PT946507E - Compostos de pirrolilo substituidos para o tratamento da inflamacao - Google Patents
Compostos de pirrolilo substituidos para o tratamento da inflamacaoInfo
- Publication number
- PT946507E PT946507E PT97950891T PT97950891T PT946507E PT 946507 E PT946507 E PT 946507E PT 97950891 T PT97950891 T PT 97950891T PT 97950891 T PT97950891 T PT 97950891T PT 946507 E PT946507 E PT 946507E
- Authority
- PT
- Portugal
- Prior art keywords
- inflammation
- compounds
- pyrrolylic
- substituted
- treatment
- Prior art date
Links
- 206010061218 Inflammation Diseases 0.000 title abstract 3
- 230000004054 inflammatory process Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3268896P | 1996-12-10 | 1996-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT946507E true PT946507E (pt) | 2004-02-27 |
Family
ID=21866300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97950891T PT946507E (pt) | 1996-12-10 | 1997-12-09 | Compostos de pirrolilo substituidos para o tratamento da inflamacao |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5935990A (pt) |
| EP (1) | EP0946507B1 (pt) |
| AT (1) | ATE250576T1 (pt) |
| AU (1) | AU5377698A (pt) |
| CA (1) | CA2273836A1 (pt) |
| DE (1) | DE69725171T2 (pt) |
| DK (1) | DK0946507T3 (pt) |
| ES (1) | ES2208964T3 (pt) |
| PT (1) | PT946507E (pt) |
| WO (1) | WO1998025896A1 (pt) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3995716B2 (ja) * | 1996-03-18 | 2007-10-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合環含有カルボン酸誘導体 |
| US5908858A (en) * | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
| US6887893B1 (en) | 1997-12-24 | 2005-05-03 | Sankyo Company, Limited | Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cachexia |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6649645B1 (en) | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
| DE19953025A1 (de) | 1999-11-04 | 2001-05-10 | Merck Patent Gmbh | Pyrrolderivate als Phosphodiesterase VII-Hemmer |
| IL144760A0 (en) * | 1999-12-08 | 2002-06-30 | Pharmacia Corp | Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
| JP2003523958A (ja) | 1999-12-23 | 2003-08-12 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法 |
| DE19963174A1 (de) * | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Pyrrol-Mannichbasen |
| WO2001054688A1 (en) | 2000-01-28 | 2001-08-02 | Merck & Co., Inc. | Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug |
| EP1276736A2 (en) * | 2000-04-25 | 2003-01-22 | Pharmacia Corporation | Regioselective synthesis of 3,4-di(carbocyclyl or heterocyclyl)thiophenes |
| US20020128267A1 (en) * | 2000-07-13 | 2002-09-12 | Rebanta Bandyopadhyay | Method of using COX-2 inhibitors in the treatment and prevention of ocular COX-2 mediated disorders |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| US7695736B2 (en) | 2001-04-03 | 2010-04-13 | Pfizer Inc. | Reconstitutable parenteral composition |
| US6673818B2 (en) | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
| UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
| AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| EP1492757A1 (en) | 2002-04-08 | 2005-01-05 | Glaxo Group Limited | (2-((2-alkoxy)-phenyl)-cyclopent-1-enyl) aromatic carbo- and heterocyclic carboxylic acid and derivatives |
| US7622117B2 (en) * | 2002-04-17 | 2009-11-24 | Dynamis Therapeutics, Inc. | 3-deoxyglucosone and skin |
| GB0212785D0 (en) * | 2002-05-31 | 2002-07-10 | Glaxo Group Ltd | Compounds |
| EP1544196B1 (en) * | 2002-08-20 | 2012-04-25 | Daiichi Sankyo Company, Limited | Process for the production of gamma-keto acetals |
| JP4601274B2 (ja) * | 2002-08-20 | 2010-12-22 | 第一三共株式会社 | γ−ケトアセタール類の製造方法 |
| GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
| JP4654035B2 (ja) | 2002-11-05 | 2011-03-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
| DE10261130A1 (de) * | 2002-12-20 | 2004-07-01 | Grünenthal GmbH | Arzneimittel enthaltend substituierte 2,5-Diaminomethyl-1H-pyrrole |
| WO2004098618A2 (en) * | 2003-05-07 | 2004-11-18 | Osteologix A/S | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
| ES2275218T3 (es) * | 2003-05-07 | 2007-06-01 | Osteologix A/S | Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos. |
| US20050131028A1 (en) * | 2003-09-11 | 2005-06-16 | Pharmacia Corporation | Methods and compositions for the extended duration treatment of pain, inflammation and inflammation-related disorders |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| GB0328024D0 (en) * | 2003-12-03 | 2004-01-07 | Glaxo Group Ltd | Compounds |
| CA2593982A1 (en) * | 2005-01-05 | 2006-07-13 | Novacea, Inc. | Prevention of thrombotic disorders with active vitamin d compounds or mimics thereof |
| FR2887548B1 (fr) * | 2005-06-27 | 2007-09-21 | Sanofi Aventis Sa | Derives de 4,5-diarylpyrrole, leur preparation et leur application en therapeutique |
| EP1928827B1 (en) * | 2005-09-27 | 2012-08-22 | Myriad Genetics, Inc. | Pyrrole derivatives as therapeutic compounds |
| JP4975758B2 (ja) * | 2005-12-27 | 2012-07-11 | ウニベルシダッド、デル、パイス、バスコ‐エウスカル、エリコ、ウニベルトシタテア、（ウペウベ‐エアチェウ） | ヒストンデアセチラーゼ阻害活性を有する新規ピロール誘導体 |
| TW200813000A (en) * | 2006-06-27 | 2008-03-16 | Abbott Lab | Thiazoline and oxazoline derivatives and their methods of use |
| ES2555511T3 (es) | 2006-08-03 | 2016-01-04 | Rottapharm Biotech S.R.L. | Inhibidores de COX-2 altamente selectivos y eficaces por vía oral de 1,5-diaril-2-alquil-pirroles 3-sustituidos |
| WO2008031034A2 (en) * | 2006-09-07 | 2008-03-13 | Myriad Genetics, Inc. | Therapeutic compounds for diseases and disorders |
| EP2170062A4 (en) | 2007-07-12 | 2010-12-29 | Tragara Pharmaceuticals Inc | METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER DISORDERS, TUMORS AND TUMOR-DISORDED DISEASES |
| HRP20170019T1 (hr) | 2008-08-15 | 2017-03-10 | Nivalis Therapeutics, Inc. | Novi pirol-inhibitori od reduktaze s-nitrozoglutationa kao terapeutska sredstva |
| WO2010019909A1 (en) | 2008-08-15 | 2010-02-18 | N30 Pharmaceuticals, Llc | Pyrrole inhibitors of s-nitrosoglutathione reductase |
| EP2318007B1 (en) * | 2008-08-15 | 2013-01-23 | N30 Pharmaceuticals, Inc. | Novel pyrrole inhibitors of s-nitrosoglutathione reductase as therapeutic agents |
| WO2016149126A1 (en) | 2015-03-13 | 2016-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Ltb4 inhibition to prevent and treat human lymphedema |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3168531A (en) * | 1963-06-12 | 1965-02-02 | Parke Davis & Co | 1-aryl-5-(p-lower alkoxyphenyl)-pyrrole-2-propionic acid compounds |
| BE633582A (pt) * | 1963-06-13 | |||
| US3427305A (en) * | 1966-11-01 | 1969-02-11 | Searle & Co | 5 - ((halo/alkoxy)phenyl) - 1 - (p - sulfonamido(phenyl/benzyl)) - 2 - pyrrolepropionic acids |
| US3531497A (en) * | 1967-02-21 | 1970-09-29 | Upjohn Co | 2,4,5 - triphenyl - (and substituted triphenyl) - 3 - acetonitriles of pyrrole |
| DE1938904A1 (de) * | 1968-08-02 | 1970-02-05 | Innothera Lab Sa | 1-Phenylpyrrole |
| US5187185A (en) * | 1988-12-09 | 1993-02-16 | Rhone-Poulenc Ag Company | Pesticidal 1-arylpyrroles |
| DE2261965A1 (de) * | 1971-12-23 | 1973-06-28 | Continental Pharma | Derivate der pyrrolessigsaeure und deren salze sowie von pyrrolacetonitril, verfahren zur herstellung dieser verbindungen, diese verbindungen enthaltende pharmazeutische produkte und verwendung dieser verbindungen und produkte |
| US4267184A (en) * | 1979-02-08 | 1981-05-12 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-(substituted-thio)pyrroles and their corresponding sulfoxides and sulfones |
| US4335136A (en) * | 1980-04-18 | 1982-06-15 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines |
| US4267190A (en) * | 1980-04-18 | 1981-05-12 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-α,α-bis(polyfluoromethyl)-1H-pyrrole-2-methanethiols |
| US4652582A (en) * | 1985-01-09 | 1987-03-24 | E. I. Du Pont De Nemours And Company | Antiinflammatory-2-halo-4,5-diarylpyrroles |
| US4694018A (en) * | 1985-11-29 | 1987-09-15 | G. D. Serale & Co. | Substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives |
| DE3739882A1 (de) * | 1987-11-25 | 1989-06-08 | Bayer Ag | Substituierte hydroxylamine |
| AU641905B2 (en) * | 1988-12-09 | 1993-10-07 | Rhone-Poulenc Agrochimie | 1-substituted-phenyl pyrrole derivatives as insecticides and methods for their production |
| US5096919A (en) * | 1989-01-05 | 1992-03-17 | Ciba-Geigy Corporation | Pyrrolylphenyl-substituted hydroxamic acid derivatives |
| DE4036706A1 (de) * | 1990-11-17 | 1992-05-21 | Hoechst Ag | Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie |
| US5128485A (en) * | 1990-12-17 | 1992-07-07 | American Cyanamid Company | Synthesis of 2-aryl-5-(trifluoromethyl)pyrroles useful as pesticidal agents and as intermediates for the preparation of said agents |
| ES2131044T3 (es) * | 1990-12-26 | 1999-07-16 | American Cyanamid Co | Procedimiento para la preparacion de compuestos 2-aril-5-(trifluorometil)pirrol 1-sustituidos utiles como agentes insecticidas, acaricidas y nematocidas y como intermedios para la fabricacion de dichos agentes. |
| US5144041A (en) * | 1990-12-26 | 1992-09-01 | American Cyanamid Company | Process for the preparation of 2-aryl-1-substituted-5-(trifluoromethyl) pyrrole compounds useful as insecticidal, acaricidal and nematocidal agents and as intermediates for the manufacture of said agents |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| CA2152792C (en) * | 1993-01-15 | 2000-02-15 | Stephen R. Bertenshaw | Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5908858A (en) * | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
-
1997
- 1997-12-09 ES ES97950891T patent/ES2208964T3/es not_active Expired - Lifetime
- 1997-12-09 AU AU53776/98A patent/AU5377698A/en not_active Abandoned
- 1997-12-09 CA CA002273836A patent/CA2273836A1/en not_active Abandoned
- 1997-12-09 US US08/987,356 patent/US5935990A/en not_active Expired - Fee Related
- 1997-12-09 DK DK97950891T patent/DK0946507T3/da active
- 1997-12-09 AT AT97950891T patent/ATE250576T1/de not_active IP Right Cessation
- 1997-12-09 WO PCT/US1997/022488 patent/WO1998025896A1/en not_active Ceased
- 1997-12-09 PT PT97950891T patent/PT946507E/pt unknown
- 1997-12-09 EP EP97950891A patent/EP0946507B1/en not_active Expired - Lifetime
- 1997-12-09 DE DE69725171T patent/DE69725171T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE250576T1 (de) | 2003-10-15 |
| AU5377698A (en) | 1998-07-03 |
| WO1998025896A1 (en) | 1998-06-18 |
| DE69725171T2 (de) | 2004-07-15 |
| US5935990A (en) | 1999-08-10 |
| CA2273836A1 (en) | 1998-06-18 |
| ES2208964T3 (es) | 2004-06-16 |
| EP0946507B1 (en) | 2003-09-24 |
| DK0946507T3 (da) | 2004-01-26 |
| DE69725171D1 (de) | 2003-10-30 |
| EP0946507A1 (en) | 1999-10-06 |
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