. Searle & Co. Novel c-mpl ligands
WO1999002709A1 (en) * 1997-07-10 1999-01-21 Beth Israel Deaconess Medical Center Recombinant erythropoietin / immunoglobulin fusion proteins
US6242570B1 (en) * 1997-07-10 2001-06-05 Beth Israel Deaconess Medical Center Production and use of recombinant protein multimers with increased biological activity
EP1012184B1 (en) * 1997-07-14 2007-10-10 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
US6342220B1 (en) * 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
AU3538799A (en) * 1998-04-30 1999-11-23 Kirin Brewery Company, Limited Human thrombopoietin mutants
AU775422B2 (en) * 1998-06-15 2004-07-29 Gtc Biotherapeutics, Inc. Erythropoietin analog-human serum albumin fusion
JP4944324B2 (ja) * 1999-07-13 2012-05-30 ボルダー バイオテクノロジー， インコーポレイテッド 免疫グロブリン融合タンパク質
CA2391080A1 (en) * 1999-11-12 2001-05-25 Merck Patent Gesellschaft Mit Beschraenkter Haftung Erythropoietin forms with improved properties

Also Published As

Publication number Publication date
AU2002300359B2 (en) 2004-12-23
JP3860097B2 (ja) 2006-12-20
CN1421461A (zh) 2003-06-04
GB2382580B (en) 2003-10-08
DE10235248B4 (de) 2004-12-23
FR2832716B1 (fr) 2004-12-03
WO2003046013A1 (en) 2003-06-05
DE10235248A1 (de) 2003-06-12
GB0218252D0 (en) 2002-09-11
ATE460483T1 (de) 2010-03-15
MXPA02008131A (es) 2004-12-13
GB2382580A (en) 2003-06-04
ZA200206172B (en) 2003-04-03
JP2003169671A (ja) 2003-06-17
DE60235603D1 (de) 2010-04-22
US7098318B2 (en) 2006-08-29
CN100390201C (zh) 2008-05-28
EP1319712A3 (en) 2003-11-12
EP1319712B1 (en) 2010-03-10
SG117416A1 (en) 2005-12-29
CA2394572C (en) 2007-08-14
BRPI0203394B1 (pt) 2015-12-01
US20030124115A1 (en) 2003-07-03
MY122935A (en) 2006-05-31
EP1319712A2 (en) 2003-06-18
ITMI20021803A1 (it) 2003-05-30
KR100467750B1 (ko) 2005-01-24
FR2832716A1 (fr) 2003-05-30
RU2225220C1 (ru) 2004-03-10
RU2002123438A (ru) 2004-03-27
BR0203394A (pt) 2004-05-11
CA2394572A1 (en) 2003-05-29
NZ520442A (en) 2003-10-31
KR20030044272A (ko) 2003-06-09
ES2339426T3 (es) 2010-05-20
TWI237056B (en) 2005-08-01

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed, e.g., due to non-payment of fee