[go: up one dir, main page]

LUC00037I2 - - Google Patents

Info

Publication number
LUC00037I2
LUC00037I2 LU00037C LUC00037C LUC00037I2 LU C00037 I2 LUC00037 I2 LU C00037I2 LU 00037 C LU00037 C LU 00037C LU C00037 C LUC00037 C LU C00037C LU C00037 I2 LUC00037 I2 LU C00037I2
Authority
LU
Luxembourg
Application number
LU00037C
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45817947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LUC00037(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of LUC00037I1 publication Critical patent/LUC00037I1/fr
Publication of LUC00037I2 publication Critical patent/LUC00037I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LU00037C 2010-09-21 2017-10-10 LUC00037I2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38505810P 2010-09-21 2010-09-21
US201161499994P 2011-06-22 2011-06-22
US201161504616P 2011-07-05 2011-07-05
PCT/US2011/052304 WO2012040167A1 (fr) 2010-09-21 2011-09-20 Inhibiteurs de la sérine protéase du vhc dérivée de la proline macrocyclique

Publications (2)

Publication Number Publication Date
LUC00037I1 LUC00037I1 (fr) 2017-10-12
LUC00037I2 true LUC00037I2 (fr) 2017-12-13

Family

ID=45817947

Family Applications (1)

Application Number Title Priority Date Filing Date
LU00037C LUC00037I2 (fr) 2010-09-21 2017-10-10

Country Status (43)

Country Link
US (7) US8648037B2 (fr)
EP (2) EP2618831B1 (fr)
JP (5) JP5857053B2 (fr)
KR (5) KR101990279B1 (fr)
CN (2) CN104829688B (fr)
AR (1) AR083052A1 (fr)
AU (2) AU2011305695B2 (fr)
BR (1) BR112013006693B1 (fr)
CA (1) CA2812261C (fr)
CL (2) CL2013000791A1 (fr)
CO (1) CO6700835A2 (fr)
CR (2) CR20180517A (fr)
CY (2) CY1117113T1 (fr)
DK (1) DK2618831T3 (fr)
DO (2) DOP2013000062A (fr)
EA (2) EA023009B1 (fr)
EC (2) ECSP13012559A (fr)
ES (1) ES2560003T3 (fr)
GT (2) GT201300077A (fr)
HK (1) HK1223955A1 (fr)
HR (1) HRP20160083T1 (fr)
HU (2) HUE028384T2 (fr)
IL (1) IL225412A (fr)
LT (1) LTC2618831I2 (fr)
LU (1) LUC00037I2 (fr)
MX (3) MX369246B (fr)
MY (1) MY164754A (fr)
NL (1) NL300900I2 (fr)
NO (2) NO2017056I2 (fr)
NZ (2) NZ703416A (fr)
PE (1) PE20140015A1 (fr)
PH (1) PH12013500533B1 (fr)
PL (1) PL2618831T3 (fr)
PT (1) PT2618831E (fr)
RS (1) RS54638B1 (fr)
SG (1) SG188618A1 (fr)
SI (1) SI2618831T1 (fr)
SM (1) SMT201600100B (fr)
TW (1) TWI523658B (fr)
UA (1) UA116616C2 (fr)
UY (2) UY33617A (fr)
WO (1) WO2012040167A1 (fr)
ZA (2) ZA201302317B (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010132163A1 (fr) * 2009-05-13 2010-11-18 Enanta Pharmaceuticals, Inc. Composés macrocycliques comme inhibiteurs du virus de l'hépatite c
US9193740B2 (en) * 2009-10-19 2015-11-24 Enanta Pharmaceuticals, Inc. Bismacrocyclic compounds as hepatitis C virus inhibitors
PE20140015A1 (es) 2010-09-21 2014-02-16 Enanta Pharm Inc Inhibidores de las proteasas de serina del vhc derivados de prolinas macrociclicas
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
WO2014062196A1 (fr) 2012-10-19 2014-04-24 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914613B1 (fr) 2012-11-02 2017-11-22 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914614B1 (fr) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
CN105164148A (zh) 2013-03-07 2015-12-16 百时美施贵宝公司 丙型肝炎病毒抑制剂
NZ631155A (en) * 2013-03-14 2016-05-27 Abbvie Inc Combination of two antivirals for treating hepatitis c
US20180042982A1 (en) * 2013-03-14 2018-02-15 Abbvie Inc. Methods for Treating HCV
EA201890507A1 (ru) * 2013-03-14 2018-07-31 Эббви Инк. Комбинация противовирусных препаратов прямого действия и рибавирина для лечения пациентов с hcv
US20200368229A9 (en) * 2013-03-14 2020-11-26 Abbvie Inc. Methods for Treating HCV
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
JP6511432B2 (ja) 2013-03-15 2019-05-15 ギリアード サイエンシーズ， インコーポレイテッド Ｃ型肝炎ウイルスの大環状二環式阻害剤
JP2016534082A (ja) * 2013-10-25 2016-11-04 アッヴィ・インコーポレイテッド Ｈｃｖの治療方法
SG11201604482QA (en) 2013-12-23 2016-07-28 Gilead Sciences Inc Synthesis of a macrocyclic hcv ns3 inhibiting tripeptide
PT3087086T (pt) * 2013-12-23 2019-02-06 Gilead Pharmasset Llc Formas cristalinas de um tripéptido inibidor de hcv ns3 macrocíclico
EP2899207A1 (fr) 2014-01-28 2015-07-29 Amikana.Biologics Nouveau procédé pour tester l'inhibition de la protéase du HCV
CA2942823C (fr) * 2014-04-02 2023-01-03 Abbvie Inc. Methodes de traitement du vhc
JP6559701B2 (ja) * 2014-04-02 2019-08-14 アッヴィ・インコーポレイテッド Ｈｃｖを処置するための方法
AU2015269306B2 (en) * 2014-06-06 2020-06-25 Abbvie Inc. Crystal forms
TWI721947B (zh) 2014-06-11 2021-03-21 美商基利法瑪席特有限責任公司 抗病毒化合物的固態形式
US9809576B1 (en) * 2014-07-18 2017-11-07 Abbvie Inc. Synthetic route to anti-viral agents
US9809534B1 (en) 2014-07-21 2017-11-07 Abbvie Inc. Difluoroalkylcyclopropyl amino acids and esters, and syntheses thereof
US10059969B1 (en) 2014-10-03 2018-08-28 Abbvie Inc. Process for the preparation of (S)-2-amino-non-8-enoic acid
US10316338B1 (en) 2015-01-30 2019-06-11 Abb Vie Inc. Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid
WO2016134058A1 (fr) 2015-02-18 2016-08-25 Abbvie Inc. Combinaisons utiles pour traiter le virus de l'hépatite c
CA2990855A1 (fr) * 2015-06-26 2016-12-29 Abbvie Inc. Compositions pharmaceutiques solides pour le traitement du vhc
US20160375017A1 (en) 2015-06-26 2016-12-29 Abbvie Inc. Solid Pharmaceutical Compositions for Treating HCV
HK1255481A1 (zh) 2015-07-08 2019-08-16 Abbvie Inc. 用於治疗hcv的方法
SG10202002900YA (en) 2015-07-17 2020-05-28 Abbvie Inc Solid pharmaceutical compositions for treating hcv
KR101726567B1 (ko) 2016-07-08 2017-04-13 박공영 수직형 식물 재배장치
EP3577100A4 (fr) 2017-02-01 2021-03-10 Abbvie Inc. Procédés enzymatiques pour la préparation d'acide (±)-2-(difluorométhyl)-1-(alcoxycarbonyl)-cyclopropanecarboxylique et d'acide (±)-2-(vinyl)-1-(alcoxycarbonyl)-cyclopropanecarboxylique
JP2018131439A (ja) 2017-02-14 2018-08-23 アッヴィ・インコーポレイテッド Ｈｃｖを処置する方法
CA2981993A1 (fr) * 2017-08-02 2019-02-02 Abbvie Inc. Methodes de traitement du vhc
US20200330460A1 (en) * 2017-09-01 2020-10-22 Abbvie Inc. Methods for Treating HCV
WO2019074507A1 (fr) 2017-10-12 2019-04-18 Abbvie Inc. Méthodes pour le traitement du vhc
CN107739319A (zh) * 2017-10-31 2018-02-27 上海同昌生物医药科技有限公司 一种Glecaprevir合成中间体及其胺盐的制备方法
WO2019084740A1 (fr) * 2017-10-31 2019-05-09 上海同昌生物医药科技有限公司 Procédé de préparation d'un intermédiaire synthétique de glecaprévir et sel d'amine de celui-ci
CN108329332A (zh) * 2018-03-16 2018-07-27 安徽华昌高科药业有限公司 一种制备Glecaprevir的方法
CN113645958A (zh) 2019-04-08 2021-11-12 艾伯维公司 用于治疗hcv的固体药物组合物
KR102681664B1 (ko) 2019-06-12 2024-07-05 엘지디스플레이 주식회사 폴더블 디스플레이와 그 구동 방법
WO2021137256A1 (fr) 2020-01-03 2021-07-08 Mylan Laboratories Limited Formes polymorphes de glecaprévir
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors
CN114085458A (zh) * 2021-12-08 2022-02-25 宁波塑之华塑化有限公司 一种高强度高韧性阻燃聚丙烯复合材料及其制备方法

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69827956T2 (de) 1997-08-11 2005-04-14 Boehringer Ingelheim (Canada) Ltd., Laval Peptidanaloga mit inhibitorischer wirkung auf hepatitis c
AU757783B2 (en) 1997-08-11 2003-03-06 Boehringer Ingelheim (Canada) Ltd. Hepatitis C inhibitor peptides
PT1058686E (pt) 1998-02-25 2007-01-31 Raymond F Schinazi 2'-fluoronucleósidos
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
AR022061A1 (es) 1998-08-10 2002-09-04 Boehringer Ingelheim Ca Ltd Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos.
UA74546C2 (en) * 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US6566365B1 (en) 1999-11-04 2003-05-20 Biochem Pharma Inc. Method for the treatment of Flaviviridea viral infection using nucleoside analogues
CA2363274A1 (fr) 1999-12-27 2001-07-05 Japan Tobacco Inc. Composes a noyaux fusionnes et leurs utilisations comme medicaments contre l'hepatite c
KR20030005197A (ko) 2000-02-18 2003-01-17 샤이어 바이오켐 인코포레이티드 뉴클레오시드유도체를 이용한 플라비바이러스 감염의 치료또는 예방 방법
MXPA02009920A (es) 2000-04-05 2003-03-27 Schering Corp Inhibidores macrociclicos de la ns3-serina proteasa, del virus de la hepatitis c9 que comprenden partes p2 n-ciclicas.
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
PE20020707A1 (es) 2000-11-20 2002-08-11 Bristol Myers Squibb Co Compuestos tripeptidicos como inhibidores de la proteasa ns3 del virus de hepatitis c
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
WO2003007945A1 (fr) 2001-07-20 2003-01-30 Boehringer Ingelheim (Canada) Ltd. Inhibiteurs de polymerase virale
EP2335700A1 (fr) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Inhibiteurs de la polymerase du virus hepatitis C avec une structure heterobicylic
EP1429759A4 (fr) 2001-09-26 2004-12-15 Bristol Myers Squibb Co Composes pour traiter le virus de l'hepatite c
US6867185B2 (en) 2001-12-20 2005-03-15 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
CA2369711A1 (fr) 2002-01-30 2003-07-30 Boehringer Ingelheim (Canada) Ltd. Peptides macrocycliques qui agissent contre le virus de l'hepatite c
CA2369970A1 (fr) 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Tri-peptides inhibiteur de l'hepatite c
CA2370396A1 (fr) 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Tri-peptides inhibiteur de l'hepatite c
AU2003301959A1 (en) 2002-05-20 2004-06-03 Bristol-Myers Squibb Company Substituted cycloalkyl p1' hepatitis c virus inhibitors
ATE481106T1 (de) 2002-05-20 2010-10-15 Bristol Myers Squibb Co Heterocyclische sulfonamid-hepatitis-c-virus- hemmer
ES2361011T3 (es) 2002-05-20 2011-06-13 Bristol-Myers Squibb Company Inhibidores del virus de la hepatitis c.
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
CA2487211C (fr) 2002-06-04 2010-09-14 Neogenesis Pharmaceuticals, Inc. Composes de pyrazolo(1,5a)pyrimidine servant d'agents antiviraux
US20040138109A1 (en) 2002-09-30 2004-07-15 Boehringer Ingelheim Pharmaceuticals, Inc. Potent inhibitor of HCV serine protease
US20050075279A1 (en) 2002-10-25 2005-04-07 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis C virus
US20050159345A1 (en) 2002-10-29 2005-07-21 Boehringer Ingelheim International Gmbh Composition for the treatment of infection by Flaviviridae viruses
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
AU2004211637C1 (en) 2003-02-07 2010-08-19 Enanta Pharmaceuticals, Inc. Macrocyclic hepatitis C serine protease inhibitors
JP4550824B2 (ja) 2003-03-05 2010-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃ型肝炎抑制化合物
US6908901B2 (en) 2003-03-05 2005-06-21 Boehringer Ingelheim International, Gmbh Hepatitis C inhibitor peptide analogs
GB0307891D0 (en) 2003-04-04 2003-05-14 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
JP4733023B2 (ja) 2003-04-16 2011-07-27 ブリストル−マイヤーズ スクイブ カンパニー Ｃ型肝炎ウイルスの大環状イソキノリンペプチド阻害剤
US7176208B2 (en) * 2003-04-18 2007-02-13 Enanta Pharmaceuticals, Inc. Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
DE602004023924D1 (en) 2003-04-18 2009-12-17 Enanta Pharm Inc Ease-hemmer
WO2004103996A1 (fr) 2003-05-21 2004-12-02 Boehringer Ingelheim International Gmbh Composes inhibiteurs de l'hepatite c
WO2004113365A2 (fr) 2003-06-05 2004-12-29 Enanta Pharmaceuticals, Inc. Inhibiteurs de la tripeptide hepatite c serine protease
US7125845B2 (en) * 2003-07-03 2006-10-24 Enanta Pharmaceuticals, Inc. Aza-peptide macrocyclic hepatitis C serine protease inhibitors
ZA200600424B (en) 2003-08-01 2007-05-30 Genelabs Tech Inc Bicyclic imidazol derivatives against flaviviridae
WO2005014543A1 (fr) 2003-08-06 2005-02-17 Japan Tobacco Inc. Compose a cycle condense utilise comme inhibiteur de la polymerase du vhc
MXPA06003141A (es) 2003-09-22 2006-06-05 Boehringer Ingelheim Int Peptidos macrociclicos activos contra el virus de la hepatitis c.
TW201245229A (en) 2003-10-14 2012-11-16 Hoffmann La Roche Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication
US7132504B2 (en) 2003-11-12 2006-11-07 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2005049622A1 (fr) 2003-11-19 2005-06-02 Japan Tobacco Inc. Compose heterocyclique fusionne a cinq branches et utilisation de celui-ci comme inhibiteur de la polymerase du vhc
US7135462B2 (en) 2003-11-20 2006-11-14 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7309708B2 (en) 2003-11-20 2007-12-18 Birstol-Myers Squibb Company Hepatitis C virus inhibitors
CA2546290A1 (fr) 2003-11-20 2005-06-09 Schering Corporation Inhibiteurs depourvus de liaisons peptidiques de la protease ns3 du virus de l'hepatite c
EP1730167B1 (fr) 2004-01-21 2011-01-12 Boehringer Ingelheim International GmbH Peptides macrocycliques actifs contre le virus de l'hepatite c
PL1718608T3 (pl) 2004-02-20 2013-11-29 Boehringer Ingelheim Int Inhibitory polimerazy wirusowej
JP4914348B2 (ja) 2004-06-28 2012-04-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃ型肝炎インヒビターペプチド類似体
PE20060569A1 (es) 2004-07-16 2006-06-22 Boehringer Ingelheim Int Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc
UY29016A1 (es) 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
EP1771454B1 (fr) 2004-07-20 2011-06-15 Boehringer Ingelheim International GmbH Analogues peptidiques inhibiteurs de l'hepatite c
JP4705164B2 (ja) * 2005-05-02 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｃｖｎｓ３プロテアーゼ阻害剤
US7470664B2 (en) 2005-07-20 2008-12-30 Merck & Co., Inc. HCV NS3 protease inhibitors
NZ565059A (en) * 2005-07-25 2011-08-26 Intermune Inc Novel macrocyclic inhibitors of hepatitus C virus replication
MX2008001588A (es) 2005-08-01 2008-02-19 Merck & Co Inc Inhibidores de proteasa ns3 del vhc.
GB0609492D0 (en) 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
GB0612423D0 (en) 2006-06-23 2006-08-02 Angeletti P Ist Richerche Bio Therapeutic agents
PE20080992A1 (es) 2006-06-26 2008-08-06 Enanta Pharm Inc Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c
US7635683B2 (en) 2006-08-04 2009-12-22 Enanta Pharmaceuticals, Inc. Quinoxalinyl tripeptide hepatitis C virus inhibitors
US7582605B2 (en) 2006-08-11 2009-09-01 Enanta Pharmaceuticals, Inc. Phosphorus-containing hepatitis C serine protease inhibitors
EP2079480B1 (fr) 2006-10-24 2013-06-05 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase ns3 du hcv
EP2079479B1 (fr) 2006-10-24 2014-11-26 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase ns3 du vhc
AU2007309546A1 (en) 2006-10-24 2008-05-02 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. HCV NS3 protease inhibitors
US20100099695A1 (en) 2006-10-27 2010-04-22 Liverton Nigel J HCV NS3 Protease Inhibitors
JP5352464B2 (ja) 2006-10-27 2013-11-27 メルク・シャープ・アンド・ドーム・コーポレーション Ｈｃｖｎｓ３プロテアーゼ阻害剤
US20080267917A1 (en) 2007-04-26 2008-10-30 Deqiang Niu N-functionalized amides as hepatitis c serine protease inhibitors
US8377872B2 (en) 2007-04-26 2013-02-19 Enanta Pharmaceuticals, Inc. Cyclic P3 tripeptide hepatitis C serine protease inhibitors
WO2008134397A1 (fr) 2007-04-26 2008-11-06 Enanta Pharmaceuticals, Inc. Inhibiteurs à base d'aza-tripeptide de la sérine protéase de l'hépatite c
US8927569B2 (en) 2007-07-19 2015-01-06 Merck Sharp & Dohme Corp. Macrocyclic compounds as antiviral agents
US8383583B2 (en) 2007-10-26 2013-02-26 Enanta Pharmaceuticals, Inc. Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
WO2009064955A1 (fr) 2007-11-14 2009-05-22 Enanta Pharmaceuticals, Inc. Inhibiteurs macrocycliques à radical tétrazolyle de la sérine protéase du virus de l'hépatite c
CL2008003384A1 (es) * 2007-11-14 2009-12-11 Enanta Pharm Inc Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c.
CA2708042A1 (fr) 2007-12-05 2009-06-11 Enanta Pharmaceuticals, Inc. Derives de quinoxalinyle
JP5529036B2 (ja) 2007-12-05 2014-06-25 エナンタ ファーマシューティカルズ インコーポレイテッド フッ素化トリペプチドｈｃｖセリンプロテアーゼ阻害剤
CN101980602A (zh) 2007-12-14 2011-02-23 益安药业 大环肟基丙型肝炎丝氨酸蛋白酶抑制剂
WO2009079353A1 (fr) 2007-12-14 2009-06-25 Enanta Pharmaceuticals, Inc. Inhibiteurs macrocycliques contenant du triazole des protéases à sérine du vhc
WO2009085978A1 (fr) 2007-12-20 2009-07-09 Enanta Pharceuticals, Inc. Inhibiteurs de protéase de sérine de virus de l'hépatite c d'oxime carbocyclique couronnés
AU2009217551B2 (en) * 2008-02-25 2014-07-31 Msd Italia S.R.L. Therapeutic compounds
US8372802B2 (en) 2008-03-20 2013-02-12 Enanta Pharmaceuticals, Inc. Fluorinated macrocyclic compounds as hepatitis C virus inhibitors
WO2009134624A1 (fr) 2008-04-28 2009-11-05 Merck & Co., Inc. Inhibiteurs de la protéase hcv ns3
WO2009134987A1 (fr) * 2008-04-30 2009-11-05 Enanta Pharmaceuticals, Inc. Composés macrocycliques contenant du difluorométhyle comme inhibiteurs du virus de l’hépatite c
BRPI0916235B8 (pt) * 2008-07-22 2021-05-25 Merck Sharp & Dohme composto, composição farmacêutica, e, uso do composto ou da composição
WO2010132163A1 (fr) * 2009-05-13 2010-11-18 Enanta Pharmaceuticals, Inc. Composés macrocycliques comme inhibiteurs du virus de l'hépatite c
WO2011014487A1 (fr) 2009-07-30 2011-02-03 Merck Sharp & Dohme Corp. Inhibiteurs de protéase ns3 du virus de l'hépatite c
US9193740B2 (en) 2009-10-19 2015-11-24 Enanta Pharmaceuticals, Inc. Bismacrocyclic compounds as hepatitis C virus inhibitors
PE20140015A1 (es) 2010-09-21 2014-02-16 Enanta Pharm Inc Inhibidores de las proteasas de serina del vhc derivados de prolinas macrociclicas
EP2618665A4 (fr) 2010-09-21 2014-08-20 Merck Sharp & Dohme Inhibiteurs de protéase ns3 du vhc

Also Published As

Publication number Publication date
PT2618831E (pt) 2016-03-04
BR112013006693B1 (pt) 2022-07-12
CL2014000612A1 (es) 2014-09-05
US20140194350A1 (en) 2014-07-10
CN103209703B (zh) 2015-05-27
CY2017033I1 (el) 2018-04-04
DK2618831T3 (en) 2016-04-04
NL300900I2 (nl) 2017-11-16
AU2011305695A1 (en) 2013-04-11
MX343275B (es) 2016-10-31
JP6352238B2 (ja) 2018-07-04
PH12013500533B1 (en) 2018-09-19
SI2618831T1 (sl) 2016-06-30
BR112013006693A2 (pt) 2016-06-14
LTPA2017034I1 (lt) 2017-11-10
MX369246B (es) 2019-11-01
EA029145B1 (ru) 2018-02-28
HK1223955A1 (en) 2017-08-11
EP2618831B1 (fr) 2016-01-06
CN104829688A (zh) 2015-08-12
JP2020015730A (ja) 2020-01-30
PL2618831T3 (pl) 2016-06-30
UY33617A (es) 2012-07-31
ECSP13012559A (es) 2014-05-31
US8648037B2 (en) 2014-02-11
US20120070416A1 (en) 2012-03-22
AU2011305695B2 (en) 2016-05-19
JP2013538235A (ja) 2013-10-10
EA201390425A1 (ru) 2013-09-30
KR20190110648A (ko) 2019-09-30
HUE028384T2 (en) 2016-12-28
CA2812261A1 (fr) 2012-03-29
ECSP19072215A (es) 2019-10-31
WO2012040167A1 (fr) 2012-03-29
JP2018162265A (ja) 2018-10-18
ZA201302317B (en) 2014-09-25
KR102128232B1 (ko) 2020-06-30
EA201500728A2 (ru) 2016-03-31
KR102163902B1 (ko) 2020-10-12
IL225412A0 (en) 2013-06-27
CO6700835A2 (es) 2013-06-28
IL225412A (en) 2017-02-28
CY2017033I2 (el) 2018-04-04
EP3020723A1 (fr) 2016-05-18
RS54638B1 (sr) 2016-08-31
UA116616C2 (uk) 2018-04-25
PE20140015A1 (es) 2014-02-16
TWI523658B (zh) 2016-03-01
NO2017056I1 (no) 2017-11-10
KR20190069623A (ko) 2019-06-19
US20160145298A1 (en) 2016-05-26
CR20130135A (es) 2013-10-04
SG188618A1 (en) 2013-04-30
NZ608720A (en) 2015-03-27
LUC00037I1 (fr) 2017-10-12
EA201500728A3 (ru) 2016-07-29
AR083052A1 (es) 2013-01-30
CN104829688B (zh) 2021-02-09
US20200270303A1 (en) 2020-08-27
CL2013000791A1 (es) 2013-07-12
US20180162905A1 (en) 2018-06-14
NO2021040I1 (no) 2021-09-16
ZA201308655B (en) 2014-11-26
JP2016104756A (ja) 2016-06-09
US9220748B2 (en) 2015-12-29
MY164754A (en) 2018-01-30
GT201300077A (es) 2014-12-16
MX2013003230A (es) 2013-10-17
AU2016204491A1 (en) 2016-07-21
HRP20160083T1 (hr) 2016-02-26
US20170088583A1 (en) 2017-03-30
KR20130098369A (ko) 2013-09-04
GT201300077AA (es) 2019-11-13
UY38339A (es) 2020-12-31
JP6574023B2 (ja) 2019-09-11
US20190263860A1 (en) 2019-08-29
CA2812261C (fr) 2017-02-21
HK1186979A1 (zh) 2014-03-28
KR20180099929A (ko) 2018-09-05
CR20180517A (es) 2018-12-06
PH12013500533A1 (en) 2013-05-06
LTC2618831I2 (lt) 2021-11-10
TW201216979A (en) 2012-05-01
JP5857053B2 (ja) 2016-02-10
EP2618831A4 (fr) 2014-11-19
ES2560003T3 (es) 2016-02-17
SMT201600100B (it) 2016-04-29
EP2618831A1 (fr) 2013-07-31
CN103209703A (zh) 2013-07-17
KR101990279B1 (ko) 2019-06-19
KR101894704B1 (ko) 2018-09-05
DOP2019000218A (es) 2019-09-15
MX2019013037A (es) 2020-02-05
DOP2013000062A (es) 2013-07-15
NZ703416A (en) 2016-06-24
KR20200117065A (ko) 2020-10-13
NO2017056I2 (no) 2018-11-26
CY1117113T1 (el) 2017-04-05
JP2021063130A (ja) 2021-04-22
HUS1700039I1 (hu) 2017-11-28
EA023009B1 (ru) 2016-04-29

Similar Documents

Publication Publication Date Title
BR112013008959A2 (fr)
BR112012030039A2 (fr)
BR112012028408A2 (fr)
BR112012029986A2 (fr)
BR112012027808A2 (fr)
BR112012024897A2 (fr)
BR112012026492A2 (fr)
BR112012031500A2 (fr)
BR112012026946A2 (fr)
BR112012025482A2 (fr)
BR112013006400A2 (fr)
BR112012031826A2 (fr)
BR112012028186A2 (fr)
BR112012025577A2 (fr)
BR112012016456A2 (fr)
BR112012027015A2 (fr)
BR112012025308A2 (fr)
BR112012027945A2 (fr)
BR112013010949A2 (fr)
BR112012024872A2 (fr)
BR112013003284A2 (fr)
BR112013002646A2 (fr)
BR112012026403A2 (fr)
BR112013006825A2 (fr)
BR112012028859A2 (fr)