PE20011230A1 - Derivados de imidazol como agonistas de alfa- 2- adrenoreceptores - Google Patents
Derivados de imidazol como agonistas de alfa- 2- adrenoreceptoresInfo
- Publication number
- PE20011230A1 PE20011230A1 PE2001000029A PE2001000029A PE20011230A1 PE 20011230 A1 PE20011230 A1 PE 20011230A1 PE 2001000029 A PE2001000029 A PE 2001000029A PE 2001000029 A PE2001000029 A PE 2001000029A PE 20011230 A1 PE20011230 A1 PE 20011230A1
- Authority
- PE
- Peru
- Prior art keywords
- imidazole derivatives
- alkyl
- alpha
- agonists
- adrenoreceptors
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title abstract 3
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 3
- 239000000556 agonist Substances 0.000 title abstract 2
- -1 1,2,3,4-TETRAHYDRONAPHTHYL Chemical class 0.000 abstract 1
- 206010065508 Orthostatic hypertension Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 abstract 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 230000002366 lipolytic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE IMIDAZOL DE FORMULA I; DONDE: X ES -CH2-(CH2)p-, -O-, =NH, -S-; R1 ES FENILO, NAFTILO, 1,2,3,4-TETRAHIDRONAFTILO, CICLOALQUILO C3-C7, CICLOALQUENILO C5-C7, CICLOALQUINILO C5-C7, HETEROCICLO, ENTRE OTROS; R2, R3, R4 Y R5 SON H, ALQUILO C1-C6; O R5 Y R7 JUNTOS FORMAN UN ENLACE; R6 ES HALOGENO, OH, NH2, HALOALQUILO C1-C6, ALQUILO C1-C6, ENTRE OTROS; R7 ES H, OH, ALQUILO C1-C4; R7 Y R5 JUNTOS FORMAN UN ENLACE; R8 ES OH, ALQUILO C1-C6, HALOALQUILO C1-C6, ALCOXILO C1-C6; m ES 0-3; n, p, r SON 0-1; t ES 0-2. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS DERIVADOS DE IMIDAZOL SON AGONISTAS DE ALFA 2 ADRENORECEPTOR Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE DIABETES, DESORDENES LIPOLITICOS, HIPERTENSION ORTOSTATICA, DISFUNCION SEXUAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20000073A FI20000073A0 (fi) | 2000-01-14 | 2000-01-14 | Uusia imidatsolijohdannaisia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011230A1 true PE20011230A1 (es) | 2001-12-08 |
Family
ID=8557065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000029A PE20011230A1 (es) | 2000-01-14 | 2001-01-12 | Derivados de imidazol como agonistas de alfa- 2- adrenoreceptores |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1261588B1 (es) |
| JP (1) | JP2003519688A (es) |
| KR (1) | KR20020084091A (es) |
| CN (1) | CN1187336C (es) |
| AR (1) | AR029432A1 (es) |
| AT (1) | ATE280161T1 (es) |
| AU (1) | AU769896B2 (es) |
| BR (1) | BR0107644A (es) |
| CA (1) | CA2397283A1 (es) |
| CZ (1) | CZ20022358A3 (es) |
| DE (1) | DE60106572T2 (es) |
| DK (1) | DK1261588T3 (es) |
| EE (1) | EE200200389A (es) |
| ES (1) | ES2228884T3 (es) |
| FI (1) | FI20000073A0 (es) |
| GC (1) | GC0000218A (es) |
| HK (1) | HK1049999B (es) |
| HU (1) | HUP0301008A3 (es) |
| IL (1) | IL150506A0 (es) |
| MX (1) | MXPA02006872A (es) |
| NO (1) | NO323117B1 (es) |
| NZ (1) | NZ519919A (es) |
| PE (1) | PE20011230A1 (es) |
| PL (1) | PL207281B1 (es) |
| PT (1) | PT1261588E (es) |
| RU (1) | RU2265598C2 (es) |
| SI (1) | SI1261588T1 (es) |
| SK (1) | SK286320B6 (es) |
| WO (1) | WO2001051472A1 (es) |
| ZA (1) | ZA200205301B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20002756A0 (fi) * | 2000-12-15 | 2000-12-15 | Orion Yhtymae Oyj | Uusi hoitomenetelmä |
| TW200930291A (en) | 2002-04-29 | 2009-07-16 | Bayer Cropscience Ag | Pesticidal heterocycles |
| FI20022159A0 (fi) * | 2002-12-05 | 2002-12-05 | Orion Corp | Uusia farmaseuttisia yhdisteitä |
| DE102004035322A1 (de) * | 2004-07-21 | 2006-02-16 | Universität des Saarlandes | Selektive Hemmstoffe humaner Corticoidsynthasen |
| EP2076497B1 (en) | 2006-10-19 | 2012-02-22 | F. Hoffmann-La Roche AG | Aminomethyl-4-imidazoles |
| JP2010510184A (ja) | 2006-11-16 | 2010-04-02 | エフ．ホフマン−ラ ロシュ アーゲー | 置換４−イミダゾール類 |
| US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
| AR090557A1 (es) * | 2012-04-02 | 2014-11-19 | Orion Corp | DERIVADOS IMIDAZOLICOS AGONISTAS ADRENERGICOS a2 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2225782A (en) * | 1988-12-09 | 1990-06-13 | Farmos Group Limited | Imidazole derivatives useful for treatment of diabetes |
| GB2244431A (en) * | 1990-05-31 | 1991-12-04 | Farmos Oy | Treatment of age related memory impairment and other cognitive disorders |
| GB9113077D0 (en) * | 1991-06-18 | 1991-08-07 | Orion Yhtymae Oy | Use of atipamezole |
| US5541211A (en) * | 1991-06-18 | 1996-07-30 | Orion-Yhtyma Oy | Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission |
| GB9127050D0 (en) * | 1991-12-20 | 1992-02-19 | Orion Yhtymae Oy | Substituted imidazole derivatives and their preparation and use |
| GB9520150D0 (en) * | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
| DE69823868T2 (de) * | 1997-12-04 | 2005-04-21 | Allergan Inc | Substituierte imidazole derivate mit agonistischähnlicher wirkung auf die alpha 2b oder 2b/2c adrenergischen rezeptoren |
| US6503935B1 (en) * | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
| TWI283669B (en) * | 1999-06-10 | 2007-07-11 | Allergan Inc | Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors |
-
2000
- 2000-01-14 FI FI20000073A patent/FI20000073A0/fi unknown
-
2001
- 2001-01-10 GC GCP20011133 patent/GC0000218A/en active
- 2001-01-12 AR ARP010100140A patent/AR029432A1/es unknown
- 2001-01-12 PE PE2001000029A patent/PE20011230A1/es not_active Application Discontinuation
- 2001-01-12 AT AT01942360T patent/ATE280161T1/de not_active IP Right Cessation
- 2001-01-12 HU HU0301008A patent/HUP0301008A3/hu unknown
- 2001-01-12 EP EP01942360A patent/EP1261588B1/en not_active Expired - Lifetime
- 2001-01-12 SK SK998-2002A patent/SK286320B6/sk not_active IP Right Cessation
- 2001-01-12 JP JP2001551854A patent/JP2003519688A/ja active Pending
- 2001-01-12 NZ NZ519919A patent/NZ519919A/en unknown
- 2001-01-12 DK DK01942360T patent/DK1261588T3/da active
- 2001-01-12 BR BR0107644-2A patent/BR0107644A/pt not_active Application Discontinuation
- 2001-01-12 SI SI200130256T patent/SI1261588T1/xx unknown
- 2001-01-12 AU AU28532/01A patent/AU769896B2/en not_active Ceased
- 2001-01-12 IL IL15050601A patent/IL150506A0/xx not_active IP Right Cessation
- 2001-01-12 RU RU2002121777/04A patent/RU2265598C2/ru not_active IP Right Cessation
- 2001-01-12 KR KR1020027009037A patent/KR20020084091A/ko not_active Ceased
- 2001-01-12 CA CA002397283A patent/CA2397283A1/en not_active Abandoned
- 2001-01-12 CZ CZ20022358A patent/CZ20022358A3/cs unknown
- 2001-01-12 EE EEP200200389A patent/EE200200389A/xx unknown
- 2001-01-12 WO PCT/FI2001/000030 patent/WO2001051472A1/en not_active Ceased
- 2001-01-12 PT PT01942360T patent/PT1261588E/pt unknown
- 2001-01-12 DE DE60106572T patent/DE60106572T2/de not_active Expired - Lifetime
- 2001-01-12 HK HK03102023.4A patent/HK1049999B/zh not_active IP Right Cessation
- 2001-01-12 CN CNB018037194A patent/CN1187336C/zh not_active Expired - Fee Related
- 2001-01-12 MX MXPA02006872A patent/MXPA02006872A/es active IP Right Grant
- 2001-01-12 PL PL356884A patent/PL207281B1/pl not_active IP Right Cessation
- 2001-01-12 ES ES01942360T patent/ES2228884T3/es not_active Expired - Lifetime
-
2002
- 2002-07-02 ZA ZA200205301A patent/ZA200205301B/xx unknown
- 2002-07-08 NO NO20023298A patent/NO323117B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |