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PE20190120A1 - Moleculas de union a bcma y metodos de uso de las mismas - Google Patents

Moleculas de union a bcma y metodos de uso de las mismas

Info

Publication number
PE20190120A1
PE20190120A1 PE2018001932A PE2018001932A PE20190120A1 PE 20190120 A1 PE20190120 A1 PE 20190120A1 PE 2018001932 A PE2018001932 A PE 2018001932A PE 2018001932 A PE2018001932 A PE 2018001932A PE 20190120 A1 PE20190120 A1 PE 20190120A1
Authority
PE
Peru
Prior art keywords
amino acid
acid sequence
sequence seq
antigen
receptor
Prior art date
Application number
PE2018001932A
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English (en)
Inventor
Jed Wiltzius
Rodriguez Ruben Alvarez
Original Assignee
Kite Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kite Pharma Inc filed Critical Kite Pharma Inc
Publication of PE20190120A1 publication Critical patent/PE20190120A1/es

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Abstract

Referido a un polinucleotido aislado que codifica un receptor de antigeno quimerico (CAR) o un receptor o un receptor de celulas T (TCR), que comprende una molecula de union a antigeno que se une especificamente a un antigeno de maduracion de celulas B (BCMA), en donde la molecula de union a antigeno comprende: (a) una region determinante de complementariedad (CDR) de una region variable de cadena pesada 1 que comprende la secuencia de aminoacidos SEQ ID NO: 145; y/o (b) un CDR de VH que comprende la secuencia de aminoacidos SEQ ID NO: 146; (c) un CDR3 de VH que comprende la secuencia aminoacidos SEQ ID NO: 147; (d) una region variable de cadena liviana (VL) CDR1 que comprende la secuencia de aminoacidos SEQ ID NO: 148; (e) una CDR2 de VL que comprende en la secuencia de aminoacidos SEQ ID NO: 149 y (f) un CDR3 de VL que comprende en la secuencia de aminoacidos SEQ ID NO: 150. En donde, estos polinucleotidos, polipeptidos y celulas in vitro, se pueden usar en una terapia de celulas T CAR modificadas geneticamente para el tratamiento de cancer como el mieloma multiple.
PE2018001932A 2016-04-01 2017-03-31 Moleculas de union a bcma y metodos de uso de las mismas PE20190120A1 (es)

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US (3) US10689450B2 (es)
EP (1) EP3436036A4 (es)
JP (2) JP7366543B2 (es)
KR (3) KR102397674B1 (es)
CN (3) CN109414455B (es)
AR (1) AR108067A1 (es)
AU (2) AU2017240150C1 (es)
BR (1) BR112018070159A2 (es)
CA (1) CA3019135A1 (es)
CL (1) CL2018002763A1 (es)
CO (1) CO2018010475A2 (es)
CR (1) CR20180462A (es)
CU (1) CU20180120A7 (es)
DO (1) DOP2018000212A (es)
EA (1) EA201891966A1 (es)
EC (1) ECSP18073836A (es)
IL (1) IL261942A (es)
MX (1) MX2023007400A (es)
NZ (1) NZ746700A (es)
PE (1) PE20190120A1 (es)
PH (1) PH12018550164A1 (es)
SG (2) SG11201808403SA (es)
TW (4) TWI795133B (es)
WO (1) WO2017173349A1 (es)
ZA (1) ZA201806962B (es)

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