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UA116616C2 - Інгібітори hcv серинової протеази, отримані з макроциклічного проліну - Google Patents

Інгібітори hcv серинової протеази, отримані з макроциклічного проліну

Info

Publication number
UA116616C2
UA116616C2 UAA201305119A UAA201305119A UA116616C2 UA 116616 C2 UA116616 C2 UA 116616C2 UA A201305119 A UAA201305119 A UA A201305119A UA A201305119 A UAA201305119 A UA A201305119A UA 116616 C2 UA116616 C2 UA 116616C2
Authority
UA
Ukraine
Prior art keywords
present
serine protease
compounds
protease inhibitors
hcv serine
Prior art date
Application number
UAA201305119A
Other languages
English (en)
Inventor
Ят Сунь Ор
Цзюнь Ма
Гоцян ВАН
Цзян ЛУН
Бінь Ван
Original Assignee
Енанта Фармасьютікалз, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45817947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA116616(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Енанта Фармасьютікалз, Інк. filed Critical Енанта Фармасьютікалз, Інк.
Publication of UA116616C2 publication Critical patent/UA116616C2/uk

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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
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    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • General Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Даний винахід стосується сполук формули (І) EMBED ISISServer , (I) які інгібують активність серинової протеази, зокрема активність NS3-NS4A протеази вірусу гепатиту С (HCV). Далі, сполуки даного винаходу перешкоджають життєвому циклу вірусу гепатиту С і також є придатними як противірусні агенти. Даний винахід також стосується фармацевтичних композицій, що містять вказані вище сполуки, для введення суб'єкту, який страждає на HCV-інфекцію. Даний винахід також стосується способів лікування HCV-інфекції у суб'єкта введенням фармацевтичної композиції, що містить сполуки даного винаходу.
UAA201305119A 2010-09-21 2011-09-20 Інгібітори hcv серинової протеази, отримані з макроциклічного проліну UA116616C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38505810P 2010-09-21 2010-09-21
US201161499994P 2011-06-22 2011-06-22
US201161504616P 2011-07-05 2011-07-05
PCT/US2011/052304 WO2012040167A1 (en) 2010-09-21 2011-09-20 Macrocyclic proline derived hcv serine protease inhibitors

Publications (1)

Publication Number Publication Date
UA116616C2 true UA116616C2 (uk) 2018-04-25

Family

ID=45817947

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UAA201305119A UA116616C2 (uk) 2010-09-21 2011-09-20 Інгібітори hcv серинової протеази, отримані з макроциклічного проліну

Country Status (43)

Country Link
US (7) US8648037B2 (uk)
EP (2) EP3020723A1 (uk)
JP (5) JP5857053B2 (uk)
KR (5) KR20200117065A (uk)
CN (2) CN103209703B (uk)
AR (1) AR083052A1 (uk)
AU (2) AU2011305695B2 (uk)
BR (1) BR112013006693B1 (uk)
CA (1) CA2812261C (uk)
CL (2) CL2013000791A1 (uk)
CO (1) CO6700835A2 (uk)
CR (2) CR20180517A (uk)
CY (2) CY1117113T1 (uk)
DK (1) DK2618831T3 (uk)
DO (2) DOP2013000062A (uk)
EA (2) EA029145B1 (uk)
EC (2) ECSP13012559A (uk)
ES (1) ES2560003T3 (uk)
GT (2) GT201300077A (uk)
HK (1) HK1223955A1 (uk)
HR (1) HRP20160083T1 (uk)
HU (2) HUE028384T2 (uk)
IL (1) IL225412A (uk)
LT (1) LTC2618831I2 (uk)
LU (1) LUC00037I2 (uk)
MX (3) MX369246B (uk)
MY (1) MY164754A (uk)
NL (1) NL300900I2 (uk)
NO (2) NO2017056I2 (uk)
NZ (2) NZ608720A (uk)
PE (1) PE20140015A1 (uk)
PH (1) PH12013500533B1 (uk)
PL (1) PL2618831T3 (uk)
PT (1) PT2618831E (uk)
RS (1) RS54638B1 (uk)
SG (1) SG188618A1 (uk)
SI (1) SI2618831T1 (uk)
SM (1) SMT201600100B (uk)
TW (1) TWI523658B (uk)
UA (1) UA116616C2 (uk)
UY (2) UY33617A (uk)
WO (1) WO2012040167A1 (uk)
ZA (2) ZA201302317B (uk)

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