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EP4006053A4 - METHOD OF TREATMENT OF AUTOIMMUNE DISEASE BY IL-17 ANTAGONISTS - Google Patents

METHOD OF TREATMENT OF AUTOIMMUNE DISEASE BY IL-17 ANTAGONISTS Download PDF

Info

Publication number
EP4006053A4
EP4006053A4 EP20845895.0A EP20845895A EP4006053A4 EP 4006053 A4 EP4006053 A4 EP 4006053A4 EP 20845895 A EP20845895 A EP 20845895A EP 4006053 A4 EP4006053 A4 EP 4006053A4
Authority
EP
European Patent Office
Prior art keywords
antagonists
treatment
autoimmune disease
autoimmune
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20845895.0A
Other languages
German (de)
French (fr)
Other versions
EP4006053A1 (en
Inventor
Piaoyang Sun
Lianshan Zhang
Jianwen Chen
Qian Xu
Qunjie GAO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of EP4006053A1 publication Critical patent/EP4006053A1/en
Publication of EP4006053A4 publication Critical patent/EP4006053A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
EP20845895.0A 2019-07-30 2020-07-29 METHOD OF TREATMENT OF AUTOIMMUNE DISEASE BY IL-17 ANTAGONISTS Pending EP4006053A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910695261 2019-07-30
CN202010523393 2020-06-10
PCT/CN2020/105510 WO2021018191A1 (en) 2019-07-30 2020-07-29 Method for treating autoimmune disease by il-17 antagonist

Publications (2)

Publication Number Publication Date
EP4006053A1 EP4006053A1 (en) 2022-06-01
EP4006053A4 true EP4006053A4 (en) 2022-10-26

Family

ID=74228555

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20845895.0A Pending EP4006053A4 (en) 2019-07-30 2020-07-29 METHOD OF TREATMENT OF AUTOIMMUNE DISEASE BY IL-17 ANTAGONISTS

Country Status (5)

Country Link
US (1) US20220267432A1 (en)
EP (1) EP4006053A4 (en)
CN (1) CN114127108A (en)
TW (1) TW202114734A (en)
WO (1) WO2021018191A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202241505A (en) * 2021-01-04 2022-11-01 大陸商江蘇恆瑞醫藥股份有限公司 Method for treating autoimmune diseases and inflammation with an anti-il-17 antibody

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3072905A1 (en) * 2013-11-18 2016-09-28 Shanghai Hengrui Pharmaceutical Co. Ltd. Il-17a conjugate and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0417487D0 (en) 2004-08-05 2004-09-08 Novartis Ag Organic compound
ES2672221T3 (en) 2005-12-13 2018-06-13 Eli Lilly And Company IL-17 anti-antibodies
ES2373069T3 (en) 2006-08-11 2012-01-31 Schering Corporation ANTIBODIES FOR IL-17A.
WO2009082624A2 (en) * 2007-12-10 2009-07-02 Zymogenetics, Inc. Antagonists of il-17a, il-17f, and il-23 and methods of using the same
CN102905727B (en) * 2009-10-30 2016-12-07 詹森生物科技公司 IL-17A Antagonist
CN103154031A (en) 2010-10-08 2013-06-12 诺华有限公司 Methods of treating psoriasis using il-17 antagonists
CA2815277A1 (en) * 2010-10-29 2012-05-03 Immunogen, Inc. Novel egfr-binding molecules and immunoconjugates thereof
WO2014001368A1 (en) * 2012-06-25 2014-01-03 Orega Biotech Il-17 antagonist antibodies
HRP20192076T1 (en) * 2013-02-08 2020-02-07 Novartis Ag ANTI-IL-17A ANTIBODIES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
CN106474470B (en) * 2015-08-28 2020-05-22 江苏恒瑞医药股份有限公司 Composition of anti-IL-17A antibody
JP2019505476A (en) * 2015-12-01 2019-02-28 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Combination treatment and method
CN107488227A (en) * 2016-06-12 2017-12-19 三生国健药业（上海）股份有限公司 Anti-human IL-17 A monoclonal antibodies, its preparation method and application
ES2992409T3 (en) * 2016-07-19 2024-12-12 Novartis Ag Treatment methods for new-onset plaque psoriasis using IL-17 antagonists
EA201990673A1 (en) * 2016-09-14 2019-08-30 Бэйцзин Ханми Фарм. Ко., Лтд. ANTIBODIES SPECIFICALLY BINDING WITH IL-17A, AND THEIR FUNCTIONAL FRAGMENTS
CN109206515B (en) * 2017-07-06 2021-10-12 北京伟峰益民科技有限公司 Fully human anti-human interleukin 17A antibody and application thereof
CN109796534B (en) * 2017-11-16 2021-08-10 北京比洋生物技术有限公司 anti-IL-17 antibody/TNFR ECD fusion protein and application thereof
CN109369806B (en) * 2019-01-14 2019-04-19 迈威(上海)生物科技有限公司 The minimizing technology of cysteine variant in Su Jin monoclonal antibody product

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3072905A1 (en) * 2013-11-18 2016-09-28 Shanghai Hengrui Pharmaceutical Co. Ltd. Il-17a conjugate and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GLATT SOPHIE: "Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation", 23 December 2017 (2017-12-23), pages 523 - 532, XP055960145, Retrieved from the Internet <URL:https://ard.bmj.com/content/annrheumdis/77/4/523.full.pdf> [retrieved on 20220912] *
See also references of WO2021018191A1 *
SILFVAST-KAISER ANNIKA ET AL: "Anti-IL17 therapies for psoriasis", vol. 19, no. 1, 31 December 2018 (2018-12-31), pages 45 - 54, XP009539080, ISSN: 1744-7682, Retrieved from the Internet <URL:https://www.tandfonline.com/doi/full/10.1080/14712598.2019.1555235> [retrieved on 20181208], DOI: 10.1080/14712598.2019.1555235 *

Also Published As

Publication number Publication date
TW202114734A (en) 2021-04-16
EP4006053A1 (en) 2022-06-01
WO2021018191A1 (en) 2021-02-04
US20220267432A1 (en) 2022-08-25
CN114127108A (en) 2022-03-01

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