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GT199800205A - Compuestos de indol 2,3-sustituidos como agentes anti-inflamatorios y analgesicos. - Google Patents

Compuestos de indol 2,3-sustituidos como agentes anti-inflamatorios y analgesicos.

Info

Publication number
GT199800205A
GT199800205A GT199800205A GT199800205A GT199800205A GT 199800205 A GT199800205 A GT 199800205A GT 199800205 A GT199800205 A GT 199800205A GT 199800205 A GT199800205 A GT 199800205A GT 199800205 A GT199800205 A GT 199800205A
Authority
GT
Guatemala
Prior art keywords
indol
inflammatory
substituted compounds
analgesic agents
compounds
Prior art date
Application number
GT199800205A
Other languages
English (en)
Inventor
Kazunari Nakao
Rodney William Stevens
Kiyoshi Kawamura
Chikara Uchida
Hiroki Koike
Stephane Caron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199800205A publication Critical patent/GT199800205A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVOS INDOLES 2,3SUSTITUIDOS COMO AGENTES FARMACEUTICOS. ESTA INVENCION SE REFIERE ESPECIFICAMENTE A COMPUESTOS, COMPOSICIONES Y PROCEDIMIENTOS PARA EL TRATAMIENTO O ALIVIO DEL DOLOR Y LA INFLAMACION, Y DE OTROS TRASTORNOS ASOCIADOS CON LA INFLAMACION, TALES COMO LA ARTRITIS. ESTOS COMPUESTOS POSEEN LA ESTRUCTURA QUIMICA (I), EN LA QUE Q, R1, X & Z, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE.
GT199800205A 1998-01-05 1998-12-29 Compuestos de indol 2,3-sustituidos como agentes anti-inflamatorios y analgesicos. GT199800205A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9800003 1998-01-05

Publications (1)

Publication Number Publication Date
GT199800205A true GT199800205A (es) 2000-06-21

Family

ID=11004645

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199800205A GT199800205A (es) 1998-01-05 1998-12-29 Compuestos de indol 2,3-sustituidos como agentes anti-inflamatorios y analgesicos.

Country Status (39)

Country Link
US (1) US6608070B1 (es)
EP (1) EP1045833B1 (es)
JP (1) JP3347136B2 (es)
KR (1) KR100404054B1 (es)
CN (1) CN1284064A (es)
AP (1) AP869A (es)
AR (1) AR016977A1 (es)
AT (1) ATE308519T1 (es)
AU (1) AU748107B2 (es)
BG (1) BG104643A (es)
BR (1) BR9813124A (es)
CA (1) CA2316863A1 (es)
CO (1) CO4970807A1 (es)
DE (1) DE69832200T2 (es)
DZ (1) DZ2700A1 (es)
EA (1) EA200000614A1 (es)
ES (1) ES2255190T3 (es)
GT (1) GT199800205A (es)
HN (1) HN1997000098A (es)
HR (1) HRP20000454A2 (es)
HU (1) HUP0102922A3 (es)
ID (1) ID24876A (es)
IL (1) IL136885A0 (es)
IS (1) IS5532A (es)
MA (1) MA24736A1 (es)
NO (1) NO20003451L (es)
OA (1) OA11441A (es)
PA (1) PA8466201A1 (es)
PE (1) PE20000055A1 (es)
PL (1) PL341696A1 (es)
SA (1) SA99191299A (es)
SK (1) SK9912000A3 (es)
TN (1) TNSN99001A1 (es)
TR (1) TR200001906T2 (es)
TW (1) TW436482B (es)
UY (2) UY25332A1 (es)
WO (1) WO1999035130A1 (es)
YU (1) YU41600A (es)
ZA (1) ZA9911B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555540B1 (en) * 1999-06-30 2003-04-29 Pfizer Inc Combinations of aldose reductase inhibitors and selective cyclooxygenase-2 inhibitors
PT1065206E (pt) * 1999-07-02 2003-01-31 Pfizer Compostos de tetrazolilalquilindole e como agentes anti-inflamatorios e analgesicos
MXPA00006605A (es) * 1999-07-02 2004-12-09 Pfizer Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
IL144760A0 (en) 1999-12-08 2002-06-30 Pharmacia Corp Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect
WO2004056319A2 (en) * 2002-12-19 2004-07-08 Elan Pharmaceuticals Inc. Substituted n-phenyl sulfonamide bradykinin antagonists
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
ES2275218T3 (es) 2003-05-07 2007-06-01 Osteologix A/S Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos.
KR100795462B1 (ko) * 2006-09-27 2008-01-16 한국생명공학연구원 인돌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 대사성 질환 예방 및 치료용 약학적 조성물
MX2009004096A (es) 2006-10-17 2009-06-16 Stiefel Laboratories Metabolitos de talarozol.
US20120022121A1 (en) * 2007-11-29 2012-01-26 Dalton James T Indoles, derivatives and analogs thereof and uses therefor
MX2012012092A (es) * 2010-04-19 2012-12-17 Metabolic Solutions Dev Co Llc Sintesis novedosa para compuestos de tiazolidinadiona.
EP2590656B1 (en) 2010-07-07 2017-11-15 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
EP2590655B1 (en) * 2010-07-07 2015-06-24 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2012006474A2 (en) 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
JP5827328B2 (ja) 2010-07-07 2015-12-02 アーデリクス,インコーポレーテッド リン酸輸送を阻害する化合物及び方法
HUE031424T2 (en) 2010-08-10 2017-07-28 Octeta Therapeutics Llc New synthesis of thiazolidinedione compounds
HUE029488T2 (en) 2010-08-10 2017-02-28 Metabolic Solutions Dev Co Llc Synthesis of Thiazolidinedione Compounds
WO2013138600A1 (en) * 2012-03-16 2013-09-19 Rosen Eliot M Radioprotector compounds
US9808443B1 (en) 2016-11-28 2017-11-07 King Saud University Cyclooxygenase inhibitors
CN111004121A (zh) * 2019-12-09 2020-04-14 南京杰运医药科技有限公司 一种4-烷氧基乙酰乙酸酯类化合物的制备方法
CN112409281B (zh) * 2020-08-20 2022-11-18 上海大学 (e)-3-(3-氯-2-氟-6-(1h-四氮唑-1-基)苯基)丙烯酸的合成方法
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar HYALURONIC ACID-CONJUGATED DIPALMITOYL PHOSPHATIDYL ETHANOLAMINE IN COMBINATION WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) FOR TREATING OR ALLEVIATING INFLAMMATORY DISEASES
JP7759065B2 (ja) * 2021-06-10 2025-10-23 延世大学校 産学協力団 ペンドリン抑制活性を有する新規化合物およびその医薬用途
CN116262721A (zh) * 2023-01-12 2023-06-16 浙江师范大学 一种二氢吲哚衍生物及吲哚衍生物的制备方法及产品

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5604253A (en) * 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
US5510368A (en) * 1995-05-22 1996-04-23 Merck Frosst Canada, Inc. N-benzyl-3-indoleacetic acids as antiinflammatory drugs
CO5190664A1 (es) * 1999-06-30 2002-08-29 Pfizer Prod Inc Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2

Also Published As

Publication number Publication date
PA8466201A1 (es) 2000-09-29
YU41600A (sh) 2003-08-29
PE20000055A1 (es) 2000-02-08
EP1045833A1 (en) 2000-10-25
SA99191299A (ar) 2005-12-03
ATE308519T1 (de) 2005-11-15
CA2316863A1 (en) 1999-07-15
EA200000614A1 (ru) 2001-02-26
JP2002500217A (ja) 2002-01-08
ID24876A (id) 2000-08-31
OA11441A (en) 2004-04-27
TR200001906T2 (tr) 2001-01-22
AU748107B2 (en) 2002-05-30
UY25590A1 (es) 1999-09-27
WO1999035130A1 (en) 1999-07-15
DE69832200D1 (de) 2005-12-08
ZA9911B (en) 2000-07-04
UY25332A1 (es) 2001-01-31
PL341696A1 (en) 2001-04-23
JP3347136B2 (ja) 2002-11-20
KR20010033859A (ko) 2001-04-25
IS5532A (is) 2000-06-13
HN1997000098A (es) 1998-12-28
AU1500599A (en) 1999-07-26
HUP0102922A2 (hu) 2001-12-28
EP1045833B1 (en) 2005-11-02
ES2255190T3 (es) 2006-06-16
DE69832200T2 (de) 2006-04-20
CO4970807A1 (es) 2000-11-07
SK9912000A3 (en) 2001-11-06
NO20003451D0 (no) 2000-07-04
TNSN99001A1 (fr) 2005-11-10
AR016977A1 (es) 2001-08-01
BR9813124A (pt) 2000-10-10
AP869A (en) 2000-09-04
HUP0102922A3 (en) 2003-06-30
BG104643A (bg) 2001-02-28
CN1284064A (zh) 2001-02-14
TW436482B (en) 2001-05-28
HRP20000454A2 (en) 2001-04-30
MA24736A1 (fr) 1999-10-01
US6608070B1 (en) 2003-08-19
KR100404054B1 (ko) 2003-11-01
IL136885A0 (en) 2001-06-14
DZ2700A1 (fr) 2003-09-01
NO20003451L (no) 2000-09-01
AP9801423A0 (en) 1998-12-31

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