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CY1108744T1 - 2-οξο-1,2,4,5-τετραϋδρo-1,3-βενζοδιαζεπιν-3-υλ-πιπεριδινες ως ανταγωνιστες της cgrp - Google Patents

2-οξο-1,2,4,5-τετραϋδρo-1,3-βενζοδιαζεπιν-3-υλ-πιπεριδινες ως ανταγωνιστες της cgrp

Info

Publication number
CY1108744T1
CY1108744T1 CY20091100128T CY091100128T CY1108744T1 CY 1108744 T1 CY1108744 T1 CY 1108744T1 CY 20091100128 T CY20091100128 T CY 20091100128T CY 091100128 T CY091100128 T CY 091100128T CY 1108744 T1 CY1108744 T1 CY 1108744T1
Authority
CY
Cyprus
Prior art keywords
benzodiazepine
piperidines
tetrahydro
oxo
cgrp antagonists
Prior art date
Application number
CY20091100128T
Other languages
English (en)
Inventor
Stephan Georg Mueller
Klaus Rudolf
Philipp Lustenberger
Dirk Stenkamp
Marco Santagostino
Fabio Paleari
Alexander Dreyer
Kristen Arndt
Henri Doods
Gerhard Schaenzle
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP06723571A external-priority patent/EP1863791B1/de
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of CY1108744T1 publication Critical patent/CY1108744T1/el

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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P39/02—Antidotes
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Diabetes (AREA)
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  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)

Abstract

Αντικείμενο της παρούσας εφεύρεσης είναι νέοι ανταγωνιστές της CGRP του γενικού τύπου (I), στον οποίο τα Β, R1 και R2 ορίζονται στην αξίωση 1, τα ταυτομερή τους, τα ισομερή τους, τα διαστερεοϊσομερή τους, τα εναντιομερή τους, οι ένυδρες ενώσεις τους, τα μείγματα τους και τα άλατα τους, καθώς και τα ένυδρα άλατα τους, ιδιαιτέρως τα φυσιολογικά αποδεκτά άλατα τους με ανόργανα ή οργανικά οξέα ή βάσεις, φάρμακα που περιέχουν τις ενώσεις αυτές, η χρήση τους και μέθοδος για την παραγωγή τους.
CY20091100128T 2004-03-29 2009-02-04 2-οξο-1,2,4,5-τετραϋδρo-1,3-βενζοδιαζεπιν-3-υλ-πιπεριδινες ως ανταγωνιστες της cgrp CY1108744T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004015723A DE102004015723A1 (de) 2004-03-29 2004-03-29 Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
PCT/EP2005/003094 WO2005092880A1 (de) 2004-03-29 2005-03-23 Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
EP06723571A EP1863791B1 (de) 2005-03-23 2006-03-21 2-oxo-1,2,4,5-tetrahydro-1,3-benzdiazepin-3-yl-piperidine als cgrp-antagonisten

Publications (1)

Publication Number Publication Date
CY1108744T1 true CY1108744T1 (el) 2014-04-09

Family

ID=34967621

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20091100128T CY1108744T1 (el) 2004-03-29 2009-02-04 2-οξο-1,2,4,5-τετραϋδρo-1,3-βενζοδιαζεπιν-3-υλ-πιπεριδινες ως ανταγωνιστες της cgrp
CY20091101109T CY1109510T1 (el) 2004-03-29 2009-10-26 Επιλεγμενοι ανταγωνιστες toy cgrp, μεθοδος για την παραγωγη τους και για τη χρηση τους ως φαρμακων

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20091101109T CY1109510T1 (el) 2004-03-29 2009-10-26 Επιλεγμενοι ανταγωνιστες toy cgrp, μεθοδος για την παραγωγη τους και για τη χρηση τους ως φαρμακων

Country Status (32)

Country Link
US (3) US7479488B2 (el)
EP (2) EP1732917B8 (el)
JP (2) JP4796567B2 (el)
KR (1) KR20070007867A (el)
CN (1) CN1976916A (el)
AR (2) AR049625A1 (el)
AT (2) ATE437868T1 (el)
AU (1) AU2005225539A1 (el)
BR (2) BRPI0509368A (el)
CA (1) CA2558889A1 (el)
CY (2) CY1108744T1 (el)
DE (2) DE102004015723A1 (el)
DK (1) DK1732917T3 (el)
EA (1) EA012111B1 (el)
EC (1) ECSP066898A (el)
ES (1) ES2330865T3 (el)
HR (1) HRP20090457T1 (el)
IL (2) IL178334A0 (el)
MX (1) MX2007011526A (el)
MY (1) MY141754A (el)
NO (1) NO20064166L (el)
NZ (2) NZ550774A (el)
PE (2) PE20091884A1 (el)
PL (1) PL1732917T3 (el)
PT (1) PT1732917E (el)
RS (1) RS51150B (el)
SI (1) SI1732917T1 (el)
TW (1) TW200602338A (el)
UA (1) UA88163C2 (el)
UY (1) UY29437A1 (el)
WO (1) WO2005092880A1 (el)
ZA (2) ZA200606056B (el)

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