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PE20080765A1 - Formas de dosificacion farmaceutica - Google Patents

Formas de dosificacion farmaceutica

Info

Publication number
PE20080765A1
PE20080765A1 PE2007001153A PE2007001153A PE20080765A1 PE 20080765 A1 PE20080765 A1 PE 20080765A1 PE 2007001153 A PE2007001153 A PE 2007001153A PE 2007001153 A PE2007001153 A PE 2007001153A PE 20080765 A1 PE20080765 A1 PE 20080765A1
Authority
PE
Peru
Prior art keywords
matrix
formulation
resistant
refers
active agent
Prior art date
Application number
PE2007001153A
Other languages
English (en)
Inventor
Richard Owen Mannion
Edward Patrick O'donnell
William Henry Mckenna
Haiyong Hugh Huang
Original Assignee
Purdue Pharma Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38754532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080765(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Purdue Pharma Lp filed Critical Purdue Pharma Lp
Publication of PE20080765A1 publication Critical patent/PE20080765A1/es

Links

Classifications

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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
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    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • B29K2071/02—Polyalkylene oxides, e.g. PEO, i.e. polyethylene oxide, or derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0035—Medical or pharmaceutical agents
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    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/25—Solid
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0088—Molecular weight
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
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Abstract

SE REFIERE A UN PROCESO DE PREPARACION DE UNA MATRIZ DE UN PRODUCTO FARMACEUTICO SOLIDO DE LIBERACION EXTENDIDA NO MANIPULABLE, CARACTERIZADO POR COMPRENDER LOS PASOS DE: A) COMBINAR UN OXIDO DE POLIETILENO DE UN PESO MOLECULAR DE 1000000 Y UN AGENTE ACTIVO; B) FORMACION DE LA MATRIZ DE LIBERACION EXTENDIDA; Y C) SOMETER A CURACION LA FORMULACION MATRICIAL, PARA REBLANDECERLA. ADICIONALMENTE COMPRENDE UN PASO DE RECUBRIMIENTO. LA FORMULACION MATRICIAL TIENE UNA DENSIDAD IGUAL O MENOR QUE 1.20 g/cm3. EL AGENTE ACTIVO ES UN OPIOIDE, COMO: ALFENTANIL, ALILPRODINA, LEVORFANOL, OPIO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA FORMULACION FARMACEUTICA. DICHO PROCESO TIENE COMO VENTAJAS SER RESISTENTE A LA EXTRACCION POR ALCOCHOL Y RESISTENTE A LA TRITURACION
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