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PE20030104A1 - Anticuerpos humanos para cd154 - Google Patents

Anticuerpos humanos para cd154

Info

Publication number
PE20030104A1
PE20030104A1 PE2001000244A PE2001000244A PE20030104A1 PE 20030104 A1 PE20030104 A1 PE 20030104A1 PE 2001000244 A PE2001000244 A PE 2001000244A PE 2001000244 A PE2001000244 A PE 2001000244A PE 20030104 A1 PE20030104 A1 PE 20030104A1
Authority
PE
Peru
Prior art keywords
phe
variable domain
sequence
chain
cdr2
Prior art date
Application number
PE2001000244A
Other languages
English (en)
Inventor
Walter Schuler
Padova Franco E Di
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20030104A1 publication Critical patent/PE20030104A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
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Abstract

SE REFIERE A UNA MOLECULA DE ENLACE DE CD154 QUE COMPRENDE UN SITIO DE ENLACE DE ANTIGENO CON POR LO MENOS UN DOMINIO VARIABLE DE CADENA PESADA DE INMUNOGLOBULINA (VH) QUE COMPRENDE SECUENCIAS DE LAS REGIONES HIPERVARIABLES CDR1, CDR2 Y CDR3 TENIENDO LA CDR1 SECUENCIA DE AMINOACIDOS Asn-Phe-Ala-Phe-Asn, TENIENDO LA CDR2 LA SECUENCIA DE AMINOACIDO Arg-Ile-Leu-Pro-Ser-Leu-Asp-Ile-Ala-Ser Y LA CDR3 UNA SECUENCIA DE Glu-Val-Asp-Gly-Gly-Phe Y SUS EQUIVALENTES DIRECTOS. SE REFIERE TAMBIEN A UNA MOLECULA DE ENLACE CD154 QUE COMPRENDE CUANDO MENOS UN SITIO DE ENLACE: a) UNA CADENA PESADA QUE COMPRENDE UN DOMINO VARIABLE IDENTICA A LA SEQ No:2 EMPEZANDO CON EL AMINOACIDO EN POSICION 1 Y TERMINANDO EN LA POSICION 118 Y LA PARTE CONSTANTE DE UNA CADENA PESADA HUMANA; b) UNA CADENA LIGERA QUE COMPRENDE UN DOMINIO VARIABLE QUE TIENE LA SEQ No: 4 EMPEZANDO EN POSICION 1 Y TERMINANDO EN POSICION 107 Y LA PARTE CONSTANTE DE LA CADENA LIGERA HUMANA. LA MOLECULA ES UTIL PARA LA INHIBICION DE UNA RESPUESTA INMUNE MEDIADA POR LAS INTERACCIONES DE LAS CELULAS POSITIVAS PARA CD154 CON CELULAS POSITIVAS PARA CD40 UTIL PARA PROCESOS INFLAMATORIOS
PE2001000244A 2000-03-16 2001-03-14 Anticuerpos humanos para cd154 PE20030104A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0006398.2A GB0006398D0 (en) 2000-03-16 2000-03-16 Organic compounds

Publications (1)

Publication Number Publication Date
PE20030104A1 true PE20030104A1 (es) 2003-03-10

Family

ID=9887779

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000244A PE20030104A1 (es) 2000-03-16 2001-03-14 Anticuerpos humanos para cd154

Country Status (10)

Country Link
US (1) US7169389B2 (es)
EP (1) EP1263959A1 (es)
JP (1) JP2003526371A (es)
AR (1) AR027976A1 (es)
AU (2) AU4835001A (es)
CA (1) CA2400106A1 (es)
CO (1) CO5280086A1 (es)
GB (1) GB0006398D0 (es)
PE (1) PE20030104A1 (es)
WO (1) WO2001068860A1 (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1101495A4 (en) * 1999-06-01 2003-05-07 Eisai Co Ltd PREVENTIVE AGENTS AGAINST IDIOPATHIC THROMOBOCYTOPENIC PURPURA
JP3845735B2 (ja) * 2002-04-03 2006-11-15 学校法人慶應義塾 Ｃｄ４０ｌアンタゴニストを有効成分とする天疱瘡治療剤
US7883538B2 (en) * 2002-06-13 2011-02-08 Guided Delivery Systems Inc. Methods and devices for termination
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
ES2216707B1 (es) * 2003-04-08 2005-12-16 Josep Maria Aran Perramon Secuencia oligoribonucleotidica homologa a una region del cdna que codifica para el receptor cd40 humano y oligoribonucleotidos duplex, vectores, composiciones farmaceuticas y usos correspondientes.
ATE482235T1 (de) * 2003-06-13 2010-10-15 Biogen Idec Inc Aglycosyl-anti-cd154 (cd40-ligand) antikörper und deren verwendungen
GB0314461D0 (en) * 2003-06-20 2003-07-23 Isis Innovation Suppression of transplant rejection
SG131943A1 (en) * 2003-07-18 2007-05-28 Amgen Inc Specific binding agents to hepatocyte growth factor
JP5102028B2 (ja) 2004-07-26 2012-12-19 バイオジェン・アイデック・エムエイ・インコーポレイテッド 抗ｃｄ１５４抗体
US7563443B2 (en) * 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
KR20080039978A (ko) * 2005-08-11 2008-05-07 알피 마토씨안-로저스 자가면역 질병의 치료 및 진단용 ｔｃｒ-ｖ-베타 관련펩티드
AU2012244244B2 (en) * 2005-08-11 2015-08-27 Arpi Matossian-Rogers TCR-V-beta related peptides for treatment and diagnosis of autoimmune disease
EP2289909B1 (en) * 2005-11-30 2014-10-29 AbbVie Inc. Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies
PT1976877E (pt) * 2005-11-30 2014-04-29 Abbvie Inc Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações
US20070178087A1 (en) * 2005-12-15 2007-08-02 Christopher Roman Method for Treating Immune Dysfunction by Regulation of CD40 Ligand Expression
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
WO2008103378A2 (en) * 2007-02-20 2008-08-28 Merrimack Pharmaceuticals, Inc. Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
EP2124952A2 (en) * 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
BRPI0809042B1 (pt) * 2007-03-22 2021-08-31 Biogen Ma Inc. Proteína de ligação a cd154 isolada, seu uso, e composição
WO2009054921A1 (en) * 2007-10-19 2009-04-30 Reiter Paul C Semi-quantitative immunochromatographic device and method for the determination of hiv/aids immune-status via measurement of soluble cd40 ligand/cd 154, a cd4+ t cell equivalent
US20090258343A1 (en) * 2007-10-19 2009-10-15 Reiter Paul C Semi-quantitative immunochromatographic device and method for the determination of HIV/AIDS immune-status via measurement of soluble CD40 Ligand/CD154, A CD4+ T cell equivalent and the simultaneous detection of HIV infection via HIV antibody detection
GB0721752D0 (en) * 2007-11-06 2007-12-19 Univ Southampton Configurable electronic device and method
US8435514B2 (en) 2008-12-05 2013-05-07 Als Therapy Development Institute Method for the treatment of neurodegenerative diseases
US9044459B2 (en) 2008-12-05 2015-06-02 Als Therapy Development Institute Method for the treatment of neurodegenerative diseases
IN2012DN02401A (es) 2009-09-24 2015-08-21 Ucb Pharma Sa
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
MX360403B (es) 2010-04-15 2018-10-31 Abbvie Inc Proteinas de union a amiloide beta.
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
JP6147665B2 (ja) 2010-08-14 2017-06-14 アッヴィ・インコーポレイテッド アミロイドベータ結合タンパク質
RS56926B1 (sr) 2011-07-13 2018-05-31 Ucb Biopharma Sprl Bakterijski soj domaćina koji izražava rekombinantnu dsbc
SMT202000091T1 (it) 2011-10-13 2020-05-08 Bristol Myers Squibb Co Polipeptidi anticorpali che antagonizzano cd40l
GB201208367D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
MA41459A (fr) 2015-02-03 2017-12-12 Als Therapy Development Inst Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l
KR101752280B1 (ko) 2015-03-31 2017-06-30 서울대학교산학협력단 영장류 cd154에 특이적인 항체 및 이를 생산하는 융합 세포주
KR20160132694A (ko) * 2015-05-11 2016-11-21 주식회사 프로젠 Cd154에 특이적으로 결합하는 항체
AU2016294417B2 (en) 2015-07-14 2022-08-04 Immunext, Inc. Anti-CD154 antibody having improved binding, functional and safety characteristics and use in human immunotherapy
US10669343B2 (en) 2015-08-05 2020-06-02 Janssen Biotech, Inc. Anti-CD154 antibodies and methods of using them
MA43302A (fr) 2015-11-27 2021-03-17 Ablynx Nv Polypeptides inhibant le ligand cd40l
EP3551050A1 (en) 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
EP4108183A1 (en) 2017-03-30 2022-12-28 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device
WO2018217918A2 (en) 2017-05-24 2018-11-29 Als Therapy Development Institute Therapeutic anti-cd40 ligand antibodies
WO2019246317A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease or condition in a tissue originating from the endoderm
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
IL312059A (en) 2018-11-19 2024-06-01 Biora Therapeutics Inc Methods and devices for treating a disease with biotherapeutics
EP3870261B1 (en) 2019-12-13 2024-01-31 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
US20240336690A1 (en) * 2021-07-30 2024-10-10 Seoul National University R&Db Foundation Anti cd154 antibody and use thereof
TW202430550A (zh) 2022-10-18 2024-08-01 日商明治製菓藥業股份有限公司 Ｔ細胞性腫瘤之治療劑
WO2024222895A1 (zh) * 2023-04-28 2024-10-31 信达生物制药(苏州)有限公司 抗cd40l抗体及其在人自身免疫疾病治疗的应用
WO2025117849A1 (en) 2023-11-28 2025-06-05 Eledon Pharmaceuticals, Inc. Methods and compositions for prevention of transplant rejection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876950A (en) * 1995-01-26 1999-03-02 Bristol-Myers Squibb Company Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
KR100654645B1 (ko) * 1995-04-27 2007-04-04 아브게닉스, 인크. 면역화된 제노마우스 유래의 인간 항체
WO1996034096A1 (en) * 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6440418B1 (en) * 1995-11-07 2002-08-27 Idec Pharmaceuticals Corporation Methods of treating autoimmune diseases with gp39-specific antibodies
US6051228A (en) 1998-02-19 2000-04-18 Bristol-Myers Squibb Co. Antibodies against human CD40

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CO5280086A1 (es) 2003-05-30
US20040038293A1 (en) 2004-02-26
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