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PE20061426A1 - Derivados de indol como inhibidores de la fosfolipasa a2 citosolica - Google Patents

Derivados de indol como inhibidores de la fosfolipasa a2 citosolica

Info

Publication number
PE20061426A1
PE20061426A1 PE2006000559A PE2006000559A PE20061426A1 PE 20061426 A1 PE20061426 A1 PE 20061426A1 PE 2006000559 A PE2006000559 A PE 2006000559A PE 2006000559 A PE2006000559 A PE 2006000559A PE 20061426 A1 PE20061426 A1 PE 20061426A1
Authority
PE
Peru
Prior art keywords
inhibitors
indol
chloro
ethyl
amino
Prior art date
Application number
PE2006000559A
Other languages
English (en)
Inventor
John C Mckew
Katherine L Lee
Richard Vargas
Cara Williams
Suzana Marusic
Kevin Pong
Valerie Clerin
James D Clark
Lihren Chen
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20061426A1 publication Critical patent/PE20061426A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE INDOL DE FORMULA (I), DONDE n1 ES 1 O 2; n2 ES 1 O 2; n3 ES 1 O 2; n5 ES 0, 1 O 2; X2 ES UN ENLACE, O, CH2, SO2; R5 ES H O ALQUILO C1-C3; R6 ES H O ALQUILO C1-C6; R7 ES OH, BENCILOXI, CH3, CF3, ENTRE OTROS; R8 ES H, OH, NO2, CF3, OCF3, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO 4-{2-[2-[2-({[2-(BENCILOXI)BENCIL]-SULFONIL}AMINO)ETIL]-5-CLORO-1-(DIFENIL-METIL)-1H-INDOL-3-IL]-ETOXI}BENZOICO, ACIDO 4-{2-[5-CLORO-1-(DIFENILMETIL)-2-(2-{[(2-HIDROXIBENCIL)SULFONIL]AMINO}ETIL)-1H-INDOL-3-IL]ETOXI}-BENZOICO, ACIDO 4-{2-[5--CLORO-2-(2-{[(2,6-DIBROMO-BENCIL)SULFONIL]AMINO}ETIL)-1-(DIFENILMETIL)-1H-INDOL-3-IL]-ETOXI}BENZOICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LAS FOSFOLIPASAS, PARTICULARMENTE, FOSFOLIPASA A2 CITOSOLICA (cPLA2), Y MAS PARTICULARMENTE DE LA ENZIMA FOSFOLIPASA A2 ALFA CITOSOLICA Y SON UTILES EN EL TRATAMIENTO DE LA INFLAMACION, DOLOR, ASMA, INFARTO, ENTRE OTROS
PE2006000559A 2005-05-27 2006-05-26 Derivados de indol como inhibidores de la fosfolipasa a2 citosolica PE20061426A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68556405P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
PE20061426A1 true PE20061426A1 (es) 2007-01-24

Family

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Application Number Title Priority Date Filing Date
PE2006000559A PE20061426A1 (es) 2005-05-27 2006-05-26 Derivados de indol como inhibidores de la fosfolipasa a2 citosolica

Country Status (32)

Country Link
US (3) US7557135B2 (es)
EP (2) EP2248801A1 (es)
JP (1) JP5116666B2 (es)
KR (1) KR101353982B1 (es)
CN (2) CN101184729B (es)
AR (1) AR054195A1 (es)
AT (1) ATE489364T1 (es)
AU (1) AU2006251946B2 (es)
BR (1) BRPI0610049A2 (es)
CA (1) CA2607857C (es)
CR (1) CR9520A (es)
CY (1) CY1111151T1 (es)
DE (1) DE602006018451D1 (es)
DK (1) DK1891006T3 (es)
ES (1) ES2354908T3 (es)
GT (1) GT200600228A (es)
HN (1) HN2006019513A (es)
IL (1) IL186912A (es)
MX (1) MX2007014589A (es)
MY (1) MY144672A (es)
NI (1) NI200700287A (es)
NO (1) NO20075627L (es)
NZ (1) NZ563736A (es)
PE (1) PE20061426A1 (es)
PL (1) PL1891006T3 (es)
PT (1) PT1891006E (es)
RU (1) RU2433997C2 (es)
SI (1) SI1891006T1 (es)
SV (1) SV2008002551A (es)
TW (1) TW200718687A (es)
UA (1) UA91053C2 (es)
WO (1) WO2006128142A2 (es)

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Publication number Publication date
WO2006128142A8 (en) 2007-12-27
SI1891006T1 (sl) 2011-02-28
EP1891006A2 (en) 2008-02-27
US20100029645A1 (en) 2010-02-04
NZ563736A (en) 2010-11-26
GT200600228A (es) 2006-12-26
SV2008002551A (es) 2008-07-23
CN102040550A (zh) 2011-05-04
CN101184729A (zh) 2008-05-21
JP2008542303A (ja) 2008-11-27
CN102040550B (zh) 2012-10-03
BRPI0610049A2 (pt) 2010-05-25
TW200718687A (en) 2007-05-16
US8283373B2 (en) 2012-10-09
WO2006128142A2 (en) 2006-11-30
IL186912A (en) 2012-05-31
EP2248801A1 (en) 2010-11-10
ATE489364T1 (de) 2010-12-15
MY144672A (en) 2011-10-31
PL1891006T3 (pl) 2011-05-31
IL186912A0 (en) 2008-02-09
US7557135B2 (en) 2009-07-07
NO20075627L (no) 2008-01-03
DK1891006T3 (da) 2011-01-24
WO2006128142A3 (en) 2007-03-29
RU2007140910A (ru) 2009-07-10
PT1891006E (pt) 2011-01-26
CA2607857C (en) 2014-02-11
US20100022536A1 (en) 2010-01-28
AU2006251946B2 (en) 2011-05-12
ES2354908T3 (es) 2011-03-21
HN2006019513A (es) 2011-03-02
HK1113680A1 (en) 2008-10-10
CY1111151T1 (el) 2015-06-11
JP5116666B2 (ja) 2013-01-09
US20070004719A1 (en) 2007-01-04
HK1152710A1 (en) 2012-03-09
CR9520A (es) 2008-02-20
EP1891006B1 (en) 2010-11-24
KR101353982B1 (ko) 2014-02-18
KR20080021618A (ko) 2008-03-07
NI200700287A (es) 2008-05-27
RU2433997C2 (ru) 2011-11-20
AU2006251946A1 (en) 2006-11-30
AR054195A1 (es) 2007-06-06
CA2607857A1 (en) 2006-11-30
MX2007014589A (es) 2008-01-21
DE602006018451D1 (de) 2011-01-05
CN101184729B (zh) 2011-02-16
UA91053C2 (en) 2010-06-25

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