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PE20011008A1 - Derivados de pirimidina como inhibidores de ciclooxigenasa 2 - Google Patents

Derivados de pirimidina como inhibidores de ciclooxigenasa 2

Info

Publication number
PE20011008A1
PE20011008A1 PE2000001249A PE0012492000A PE20011008A1 PE 20011008 A1 PE20011008 A1 PE 20011008A1 PE 2000001249 A PE2000001249 A PE 2000001249A PE 0012492000 A PE0012492000 A PE 0012492000A PE 20011008 A1 PE20011008 A1 PE 20011008A1
Authority
PE
Peru
Prior art keywords
trifluoromethyl
pyrimidin
amine
phenyl
cyclooxygenase
Prior art date
Application number
PE2000001249A
Other languages
English (en)
Inventor
Charles David Hartley
Green Richard Howard
Neil Anthony Pegg
Jeremy John Payne
Alan Naylor
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20011008A1 publication Critical patent/PE20011008A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P11/16—Central respiratory analeptics
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    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
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    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Abstract

SE REFIERE A DERIVADOS DE TRIFLUOROMETIL PIRIMIDINA DONDE R1 Y R2 SON H, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C3-C6, CICLOALQUILO C3-C10-ALQUILO C0-C6; R3 ES ALQUILO C1-C6, NH2. SON COMPUESTOS PREFERIDOS N-CICLOPENTIL-4-[4-(METILSULFONIL)FENIL]-6-(TRIFLUOROMETIL)PIRIMIDIN-2-AMINA; N-CICLOHEXIL-4-[4-(METILSULFONIL)FENIL]-6-(TRIFLUOROMETIL)PIRIMIDIN-2-AMINA; N-ISOBUTIL-4-[4-(METILSULFONIL)FENIL]-6-(TRIFLUOROMETIL)PIRIMIDIN-2-AMINA; N-(CICLOBUTILMETIL)-4-[4-(METILSULFONIL)FENIL]-6-(TRIFLUOROMETIL)PIRIMIDIN-2-AMINA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN INHIBIDOR DE CICLOOXIGENASA 2 Y PUEDE SER UTIL PARA EL TRATAMIENTO DE UNA ALTERACION INFLAMATORIA
PE2000001249A 1999-11-26 2000-11-23 Derivados de pirimidina como inhibidores de ciclooxigenasa 2 PE20011008A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9927844.2A GB9927844D0 (en) 1999-11-26 1999-11-26 Chemical compounds

Publications (1)

Publication Number Publication Date
PE20011008A1 true PE20011008A1 (es) 2001-10-15

Family

ID=10865107

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001249A PE20011008A1 (es) 1999-11-26 2000-11-23 Derivados de pirimidina como inhibidores de ciclooxigenasa 2

Country Status (21)

Country Link
US (1) US6780869B1 (es)
EP (1) EP1235812B1 (es)
JP (1) JP2003514898A (es)
KR (1) KR20020063899A (es)
CN (1) CN1399633A (es)
AT (1) ATE316962T1 (es)
AU (1) AU2508401A (es)
BR (1) BR0015821A (es)
CA (1) CA2395049A1 (es)
CO (1) CO5271666A1 (es)
CZ (1) CZ20021802A3 (es)
DE (1) DE60025848T2 (es)
ES (1) ES2256086T3 (es)
GB (1) GB9927844D0 (es)
HU (1) HUP0203385A3 (es)
IL (1) IL149586A0 (es)
MX (1) MXPA02005231A (es)
NO (1) NO20022470L (es)
PE (1) PE20011008A1 (es)
PL (1) PL356237A1 (es)
WO (1) WO2001038311A2 (es)

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GB9927844D0 (en) 1999-11-26 2000-01-26 Glaxo Group Ltd Chemical compounds
GB0003224D0 (en) 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds
GB0021494D0 (en) 2000-09-01 2000-10-18 Glaxo Group Ltd Chemical comkpounds
GB0112810D0 (en) * 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112802D0 (en) * 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112803D0 (en) * 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0119477D0 (en) * 2001-08-09 2001-10-03 Glaxo Group Ltd Pyrimidine derivatives
EP1437338B1 (en) * 2001-10-10 2009-09-16 Hitachi High-Technologies Corporation Luminous compounds and labeling reagents using the same
AU2003246864A1 (en) * 2002-02-22 2003-09-09 Warner-Lambert Company Llc Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2
DE60305053T2 (de) * 2002-08-19 2006-08-31 Glaxo Group Ltd., Greenford Pyrimidinderivate als selektive cox-2-inhibitoren
UY27939A1 (es) * 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
GB0221443D0 (en) * 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
GB0227443D0 (en) * 2002-11-25 2002-12-31 Glaxo Group Ltd Pyrimidine derivatives
WO2005000227A2 (en) * 2003-06-06 2005-01-06 Intermune, Inc. Methods of treating tnf-mediated disorders
GB0319037D0 (en) * 2003-08-13 2003-09-17 Glaxo Group Ltd 7-Azaindole Derivatives
GB0813142D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
CN102438993A (zh) * 2009-05-19 2012-05-02 陶氏益农公司 用于控制真菌的化合物和方法
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) * 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
ES2529233T3 (es) 2010-07-09 2015-02-18 Convergence Pharmaceuticals Limited Compuestos tetrazol como bloqueadores de canales de calcio
AU2016222804C1 (en) 2015-02-25 2021-10-14 The Regents Of The University Of California 5HT agonists for treating disorders

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US6020343A (en) 1995-10-13 2000-02-01 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
CN1152863C (zh) 1996-07-18 2004-06-09 麦克弗罗斯特(加拿大)公司 作为环氧合酶-2选择性抑制剂的取代的吡啶类化合物及其组合物
TW520362B (en) 1996-12-05 2003-02-11 Amgen Inc Substituted pyrimidine compounds and pharmaceutical composition comprising same
GB9927844D0 (en) 1999-11-26 2000-01-26 Glaxo Group Ltd Chemical compounds
GB0003224D0 (en) 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
PL356237A1 (en) 2004-06-28
WO2001038311A3 (en) 2001-11-01
IL149586A0 (en) 2002-11-10
NO20022470D0 (no) 2002-05-24
WO2001038311A2 (en) 2001-05-31
GB9927844D0 (en) 2000-01-26
DE60025848D1 (en) 2006-04-13
CO5271666A1 (es) 2003-04-30
EP1235812B1 (en) 2006-02-01
BR0015821A (pt) 2002-07-30
HUP0203385A2 (en) 2003-05-28
CA2395049A1 (en) 2001-05-31
HUP0203385A3 (en) 2003-07-28
EP1235812A2 (en) 2002-09-04
JP2003514898A (ja) 2003-04-22
KR20020063899A (ko) 2002-08-05
CZ20021802A3 (cs) 2002-10-16
ATE316962T1 (de) 2006-02-15
MXPA02005231A (es) 2002-11-07
AU2508401A (en) 2001-06-04
NO20022470L (no) 2002-07-18
ES2256086T3 (es) 2006-07-16
DE60025848T2 (de) 2006-08-03
CN1399633A (zh) 2003-02-26
US6780869B1 (en) 2004-08-24

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