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PE20060419A1 - Derivados de pirrol como antagonistas de receptores cb1 - Google Patents

Derivados de pirrol como antagonistas de receptores cb1

Info

Publication number
PE20060419A1
PE20060419A1 PE2005000908A PE2005000908A PE20060419A1 PE 20060419 A1 PE20060419 A1 PE 20060419A1 PE 2005000908 A PE2005000908 A PE 2005000908A PE 2005000908 A PE2005000908 A PE 2005000908A PE 20060419 A1 PE20060419 A1 PE 20060419A1
Authority
PE
Peru
Prior art keywords
alkyl
pyrrol
methyl
antagonists
receptors
Prior art date
Application number
PE2005000908A
Other languages
English (en)
Inventor
Francis Barth
Christian Congy
Murielle Rinaldi-Carmona
Laurent Hortala
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20060419A1 publication Critical patent/PE20060419A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, ALQUILO C1-C4; R2 ES ALQUILO C3-C10 SUSTITUIDO O NO POR TRIFLUOROMETILO, INDANILO, RADICAL CARBOCICLICO NO AROMATICO C3-C12 SUSTITUIDO O NO POR ALQUILO C1-C4, HIDROXILO, CIANO, ENTRE OTROS; R3, R4, R5, R6, R7 Y R8 SON CADA UNO H, HALOGENO, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; R9 ES ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS: 4-(2,4-DICLOROFENIL)-5-(4-METOXIFENIL)-1-METIL-N-PIPERIDIN-1-IL-1H-PIRROL-2-CARBOXAMIDA; 1-(1-((5-(4-CLROFENIL)-4-(2,4-DICOLOROFENIL)-1-METIL-1H-PIRROL-2-IL)CARBOXIL)-4-FENILPIPERIDIN-4-IL)ETANONA; N-(1-BENCIL-2-METOXIETIL)-4-(2-CLOROFENIL)-5-(4-CLOROFENIL)-1-METIL-1H-PIRROL-2-CARBOXAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES CANNABINOIDES CB1, UTILES EN EL TRATAMIENTO DE ALTERACIONES PSIQUIATRICAS, MIGRANA, ESTRES, EPILEPSIA, DEMENCIA SENIL, TRSTORNOS DEL APETITO, ENTRE OTROS
PE2005000908A 2004-08-09 2005-08-05 Derivados de pirrol como antagonistas de receptores cb1 PE20060419A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0408773A FR2874012B1 (fr) 2004-08-09 2004-08-09 Derives de pyrrole, leur preparation et leur utlisation en therapeutique

Publications (1)

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PE20060419A1 true PE20060419A1 (es) 2006-06-20

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PE2005000908A PE20060419A1 (es) 2004-08-09 2005-08-05 Derivados de pirrol como antagonistas de receptores cb1

Country Status (20)

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US (2) US7381727B2 (es)
EP (1) EP1781636A1 (es)
JP (1) JP2008509202A (es)
KR (1) KR20070054649A (es)
CN (1) CN101014588A (es)
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BRPI0514235A (pt) 2008-06-03
AU2005279086A1 (en) 2006-03-09
MX2007001383A (es) 2007-04-19
US7381727B2 (en) 2008-06-03
FR2874012A1 (fr) 2006-02-10
AR050447A1 (es) 2006-10-25
CA2576717A1 (fr) 2006-03-09
ZA200700950B (en) 2008-06-25
JP2008509202A (ja) 2008-03-27
US7879902B2 (en) 2011-02-01
IL180867A0 (en) 2007-07-04
WO2006024777A1 (fr) 2006-03-09
EP1781636A1 (fr) 2007-05-09
TW200616948A (en) 2006-06-01
US20070149596A1 (en) 2007-06-28
KR20070054649A (ko) 2007-05-29
FR2874012B1 (fr) 2008-08-22
US20080194581A1 (en) 2008-08-14
NO20071209L (no) 2007-03-05
UY29054A1 (es) 2006-03-31
MA28847B1 (fr) 2007-09-03
EA200700179A1 (ru) 2007-08-31
CN101014588A (zh) 2007-08-08

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