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PE20191075A1 - Anticuerpo que se une especificamente a il-17a y fragmento funcional del mismo - Google Patents

Anticuerpo que se une especificamente a il-17a y fragmento funcional del mismo

Info

Publication number
PE20191075A1
PE20191075A1 PE2019000527A PE2019000527A PE20191075A1 PE 20191075 A1 PE20191075 A1 PE 20191075A1 PE 2019000527 A PE2019000527 A PE 2019000527A PE 2019000527 A PE2019000527 A PE 2019000527A PE 20191075 A1 PE20191075 A1 PE 20191075A1
Authority
PE
Peru
Prior art keywords
cdr
seq
functional fragment
antibody
same
Prior art date
Application number
PE2019000527A
Other languages
English (en)
Inventor
Nanmeng Song
Jiawang Liu
Yaping Yang
Yang Yang
Dongge Yang
Hongjuan Zhang
Mengxie Jin
Original Assignee
Beijing hanmi pharm co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing hanmi pharm co ltd filed Critical Beijing hanmi pharm co ltd
Publication of PE20191075A1 publication Critical patent/PE20191075A1/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • A61K51/1021—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against cytokines, e.g. growth factors, VEGF, TNF, lymphokines or interferons
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Abstract

Se refiere a un anticuerpo o fragmento funcional del mismo capaz de unirse de forma especifica a la interleuquina 17-A (IL-17A), comprendiendo una cadena ligera, la cual comprende una CDR de cadena ligera que consiste en CDR-L1 de SEQ ID NO:1, CDR-L2 de SEQ ID NO:2, y CDR-L3 de SEQ ID NO:3, y una cadena pesada, la cual comprende una CDR de cadena pesada que consiste en CDR-H1 de SEQ ID NO:4, CDR-H2 de SEQ ID NO:5 y CDR-H3 de SEQ ID NO:6, y que incluye a un anticuerpo quimerico de IL-17A y un fragmento funcional del mismo, y a un anticuerpo humanizado de IL-17A y un fragmento funcional del mismo. Tambien se refiere a una molecula de acido nucleico, a una composicion que comprende al anticuerpo o fragmento funcional del mismo y a metodos de preparacion. La presente invencion es util para la prevencion y el tratamiento de enfermedades asociadas con la expresion y liberacion en exceso de IL-17A
PE2019000527A 2016-09-14 2017-09-08 Anticuerpo que se une especificamente a il-17a y fragmento funcional del mismo PE20191075A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610827097 2016-09-14
PCT/CN2017/101083 WO2018050028A1 (zh) 2016-09-14 2017-09-08 一种能够特异性地结合il-17a的抗体及其功能片段

Publications (1)

Publication Number Publication Date
PE20191075A1 true PE20191075A1 (es) 2019-08-20

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Family Applications (1)

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PE2019000527A PE20191075A1 (es) 2016-09-14 2017-09-08 Anticuerpo que se une especificamente a il-17a y fragmento funcional del mismo

Country Status (22)

Country Link
US (1) US11072651B2 (es)
EP (1) EP3514176B1 (es)
JP (1) JP6802381B2 (es)
KR (1) KR102329490B1 (es)
CN (2) CN109715660A (es)
AU (1) AU2017328310B2 (es)
BR (1) BR112019004990A2 (es)
CA (1) CA3036913C (es)
CL (1) CL2019000659A1 (es)
CO (1) CO2019002370A2 (es)
DO (1) DOP2019000062A (es)
EA (1) EA201990673A1 (es)
EC (1) ECSP19018356A (es)
ES (1) ES2905917T3 (es)
IL (1) IL265350B2 (es)
MX (1) MX2019002970A (es)
MY (1) MY185578A (es)
PE (1) PE20191075A1 (es)
PH (1) PH12019500551A1 (es)
SA (1) SA519401307B1 (es)
TN (1) TN2019000082A1 (es)
WO (1) WO2018050028A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201990673A1 (ru) * 2016-09-14 2019-08-30 Бэйцзин Ханми Фарм. Ко., Лтд. Антитела, специфически связывающиеся с il-17a, и их функциональные фрагменты
GB201719447D0 (en) 2017-11-23 2018-01-10 Ucb Biopharma Sprl Pharmaceutical composition
CN110551215A (zh) * 2018-05-30 2019-12-10 中山康方生物医药有限公司 抗白细胞介素-17a抗体、其药物组合物及其用途
KR20210088611A (ko) * 2018-11-05 2021-07-14 베이징 한미 파마슈티컬 컴퍼니 리미티드 항TNFα/항IL-17A 천연항체 구조 형태의 헤테로다이머 이중특이성 항체 및 그 제조방법
CN109402178B (zh) * 2018-11-16 2021-08-03 佛山科学技术学院 一种小鼠精原干细胞高效重编程的方法及应用
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