PE20070359A1 - Inhibidores de pirimidinilpirazol de aurora quinasas - Google Patents
Inhibidores de pirimidinilpirazol de aurora quinasasInfo
- Publication number
- PE20070359A1 PE20070359A1 PE2006001028A PE2006001028A PE20070359A1 PE 20070359 A1 PE20070359 A1 PE 20070359A1 PE 2006001028 A PE2006001028 A PE 2006001028A PE 2006001028 A PE2006001028 A PE 2006001028A PE 20070359 A1 PE20070359 A1 PE 20070359A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- ethyl
- morpholin
- pyrimidinyl
- Prior art date
Links
- 102000003989 Aurora kinases Human genes 0.000 title abstract 2
- 108090000433 Aurora kinases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 3
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- AIMMVWOEOZMVMS-UHFFFAOYSA-N cyclopropanecarboxamide Chemical compound NC(=O)C1CC1 AIMMVWOEOZMVMS-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES FENILO, HETEROARILO, ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS; R2 Y R3 SON CADA UNO H, HALOGENO, ALQUILO C1-C3, O-(ALQUILO C1-C3); R4 ES UN SUSTITUYENTE DE UNO DE LOS ATOMOS DE NITROGENO SIENDO H, ALQUILO C1-C6, CICLOALQUILO C3-C6, -C(O)(ALQUILO C1-C6), ENTRE OTROS; R5, R5' Y R6 SON CADA UNO H, HALOGENO, ALQUILO C1-C6, -O-(ALQUILO C1-C6), HIDROXILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(4-{4-[2-({3-[2-(4-MORFOLIN)ETIL]FENIL}AMINO)-4-PIRIMIDINIL]-1H-PIRAZOL-5-IL}FENIL)BENZAMIDA; N-(4-{1-METIL-4-[2-({3-[2-(4-MORFOLIN)ETIL]FENIL}AMINO)-4-PIRIMIDINIL]-1H-PIRAZOL-5-IL}FENIL)CICLOPROPANCARBOXAMIDA; N-PROPIL-N'-(4-{1-ETIL-4-[2-({3-[2-(4-MORFOLIN)ETIL]FENIL}AMINO)-4-PIRIMIDINIL]-1H-PIRAZOL-5-IL}FENIL)UREA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE AURORA QUINASA UTILES EN EL TRATAMIENTO DE ENFERMEDADES DE PROLIFERACION CELULAR
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71197905P | 2005-08-26 | 2005-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070359A1 true PE20070359A1 (es) | 2007-04-05 |
Family
ID=37772278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001028A PE20070359A1 (es) | 2005-08-26 | 2006-08-24 | Inhibidores de pirimidinilpirazol de aurora quinasas |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080242667A1 (es) |
| EP (1) | EP1917258A2 (es) |
| JP (1) | JP2009506040A (es) |
| AR (1) | AR058029A1 (es) |
| PE (1) | PE20070359A1 (es) |
| TW (1) | TW200800211A (es) |
| WO (1) | WO2007024843A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100144756A1 (en) * | 2007-07-13 | 2010-06-10 | Bolea Christelle | Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors |
| CN101883764B (zh) | 2007-12-07 | 2013-11-13 | 诺华股份有限公司 | 吡唑衍生物及其作为细胞周期蛋白依赖性激酶抑制剂的用途 |
| MX2010008926A (es) | 2008-02-15 | 2011-02-23 | Rigel Pharmaceuticals Inc | Compuestos de pirimidin-2-amina y su uso como inhibidores de jak cinasas. |
| PT2324008E (pt) | 2008-07-24 | 2012-06-25 | Nerviano Medical Sciences Srl | 3,4-diarilpirazoles como inibidores da proteína quinase |
| CN102459265A (zh) * | 2009-05-27 | 2012-05-16 | 雅培制药有限公司 | 激酶活性的嘧啶抑制剂 |
| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| CN102762551A (zh) | 2009-12-21 | 2012-10-31 | 拜尔农作物科学股份公司 | 噻吩基吡(嘧)啶基吡唑及其用于防治植物致病菌的用途 |
| JP5806239B2 (ja) * | 2010-01-27 | 2015-11-10 | ネルヴィアーノ・メディカル・サイエンシズ・ソチエタ・ア・レスポンサビリタ・リミタータ | プロテインキナーゼ阻害剤としての３，４−ジアリールピラゾールのスルホンアミド誘導体 |
| US9114137B2 (en) | 2010-08-03 | 2015-08-25 | Nerviano Medical Sciences S.R.L. | Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents |
| AR086992A1 (es) | 2011-06-20 | 2014-02-05 | Bayer Ip Gmbh | Tienilpiri(mi)dinilpirazoles |
| PL2763993T3 (pl) | 2011-10-06 | 2017-09-29 | Bayer Intellectual Property Gmbh | Heterocyklilopiry(mi)dynylopirazol |
| JP6042896B2 (ja) | 2011-10-06 | 2016-12-14 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 殺菌剤としての複素環ピリ（ミ）ジニルピラゾール |
| CA2855243C (en) | 2011-11-11 | 2020-04-14 | Novartis Ag | Method of treating a proliferative disease |
| PT2782557T (pt) | 2011-11-23 | 2018-11-26 | Array Biopharma Inc | Formulações farmacêuticas |
| TWI485146B (zh) * | 2012-02-29 | 2015-05-21 | Taiho Pharmaceutical Co Ltd | Novel piperidine compounds or salts thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0129476D0 (en) * | 2001-12-10 | 2002-01-30 | Syngenta Participations Ag | Organic compounds |
-
2006
- 2006-08-23 EP EP06802071A patent/EP1917258A2/en not_active Withdrawn
- 2006-08-23 JP JP2008528062A patent/JP2009506040A/ja not_active Withdrawn
- 2006-08-23 US US12/064,820 patent/US20080242667A1/en not_active Abandoned
- 2006-08-23 WO PCT/US2006/032746 patent/WO2007024843A2/en not_active Ceased
- 2006-08-24 TW TW095131061A patent/TW200800211A/zh unknown
- 2006-08-24 PE PE2006001028A patent/PE20070359A1/es not_active Application Discontinuation
- 2006-08-25 AR ARP060103710A patent/AR058029A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009506040A (ja) | 2009-02-12 |
| WO2007024843A3 (en) | 2007-08-09 |
| WO2007024843A2 (en) | 2007-03-01 |
| EP1917258A2 (en) | 2008-05-07 |
| TW200800211A (en) | 2008-01-01 |
| US20080242667A1 (en) | 2008-10-02 |
| AR058029A1 (es) | 2008-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |