PA8466201A1 - Compuestos de indol 2,3-sustituidos como agentes antiinflamatorios y analgesicos - Google Patents
Compuestos de indol 2,3-sustituidos como agentes antiinflamatorios y analgesicosInfo
- Publication number
- PA8466201A1 PA8466201A1 PA19998466201A PA8466201A PA8466201A1 PA 8466201 A1 PA8466201 A1 PA 8466201A1 PA 19998466201 A PA19998466201 A PA 19998466201A PA 8466201 A PA8466201 A PA 8466201A PA 8466201 A1 PA8466201 A1 PA 8466201A1
- Authority
- PA
- Panama
- Prior art keywords
- alkyl
- halo
- substituted
- alcoxi
- indol
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000000730 antalgic agent Substances 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
ESTA INVENCION PROPORCIONA UN COMPUESTO DE LA SIGUIENTE FORMULA: (I) O LAS SALES FARMACEUTICAMENTE ACEPTABLES DEL MISMO, EN LA QUE Z ES OH, ALCOXI C1-6, -NR2R3 O HETEROCICLO; Q SE SELECCIONA ENTRE LOS SIGUIENTES: (A) FENILO OPCIONALMENTE SUSTITUIDO, (B) UN GRUPO AROMATICO MONOCICLICO DE 6 ESLABONES QUE CONTIENE UNO, DOS, TRES O CUATRO ATOMOS DE NITROGENO, (C) UN GRUPO AROMATICO MONOCICLICO DE 5 ESLABONES QUE CONTIENE UN HETEROATOMO SELECCIONADO ENTRE O, S Y N Y QUE CONTIENE OPCIONALMENTE UNO, DOS O TRES ATOMO (S) DE NITROGENO ADEMAS DE DICHO HETEROATOMO, (D) UN CICLOALQUILO C3-7 OPCIONALMENTE SUSTITUIDO Y (E) UN HETEROCICLO CONDENSADO CON BENCENO OPCIONALMENTE SUSTITUIDO; R1 ES HIDROGENO, ALQUILO C1-4 O HALO; R2 Y R3 SON, INDEPENDIENTEMENTE, HIDROGENO, OH, ALCOXI C1-4, ALQUILO C1-4 O ALQUILO C1-4 HALO-SUSTITUIDO, OH, ALCOXI C1-4, NH2, O CN; X SE SELECCIONA INDEPENDIENTEMENTE ENTRE H, HALO, ALQUILO C1-4, ALQUILO C1-4 HALO-SUSTITUIDO, OH, ALCOXI C1-4, ALCOXI C1-4 HALO-SUSTITUIDO, ALQUILTIO C1-4, NO2, NH2, DI-(ALQUIL C1-4)AMINO Y CN; Y N ES 0, 1, 2, 3, Ó 4. ESTA INVENCION TAMBIEN PROPORCIONA UNA COMPOSICION FARMACEUTICA UTIL PARA EL TRATAMIENTO DE UNA AFECCION MEDICA EN LA QUE ESTAN IMPLICADAS LAS PROSTAGLANDINAS COMO PATOGENOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB9800003 | 1998-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8466201A1 true PA8466201A1 (es) | 2000-09-29 |
Family
ID=11004645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA19998466201A PA8466201A1 (es) | 1998-01-05 | 1999-01-05 | Compuestos de indol 2,3-sustituidos como agentes antiinflamatorios y analgesicos |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US6608070B1 (es) |
| EP (1) | EP1045833B1 (es) |
| JP (1) | JP3347136B2 (es) |
| KR (1) | KR100404054B1 (es) |
| CN (1) | CN1284064A (es) |
| AP (1) | AP869A (es) |
| AR (1) | AR016977A1 (es) |
| AT (1) | ATE308519T1 (es) |
| AU (1) | AU748107B2 (es) |
| BG (1) | BG104643A (es) |
| BR (1) | BR9813124A (es) |
| CA (1) | CA2316863A1 (es) |
| CO (1) | CO4970807A1 (es) |
| DE (1) | DE69832200T2 (es) |
| DZ (1) | DZ2700A1 (es) |
| EA (1) | EA200000614A1 (es) |
| ES (1) | ES2255190T3 (es) |
| GT (1) | GT199800205A (es) |
| HN (1) | HN1997000098A (es) |
| HR (1) | HRP20000454A2 (es) |
| HU (1) | HUP0102922A3 (es) |
| ID (1) | ID24876A (es) |
| IL (1) | IL136885A0 (es) |
| IS (1) | IS5532A (es) |
| MA (1) | MA24736A1 (es) |
| NO (1) | NO20003451L (es) |
| OA (1) | OA11441A (es) |
| PA (1) | PA8466201A1 (es) |
| PE (1) | PE20000055A1 (es) |
| PL (1) | PL341696A1 (es) |
| SA (1) | SA99191299A (es) |
| SK (1) | SK9912000A3 (es) |
| TN (1) | TNSN99001A1 (es) |
| TR (1) | TR200001906T2 (es) |
| TW (1) | TW436482B (es) |
| UY (2) | UY25332A1 (es) |
| WO (1) | WO1999035130A1 (es) |
| YU (1) | YU41600A (es) |
| ZA (1) | ZA9911B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6555540B1 (en) * | 1999-06-30 | 2003-04-29 | Pfizer Inc | Combinations of aldose reductase inhibitors and selective cyclooxygenase-2 inhibitors |
| MXPA00006605A (es) * | 1999-07-02 | 2004-12-09 | Pfizer | Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos. |
| EP1065206B1 (en) * | 1999-07-02 | 2002-10-09 | Pfizer Inc. | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents |
| DE60016191T2 (de) | 1999-12-08 | 2005-12-22 | Pharmacia Corp., Chicago | Cyclooxygenase-2 hemmer enthaltende zusammensetzungen mit schnellem wirkungseintritt |
| EP1572678A4 (en) * | 2002-12-19 | 2008-05-07 | Elan Pharm Inc | SUBSTITUTED N-PHENYL SULPHONAMIDES ALSBRADYKININ ANTAGONISTS |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| EP1534305B9 (en) | 2003-05-07 | 2007-03-07 | Osteologix A/S | Treating cartilage / bone conditions with water-soluble strontium salts |
| KR100795462B1 (ko) | 2006-09-27 | 2008-01-16 | 한국생명공학연구원 | 인돌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 대사성 질환 예방 및 치료용 약학적 조성물 |
| CN101611016B (zh) | 2006-10-17 | 2012-01-25 | 斯蒂菲尔实验室公司 | 他拉罗唑代谢物 |
| US20120022121A1 (en) * | 2007-11-29 | 2012-01-26 | Dalton James T | Indoles, derivatives and analogs thereof and uses therefor |
| US8937182B2 (en) | 2010-04-19 | 2015-01-20 | Metabolic Solutions Development Company, Llc | Synthesis for thiazolidinedione compounds |
| WO2012006477A1 (en) | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP2590656B1 (en) | 2010-07-07 | 2017-11-15 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP2590655B1 (en) | 2010-07-07 | 2015-06-24 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP2590965B1 (en) | 2010-07-07 | 2016-04-20 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| CA2807815C (en) | 2010-08-10 | 2018-10-02 | Metabolic Solutions Development Company, Llc | Novel synthesis for thiazolidinedione compounds |
| US8933240B2 (en) | 2010-08-10 | 2015-01-13 | Metabolic Solutions Development Company, Llc | Synthesis for thiazolidinedione compounds |
| WO2013138600A1 (en) * | 2012-03-16 | 2013-09-19 | Rosen Eliot M | Radioprotector compounds |
| US9808443B1 (en) | 2016-11-28 | 2017-11-07 | King Saud University | Cyclooxygenase inhibitors |
| CN111004121A (zh) * | 2019-12-09 | 2020-04-14 | 南京杰运医药科技有限公司 | 一种4-烷氧基乙酰乙酸酯类化合物的制备方法 |
| CN112409281B (zh) * | 2020-08-20 | 2022-11-18 | 上海大学 | (e)-3-(3-氯-2-氟-6-(1h-四氮唑-1-基)苯基)丙烯酸的合成方法 |
| WO2022195579A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
| KR20220166745A (ko) * | 2021-06-10 | 2022-12-19 | 주식회사 아보메드 | 펜드린 억제 활성을 갖는 신규 화합물 및 이의 의약 용도 |
| CN116262721A (zh) * | 2023-01-12 | 2023-06-16 | 浙江师范大学 | 一种二氢吲哚衍生物及吲哚衍生物的制备方法及产品 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510368A (en) * | 1995-05-22 | 1996-04-23 | Merck Frosst Canada, Inc. | N-benzyl-3-indoleacetic acids as antiinflammatory drugs |
| US5604253A (en) * | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
| CO5190664A1 (es) * | 1999-06-30 | 2002-08-29 | Pfizer Prod Inc | Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2 |
-
1998
- 1998-12-17 AP APAP/P/1998/001423A patent/AP869A/en active
- 1998-12-18 US US09/355,494 patent/US6608070B1/en not_active Expired - Fee Related
- 1998-12-18 EP EP98959082A patent/EP1045833B1/en not_active Expired - Lifetime
- 1998-12-18 IL IL13688598A patent/IL136885A0/xx unknown
- 1998-12-18 HU HU0102922A patent/HUP0102922A3/hu unknown
- 1998-12-18 YU YU41600A patent/YU41600A/sh unknown
- 1998-12-18 DE DE69832200T patent/DE69832200T2/de not_active Expired - Fee Related
- 1998-12-18 AU AU15005/99A patent/AU748107B2/en not_active Ceased
- 1998-12-18 EA EA200000614A patent/EA200000614A1/ru unknown
- 1998-12-18 CA CA002316863A patent/CA2316863A1/en not_active Abandoned
- 1998-12-18 BR BR9813124-9A patent/BR9813124A/pt not_active IP Right Cessation
- 1998-12-18 KR KR10-2000-7007419A patent/KR100404054B1/ko not_active Expired - Fee Related
- 1998-12-18 WO PCT/IB1998/002065 patent/WO1999035130A1/en not_active Ceased
- 1998-12-18 ID IDW20001286A patent/ID24876A/id unknown
- 1998-12-18 CN CN98813530A patent/CN1284064A/zh active Pending
- 1998-12-18 AT AT98959082T patent/ATE308519T1/de not_active IP Right Cessation
- 1998-12-18 SK SK991-2000A patent/SK9912000A3/sk unknown
- 1998-12-18 ES ES98959082T patent/ES2255190T3/es not_active Expired - Lifetime
- 1998-12-18 PL PL98341696A patent/PL341696A1/xx unknown
- 1998-12-18 HR HR20000454A patent/HRP20000454A2/hr not_active Application Discontinuation
- 1998-12-18 TR TR2000/01906T patent/TR200001906T2/xx unknown
- 1998-12-18 JP JP2000527531A patent/JP3347136B2/ja not_active Expired - Fee Related
- 1998-12-22 TW TW087120865A patent/TW436482B/zh active
- 1998-12-28 HN HN1997000098A patent/HN1997000098A/es unknown
- 1998-12-28 PE PE1998001288A patent/PE20000055A1/es not_active Application Discontinuation
- 1998-12-29 GT GT199800205A patent/GT199800205A/es unknown
- 1998-12-30 CO CO98077588A patent/CO4970807A1/es unknown
- 1998-12-31 UY UY25332A patent/UY25332A1/es not_active IP Right Cessation
-
1999
- 1999-01-04 AR ARP990100010A patent/AR016977A1/es not_active Application Discontinuation
- 1999-01-04 ZA ZA9900011A patent/ZA9911B/xx unknown
- 1999-01-04 MA MA25414A patent/MA24736A1/fr unknown
- 1999-01-04 DZ DZ990001A patent/DZ2700A1/xx active
- 1999-01-04 TN TNTNSN99001A patent/TNSN99001A1/fr unknown
- 1999-01-05 PA PA19998466201A patent/PA8466201A1/es unknown
- 1999-04-13 SA SA99191299A patent/SA99191299A/ar unknown
- 1999-06-28 UY UY25590A patent/UY25590A1/es not_active Application Discontinuation
-
2000
- 2000-06-13 IS IS5532A patent/IS5532A/is unknown
- 2000-06-30 OA OA1200000195A patent/OA11441A/en unknown
- 2000-07-04 NO NO20003451A patent/NO20003451L/no unknown
- 2000-07-28 BG BG104643A patent/BG104643A/bg unknown
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