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EA200900799A1 - Гетероарилгетероарильные соединения как ингибиторы cdk, предназначенные для лечения рака, воспаления и борьбы с вирусными инфекциями - Google Patents

Гетероарилгетероарильные соединения как ингибиторы cdk, предназначенные для лечения рака, воспаления и борьбы с вирусными инфекциями

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Publication number
EA200900799A1
EA200900799A1 EA200900799A EA200900799A EA200900799A1 EA 200900799 A1 EA200900799 A1 EA 200900799A1 EA 200900799 A EA200900799 A EA 200900799A EA 200900799 A EA200900799 A EA 200900799A EA 200900799 A1 EA200900799 A1 EA 200900799A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inflammation
cancer
treatment
heteroarylheteroaryl
cdk
Prior art date
Application number
EA200900799A
Other languages
English (en)
Inventor
Рохан Эрик Джон Бекуит
Даниел Тим Кертис
Эдмунд Харрингтон
Юрген Ханс-Германн Хинрикс
Джон Антони Талларико
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA200900799A1 publication Critical patent/EA200900799A1/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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Abstract

В заявке описаны органические соединения формулы (I), в которой m равно 0 или 1; n равно 0 или 1; А, А, Аи А, все независимо обозначают С, С(Н) или N, которые применимы для лечения нарушений, связанных с протеинкиназой. Они особенно полезны для устранения, предупреждения или облегчения одного или большего количества симптомов рака, воспаления, гипертрофии сердца и ВИЧ путем модулирования активности протеинкиназ, таких как CDK1, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK8 и CDK9 и их комбинации.
EA200900799A 2006-12-22 2007-12-20 Гетероарилгетероарильные соединения как ингибиторы cdk, предназначенные для лечения рака, воспаления и борьбы с вирусными инфекциями EA200900799A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87147106P 2006-12-22 2006-12-22
PCT/US2007/088292 WO2008079933A2 (en) 2006-12-22 2007-12-20 Heteroaryl-heteroaryl compounds as cdk inhibitors for the treatment of cancer, inflammation and viral infections

Publications (1)

Publication Number Publication Date
EA200900799A1 true EA200900799A1 (ru) 2009-12-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900799A EA200900799A1 (ru) 2006-12-22 2007-12-20 Гетероарилгетероарильные соединения как ингибиторы cdk, предназначенные для лечения рака, воспаления и борьбы с вирусными инфекциями

Country Status (11)

Country Link
US (1) US20100048597A1 (ru)
EP (1) EP2094682A2 (ru)
JP (1) JP2010514689A (ru)
KR (1) KR20090091306A (ru)
CN (1) CN101568529A (ru)
AU (1) AU2007336933A1 (ru)
BR (1) BRPI0720635A2 (ru)
CA (1) CA2672518A1 (ru)
EA (1) EA200900799A1 (ru)
MX (1) MX2009006536A (ru)
WO (1) WO2008079933A2 (ru)

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