PE20040667A1 - Derivados de cinamida - Google Patents
Derivados de cinamidaInfo
- Publication number
- PE20040667A1 PE20040667A1 PE2003000706A PE2003000706A PE20040667A1 PE 20040667 A1 PE20040667 A1 PE 20040667A1 PE 2003000706 A PE2003000706 A PE 2003000706A PE 2003000706 A PE2003000706 A PE 2003000706A PE 20040667 A1 PE20040667 A1 PE 20040667A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- methyl
- benzyloxy
- acrylamide
- phenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- OOIGWKWLXFQPAY-UHFFFAOYSA-N 3-[4-[(4-fluorophenyl)methoxy]phenyl]-n-methylprop-2-enamide Chemical compound C1=CC(C=CC(=O)NC)=CC=C1OCC1=CC=C(F)C=C1 OOIGWKWLXFQPAY-UHFFFAOYSA-N 0.000 abstract 1
- 102000010909 Monoamine Oxidase Human genes 0.000 abstract 1
- 108010062431 Monoamine oxidase Proteins 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- FNAFUMTVFAVBMB-UHFFFAOYSA-N n-methyl-3-[4-[(4-methylphenyl)methoxy]phenyl]prop-2-enamide Chemical compound C1=CC(C=CC(=O)NC)=CC=C1OCC1=CC=C(C)C=C1 FNAFUMTVFAVBMB-UHFFFAOYSA-N 0.000 abstract 1
- MKCXURIGNDNTQM-UHFFFAOYSA-N n-methyl-3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]prop-2-enamide Chemical compound C1=CC(C=CC(=O)NC)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1 MKCXURIGNDNTQM-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 ES ALQUILO C1-C3, HALOGENO, CIANO, ENTRE OTROS; R3 ES H O ALQUILO C1-C3; R21, R22, R23 Y R24 SON CADA UNO H, F; A ES GRUPO DIVALENTE DE FORMULA (a), (b), (c); R4 ES H, ALQUILO C1-C3; R5, R6, R7 SON CADA UNO H, ALQUILO C1-C6; n ES 1-3. SON COMPUESTOS PREFERIDOS: N-METIL-3-[4-(4-METIL-BENCILOXI)-FENIL]-ACRILAMIDA; N-METIL-3-[4-(4-TRIFLUOROMETIL-BENCILOXI)-FENIL]-ACRILAMIDA Y 3-[4-(4-FLUORO-BENCILOXI)-FENIL]-N-METIL-ACRILAMIDA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE MAO-B UTILES EN EL TRATAMIENTO Y PREVENCION DE LA ENFERMEDAD DE ALZHEIMER O DEMENCIA SENIL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02015583 | 2002-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040667A1 true PE20040667A1 (es) | 2004-09-25 |
Family
ID=30011071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000706A PE20040667A1 (es) | 2002-07-15 | 2003-07-15 | Derivados de cinamida |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6900354B2 (es) |
| EP (1) | EP1523469B1 (es) |
| JP (1) | JP4108679B2 (es) |
| KR (1) | KR20050029206A (es) |
| CN (1) | CN1305838C (es) |
| AR (1) | AR040489A1 (es) |
| AT (1) | ATE410407T1 (es) |
| AU (1) | AU2003281030B2 (es) |
| BR (1) | BR0312658A (es) |
| CA (1) | CA2493372A1 (es) |
| DE (1) | DE60323981D1 (es) |
| ES (1) | ES2314219T3 (es) |
| MX (1) | MXPA05000583A (es) |
| PA (1) | PA8577201A1 (es) |
| PE (1) | PE20040667A1 (es) |
| PL (1) | PL373390A1 (es) |
| RU (1) | RU2318802C2 (es) |
| TW (1) | TW200404760A (es) |
| UY (1) | UY27894A1 (es) |
| WO (1) | WO2004007429A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1588704A1 (en) * | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
| US7667041B2 (en) * | 2004-05-26 | 2010-02-23 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
| ATE458729T1 (de) * | 2004-10-26 | 2010-03-15 | Eisai R&D Man Co Ltd | Amorphe form einer zimtsäureamidverbindung |
| JP2008531509A (ja) | 2005-02-25 | 2008-08-14 | エフ．ホフマン−ラ ロシュ アーゲー | 医薬品成分の改良された分散性を有する錠剤 |
| US8022249B2 (en) | 2005-04-01 | 2011-09-20 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| WO2007008963A1 (en) * | 2005-07-13 | 2007-01-18 | Jenrin Discovery | Mao-b inhibitors useful for treating obesity |
| PL209602B1 (pl) | 2005-10-20 | 2011-09-30 | Inst Chemii Bioorg Pan | Sposób otrzymywania amidu kwasu 3-(4-hydroksyfenylo)propanowego |
| US20090270623A1 (en) * | 2005-11-18 | 2009-10-29 | Naoyuki Shimomura | Process for production of cinnamide derivative |
| US20090048448A1 (en) * | 2005-11-18 | 2009-02-19 | Ikuo Kushida | Salts of cynnamide compound or solvates thereof |
| KR20080069221A (ko) * | 2005-11-24 | 2008-07-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 모르폴린 타입의 신나미드 화합물 |
| TWI370130B (en) * | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| CN101312965B (zh) * | 2005-11-24 | 2011-07-20 | 卫材R&D管理有限公司 | 吗啉型肉桂酰胺化合物 |
| TWI378091B (en) * | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| US7737141B2 (en) * | 2006-07-28 | 2010-06-15 | Eisai R&D Management Co., Ltd. | Prodrug of cinnamide compound |
| US20080207900A1 (en) * | 2007-02-28 | 2008-08-28 | Teiji Kimura | Two cyclic oxomorphorin derivatives |
| CA2687262A1 (en) * | 2007-05-16 | 2008-11-20 | Naoyuki Shimomura | One-pot production process for cinnamide derivative |
| US7986144B2 (en) * | 2007-07-26 | 2011-07-26 | Schlumberger Technology Corporation | Sensor and insulation layer structure for well logging instruments |
| TW200916469A (en) | 2007-08-31 | 2009-04-16 | Eisai R & Amp D Man Co Ltd | Multi-cyclic compounds |
| US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| AU2009210070A1 (en) * | 2008-01-28 | 2009-08-06 | Eisai R & D Management Co., Ltd. | Crystalline cinnamide compounds or salts thereof |
| NL2005655A (en) | 2009-12-09 | 2011-06-14 | Asml Netherlands Bv | A lithographic apparatus and a device manufacturing method. |
| CN104030941B (zh) * | 2014-06-23 | 2016-04-27 | 常州大学 | 一种3-（4-羟基苯基）丙酰胺的合成方法 |
| CN107011313B (zh) | 2016-01-27 | 2021-11-30 | 天士力医药集团股份有限公司 | 取代桂皮酰胺衍生物在制备抗焦虑药物中的应用 |
| RU2020122331A (ru) | 2018-01-10 | 2022-02-10 | Брайтсид, Инк. | Способ модуляции метаболизма |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2645019A1 (es) * | 1989-03-30 | 1990-10-05 | Fournier Innovation Synergie | |
| US5679715A (en) | 1995-06-07 | 1997-10-21 | Harris; Richard Y. | Method for treating multiple sclerosis |
| CN1116870C (zh) | 1996-03-15 | 2003-08-06 | 萨默塞特药品有限公司 | 司立吉林在制备用于预防或治疗外周神经病的药物中的应用 |
| WO2001034172A2 (en) | 1999-11-05 | 2001-05-17 | Vela Pharmaceuticals Inc. | Methods and compositions for treating reward deficiency syndrome |
-
2003
- 2003-07-03 US US10/613,785 patent/US6900354B2/en not_active Expired - Fee Related
- 2003-07-07 EP EP03740425A patent/EP1523469B1/en not_active Expired - Lifetime
- 2003-07-07 CA CA002493372A patent/CA2493372A1/en not_active Abandoned
- 2003-07-07 WO PCT/EP2003/007231 patent/WO2004007429A1/en not_active Ceased
- 2003-07-07 MX MXPA05000583A patent/MXPA05000583A/es active IP Right Grant
- 2003-07-07 KR KR1020057000637A patent/KR20050029206A/ko not_active Ceased
- 2003-07-07 JP JP2004520497A patent/JP4108679B2/ja not_active Expired - Fee Related
- 2003-07-07 PL PL03373390A patent/PL373390A1/xx unknown
- 2003-07-07 CN CNB038160579A patent/CN1305838C/zh not_active Expired - Fee Related
- 2003-07-07 ES ES03740425T patent/ES2314219T3/es not_active Expired - Lifetime
- 2003-07-07 AT AT03740425T patent/ATE410407T1/de not_active IP Right Cessation
- 2003-07-07 DE DE60323981T patent/DE60323981D1/de not_active Expired - Fee Related
- 2003-07-07 RU RU2005104104/04A patent/RU2318802C2/ru not_active IP Right Cessation
- 2003-07-07 AU AU2003281030A patent/AU2003281030B2/en not_active Ceased
- 2003-07-07 BR BR0312658-7A patent/BR0312658A/pt not_active IP Right Cessation
- 2003-07-10 PA PA20038577201A patent/PA8577201A1/es unknown
- 2003-07-11 AR AR20030102502A patent/AR040489A1/es not_active Application Discontinuation
- 2003-07-14 UY UY27894A patent/UY27894A1/es not_active Application Discontinuation
- 2003-07-15 TW TW092119275A patent/TW200404760A/zh unknown
- 2003-07-15 PE PE2003000706A patent/PE20040667A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1523469A1 (en) | 2005-04-20 |
| ES2314219T3 (es) | 2009-03-16 |
| BR0312658A (pt) | 2005-04-26 |
| AU2003281030B2 (en) | 2009-05-28 |
| RU2318802C2 (ru) | 2008-03-10 |
| WO2004007429A1 (en) | 2004-01-22 |
| KR20050029206A (ko) | 2005-03-24 |
| CA2493372A1 (en) | 2004-01-22 |
| ATE410407T1 (de) | 2008-10-15 |
| US6900354B2 (en) | 2005-05-31 |
| PL373390A1 (en) | 2005-08-22 |
| AR040489A1 (es) | 2005-04-06 |
| JP4108679B2 (ja) | 2008-06-25 |
| CN1665774A (zh) | 2005-09-07 |
| JP2005533092A (ja) | 2005-11-04 |
| DE60323981D1 (de) | 2008-11-20 |
| UY27894A1 (es) | 2003-12-31 |
| AU2003281030A1 (en) | 2004-02-02 |
| PA8577201A1 (es) | 2004-02-07 |
| RU2005104104A (ru) | 2005-10-10 |
| MXPA05000583A (es) | 2005-04-19 |
| CN1305838C (zh) | 2007-03-21 |
| US20040034096A1 (en) | 2004-02-19 |
| TW200404760A (en) | 2004-04-01 |
| EP1523469B1 (en) | 2008-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |