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PE20061158A1 - 2-anilinopirimidinas sustituidas como inhibidores de la quinasa del ciclo celular o del receptor de la tirosina quinasa y su preparacion - Google Patents

2-anilinopirimidinas sustituidas como inhibidores de la quinasa del ciclo celular o del receptor de la tirosina quinasa y su preparacion

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Publication number
PE20061158A1
PE20061158A1 PE2005001148A PE2005001148A PE20061158A1 PE 20061158 A1 PE20061158 A1 PE 20061158A1 PE 2005001148 A PE2005001148 A PE 2005001148A PE 2005001148 A PE2005001148 A PE 2005001148A PE 20061158 A1 PE20061158 A1 PE 20061158A1
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PE
Peru
Prior art keywords
kinase
alkyl
inhibitors
tirosine
bencensulfonamide
Prior art date
Application number
PE2005001148A
Other languages
English (en)
Inventor
Arwed Cleve
Ulrich Lucking
Hans Briem
Martin Kruger
Philip Lienau
Rolf Jautelat
Gerhard Siemeister
Christopher West
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35447860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20061158(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE102004049622A external-priority patent/DE102004049622A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20061158A1 publication Critical patent/PE20061158A1/es

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    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
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    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
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Abstract

REFERIDA A UN COMPUESTO DERIVADO DE ANILINOPIRIMIDINA DE FORMULA I, DONDE A Y D SON HALOGENO, OH, CIANO, ALQUILO C1-C4, ENTRE OTROS; X ES NH, N(ALQUILO C1-C3) U O EN DONDE EL RADICAL ALQUILO PUEDE SER RAMIFICADO; R1 ES HALOGENO O CIANO; R2 ES HIDROXIALQUILO C1-C8, CICLOALQUILO C3-C7, ENTRE OTROS; R3 Y R4 SON H, ALQUILO C1-C3, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-[5-BROMO-4-((R)-2-HIDROXI-1-METIL-ETIL-AMINO)PIRIMIDIN-2-ILAMINO]-2,6-DIMETIL-BENCENSULFONAMIDA, 4-(5-CIANO-4-CICLOHEXILAMINO-PIRIMIDIN-2-ILAMINO)-2,6-DIMETIL-BENCENSULFONAMIDA, 4-[5-BROMO-4-((1R,2R)-2-HIDROXI-1-METIL-PROPOXI)PIRIMIDIN-2-ILAMINO]-2,6-DIMETIL-BENCENSULFONAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LAS QUINASAS DEPENDIENTES DE LAS CICLINAS, TALES COMO CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK8 Y CDK9, ASI COMO DE LOS RECEPTORES DE VEGF DE TIROSINA QUINASAS Y SON UTILES PARA EL TRATAMIENTO DEL CANCER, ENFERMEDADES CAUSADAS POR TRASTORNOS DE LA PROLIFERACION CELULAR, ENTRE OTRAS
PE2005001148A 2004-09-29 2005-09-29 2-anilinopirimidinas sustituidas como inhibidores de la quinasa del ciclo celular o del receptor de la tirosina quinasa y su preparacion PE20061158A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61396404P 2004-09-29 2004-09-29
DE102004049622A DE102004049622A1 (de) 2004-10-06 2004-10-06 Subtituierte 2-Anilinopyrimidine als Zellzyklus-kinase oder Rezeptortyrosin-kinase Inhibitoren, deren Herstellung und Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
PE20061158A1 true PE20061158A1 (es) 2006-11-12

Family

ID=35447860

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PE2005001148A PE20061158A1 (es) 2004-09-29 2005-09-29 2-anilinopirimidinas sustituidas como inhibidores de la quinasa del ciclo celular o del receptor de la tirosina quinasa y su preparacion

Country Status (11)

Country Link
US (1) US20060111378A1 (es)
EP (1) EP1794134A1 (es)
JP (1) JP2008514571A (es)
AR (1) AR052312A1 (es)
GT (1) GT200500272A (es)
PA (1) PA8647401A1 (es)
PE (1) PE20061158A1 (es)
SV (1) SV2006002245A (es)
TW (1) TW200628452A (es)
UY (1) UY29145A1 (es)
WO (1) WO2006034872A1 (es)

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TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
GB0205690D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205688D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205693D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
AU2003208479A1 (en) 2002-03-09 2003-09-22 Astrazeneca Ab 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity
DK1534286T3 (da) 2002-07-29 2010-04-26 Rigel Pharmaceuticals Inc Fremgangsmåder til behandling eller forebyggelse af autoimmune sygdomme med 2,4-pyrimidindiamin-forbindelser
GB0311276D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
GB0311274D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
US7122542B2 (en) 2003-07-30 2006-10-17 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
JP2008524191A (ja) * 2004-12-17 2008-07-10 アストラゼネカ アクチボラグ Cdk阻害剤としての4−(4−(イミダゾール−4−イル)ピリミジン−2−イルアミノ)ベンズアミド
CA2591948C (en) 2005-01-19 2013-11-12 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
GB0504753D0 (en) * 2005-03-08 2005-04-13 Astrazeneca Ab Chemical compounds
SG137989A1 (en) * 2005-06-08 2008-01-28 Rigel Pharmaceuticals Inc Compositions and methods for inhibition of the JAK pathway
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US20080280906A1 (en) * 2005-07-30 2008-11-13 David Andrews Imidazolyl-Pyrimidine Compounds for Use in the Treatment of Proliferative Disorders
EP1934213A1 (en) * 2005-09-30 2008-06-25 Astra Zeneca AB Imidazo [1,2-a] pyridine having anti-cell-proliferation activity
DE102005062742A1 (de) * 2005-12-22 2007-06-28 Bayer Schering Pharma Ag Sulfoximin substituierte Pyrimidine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel
WO2007120980A2 (en) 2006-02-17 2007-10-25 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases
JP2009528295A (ja) 2006-02-24 2009-08-06 ライジェル ファーマシューティカルズ, インコーポレイテッド Jak経路の阻害のための組成物および方法
TW200811169A (en) * 2006-05-26 2008-03-01 Astrazeneca Ab Chemical compounds
EP2179991A1 (de) * 2008-10-21 2010-04-28 Bayer Schering Pharma Aktiengesellschaft Sulfoximinsubstituierte Anilino-Pyrimidinderivate als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
GB0821537D0 (en) * 2008-11-25 2008-12-31 Union Life Sciences Ltd Therapeutic target
MX337849B (es) * 2009-07-28 2016-03-09 Rigel Pharmaceuticals Inc Composiciones y metodos para inhibicion de la via jak.
US8466155B2 (en) * 2009-10-02 2013-06-18 Boehringer Ingelheim International Gmbh Pyrimidines
WO2011047796A1 (en) * 2009-10-21 2011-04-28 Bayer Schering Pharma Aktiengesellschaft Substituted halophenoxybenzamide derivatives
EP2353591A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
RU2016129380A (ru) 2013-12-20 2018-01-25 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Замещенные диаминопиримидильные соединения, их композиции и способы лечения с их участием
AU2020256220A1 (en) 2019-04-04 2021-09-16 Dana-Farber Cancer Institute, Inc. CDK2/5 degraders and uses thereof

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JPS58183665A (ja) * 1982-04-19 1983-10-26 Sumitomo Chem Co Ltd スルホニルクロリドの製造方法
GB0016877D0 (en) * 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
PL367130A1 (en) * 2001-05-29 2005-02-21 Schering Aktiengesellschaft Cdk inhibiting pyrimidines, production thereof and their use as medicaments
EP1483260A1 (de) * 2002-03-11 2004-12-08 Schering Aktiengesellschaft Cdk inhibitorische 2-heteroaryl-pyrimidine, deren herstellung und verwendung als arzneimittel
US7288547B2 (en) * 2002-03-11 2007-10-30 Schering Ag CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents

Also Published As

Publication number Publication date
AR052312A1 (es) 2007-03-14
SV2006002245A (es) 2006-05-25
TW200628452A (en) 2006-08-16
UY29145A1 (es) 2006-04-28
PA8647401A1 (es) 2006-07-03
JP2008514571A (ja) 2008-05-08
US20060111378A1 (en) 2006-05-25
GT200500272A (es) 2006-06-06
WO2006034872A1 (de) 2006-04-06
EP1794134A1 (de) 2007-06-13

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