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PE20010921A1 - Composiciones inhibidoras de ciclooxigenasa-2 que tienen un inicio rapido del efecto terapeutico - Google Patents

Composiciones inhibidoras de ciclooxigenasa-2 que tienen un inicio rapido del efecto terapeutico

Info

Publication number
PE20010921A1
PE20010921A1 PE2000001301A PE0013012000A PE20010921A1 PE 20010921 A1 PE20010921 A1 PE 20010921A1 PE 2000001301 A PE2000001301 A PE 2000001301A PE 0013012000 A PE0013012000 A PE 0013012000A PE 20010921 A1 PE20010921 A1 PE 20010921A1
Authority
PE
Peru
Prior art keywords
cyclooxygenase
therapeutic effect
phenyl
methyl
rapid onset
Prior art date
Application number
PE2000001301A
Other languages
English (en)
Inventor
Subhash Desai
Tugrul T Kararli
Mark J Kontny
Michael J Hageman
Royal J Haskell Iii
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46125549&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20010921(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of PE20010921A1 publication Critical patent/PE20010921A1/es

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    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONTIENE UN INHIBIDOR DE CICLOOXIGENASA 2 DE BAJA SOLUBILIDAD DE FORMULA I, DONDE Ra ES METILO, AMINO; R4 ES H, ALQUILO C1-C4; ALCOXI; X ES N, CR5; R5 ES H, HALOGENO; Y Y Z SON C, N; TAL COMO CELECOXIB, DERACOXIB, VALDECOXIB, ROFECOXIB, 5-(CLORO-3-(4-METILSULFONIL)FENIL-2-(2-METIL-5-PIRIDINIL)PIRIDINA, 2-(3,5-DIFLUOROFENIL)-3-[4-(METILSULFONIL)FENIL]-2-CICLOPENTEN-1-ONA, (S)-6,8-DICLORO-2-(TRIFLUOROMETIL)-2H-1-BENZOPIRAN-3-ACIDO CARBOXILICO SE CARACTERIZA PORQUE LA DROGA ESTA PRESENTE EN TAMANO DE PARTICULAS D90 DE 0,01µm A 200µm; O D25 DE 450nm A 1000nm; UNA PORCION SUFICIENTE DE PARTICULAS QUE SON MENORES DE 1µm PARA DAR UNA CONCENTRACION MAXIMA MAYOR O TIEMPO MAXIMO MAS CORTO EN COMPARACION CON OTRA COMPOSICION DE TAMANO DE PARTICULAS MAYOR A 1µm. LA COMPOSICION PUEDE SER UTIL CUANDO SE DESEA UN RAPIDO INICIO DEL EFECTO
PE2000001301A 1999-12-08 2000-12-06 Composiciones inhibidoras de ciclooxigenasa-2 que tienen un inicio rapido del efecto terapeutico PE20010921A1 (es)

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