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PA8850301A1 - Nuevas octahidrociclopenta[c]pirrol-4-aminas sustituidas como bloqueantes de los canales de calcio - Google Patents

Nuevas octahidrociclopenta[c]pirrol-4-aminas sustituidas como bloqueantes de los canales de calcio

Info

Publication number
PA8850301A1
PA8850301A1 PA20098850301A PA8850301A PA8850301A1 PA 8850301 A1 PA8850301 A1 PA 8850301A1 PA 20098850301 A PA20098850301 A PA 20098850301A PA 8850301 A PA8850301 A PA 8850301A PA 8850301 A1 PA8850301 A1 PA 8850301A1
Authority
PA
Panama
Prior art keywords
octahydrociclopenta
aminas
pirrol
blockers
replaced
Prior art date
Application number
PA20098850301A
Other languages
English (en)
Inventor
Didomenico Stanley
O Stewart Andrew
B Searle Xenia
Darczak Daria
C Yeung Ming
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42124348&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8850301(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of PA8850301A1 publication Critical patent/PA8850301A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

INHIBIDORES QUE CONTIENEN COMPUESTOS DE LA FÓRMULA (I) EN DONDE L1, L2, R1, R2 Y R3 SON COMO SE DEFINEN EN LA MEMORIA DESCRIPTIVA. LA PRESENTE SOLICITUD TAMBIÉN SE RELACIONA COM COMPOSICIONES QUE COMPRENDEN DICHOS COMPUESTOS, Y MÉTODOS DE TRATAMIENTO DE CONDICIONES Y TRASTORNOS USANDO TALES COMPUESTOS Y COMPOSICIONES.
PA20098850301A 2008-11-26 2009-11-25 Nuevas octahidrociclopenta[c]pirrol-4-aminas sustituidas como bloqueantes de los canales de calcio PA8850301A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11799508P 2008-11-26 2008-11-26

Publications (1)

Publication Number Publication Date
PA8850301A1 true PA8850301A1 (es) 2010-07-27

Family

ID=42124348

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20098850301A PA8850301A1 (es) 2008-11-26 2009-11-25 Nuevas octahidrociclopenta[c]pirrol-4-aminas sustituidas como bloqueantes de los canales de calcio

Country Status (23)

Country Link
US (1) US8129417B2 (es)
EP (1) EP2367790A2 (es)
JP (1) JP2012509940A (es)
KR (1) KR20110091784A (es)
CN (1) CN102292319A (es)
AR (1) AR074226A1 (es)
AU (1) AU2009319796A1 (es)
BR (1) BRPI0921184A2 (es)
CA (1) CA2742350A1 (es)
CL (1) CL2011001176A1 (es)
CO (1) CO6382118A2 (es)
CR (1) CR20110304A (es)
EC (1) ECSP11011160A (es)
IL (1) IL212484A0 (es)
MX (1) MX2011005537A (es)
NZ (1) NZ592507A (es)
PA (1) PA8850301A1 (es)
PE (1) PE20110833A1 (es)
RU (1) RU2011126215A (es)
TW (1) TW201028378A (es)
UY (1) UY32261A (es)
WO (1) WO2010062927A2 (es)
ZA (1) ZA201103538B (es)

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TW201028378A (en) 2008-11-26 2010-08-01 Abbott Lab Novel substituted octahydrocyclopenta[c]pyrrol-4-amines as calcium channel blockers
WO2010068851A1 (en) * 2008-12-12 2010-06-17 Vanderbilt Universtiy 3.3.0 bicyclic glyt1 inhibitors and methods of making and using same
WO2011115813A1 (en) * 2010-03-18 2011-09-22 Abbott Laboratories Lactam acetamides as calcium channel blockers
WO2011149993A2 (en) * 2010-05-25 2011-12-01 Abbott Laboratories SUBSTITUTED OCTAHYDROCYCLOPENTA[c]PYRROLES AS CALCIUM CHANNEL MODULATORS
WO2011149995A1 (en) * 2010-05-25 2011-12-01 Abbott Laboratories Novel substituted octahydrocyclopenta [c]pyrrol-4-amines as calcium channel blockers
FR2976285B1 (fr) * 2011-06-08 2013-05-24 Servier Lab Procede de synthese et forme cristalline du chlorhydrate de 4-{3-[cis-hexahydrocypenta[c]pyrrol-2(1h)-yl]propoxy}benzamide ainsi que les compositions pharmaceutiques qui la contiennent
US8669255B2 (en) 2011-09-29 2014-03-11 Abbvie Inc. Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers
TW201321384A (zh) 2011-09-29 2013-06-01 Abbvie Inc 作為鈣通道阻斷劑之經取代之八氫吡咯并［１，２－ａ］吡□磺醯胺
US9029361B2 (en) 2012-12-12 2015-05-12 Abbvie Inc. Agents for treating pain and uses thereof
WO2017063563A1 (zh) * 2015-10-13 2017-04-20 四川海思科制药有限公司 一种八氢环戊烷并[c]吡咯衍生物及其制备方法和在医药上的用途
MA50245A (fr) * 2017-09-11 2020-07-22 Krouzon Pharmaceuticals Inc Inhibiteurs allostériques octahydrocyclopenta[c]pyrrole de shp2
CA3091805A1 (en) 2018-03-05 2019-09-12 Arcus Biosciences, Inc. Arginase inhibitors
CN117120435A (zh) * 2021-04-01 2023-11-24 小野药品工业株式会社 Abhd6拮抗剂
KR20240046089A (ko) 2022-09-30 2024-04-08 오노 야꾸힝 고교 가부시키가이샤 Abhd6 길항제를 함유하는 약학 조성물
TW202421635A (zh) 2022-09-30 2024-06-01 日商小野藥品工業股份有限公司 Abhd6拮抗劑
JP2024052624A (ja) * 2022-09-30 2024-04-11 小野薬品工業株式会社 Ａｂｈｄ６アンタゴニストを含有する医薬組成物

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JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
ATE269848T1 (de) * 1999-04-07 2004-07-15 Univ Virginia Calciumkanalblocker als antikrebsmittel
US8163769B2 (en) * 2002-03-12 2012-04-24 Abbott Laboratories Antibacterial compounds
US7223754B2 (en) * 2003-03-10 2007-05-29 Dynogen Pharmaceuticals, Inc. Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders
MXPA05009688A (es) * 2003-03-12 2005-12-05 Abbott Lab Derivados de naftiridina como agentes antibacterianos.
US7230022B2 (en) * 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
US7381738B2 (en) 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
EP1778688A1 (en) * 2004-07-22 2007-05-02 Glaxo Group Limited Antibacterial agents
DE102004039789A1 (de) * 2004-08-16 2006-03-02 Sanofi-Aventis Deutschland Gmbh Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2006113471A2 (en) 2005-04-19 2006-10-26 Merck & Co., Inc. N-alkyl-azacycloalkyl nmda/nr2b antagonists
WO2010039947A1 (en) 2008-10-02 2010-04-08 Abbott Laboratories Novel compounds as calcium channel blockers
TW201028378A (en) 2008-11-26 2010-08-01 Abbott Lab Novel substituted octahydrocyclopenta[c]pyrrol-4-amines as calcium channel blockers
WO2010068851A1 (en) 2008-12-12 2010-06-17 Vanderbilt Universtiy 3.3.0 bicyclic glyt1 inhibitors and methods of making and using same

Also Published As

Publication number Publication date
CA2742350A1 (en) 2010-06-03
WO2010062927A2 (en) 2010-06-03
PE20110833A1 (es) 2011-12-21
AU2009319796A1 (en) 2010-06-03
AU2009319796A8 (en) 2011-06-30
CN102292319A (zh) 2011-12-21
IL212484A0 (en) 2011-06-30
US8129417B2 (en) 2012-03-06
CR20110304A (es) 2011-10-27
BRPI0921184A2 (pt) 2018-03-13
WO2010062927A3 (en) 2010-07-22
RU2011126215A (ru) 2013-01-10
JP2012509940A (ja) 2012-04-26
MX2011005537A (es) 2011-06-21
KR20110091784A (ko) 2011-08-12
AR074226A1 (es) 2010-12-29
TW201028378A (en) 2010-08-01
CL2011001176A1 (es) 2011-11-11
NZ592507A (en) 2013-08-30
ECSP11011160A (es) 2011-07-29
EP2367790A2 (en) 2011-09-28
ZA201103538B (en) 2012-11-28
CO6382118A2 (es) 2012-02-15
UY32261A (es) 2010-06-30
US20100130558A1 (en) 2010-05-27

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