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PE20030188A1 - Compuesto de anillo fundido como inhibidores de polimerasa del virus de la hepatitis c - Google Patents

Compuesto de anillo fundido como inhibidores de polimerasa del virus de la hepatitis c

Info

Publication number
PE20030188A1
PE20030188A1 PE2002000573A PE2002000573A PE20030188A1 PE 20030188 A1 PE20030188 A1 PE 20030188A1 PE 2002000573 A PE2002000573 A PE 2002000573A PE 2002000573 A PE2002000573 A PE 2002000573A PE 20030188 A1 PE20030188 A1 PE 20030188A1
Authority
PE
Peru
Prior art keywords
hepatitis
cycloalkyl
ring
virus polymerase
ring compound
Prior art date
Application number
PE2002000573A
Other languages
English (en)
Inventor
Hiromasa Hashimoto
Kenji Mizutani
Atsuhito Yoshida
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of PE20030188A1 publication Critical patent/PE20030188A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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Abstract

SE REFIERE A COMPUESTOS FUSIONADOS DE FORMULA I DONDE G1 ES CR1, N; G2 ES CR2, N; G3 ES CR3, N; G4 ES CR4, N; G5, G6, G8, G9 SON C, N; G7 ES CR7, O, S, N OPCIONALMENTE SUSTITUIDO CON R8; R1, R2, R3, R4 SON N, ALCANOIL C1-C6, CARBOXIL, CIANO, NITRO, ALQUILO C1-C6, ENTRE OTROS; ANILLO CY ES CICLOALQUILO C3-C8, CICLOALQUENILO C3-C8; ANILLO A ES ARILO C6-C14, CICLOALQUILO C3-C8, HETEROCICLICO; R5 Y R6 SON H, HALOGENO, ALQUILO C1-C6, ORa8, ENTRE OTROS; X ES H, HALOGENO, CIANO, NITRO, AMINO, ENTRE OTROS; ANILLO B ES ARILO C6-C14, CICLOALQUILO C3-C8; SON COMPUESTOS PREFERIDOS 1-(4'-CLORO-2-HIDROXIMETIL-BIFENIL-4-LIL)-2-PIRROLIDINONA; 4-(4-FLUOROFENIL)-5-HIDROXIMETIL-2-METILTIAZOL 4-(4-FLUOROFENIL)-5-CLOROMETIL-2-METILTIAZOL; ETIL 2-[4-(3-BROMOFENOXI)FENIL]-1-CICLOHEXILBENCIMIDAZOL-5-CARBOXILATO; ETIL 1-CICLOHEXIL-2-(4-HIDROXIFENIL)BENCIMIDAZOL-5-CARBOXILATO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS UN AGENTE ANTIVIRAL, ANTIINFLAMATORIO, INMUNOESTIMULANTE, UN INTERFERON. LOS COMPUESTOS SON INHIBIDORES DE POLIMERASA DEL VIRUS DE HEPATITIS C
PE2002000573A 2001-06-26 2002-06-26 Compuesto de anillo fundido como inhibidores de polimerasa del virus de la hepatitis c PE20030188A1 (es)

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