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PE20091456A1 - Nuevas formas cristalinas de acido 4-[4-(2-adamantilcarbamoil)-5-tert-butil-pirazol-1-il]benzoico- 471 - Google Patents

Nuevas formas cristalinas de acido 4-[4-(2-adamantilcarbamoil)-5-tert-butil-pirazol-1-il]benzoico- 471

Info

Publication number
PE20091456A1
PE20091456A1 PE2009000164A PE2009000164A PE20091456A1 PE 20091456 A1 PE20091456 A1 PE 20091456A1 PE 2009000164 A PE2009000164 A PE 2009000164A PE 2009000164 A PE2009000164 A PE 2009000164A PE 20091456 A1 PE20091456 A1 PE 20091456A1
Authority
PE
Peru
Prior art keywords
adamantilcarbamoil
pirazol
tert
butyl
benzoic acid
Prior art date
Application number
PE2009000164A
Other languages
English (en)
Inventor
Gary Peter Bembridge
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2008/000454 external-priority patent/WO2008099145A1/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20091456A1 publication Critical patent/PE20091456A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE REFIERE A UNA FORMA CRISTALINA DE ACIDO 4-[4-(2-ADAMANTILCARBAMOIL)-5-TERT-BUTIL-PIRAZOL-1-IL]BENZOICO QUE TIENE UN PATRON DE DIFRACCION DE RAYOS X CON PICOS EXPRESADOS EN 2-THETA DE 18,0; 17,7; 18,4; 8,9; 20,5; 10,4; 21,9; 13,4; 27,6; 16,7; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE CONTIENE DICHA FORMA CRISTALINA. DICHO COMPUESTO ES INHIBIDOR DE LA ENZIMA 11-B-HIDROXIESTEROIDE DESHIDROGENASA DE TIPO 1 HUMANA (11BHSD1) SIENDO UTIL EN EL TRATAMIENTO DE DIABETES DE TIPO 2
PE2009000164A 2008-02-04 2009-02-04 Nuevas formas cristalinas de acido 4-[4-(2-adamantilcarbamoil)-5-tert-butil-pirazol-1-il]benzoico- 471 PE20091456A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PK10808 2008-02-04
PCT/GB2008/000454 WO2008099145A1 (en) 2007-02-12 2008-02-11 Pyrazole derivatives as 11-beta-hsd1 inhibitors
US8229308P 2008-07-21 2008-07-21

Publications (1)

Publication Number Publication Date
PE20091456A1 true PE20091456A1 (es) 2009-10-24

Family

ID=42782026

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000164A PE20091456A1 (es) 2008-02-04 2009-02-04 Nuevas formas cristalinas de acido 4-[4-(2-adamantilcarbamoil)-5-tert-butil-pirazol-1-il]benzoico- 471

Country Status (15)

Country Link
US (3) US7951833B2 (es)
EP (1) EP2244705A1 (es)
JP (1) JP2011510966A (es)
KR (1) KR20100126306A (es)
CN (1) CN101969946A (es)
AR (1) AR070560A1 (es)
AU (1) AU2009211215B2 (es)
CA (1) CA2713409A1 (es)
MX (1) MX2010008583A (es)
PE (1) PE20091456A1 (es)
RU (1) RU2010133483A (es)
SA (1) SA109300090B1 (es)
TW (1) TW200946506A (es)
UY (1) UY31627A1 (es)
WO (1) WO2009098501A1 (es)

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TWI399367B (zh) 2005-11-21 2013-06-21 Shionogi & Co 具有Ｉ型１１β羥基類固醇脫氫酶抑制活性之雜環化合物
TW200827346A (en) * 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
TW200836719A (en) * 2007-02-12 2008-09-16 Astrazeneca Ab Chemical compounds
MX2009012283A (es) 2007-05-18 2009-11-25 Shionogi & Co Derivado heterociclico que contiene nitrogeno que tiene actividad inhibitoria de 11beta-hidroxiesteroide-deshidrogenasa tipo 1.
EP2244705A1 (en) * 2008-02-04 2010-11-03 AstraZeneca AB Novel crystalline forms of 4- [4- (2-adamantylcarbam0yl) -5-tert-butyl-pyrazol-1-yl]benzoic acid
EP2271629A1 (en) * 2008-04-22 2011-01-12 AstraZeneca AB Substituted pyrimidin-5-carboxamides 281
JP2012516327A (ja) * 2009-01-30 2012-07-19 アストラゼネカ アクチボラグ カルボキシ含有ピラゾールアミド化合物を製造するための新規な方法
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
KR102509478B1 (ko) * 2016-10-28 2023-03-10 아스트라제네카 아베 (1r,2r)-2-[4-(3-메틸-1h-피라졸-5-일)벤조일]-n-(4-옥소-4,5,6,7-테트라하이드로피라졸로[1,5-a]피라진-3-일)사이클로헥산카복스아미드의 결정형

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GR66581B (es) * 1978-02-21 1981-03-27 Delalande Sa
US7273868B2 (en) * 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
JP4629657B2 (ja) * 2003-04-11 2011-02-09 ハイ・ポイント・ファーマスーティカルズ、エルエルシー １１β−ヒドロキシステロイドデヒドロゲナーゼ１型化活性化合物
JP2007501789A (ja) 2003-08-07 2007-02-01 メルク　エンド　カムパニー　インコーポレーテッド １１−β−ヒドロキシステロイドデヒドロゲナーゼ−１の阻害剤としてのピラゾールカルボキサミド
EP1745019A1 (en) 2004-05-06 2007-01-24 Pfizer Inc. Novel compounds of proline and morpholine derivatives
CA2585735A1 (en) 2004-11-02 2006-05-11 Pfizer Inc. Novel compounds of substituted and unsubstituted adamantyl amides
ATE519744T1 (de) 2005-04-05 2011-08-15 Hoffmann La Roche 1h-pyrazol-4-carbonsäure-amide, deren herstellung und verwendung als 11-beta-hydroxysteroid- dehydrogenase-hemmer
CN101155781B (zh) 2005-04-06 2012-11-07 霍夫曼-拉罗奇有限公司 作为cb1逆激动剂的吡啶-3-甲酰胺衍生物
WO2006113261A2 (en) 2005-04-14 2006-10-26 Bristol-Myers Squibb Company Inhibitors of 11-beta hydroxysteroid dehydrogenase type i
JP5147109B2 (ja) 2005-06-07 2013-02-20 塩野義製薬株式会社 Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有するヘテロ環化合物
EP1889842A4 (en) 2005-06-08 2009-07-29 Japan Tobacco Inc HETEROCYCLIC CONNECTION
WO2007052843A1 (ja) 2005-11-04 2007-05-10 Takeda Pharmaceutical Company Limited 複素環アミド化合物およびその用途
TWI399367B (zh) 2005-11-21 2013-06-21 Shionogi & Co 具有Ｉ型１１β羥基類固醇脫氫酶抑制活性之雜環化合物
KR20110007258A (ko) * 2006-03-22 2011-01-21 에프. 호프만-라 로슈 아게 11-베타-ｈｓｄ-1로서의 피라졸
WO2008012532A2 (en) 2006-07-27 2008-01-31 Astrazeneca Ab : pyridine-3-carboxamide compounds and their use for inhibiting 11-beta-hydroxysteroid dehydrogenase
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
TW200836719A (en) * 2007-02-12 2008-09-16 Astrazeneca Ab Chemical compounds
MX2009012283A (es) 2007-05-18 2009-11-25 Shionogi & Co Derivado heterociclico que contiene nitrogeno que tiene actividad inhibitoria de 11beta-hidroxiesteroide-deshidrogenasa tipo 1.
RU2440989C2 (ru) 2007-07-17 2012-01-27 Ф.Хоффманн-Ля Рош Аг ИНГИБИТОРЫ 11β-ГИДРОКСИСТЕРОИДНОЙ ДЕГИДРОГЕНАЗЫ
CN101909621A (zh) * 2007-11-06 2010-12-08 阿斯利康(瑞典)有限公司 4-[4-(2-金刚烷基氨基甲酰基)-5-叔丁基-吡唑-1-基]苯甲酸-465
EP2244705A1 (en) * 2008-02-04 2010-11-03 AstraZeneca AB Novel crystalline forms of 4- [4- (2-adamantylcarbam0yl) -5-tert-butyl-pyrazol-1-yl]benzoic acid
EP2271629A1 (en) 2008-04-22 2011-01-12 AstraZeneca AB Substituted pyrimidin-5-carboxamides 281
US20110092526A1 (en) * 2009-10-20 2011-04-21 Astrazeneca Ab Adamantyl Iminocarbonyl-Substituted Pyrimidines As Inhibitors Of 11-Beta-HSD1 826

Also Published As

Publication number Publication date
SA109300090B1 (ar) 2011-10-03
MX2010008583A (es) 2010-08-30
UY31627A1 (es) 2009-08-31
WO2009098501A1 (en) 2009-08-13
KR20100126306A (ko) 2010-12-01
AU2009211215A1 (en) 2009-08-13
AR070560A1 (es) 2010-04-21
JP2011510966A (ja) 2011-04-07
TW200946506A (en) 2009-11-16
US20110028530A1 (en) 2011-02-03
CN101969946A (zh) 2011-02-09
US20110028529A1 (en) 2011-02-03
US20090221660A1 (en) 2009-09-03
US7951833B2 (en) 2011-05-31
CA2713409A1 (en) 2009-08-13
AU2009211215B2 (en) 2011-11-03
EP2244705A1 (en) 2010-11-03
RU2010133483A (ru) 2012-03-20

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