PE20090619A1 - USO DE ANTAGONISTAS DE mGluR5 PARA EL TRATAMIENTO DE LA GERD - Google Patents
USO DE ANTAGONISTAS DE mGluR5 PARA EL TRATAMIENTO DE LA GERDInfo
- Publication number
- PE20090619A1 PE20090619A1 PE2008001400A PE2008001400A PE20090619A1 PE 20090619 A1 PE20090619 A1 PE 20090619A1 PE 2008001400 A PE2008001400 A PE 2008001400A PE 2008001400 A PE2008001400 A PE 2008001400A PE 20090619 A1 PE20090619 A1 PE 20090619A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- fluor
- alkyl
- gerd
- pyridine
- Prior art date
Links
- 208000021302 gastroesophageal reflux disease Diseases 0.000 title abstract 3
- 102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 title abstract 2
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- -1 PYRIDINE DERIVATIVE COMPOUNDS Chemical class 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 102000006239 metabotropic receptors Human genes 0.000 abstract 1
- 108020004083 metabotropic receptors Proteins 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRIDINA DE FORMULA (I) DONDE A O E ES N Y EL OTRO ES C; R1 ES HALOGENO; R2 ES ALQUILO(C1-C6); R3 ES FENILO, PIRIMIDINILO, PIRAZINILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6), ENTRE OTROS SUSTITUYENTES; R4 ES CHF2, CF3, CH2OH O ALQUILO(C1-C6). SON COMPUESTOS PREFERIDOS: 2-CLORO-4-[1-(4-FLUOR-FENIL)-2,5-DIMETIL-1H-IMIDAZOL-4-IL-ETINIL]-PIRIDINA, 2-CLORO-4-[5-DIFLUORMETIL-1-(4-FLUOR-FENIL)-2-METIL-1H-IMIDAZOL-4-ILETINIL]-PIRIDINA, [5-(2-CLORO-PIRIDIN-4-ILETINIL)-3-(4-FLUOR-FENIL)-2-METIL-3H-IMIDAZOL-4-IL]-METANOL, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES METABOTROPICOS DE GLUTAMATO DE TIPO 5 (mGluR5) SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DEL REFLUJO GASTRO-ESOFAGICO (GERD)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07114582 | 2007-08-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090619A1 true PE20090619A1 (es) | 2009-05-16 |
Family
ID=40040052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001400A PE20090619A1 (es) | 2007-08-20 | 2008-08-18 | USO DE ANTAGONISTAS DE mGluR5 PARA EL TRATAMIENTO DE LA GERD |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090054490A1 (es) |
| AR (1) | AR070020A1 (es) |
| CL (1) | CL2008002440A1 (es) |
| PE (1) | PE20090619A1 (es) |
| TW (1) | TW200924764A (es) |
| WO (1) | WO2009024491A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8642626B2 (en) | 2010-07-29 | 2014-02-04 | Taisho Pharmaceutical Co., Ltd. | Ethinyl-pyrazole derivative |
| US20120039999A1 (en) * | 2010-08-11 | 2012-02-16 | Ashish Chatterji | Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists |
| US20130274294A1 (en) * | 2010-12-20 | 2013-10-17 | David Carcache | 4-(Hetero)Aryl-Ethynyl-Octahydro-Indole-1-Esters |
| WO2020163689A1 (en) | 2019-02-08 | 2020-08-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | 20-hete formation inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0201943D0 (sv) * | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New use |
| ATE495168T1 (de) * | 2003-06-12 | 2011-01-15 | Hoffmann La Roche | Heteroarylsubstituierte imidazolderivate als glutamatrezeptorantagonisten |
| CN1960984B (zh) * | 2004-06-01 | 2010-05-12 | 弗·哈夫曼-拉罗切有限公司 | 作为mglu5受体拮抗剂的吡啶-4-基-乙炔基-咪唑和吡唑 |
| GB0514296D0 (en) * | 2005-07-12 | 2005-08-17 | Novartis Ag | Organic compounds |
-
2008
- 2008-08-11 WO PCT/EP2008/060509 patent/WO2009024491A1/en not_active Ceased
- 2008-08-13 US US12/190,614 patent/US20090054490A1/en not_active Abandoned
- 2008-08-18 PE PE2008001400A patent/PE20090619A1/es not_active Application Discontinuation
- 2008-08-19 TW TW097131610A patent/TW200924764A/zh unknown
- 2008-08-19 CL CL2008002440A patent/CL2008002440A1/es unknown
- 2008-08-19 AR ARP080103602A patent/AR070020A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20090054490A1 (en) | 2009-02-26 |
| TW200924764A (en) | 2009-06-16 |
| AR070020A1 (es) | 2010-03-10 |
| WO2009024491A1 (en) | 2009-02-26 |
| CL2008002440A1 (es) | 2009-07-31 |
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| PE20090619A1 (es) | USO DE ANTAGONISTAS DE mGluR5 PARA EL TRATAMIENTO DE LA GERD |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |