[go: up one dir, main page]

ES2221950T3 - Dihidrobenzofurano y compuestos relacionados utiles como agentes anti-inflamatorios. - Google Patents

Dihidrobenzofurano y compuestos relacionados utiles como agentes anti-inflamatorios.

Info

Publication number
ES2221950T3
ES2221950T3 ES97904019T ES97904019T ES2221950T3 ES 2221950 T3 ES2221950 T3 ES 2221950T3 ES 97904019 T ES97904019 T ES 97904019T ES 97904019 T ES97904019 T ES 97904019T ES 2221950 T3 ES2221950 T3 ES 2221950T3
Authority
ES
Spain
Prior art keywords
dihydrobenzofuran
inflammatory agents
compounds useful
related compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97904019T
Other languages
English (en)
Inventor
Laurence Ichih Wu
John Michael Janusz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Application granted granted Critical
Publication of ES2221950T3 publication Critical patent/ES2221950T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN COMPUESTO DE ESTRUCTURA (I), DONDE (A) N ESTA COMPRENDIDO ENTRE 1 Y APROX. 3; (B) X SE SELECCIONA A PARTIR DEL GRUPO FORMADO POR O, S, SO O SO 2 ; (C) Y ES INDEPENDIENTEMENTE HIDROGENO O ALQUILO LINEAL, RAMIFICADO O CICLICO QUE TIENE DE 1 A 4 ATOMOS DE CARBONO, O BIEN LAS YES ESTAN UNIDAS ENTRE SI FORMANDO UN CICLO DE ALCANILO QUE TIENE ENTRE 3 Y 7 ATOMOS DISTINTOS DEL HIDROGENO; (D) Z ES HIDROGENO O ALQUILO LINEAL, RAMIFICADO O CICLICO, TENIENDO Z ENTRE 3 Y APROX. 10 ATOMOS DISTINTOS DEL HIDROGENO; (E) R 1 ES HIDRO GENO O ALQUILO LINEAL, RAMIFICADO O CICLICO, HALO, CARBOXILO, CARBOXAMIDO, ALCOXICARBONILO O ALQUILCARBONILO; (F) T ES O O S; (G) U ES O, S, N O N - R 2 ; (H) W ES CR 3 R 4 , C = O, C = S, C = NR 5 , C - O - R 6 , C - S - R 6, C - NH 2 , C - NH -R 7 O C NR 6 R 7 ; (I) V ES (CH 2 ) M , O, S, O N R 2 ; (J) R 2 ES HIDROGENO, ALQUILO, HALO, HIDROXILO, ALCOXI, MERCAPTO, ALQUILTIO O CIANO; (L) R 5 ES HIDROGENO, ALQUILO, HIDROXILO O ALCOXI; (J) R 6 ES HIDROGENO O ALQUILO; Y (K) R 7 ES HID ROGENO, ALQUILO O C (= NH) N (R 6 ) 2 . LA INVENCION INCLUYE LAS COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN DICHOS COMPUESTOS Y METODOS PARA TRATAR LA INFLAMACION O EL DOLOR, UTILIZANDO DICHOS COMPUESTOS.
ES97904019T 1996-02-01 1997-01-30 Dihidrobenzofurano y compuestos relacionados utiles como agentes anti-inflamatorios. Expired - Lifetime ES2221950T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/595,337 US5618835A (en) 1996-02-01 1996-02-01 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
ES2221950T3 true ES2221950T3 (es) 2005-01-16

Family

ID=24382842

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97904019T Expired - Lifetime ES2221950T3 (es) 1996-02-01 1997-01-30 Dihidrobenzofurano y compuestos relacionados utiles como agentes anti-inflamatorios.

Country Status (15)

Country Link
US (1) US5618835A (es)
EP (1) EP0888323B1 (es)
JP (1) JP3095424B2 (es)
KR (1) KR100322402B1 (es)
CN (1) CN1125062C (es)
AT (1) ATE267187T1 (es)
AU (1) AU730262B2 (es)
BR (1) BR9707247A (es)
CA (1) CA2244203A1 (es)
DE (1) DE69729183T2 (es)
DK (1) DK0888323T3 (es)
ES (1) ES2221950T3 (es)
MX (1) MX9806250A (es)
NO (1) NO983530L (es)
WO (1) WO1997028147A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039967A1 (en) * 1997-03-12 1998-09-17 The General Hospital Corporation A method for treating or preventing alzheimer's disease
US6281229B1 (en) * 1997-06-27 2001-08-28 Kaneka Corporation Heat shock factor activity inhibitors
EP1026162A4 (en) 1997-10-24 2001-01-17 Shionogi & Co ANTI-RHUMATISMAL AGENT
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
US6191154B1 (en) 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
ES2315365T3 (es) 2001-06-13 2009-04-01 Magnachem International Laboratories, Inc. Formulaciones de lactona y metodo de uso.
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
US8188145B2 (en) 2002-06-12 2012-05-29 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
US7323495B2 (en) 2002-11-05 2008-01-29 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
ES2315566T3 (es) * 2002-11-22 2009-04-01 Smithkline Beecham Corporation Tiazolidin-4-onas para inhibir proteinas hyak3.
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
PE20070083A1 (es) * 2005-06-08 2007-01-27 Smithkline Beecham Corp (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)amino]-1,3-tiazol-4(5h)-ona
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
US20100286041A1 (en) * 2007-03-22 2010-11-11 Smithkline Beecham Corporation (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one
MX2011004331A (es) 2008-10-24 2011-09-21 Magnachem Int Lab Inc Metodo para busqueda de compuestos que interactuan selectivamente con rad9.
JP5483601B2 (ja) 2009-01-27 2014-05-07 国立大学法人名古屋大学 膜張力測定装置
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019305B2 (ja) * 1976-07-02 1985-05-15 ウェルファイド株式会社 ジヒドロベンゾフラン誘導体
IT1093805B (it) * 1978-01-31 1985-07-26 Erba Carlo Spa Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
US4470440A (en) * 1982-09-30 1984-09-11 Thor Harry A Impact producing tool
DE3777366D1 (de) * 1986-12-27 1992-04-16 Takeda Chemical Industries Ltd 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
FR2645537B1 (fr) * 1989-04-05 1994-03-04 Fabre Medicament Pierre Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique
US4975457A (en) * 1989-09-25 1990-12-04 Merck & Co., Inc. Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis
KR920701190A (ko) * 1989-11-17 1992-08-11 나까야마 히사시 벤조푸란유도체, 그의 제조법 및 이를 유효성분으로 하는 의약
US5091533A (en) * 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
EP0522000A1 (en) * 1990-03-27 1993-01-13 Smithkline Beecham Corporation 5-lipoxygenase inhibitors
NZ290080A (en) * 1994-07-27 1999-04-29 Procter & Gamble Dihydrobenzo(thio)furan derivatives and pharmaceutical compositions
US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents

Also Published As

Publication number Publication date
AU730262B2 (en) 2001-03-01
NO983530D0 (no) 1998-07-31
CN1210530A (zh) 1999-03-10
KR19990082222A (ko) 1999-11-25
KR100322402B1 (ko) 2002-05-09
DK0888323T3 (da) 2004-08-09
US5618835A (en) 1997-04-08
NO983530L (no) 1998-09-30
AU1843397A (en) 1997-08-22
JPH11506121A (ja) 1999-06-02
EP0888323B1 (en) 2004-05-19
DE69729183T2 (de) 2004-10-07
JP3095424B2 (ja) 2000-10-03
MX9806250A (es) 1998-11-30
ATE267187T1 (de) 2004-06-15
CN1125062C (zh) 2003-10-22
WO1997028147A1 (en) 1997-08-07
DE69729183D1 (de) 2004-06-24
EP0888323A1 (en) 1999-01-07
BR9707247A (pt) 1999-07-20
CA2244203A1 (en) 1997-08-07

Similar Documents

Publication Publication Date Title
ES2221950T3 (es) Dihidrobenzofurano y compuestos relacionados utiles como agentes anti-inflamatorios.
SE9504661D0 (sv) New compounds
FI973828A0 (fi) Yhdisteitä ja koostumuksia aktiivisten aineiden annostelemiseksi
EE04799B1 (et) Ühendid, mis on kasulikud põletikuvastaste vahenditena, nende ühendite valmistamise meetodid ja neid sisaldavad farmatseutilised kompositsioonid
DE122009000012I1 (de) Substituierte pyrazolyl-benzolsulfonamide zur behandlung von entzundungen.
DE69739583D1 (de) Topische zusammensetzungen enthaltend als therapeutisch aktiven wirkstoff ein monoglycerid zur behandlung von schleimhautinfektionen
TR200100922T2 (tr) Aktif maddelerin akciğerler yolu ile tatbik edilmesi.
AR004357A1 (es) Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol, y procedimiento de preparacion para dichos compuestos.
EA200000920A1 (ru) Производные бициклических гидроксамовых кислот
FI970810A0 (fi) Ionipolymeerejä sisältäviä biologisesti aktiivisia anioneja
PT902789E (pt) Derivados de androsteno
DE69919179D1 (de) Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen
SE9802208D0 (sv) Novel compounds
EA200400041A1 (ru) Сочетание действующих ингредиентов, используемое в качестве вызывающего привыкание фармакологического средства или для интоксикационной терапии
SE9801494D0 (sv) Novel use
ID18832A (id) Komposisi insektisida
ID29966A (id) Sulfoniloksazolamina-sulfoniloksazolamina sebagai senyawa-senyawa aktif terapi
BR9611472A (pt) Compostos de di-terc-butilfenol contendo enxofre úteis como agentes antiinflamatórios
ID17875A (id) Komposisi farmasi yang mengandung asam 4-oksobutanoat
SE9802209D0 (sv) Novel compounds
SE9504662D0 (sv) New compounds
BG100248A (bg) Инхибитори на скваленсинтетаза
NO982562D0 (no) Sammensetning for behandling av smerte
BR9707249A (pt) Dihidrobenzofurano e composto correlatos uteis como agentes antiinflamatorios
ITRM920305A1 (it) Composizione farmaceutica per il trattamento dello shock, particolarmente dello shock cardiogeno e dello shock settico.