PE20010631A1 - Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen - Google Patents
Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienenInfo
- Publication number
- PE20010631A1 PE20010631A1 PE2000001065A PE0010652000A PE20010631A1 PE 20010631 A1 PE20010631 A1 PE 20010631A1 PE 2000001065 A PE2000001065 A PE 2000001065A PE 0010652000 A PE0010652000 A PE 0010652000A PE 20010631 A1 PE20010631 A1 PE 20010631A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- imidazo
- cycloalkyl
- amines
- phenyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- -1 1,1,3,3-TETRAMETHYLBUTYL Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KFRQMVYLVUAVAV-UHFFFAOYSA-N 2h-pyrimidine-1,5-diamine Chemical compound NN1CN=CC(N)=C1 KFRQMVYLVUAVAV-UHFFFAOYSA-N 0.000 abstract 1
- 241000347391 Umbrina cirrosa Species 0.000 abstract 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical group [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 1
- ZHZZWIQPCAMTIM-UHFFFAOYSA-N [C]1=CC=CC2=CC=CC=C12 Chemical class [C]1=CC=CC2=CC=CC=C12 ZHZZWIQPCAMTIM-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical group C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A IMIDAZO-3-IL-AMINAS BICICLICAS DE FORMULA I; DONDE X ES CR4, N; Y ES CR5, N; X E Y NO SON N A LA VEZ; R1 ES (CH2)nCN, FENILO, CICLOALQUILO C4-C8, CH2CH2R, 1,1,3,3-TETRAMETILBUTILO, CH2Ra, ENTRE OTROS; n ES 4-6, R ES 4-MORFOLINO; Ra ES H, OH, ALQUILO C1-C8, ENTRE OTROS; R2 ES H, CORb; Rb ES ALQUILO C1-C4, CICLOALQUILO C3-C8, CH2CH2CO(ORc); Rc ES ALQUILO C1-C4, ADAMANTILO, FENILO, 1-NAFTILO, ENTRE OTROS; R3 ES ALQUILO C1-C8, CICLOALQUILO C3-C8, FENILO, NAFTILO, ENTRE OTROS; R4, R5, R6, R7 SON H, ALQUILO C1-C4, NO2, NH2, OH, CF3, Cl, F, Br, O SON UN PUENTE C1-C4 EVENTUALMENTE CON DOBLES ENLACES, HETEROATOMOS, ENTRE OTROS; TODOS LOS RADICALES QUE NO INTEGREN EL PUENTE SON H; AL MENOS UNO DE R4, R5, R6, R7 NO ES H; CUANDO R1 ES METILO, ETILO, PROPILO, n-BUTILO, ENTRE OTROS; R3 NO ES EMTILO; CUANDO R4, R5, R6, R7 SON O-BENCILO, O R4 ES O-CICLOALQUILO C1-C4; R1 NO ES CH2Ra; Ra ES H, ALQUILO C1-C5. SON COMPUESTOS PREFERIDOS 7-CLORO-2-FURAN-2-IL-(6-ISOCIANOHEXIL)-IMIDAZO[1,2-a]PIRIMIDIN-3,5-DIAMINA, (5,7-DIMETIL-2-PIRIDIN-2-IL-IMIDAZO[1,2-a]PIRIMIDIN-3-IL)-(6-ISOCIANO-HEXIL)-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DEL DOLOR
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19948434A DE19948434A1 (de) | 1999-10-08 | 1999-10-08 | Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine |
| DE1999148437 DE19948437A1 (de) | 1999-10-08 | 1999-10-08 | Am Sechsring substituierte, bicyclische Imidazo-3-aminderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010631A1 true PE20010631A1 (es) | 2001-07-07 |
Family
ID=26055217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001065A PE20010631A1 (es) | 1999-10-08 | 2000-10-06 | Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6849642B2 (es) |
| EP (1) | EP1218380B1 (es) |
| JP (1) | JP2003517466A (es) |
| KR (1) | KR20020038804A (es) |
| CN (1) | CN1222525C (es) |
| AR (1) | AR025961A1 (es) |
| AT (1) | ATE256684T1 (es) |
| AU (1) | AU780823B2 (es) |
| BR (1) | BR0014826A (es) |
| CA (1) | CA2386813C (es) |
| CO (1) | CO5210870A1 (es) |
| CZ (1) | CZ300315B6 (es) |
| DE (1) | DE50004817D1 (es) |
| DK (1) | DK1218380T3 (es) |
| ES (1) | ES2213044T3 (es) |
| HK (1) | HK1047748B (es) |
| HU (1) | HUP0203739A3 (es) |
| IL (2) | IL148998A0 (es) |
| MX (1) | MXPA02003547A (es) |
| NO (1) | NO20021563L (es) |
| NZ (1) | NZ518637A (es) |
| PE (1) | PE20010631A1 (es) |
| PT (1) | PT1218380E (es) |
| RU (1) | RU2002110282A (es) |
| SK (1) | SK286450B6 (es) |
| UY (1) | UY26371A1 (es) |
| WO (1) | WO2001027110A2 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10043845A1 (de) * | 2000-09-06 | 2002-03-14 | Gruenenthal Gmbh | Verfahren zur Messung der Aktivität der NO-Synthase |
| WO2002048146A2 (de) * | 2000-12-13 | 2002-06-20 | Basf Aktiengesellschaft | Verwendung von substituierten imidazoazinen, neue imidazoazine, verfahren zu deren herstellung, sowie sie enthaltende mittel |
| US7157460B2 (en) | 2003-02-20 | 2007-01-02 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| US7186832B2 (en) | 2003-02-20 | 2007-03-06 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| DE102004021716A1 (de) * | 2004-04-30 | 2005-12-01 | Grünenthal GmbH | Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen |
| DE102004044884A1 (de) * | 2004-09-14 | 2006-05-24 | Grünenthal GmbH | Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen |
| DE102005016547A1 (de) * | 2005-04-08 | 2006-10-12 | Grünenthal GmbH | Substituierte 5,6,7,8-Tetrahydro-imidazo(1,2-a)pyridin-2-ylamin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| US7709468B2 (en) | 2005-09-02 | 2010-05-04 | Abbott Laboratories | Imidazo based heterocycles |
| MX2008015057A (es) * | 2006-05-31 | 2008-12-10 | Galapagos Nv | Compuestos de triazolopirazina utiles para el tratamiento de enfermedades degenerativas e inflamatorias. |
| WO2008134553A1 (en) * | 2007-04-26 | 2008-11-06 | Xenon Pharmaceuticals Inc. | Methods of using bicyclic compounds in treating sodium channel-mediated diseases |
| CA2693232A1 (en) | 2007-07-18 | 2009-01-22 | Novartis Ag | Bicyclic heteroaryl compounds and their use as kinase inhibitors |
| KR101573091B1 (ko) * | 2007-11-16 | 2015-11-30 | 리겔 파마슈티칼스, 인크. | 대사성 장애를 위한 카르복스아미드, 술폰아미드 및 아민 화합물 |
| US8129390B2 (en) * | 2007-12-12 | 2012-03-06 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds and methods for using the same |
| PT2266990E (pt) * | 2008-04-15 | 2012-12-27 | Eisai R&D Man Co Ltd | Composto de 3-fenilpirazolo[5,1-b]tiazole |
| ES2552549T3 (es) * | 2008-04-23 | 2015-11-30 | Rigel Pharmaceuticals, Inc. | Compuestos de carboxamida para el tratamiento de trastornos metabólicos |
| CN102216298B (zh) * | 2008-09-16 | 2014-04-16 | Csir公司 | 作为hiv-1逆转录酶抑制剂的咪唑并吡啶和咪唑并嘧啶 |
| EP2417136B1 (en) * | 2009-04-07 | 2016-01-06 | University Of Witwatersrand, Johannesburg | Imidazo [1,2-a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture |
| AR078521A1 (es) * | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
| PH12012501841B1 (en) * | 2010-03-18 | 2018-01-12 | Inst Nat Sante Rech Med | Anti-infective compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489755A (en) | 1966-08-03 | 1970-01-13 | Pfizer & Co C | Imidazo (1,2-b) pyridazines |
| DE3269604D1 (en) | 1981-06-26 | 1986-04-10 | Schering Corp | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| EP0266890A1 (en) * | 1986-10-07 | 1988-05-11 | Yamanouchi Pharmaceutical Co. Ltd. | Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them |
| TW274551B (es) * | 1991-04-16 | 1996-04-21 | Takeda Pharm Industry Co Ltd | |
| EP0822194A4 (en) * | 1995-04-21 | 1998-04-29 | Shinnippon Pharmaceutical Inc | ANNELLLIED IMIDAZO [1,2-a] PYRIDINE |
-
2000
- 2000-09-18 EP EP00964191A patent/EP1218380B1/de not_active Expired - Lifetime
- 2000-09-18 MX MXPA02003547A patent/MXPA02003547A/es active IP Right Grant
- 2000-09-18 ES ES00964191T patent/ES2213044T3/es not_active Expired - Lifetime
- 2000-09-18 DE DE50004817T patent/DE50004817D1/de not_active Expired - Lifetime
- 2000-09-18 KR KR1020027004504A patent/KR20020038804A/ko not_active Withdrawn
- 2000-09-18 AU AU75199/00A patent/AU780823B2/en not_active Ceased
- 2000-09-18 IL IL14899800A patent/IL148998A0/xx active IP Right Grant
- 2000-09-18 AT AT00964191T patent/ATE256684T1/de active
- 2000-09-18 SK SK461-2002A patent/SK286450B6/sk not_active IP Right Cessation
- 2000-09-18 CZ CZ20021243A patent/CZ300315B6/cs not_active IP Right Cessation
- 2000-09-18 NZ NZ518637A patent/NZ518637A/xx unknown
- 2000-09-18 CN CNB008164304A patent/CN1222525C/zh not_active Expired - Fee Related
- 2000-09-18 PT PT00964191T patent/PT1218380E/pt unknown
- 2000-09-18 HK HK02109383.4A patent/HK1047748B/zh not_active IP Right Cessation
- 2000-09-18 HU HU0203739A patent/HUP0203739A3/hu unknown
- 2000-09-18 CA CA002386813A patent/CA2386813C/en not_active Expired - Fee Related
- 2000-09-18 JP JP2001530328A patent/JP2003517466A/ja not_active Withdrawn
- 2000-09-18 RU RU2002110282/04A patent/RU2002110282A/ru not_active Application Discontinuation
- 2000-09-18 BR BR0014826-1A patent/BR0014826A/pt not_active IP Right Cessation
- 2000-09-18 WO PCT/EP2000/009095 patent/WO2001027110A2/de not_active Ceased
- 2000-09-18 DK DK00964191T patent/DK1218380T3/da active
- 2000-10-02 CO CO00074643A patent/CO5210870A1/es not_active Application Discontinuation
- 2000-10-05 UY UY26371A patent/UY26371A1/es not_active Application Discontinuation
- 2000-10-05 AR ARP000105253A patent/AR025961A1/es unknown
- 2000-10-06 PE PE2000001065A patent/PE20010631A1/es not_active Application Discontinuation
-
2002
- 2002-04-03 NO NO20021563A patent/NO20021563L/no not_active Application Discontinuation
- 2002-04-04 IL IL148998A patent/IL148998A/en not_active IP Right Cessation
- 2002-04-08 US US10/117,334 patent/US6849642B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |