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PE20060316A1 - Derivados de prolina como inhibidores de dipeptidil peptidasa-iv - Google Patents

Derivados de prolina como inhibidores de dipeptidil peptidasa-iv

Info

Publication number
PE20060316A1
PE20060316A1 PE2005000515A PE2005000515A PE20060316A1 PE 20060316 A1 PE20060316 A1 PE 20060316A1 PE 2005000515 A PE2005000515 A PE 2005000515A PE 2005000515 A PE2005000515 A PE 2005000515A PE 20060316 A1 PE20060316 A1 PE 20060316A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
diabetic
inhibitors
difluoropyrrolidin
Prior art date
Application number
PE2005000515A
Other languages
English (en)
Inventor
Bernard Hulin
David Walter Piotrowski
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966115&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060316(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20060316A1 publication Critical patent/PE20060316A1/es

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE R1 ES ALQUILO(C1-C6), ARILO, HETEROARILO, OPCIONALMENTE SUSTITUIDO CON 1 A 3 CIANO, HALOGENO, NITRO, CF3, ALQUILO(C1-C6), ALCOXI(C1-C6), CICLOALQUILO(C3-C6) O FENILO; R2 Y R3 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C6), ENTRE OTROS, Q ES UN ENLACE COVALENTE, -C(O)-, O -S(O)2-; HET ES HETEROCICLOALQUILO TAL COMO AZETIDINILO, PIPERAZINILO, PIPERIDINILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (3,3-DIFLUOROPIRROLIDIN-1-IL)-((2S,4S)-4-(4-(PIRIMIDIN-2-IL)PIPERAZIN-1-IL)PIRROLIDIN-2-IL)METANONA, ((2S,4S)-4-(3-(TRIFLUOROMETIL)-5,6-DIHIDRO-[1,2,4]TRIAZOLO[4,3-a]PIRAZIN-7(8H)-IL)PIRROLIDIN-2-IL)-(3,3-DIFLUOROPIRROLIDIN-1-IL)METANONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES SELECTIVOS DE LA ENZIMA DIPEPTIDIL PEPTIDASA-IV (DPP-IV), POR LO QUE SON UTILES PARA TRATAR COMPLICACIONES DIABETICAS, NEFROPATIA DIABETICA, MICROANGIOPATIA DIABETICA Y SIMILARES
PE2005000515A 2004-05-12 2005-05-09 Derivados de prolina como inhibidores de dipeptidil peptidasa-iv PE20060316A1 (es)

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US57030004P 2004-05-12 2004-05-12
US66430505P 2005-03-21 2005-03-21

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PE20060316A1 true PE20060316A1 (es) 2006-05-08

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SI1757606T1 (sl) * 2001-02-24 2009-10-31 Boehringer Ingelheim Pharma Ksantinski derivati za uporabo kot zdravila kot tudi postopek za njihovo pripravo
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
GEP20084421B (en) 2004-05-12 2008-07-10 Pfizer Prod Inc Proline derivatives and their use as dipeptidyl peptidase iv inhibitors
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US7291618B2 (en) 2007-11-06
US20050256310A1 (en) 2005-11-17
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