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PE20181952A1 - Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos - Google Patents

Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos

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Publication number
PE20181952A1
PE20181952A1 PE2018002029A PE2018002029A PE20181952A1 PE 20181952 A1 PE20181952 A1 PE 20181952A1 PE 2018002029 A PE2018002029 A PE 2018002029A PE 2018002029 A PE2018002029 A PE 2018002029A PE 20181952 A1 PE20181952 A1 PE 20181952A1
Authority
PE
Peru
Prior art keywords
cdr
seq
group
kabat numbering
antibody
Prior art date
Application number
PE2018002029A
Other languages
English (en)
Inventor
Laird Bloom
Karl Henry Nocka
James Reasoner Apgar
Mark A Farmer
Matthew Allister Lambert
Original Assignee
Pfizer
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Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20181952A1 publication Critical patent/PE20181952A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N5/12—Fused cells, e.g. hybridomas
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/515—Complete light chain, i.e. VL + CL
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

Referido a un anticuerpo o fragmento de union al antigeno del mismo, que se une especificamente a interleucina 33 (IL-33) humana, caracterizado porque comprende cualquiera de: (i) una CDR-L1 seleccionada del grupo que consiste de SEQ ID NO: 20, 37, 190, 193, 257, 258, 259 y 260 de acuerdo con la numeracion Kabat; (ii) una CDR-L2 seleccionada del grupo que consiste de SEQ ID NO: 21, 196, 199, 261, 262, 263, y 264 de acuerdo con la numeracion Kabat; (iii) una CDR-L3 seleccionada del grupo que consiste de SEQ ID NO: 22, 38, 208, 265, 26, 267 y 268 de acuerdo con la numeracion Kabat; (iv) una CDR-H1 seleccionada del grupo que consiste de SEQ ID NO: 16, 33, 269, 270 y 271 de acuerdo con la numeracion Kabat; (v) una CDR-H2 seleccionada del grupo que consiste de SEQ ID NO: 17, 34, 168, 171 ,174, 180, 202, 205, 211, 214, 217, 220, 223, 226, 229, 232, 235, 272, 273, 274, y 275 de acuerdo con la numeracion Kabat, y (vi) una CDR-H3 seleccionada del grupo que consiste de SEQ ID NO: 18, 35, 114, 119, 122, 127, 130, 133, 136, 139, 142, 145, 148, 153, 156, 159, 177, 187, 276, 277, 278, y 279 de acuerdo con la numeracion Kabat. En donde, este anticuerpo o fragmento de union al antigeno del mismo, comprende una o ambas secuencias de marco VL y VH es al menos 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% o 99% identica a la secuencia de la linea germinal de humano a partir de la cual se deriva. Tambien se refiere a una molecula aislada de acidos nucleicos, un vector, una celula huesped y un metodo para elaborar un anticuerpo. Una composicion farmaceutica que comprende un anticuerpo y metodos para tratar enfermedades inflamatorias, alergias, entre otras.
PE2018002029A 2016-04-27 2017-04-20 Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos PE20181952A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662328294P 2016-04-27 2016-04-27
US201762483781P 2017-04-10 2017-04-10

Publications (1)

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PE20181952A1 true PE20181952A1 (es) 2018-12-17

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PE2018002029A PE20181952A1 (es) 2016-04-27 2017-04-20 Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos

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US (2) US10544212B2 (es)
EP (1) EP3448888A1 (es)
JP (1) JP2019516362A (es)
KR (1) KR20180128028A (es)
CN (1) CN109415436A (es)
AU (1) AU2017257330A1 (es)
BR (1) BR112018071276A2 (es)
CA (1) CA2965089A1 (es)
CO (1) CO2018011364A2 (es)
IL (1) IL262497A (es)
MX (1) MX2018013038A (es)
PE (1) PE20181952A1 (es)
PH (1) PH12018502225A1 (es)
RU (1) RU2740309C2 (es)
SG (1) SG11201808693WA (es)
TW (2) TWI679211B (es)
WO (1) WO2017187307A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016077381A1 (en) 2014-11-10 2016-05-19 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
WO2016077366A1 (en) 2014-11-10 2016-05-19 Genentec, Inc. Therapeutic and diagnostic methods for il-33-mediated disorders
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
CN110997725B (zh) 2017-06-12 2024-08-09 蓝鳍生物医药公司 抗-il1rap抗体和抗体药物缀合物
EP3723803A4 (en) 2017-12-12 2021-09-15 Pionyr Immunotherapeutics, Inc. ANTI-TREM2 ANTIBODIES AND RELATED METHODS
AR115320A1 (es) * 2018-03-30 2020-12-23 Merus Nv Anticuerpo multivalente
IL277890B2 (en) 2018-04-11 2024-03-01 Regeneron Pharma Methods for quantifying il-33
WO2020123664A1 (en) * 2018-12-11 2020-06-18 Pionyr Immunotherapeutics, Inc. Methods of using anti-trem2 antibodies
CN112480252B (zh) * 2019-09-12 2023-02-07 上海麦济生物技术有限公司 抗白细胞介素-33抗体及其制备方法和应用
US12435127B2 (en) 2019-09-25 2025-10-07 The General Hospital Corporation Therapeutic neutralization antibodies for the treatment of peanut allergy
EP4055044A1 (en) * 2019-11-04 2022-09-14 MedImmune Limited Anti il-33 therapeutic agent for treating renal disorders
TW202134261A (zh) 2019-11-04 2021-09-16 英商梅迪繆思有限公司 使用il-33拮抗劑之方法
CN113214395A (zh) * 2020-01-21 2021-08-06 迈威(上海)生物科技股份有限公司 抗st2抗体及其应用
JP2023516497A (ja) 2020-03-13 2023-04-19 メドイミューン・リミテッド Ｉｌ３３にリスクアレルを有する対象を治療するための治療方法
PE20230252A1 (es) * 2020-03-13 2023-02-07 Genentech Inc Anticuerpos anti-interleucina-33 y sus usos de estos
US20230174637A1 (en) * 2020-04-06 2023-06-08 Medimmune Limited Treating acute respiratory distress syndrome with il-33 axis binding antagonists
IL297841A (en) 2020-05-11 2023-01-01 Medimmune Ltd Formulations of anti-il-33 antibodies
IL298075A (en) * 2020-05-12 2023-01-01 Chia Tai Tianqing Pharmaceutical Group Co Ltd St2 antigen binding protein
CN111620948B (zh) * 2020-06-10 2022-04-08 南京赛新生物科技有限公司 针对il-33的抗体
KR102789102B1 (ko) * 2020-08-18 2025-03-28 성균관대학교산학협력단 Il-33 항체 또는 이의 항원 결합 단편
CN114249825A (zh) * 2020-09-25 2022-03-29 三生国健药业（上海）股份有限公司 结合人il-33的抗体、其制备方法和用途
CN117858898A (zh) * 2021-08-27 2024-04-09 免疫医疗有限公司 用抗白介素-33抗体治疗慢性阻塞性肺病
CN113603775B (zh) * 2021-09-03 2022-05-20 江苏荃信生物医药股份有限公司 抗人白介素-33单克隆抗体及其应用
WO2023108101A1 (en) * 2021-12-09 2023-06-15 Emory University Antibodies that inhibit glycoprotein ib-ix mediated platelet signaling and uses in managing bleeding conditions
CN114397289A (zh) * 2022-01-14 2022-04-26 长春工业大学 一种土壤中重金属元素定量分析方法及相关设备
CN119183384A (zh) * 2022-02-24 2024-12-24 中国抗体制药有限公司 针对警报素的双特异性结合蛋白及其用途
TW202402790A (zh) 2022-03-25 2024-01-16 英商梅迪繆思有限公司 減少呼吸系統感染之方法
WO2024038185A1 (en) 2022-08-19 2024-02-22 Medimmune Limited Method of selecting patients for treatment with an il-33 axis antagonist
CN115947844B (zh) * 2022-12-09 2024-06-14 江苏荃信生物医药股份有限公司 一种新的抗人il-33单克隆抗体、包含其的试剂盒及其检测方法
WO2025114862A1 (en) * 2023-11-27 2025-06-05 Glaxosmithkline Intellectual Property Development Limited Il-33 binding antibodies
WO2025120567A1 (en) 2023-12-07 2025-06-12 Medimmune Limited Method of treatment of asthma
WO2025210099A1 (en) 2024-04-04 2025-10-09 Medimmune Limited Method of treatment and selecting a subject

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4754065A (en) 1984-12-18 1988-06-28 Cetus Corporation Precursor to nucleic acid probe
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
US7771951B2 (en) 2001-12-03 2010-08-10 Amgen Fremont Inc. Antibody categorization based on binding characteristics
ATE553128T1 (de) 2002-12-24 2012-04-15 Rinat Neuroscience Corp Anti-ngf-antikörper und verfahren zu ihrer verwendung
NZ549040A (en) 2004-02-17 2009-07-31 Schering Corp Use for interleukin-33 (IL33) and the IL-33 receptor complex
WO2008144610A1 (en) 2007-05-18 2008-11-27 Medimmune, Llc Il-33 in inflammatory disease
WO2009124090A1 (en) 2008-03-31 2009-10-08 Genentech, Inc. Compositions and methods for treating and diagnosing asthma
ES2655079T3 (es) 2009-09-10 2018-02-16 Merck Sharp & Dohme Corp. Uso de antagonistas de IL-33 para tratar enfermedades fibróticas
AU2011343570B2 (en) 2010-12-16 2016-11-03 Genentech, Inc. Diagnosis and treatments relating to TH2 inhibition
EP2678358B1 (en) 2011-02-23 2015-07-22 F.Hoffmann-La Roche Ag Antibodies against human il33r and uses thereof
FR2972006B1 (fr) 2011-02-24 2016-03-25 Centre Nat Rech Scient Nouveaux fragments d'il-33 superactifs et leurs utilisations
AU2013222129B2 (en) 2012-02-24 2018-02-15 Children's Hospital Medical Center Esophageal microRNA expression profiles in eosinophilic esophagitis
AR091069A1 (es) 2012-05-18 2014-12-30 Amgen Inc Proteinas de union a antigeno dirigidas contra el receptor st2
EP2897979B1 (en) 2012-09-19 2019-02-13 Innate Pharma Kir3dl2 binding agents
US20150250808A1 (en) 2012-10-15 2015-09-10 Vojo P. Deretic Treatment of autophagy-based disorders and related pharmaceutical compositions, diagnostic and screening assays and kits
JO3532B1 (ar) * 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
CA2904377C (en) 2013-03-15 2021-07-13 Regeneron Pharmaceuticals, Inc. Il-33 antagonists and uses thereof
CA3190793A1 (en) * 2013-12-26 2015-07-02 Mitsubishi Tanabe Pharma Corporation Human anti-il-33 neutralizing monoclonal antibody
WO2015106080A2 (en) * 2014-01-10 2015-07-16 Anaptysbio, Inc. Antibodies directed against interleukin-33 (il-33)
EP3134120B1 (en) 2014-04-21 2024-01-24 The Children's Hospital of Philadelphia Compositions and methods for treating cytokine-related disorders
WO2016077381A1 (en) 2014-11-10 2016-05-19 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
WO2016077366A1 (en) 2014-11-10 2016-05-19 Genentec, Inc. Therapeutic and diagnostic methods for il-33-mediated disorders
SI3277717T1 (sl) 2015-03-31 2021-03-31 Medimmune Limited, Milstein Nova oblika IL33, mutirane oblike IL33, protitelesa, testi in postopki njihove uporabe
US10005834B2 (en) 2015-10-06 2018-06-26 Regeneron Pharmaceuticals, Inc. Biomarkers related to interleukin-33 (IL-33)-mediated diseases and uses thereof
JP2019508382A (ja) 2016-01-14 2019-03-28 アナプティスバイオ インコーポレイティッド Ｉｌ−３３阻害剤を使用したアレルギー反応の阻害

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